inositol has been researched along with Neuroblastoma in 50 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We used a human neuroblastoma cell line, SH-SY5Y, to investigate the effect of cilostazol, a specific cAMP phosphodiesterase inhibitor, on NO production and Na+, K+-ATPase activity." | 7.70 | Cilostazol, a cyclic AMP phosphodiesterase inhibitor, stimulates nitric oxide production and sodium potassium adenosine triphosphatase activity in SH-SY5Y human neuroblastoma cells. ( Inada, H; Onaya, T; Shindo, H; Tawata, M, 1999) |
| "Administration of myo-[3H]inositol to SK-N-BE(2) human neuroblastoma cells for 24 hr resulted in equilibrium labelling of phosphatidylinositol (PI), phosphatidylinositol 4-phosphate (PIP) and phosphatidylinositol 4,5-bisphosphate (PIP2), as well as in retention of a large intracellular pool of free myo-[3H]inositol." | 7.69 | Effects of perphenazine on the metabolism of inositol phospholipids in SK-N-BE(2) human neuroblastoma cells. ( Limatola, C; Pacini, L; Palma, E; Spinedi, A, 1994) |
| "The incorporation of [3H]serine into lipids, water-soluble metabolites and proteins by the human neuroblastoma cell line LA-N-1 exposed to oxotremorine-M, a muscarinic agonist, was investigated." | 7.69 | Modulation of phosphatidylserine synthesis by a muscarinic receptor occupancy in human neuroblastoma cell line LA-N-1. ( Kanfer, JN; Massarelli, R; Mikhaevitch, IS; Singh, IN; Sorrentino, G, 1994) |
| " Neuroblastoma cells were cultured for two weeks in media containing 30 mM glucose, fructose, galactose or mannose with or without 0." | 7.69 | Reduced Na+/K+ ATPase transport activity, resting membrane potential, and bradykinin-stimulated phosphatidylinositol synthesis by polyol accumulation in cultured neuroblastoma cells. ( Davidson, EP; Dunlap, JA; Stefani, MR; Yorek, MA, 1994) |
| "myo-Inositol uptake by culture neuroblastoma cells at a concentration of myo-inositol less than 50 microM was largely Na+ dependent." | 7.68 | Restoration of Na(+)-K+ pump activity and resting membrane potential by myo-inositol supplementation in neuroblastoma cells chronically exposed to glucose or galactose. ( Dunlap, JA; Stefani, MR; Yorek, MA, 1991) |
| "myo-Inositol accumulation and incorporation into phosphoinositides was decreased in neuroblastoma cells chronically exposed to medium containing 30 mmol/L glucose or 30 mmol/L galactose." | 7.68 | Reversal of hyperglycemic-induced defects in myo-inositol metabolism and Na+/K+ pump activity in cultured neuroblastoma cells by normalizing glucose levels. ( Davidson, EP; Dunlap, JA; Stefani, MR; Yorek, MA, 1993) |
| "Neuroblastoma cells were used to examine the effect of high concentrations of glucose or galactose and accumulation of polyols on the resting membrane potential." | 7.68 | Resting membrane potential in 41A3 mouse neuroblastoma cells. Effect of increased glucose and galactose concentrations. ( Dunlap, JA; Yorek, MA, 1991) |
| "Electrically permeabilised [3H]inositol-labelled SH-SY5Y human neuroblastoma cells were employed to examine the effects of two synthetic, phosphatase-resistant analogues of inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] on the metabolism of cell membrane-derived [3H]Ins(1,4,5)P3 or exogenous [5-32P]Ins(1,4,4)P3." | 7.68 | Inhibition of inositol 1,4,5-trisphosphate metabolism in permeabilised SH-SY5Y human neuroblastoma cells by a phosphorothioate-containing analogue of inositol 1,4,5-trisphosphate. ( Cooke, AM; Nahorski, SR; Potter, BV; Wojcikiewicz, RJ, 1990) |
| "Inositol uptake was studied in the rat CNS neuroblastoma B50 cell line." | 7.68 | Inositol metabolism during neuroblastoma B50 cell differentiation: effects of differentiating agents on inositol uptake. ( Reboulleau, CP, 1990) |
| "To investigate the timing of inositol lipid turnover in relation to the cell cycle, inositol phosphates and lipids were measured in neuroblastoma (Neuro-2A) cells that were prelabeled with [3H]inositol and synchronized by a mitotic shakeoff technique." | 7.67 | Cell cycle dependence of inositol phosphate levels in neuroblastoma cells. ( Cantley, L; Fleischman, LF, 1988) |
| "myo-Inositol uptake was investigated in a murine neuroblastoma clone (N1E-115) to determine the effect of altered Na+,K+-ATPase activity." | 7.67 | Acute changes in myo-inositol uptake and 22Na+ flux in murine neuroblastoma cells (N1E-115) following insulin. ( Dimitriadis, E; Dunlop, M; Larkins, RG, 1987) |
| "Neuroblastoma cells were used to determine the effect of high carbohydrate and polyol levels on myo-inositol metabolism." | 7.67 | myo-Inositol metabolism in 41A3 neuroblastoma cells: effects of high glucose and sorbitol levels. ( Dunlap, JA; Ginsberg, BH; Yorek, MA, 1987) |
| "Murine neuroblastoma cells (clone N1E-115) possess neurotensin receptors that mediate cyclic GMP synthesis." | 7.67 | Neurotensin stimulates inositol phospholipid metabolism and calcium mobilization in murine neuroblastoma clone N1E-115. ( Forray, C; Pfenning, M; Richelson, E; Snider, RM, 1986) |
| "Neuroblastoma cells were used to analyze the effect of galactose supplementation on myo-inositol metabolism, polyol accumulation, and Na+-K+ pump activity." | 7.67 | Effect of galactose and glucose levels and sorbinil treatment on myo-inositol metabolism and Na+-K+ pump activity in cultured neuroblastoma cells. ( Dunlap, JA; Leeney, EM; Yorek, MA, 1989) |
| "Neuroblastoma cells were used to determine the effect of sorbinil on myo-inositol metabolism in cells exposed to elevated levels of glucose in culture." | 7.67 | Effect of sorbinil on myo-inositol metabolism in cultured neuroblastoma cells exposed to increased glucose levels. ( Dunlap, JA; Ginsberg, BH; Yorek, MA, 1988) |
| "We have examined the effects of phorbol esters on phosphatidylcholine (PtdCho) metabolism in the neuroblastoma-glioma hybrid cell line NG108-15." | 7.67 | Phosphatidylcholine biosynthesis in the neuroblastoma-glioma hybrid cell line NG108-15: stimulation by phorbol esters. ( Blusztajn, JK; Freese, A; Liscovitch, M; Wurtman, RJ, 1986) |
| "myo-Inositol (mI) is a key metabolic precursor to the phospoinositide (PI) metabolic pathway as a key component of central G-protein coupled receptor signaling systems, including several subtypes of adrenergic, cholinergic, serotonergic and metabotropic glutamatergic receptors." | 5.32 | Effects of myo-inositol versus fluoxetine and imipramine pretreatments on serotonin 5HT2A and muscarinic acetylcholine receptors in human neuroblastoma cells. ( Brink, CB; de Kock, SE; Harvey, BH; Stein, DJ; Viljoen, SL, 2004) |
| " The dose-response curve for this suppression was very similar to that for stimulation of inositol monophosphate (IP1) formation and for stimulation of the initial rise of [Ca2+]i elicited by carbachol." | 5.28 | Suppressive effect of carbachol on forskolin-stimulated neurite outgrowth in human neuroblastoma NB-OK1 cells. ( Nakagawa-Yagi, Y; Nakamura, H; Saito, Y; Takada, Y, 1992) |
| " We used a human neuroblastoma cell line, SH-SY5Y, to investigate the effect of cilostazol, a specific cAMP phosphodiesterase inhibitor, on NO production and Na+, K+-ATPase activity." | 3.70 | Cilostazol, a cyclic AMP phosphodiesterase inhibitor, stimulates nitric oxide production and sodium potassium adenosine triphosphatase activity in SH-SY5Y human neuroblastoma cells. ( Inada, H; Onaya, T; Shindo, H; Tawata, M, 1999) |
| "The incorporation of [3H]serine into lipids, water-soluble metabolites and proteins by the human neuroblastoma cell line LA-N-1 exposed to oxotremorine-M, a muscarinic agonist, was investigated." | 3.69 | Modulation of phosphatidylserine synthesis by a muscarinic receptor occupancy in human neuroblastoma cell line LA-N-1. ( Kanfer, JN; Massarelli, R; Mikhaevitch, IS; Singh, IN; Sorrentino, G, 1994) |
| "Administration of myo-[3H]inositol to SK-N-BE(2) human neuroblastoma cells for 24 hr resulted in equilibrium labelling of phosphatidylinositol (PI), phosphatidylinositol 4-phosphate (PIP) and phosphatidylinositol 4,5-bisphosphate (PIP2), as well as in retention of a large intracellular pool of free myo-[3H]inositol." | 3.69 | Effects of perphenazine on the metabolism of inositol phospholipids in SK-N-BE(2) human neuroblastoma cells. ( Limatola, C; Pacini, L; Palma, E; Spinedi, A, 1994) |
| " Neuroblastoma cells were cultured for two weeks in media containing 30 mM glucose, fructose, galactose or mannose with or without 0." | 3.69 | Reduced Na+/K+ ATPase transport activity, resting membrane potential, and bradykinin-stimulated phosphatidylinositol synthesis by polyol accumulation in cultured neuroblastoma cells. ( Davidson, EP; Dunlap, JA; Stefani, MR; Yorek, MA, 1994) |
| " Despite rapid increases in internal Ins(1,4,5)P3 levels after stimulation with 1 mM carbachol, there was no change in external levels in both rat brain cortical slices and human neuroblastoma SH-SY5Y cells." | 3.69 | Studies of inositol phosphate export from neuronal tissue in vitro. ( Kendall, DA; Marsden, CA; Roberts, RE, 1997) |
| "myo-Inositol accumulation and incorporation into phosphoinositides was decreased in neuroblastoma cells chronically exposed to medium containing 30 mmol/L glucose or 30 mmol/L galactose." | 3.68 | Reversal of hyperglycemic-induced defects in myo-inositol metabolism and Na+/K+ pump activity in cultured neuroblastoma cells by normalizing glucose levels. ( Davidson, EP; Dunlap, JA; Stefani, MR; Yorek, MA, 1993) |
| "Cultured neuroblastoma, cerebral microvessel endothelial, and retinoblastoma cells were used to examine the mechanism of acute inhibition by D-glucose of myo-inositol uptake." | 3.68 | Trans-hydroxyl group configuration on carbons 2 and 3 of glucose. Responsible for acute inhibition of myo-inositol transport? ( Davidson, EP; Dunlap, JA; Ro, KS; Stefani, MR; Yorek, MA, 1991) |
| "Inositol uptake was studied in the rat CNS neuroblastoma B50 cell line." | 3.68 | Inositol metabolism during neuroblastoma B50 cell differentiation: effects of differentiating agents on inositol uptake. ( Reboulleau, CP, 1990) |
| "Electrically permeabilised [3H]inositol-labelled SH-SY5Y human neuroblastoma cells were employed to examine the effects of two synthetic, phosphatase-resistant analogues of inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] on the metabolism of cell membrane-derived [3H]Ins(1,4,5)P3 or exogenous [5-32P]Ins(1,4,4)P3." | 3.68 | Inhibition of inositol 1,4,5-trisphosphate metabolism in permeabilised SH-SY5Y human neuroblastoma cells by a phosphorothioate-containing analogue of inositol 1,4,5-trisphosphate. ( Cooke, AM; Nahorski, SR; Potter, BV; Wojcikiewicz, RJ, 1990) |
| "Neuroblastoma cells were used to examine the effect of high concentrations of glucose or galactose and accumulation of polyols on the resting membrane potential." | 3.68 | Resting membrane potential in 41A3 mouse neuroblastoma cells. Effect of increased glucose and galactose concentrations. ( Dunlap, JA; Yorek, MA, 1991) |
| " Beryllium has been identified as a potent inhibitor of partially purified myo-inositol monophosphatase isolated from rat brain (Ki = 150 nM), bovine brain (Ki = 35 nM), and from the human neuroblastoma cell line SK-N-SH (Ki = 85 nM)." | 3.68 | Beryllium competitively inhibits brain myo-inositol monophosphatase, but unlike lithium does not enhance agonist-induced inositol phosphate accumulation. ( Bakker, AV; Faraci, WS; Jackson, E; Pratt, K; Zorn, SH, 1993) |
| "Previous studies have shown that in the neuroblastoma x glioma hybrid cell line NG108-15 lithium is able to induce an increase in diacylglycerol levels." | 3.68 | Elevated phosphatidyl-CMP is not the source of diacylglycerol accumulation induced by lithium in NG108-15 cells. ( Brami, BA; Hauser, G; Leli, U, 1993) |
| "Neuroblastoma cells were used to analyze the effect of galactose supplementation on myo-inositol metabolism, polyol accumulation, and Na+-K+ pump activity." | 3.67 | Effect of galactose and glucose levels and sorbinil treatment on myo-inositol metabolism and Na+-K+ pump activity in cultured neuroblastoma cells. ( Dunlap, JA; Leeney, EM; Yorek, MA, 1989) |
| "Accumulation of inositol phosphates in NG108-15 neuroblastoma x glioma hybrid cells, pre-labeled for 24h to equilibrium, was stimulated by bradykinin, guanosine 5'-O-(3-thiotriphosphate) and the diacylglycerol kinase inhibitor R59022." | 3.67 | Effects of bradykinin, GTP gamma S, R59022 and N-ethylmaleimide on inositol phosphate production in NG108-15 cells. ( Chiang, CF; Hauser, G, 1989) |
| "Neuroblastoma cells were used to analyze the effect of elevated glucose levels on myo-inositol metabolism and Na+/K+-pump activity." | 3.67 | Effect of increased glucose levels on Na+/K+-pump activity in cultured neuroblastoma cells. ( Dunlap, JA; Ginsberg, BH; Yorek, MA, 1988) |
| "Bradykinin analogues with specific antagonist activity in several bioassays were evaluated for effects on [3H]-bradykinin receptor binding sites and inositol phosphate production in neuroblastoma N1E-115 cells." | 3.67 | Bradykinin analogues: differential agonist and antagonist activities suggesting multiple receptors. ( Braas, KM; Manning, DC; Perry, DC; Snyder, SH, 1988) |
| "Murine neuroblastoma cells (clone N1E-115) possess neurotensin receptors that mediate cyclic GMP synthesis." | 3.67 | Neurotensin stimulates inositol phospholipid metabolism and calcium mobilization in murine neuroblastoma clone N1E-115. ( Forray, C; Pfenning, M; Richelson, E; Snider, RM, 1986) |
| "Neuroblastoma cells were used to determine the effect of high carbohydrate and polyol levels on myo-inositol metabolism." | 3.67 | myo-Inositol metabolism in 41A3 neuroblastoma cells: effects of high glucose and sorbitol levels. ( Dunlap, JA; Ginsberg, BH; Yorek, MA, 1987) |
| "To investigate the timing of inositol lipid turnover in relation to the cell cycle, inositol phosphates and lipids were measured in neuroblastoma (Neuro-2A) cells that were prelabeled with [3H]inositol and synchronized by a mitotic shakeoff technique." | 3.67 | Cell cycle dependence of inositol phosphate levels in neuroblastoma cells. ( Cantley, L; Fleischman, LF, 1988) |
| "Neuroblastoma cells were used to determine the effect of sorbinil on myo-inositol metabolism in cells exposed to elevated levels of glucose in culture." | 3.67 | Effect of sorbinil on myo-inositol metabolism in cultured neuroblastoma cells exposed to increased glucose levels. ( Dunlap, JA; Ginsberg, BH; Yorek, MA, 1988) |
| "The uptake of myo-[2-3H]inositol by mouse neuroblastoma, human Y79 retinoblastoma, human HL60, and bovine pulmonary artery endothelial cells occurs by a saturable, Na+-dependent and partially energy-dependent mechanism." | 3.67 | Myoinositol uptake by four cultured mammalian cell lines. ( Dunlap, JA; Ginsberg, BH; Yorek, MA, 1986) |
| "We have examined the effects of phorbol esters on phosphatidylcholine (PtdCho) metabolism in the neuroblastoma-glioma hybrid cell line NG108-15." | 3.67 | Phosphatidylcholine biosynthesis in the neuroblastoma-glioma hybrid cell line NG108-15: stimulation by phorbol esters. ( Blusztajn, JK; Freese, A; Liscovitch, M; Wurtman, RJ, 1986) |
| "Phosphoinositide and inositol metabolism was compared in glioma (C6), neuroblastoma (N1E-115) and neuroblastoma X glioma hybrid (NG 108-15) cells." | 3.67 | Differences in the metabolism of inositol and phosphoinositides by cultured cells of neuronal and glial origin. ( Byers, DM; Cook, HW; Glanville, NT; Palmer, FB; Spence, MW, 1989) |
| "Inositol is an essential metabolite that serves as a precursor for inositol lipids and inositol phosphates." | 1.42 | Inositol synthesis regulates the activation of GSK-3α in neuronal cells. ( Greenberg, ML; Ye, C, 2015) |
| "myo-Inositol (mI) is a key metabolic precursor to the phospoinositide (PI) metabolic pathway as a key component of central G-protein coupled receptor signaling systems, including several subtypes of adrenergic, cholinergic, serotonergic and metabotropic glutamatergic receptors." | 1.32 | Effects of myo-inositol versus fluoxetine and imipramine pretreatments on serotonin 5HT2A and muscarinic acetylcholine receptors in human neuroblastoma cells. ( Brink, CB; de Kock, SE; Harvey, BH; Stein, DJ; Viljoen, SL, 2004) |
| "myo-Inositol plays a key role in signal transduction and osmotic regulation events in the CNS." | 1.30 | Differentiated human NT2-N neurons possess a high intracellular content of myo-inositol. ( Agranoff, BW; Fisher, SK; Novak, JE; Turner, RS, 1999) |
| "Gaucher disease is the most common lysosomal glycosphingolipid storage disease; decreased activity of glucosylceramide beta-glucosidase (GCase) results in the accumulation of glucocerebroside (GlcCer) in macrophage-derived cells." | 1.29 | In vitro accumulation of glucocerebroside in neuroblastoma cells: a model for study of Gaucher disease pathobiology. ( Chaturvedi, P; Newburg, DS; Prence, EM, 1996) |
| " The dose-response curve for this suppression was very similar to that for stimulation of inositol monophosphate (IP1) formation and for stimulation of the initial rise of [Ca2+]i elicited by carbachol." | 1.28 | Suppressive effect of carbachol on forskolin-stimulated neurite outgrowth in human neuroblastoma NB-OK1 cells. ( Nakagawa-Yagi, Y; Nakamura, H; Saito, Y; Takada, Y, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (30.00) | 18.7374 |
| 1990's | 30 (60.00) | 18.2507 |
| 2000's | 4 (8.00) | 29.6817 |
| 2010's | 1 (2.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ye, C | 1 |
| Greenberg, ML | 1 |
| Vekrellis, K | 1 |
| Xilouri, M | 1 |
| Emmanouilidou, E | 1 |
| Stefanis, L | 1 |
| Manning-Boğ, AB | 1 |
| Schüle, B | 1 |
| Langston, JW | 1 |
| Loveday, D | 1 |
| Heacock, AM | 1 |
| Fisher, SK | 3 |
| Brink, CB | 1 |
| Viljoen, SL | 1 |
| de Kock, SE | 1 |
| Stein, DJ | 1 |
| Harvey, BH | 1 |
| Singh, IN | 2 |
| McCartney, DG | 1 |
| Kanfer, JN | 2 |
| Gyngell, ML | 1 |
| Els, T | 1 |
| Hoehn-Berlage, M | 1 |
| Hossmann, KA | 1 |
| Pacini, L | 2 |
| Limatola, C | 2 |
| Palma, E | 1 |
| Spinedi, A | 2 |
| Mikhaevitch, IS | 1 |
| Sorrentino, G | 1 |
| Massarelli, R | 1 |
| Yorek, MA | 14 |
| Dunlap, JA | 13 |
| Stefani, MR | 7 |
| Davidson, EP | 5 |
| Zhu, X | 1 |
| Eichberg, J | 1 |
| Faraci, WS | 1 |
| Zorn, SH | 1 |
| Bakker, AV | 1 |
| Jackson, E | 1 |
| Pratt, K | 1 |
| Dunlap, J | 1 |
| Stefani, M | 1 |
| Davidson, E | 1 |
| Brami, BA | 1 |
| Leli, U | 1 |
| Hauser, G | 2 |
| Stubbs, EB | 1 |
| Agranoff, BW | 2 |
| Shindo, H | 2 |
| Thomas, TP | 1 |
| Larkin, DD | 1 |
| Karihaloo, AK | 1 |
| Inada, H | 2 |
| Onaya, T | 2 |
| Stevens, MJ | 1 |
| Greene, DA | 1 |
| Prence, EM | 1 |
| Chaturvedi, P | 1 |
| Newburg, DS | 1 |
| Roberts, RE | 1 |
| Marsden, CA | 1 |
| Kendall, DA | 1 |
| Novak, JE | 1 |
| Turner, RS | 1 |
| Tawata, M | 1 |
| Yuan, P | 1 |
| Chen, G | 1 |
| Manji, HK | 1 |
| Nakagawa-Yagi, Y | 1 |
| Saito, Y | 1 |
| Takada, Y | 1 |
| Nakamura, H | 1 |
| Luly, P | 1 |
| Thompson, AK | 1 |
| Mostafapour, SP | 1 |
| Denlinger, LC | 1 |
| Bleasdale, JE | 1 |
| Ro, KS | 1 |
| Lambert, DG | 1 |
| Challiss, RA | 1 |
| Nahorski, SR | 2 |
| Leeney, EM | 2 |
| Ponzoni, M | 1 |
| Lanciotti, M | 1 |
| Reboulleau, CP | 1 |
| Wojcikiewicz, RJ | 1 |
| Cooke, AM | 1 |
| Potter, BV | 1 |
| Carrithers, MD | 1 |
| Raman, VK | 1 |
| Masuda, S | 1 |
| Weyhenmeyer, JA | 1 |
| Glanville, NT | 1 |
| Byers, DM | 1 |
| Cook, HW | 1 |
| Spence, MW | 1 |
| Palmer, FB | 1 |
| Chiang, CF | 1 |
| Jackson, TR | 1 |
| Patterson, SI | 1 |
| Wong, YH | 1 |
| Hanley, MR | 1 |
| Ehrlich, YH | 1 |
| Snider, RM | 2 |
| Kornecki, E | 1 |
| Garfield, MG | 1 |
| Lenox, RH | 1 |
| Ginsberg, BH | 4 |
| Braas, KM | 1 |
| Manning, DC | 1 |
| Perry, DC | 1 |
| Snyder, SH | 1 |
| Forray, C | 1 |
| Pfenning, M | 1 |
| Richelson, E | 1 |
| Dunlop, ME | 1 |
| Hill, MA | 1 |
| Larkins, RG | 2 |
| Fleischman, LF | 1 |
| Cantley, L | 1 |
| Dunlop, M | 1 |
| Dimitriadis, E | 1 |
| Liscovitch, M | 1 |
| Freese, A | 1 |
| Blusztajn, JK | 1 |
| Wurtman, RJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ambroxol as a Novel Disease Modifying Treatment for Lewy Body Dementia[NCT04405596] | Phase 1/Phase 2 | 15 participants (Anticipated) | Interventional | 2025-01-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
50 other studies available for inositol and Neuroblastoma
| Article | Year |
|---|---|
Inositol synthesis regulates the activation of GSK-3α in neuronal cells.
Topics: Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expr | 2015 |
Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death.
Topics: alpha-Synuclein; Amino Acid Chloromethyl Ketones; Apoptosis; bcl-X Protein; Caspases; Cell Different | 2009 |
Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism.
Topics: alpha-Synuclein; Analysis of Variance; Animals; Cell Differentiation; Disease Models, Animal; Dose-R | 2009 |
Activation of muscarinic cholinergic receptors enhances the volume-sensitive efflux of myo-inositol from SH-SY5Y neuroblastoma cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Calcium; Humans; Inositol; Ion Channels; Muscarini | 2003 |
Effects of myo-inositol versus fluoxetine and imipramine pretreatments on serotonin 5HT2A and muscarinic acetylcholine receptors in human neuroblastoma cells.
Topics: Adrenergic Uptake Inhibitors; Androstadienes; Atropine; Cell Line, Tumor; Enzyme Inhibitors; Estrene | 2004 |
Amyloid beta protein (25-35) stimulation of phospholipases A, C and D activities of LA-N-2 cells.
Topics: Amyloid beta-Peptides; Bombesin; Cell Line; Enzyme Activation; Humans; Inositol; Inositol Phosphates | 1995 |
Proton MR spectroscopy of experimental brain tumors in vivo.
Topics: Animals; Aspartic Acid; Blood Glucose; Brain Edema; Brain Neoplasms; Caudate Nucleus; Cell Line; Cho | 1994 |
Effects of perphenazine on the metabolism of inositol phospholipids in SK-N-BE(2) human neuroblastoma cells.
Topics: Cell Line; Humans; Inositol; Neuroblastoma; Perphenazine; Phosphatidylinositol 4,5-Diphosphate; Phos | 1994 |
Modulation of phosphatidylserine synthesis by a muscarinic receptor occupancy in human neuroblastoma cell line LA-N-1.
Topics: Acetylcholine; Adenosine Triphosphate; Atropine; Cell Line; GTP-Binding Proteins; Guanosine 5'-O-(3- | 1994 |
Reduced Na+/K+ ATPase transport activity, resting membrane potential, and bradykinin-stimulated phosphatidylinositol synthesis by polyol accumulation in cultured neuroblastoma cells.
Topics: Animals; Bradykinin; Cell Line; Fructose; Galactose; Glucose; Inositol; Kinetics; Mannose; Membrane | 1994 |
Decreased myo-inositol uptake is associated with reduced bradykinin-stimulated phosphatidylinositol synthesis and diacylglycerol content in cultured neuroblastoma cells exposed to L-fucose.
Topics: Animals; Biological Transport; Bradykinin; Cell Line; Diglycerides; Dose-Response Relationship, Drug | 1994 |
Beryllium competitively inhibits brain myo-inositol monophosphatase, but unlike lithium does not enhance agonist-induced inositol phosphate accumulation.
Topics: Animals; Beryllium; Binding, Competitive; Brain; Cattle; Humans; Hydrolysis; Inositol; Inositol Phos | 1993 |
Increased glucose concentration inhibits myo-inositol metabolism by two different mechanisms in cultured mammalian cells.
Topics: Animals; Cell Line; Cerebrovascular Circulation; Endothelium, Vascular; Eye Neoplasms; Glucose; Huma | 1993 |
Reversal of hyperglycemic-induced defects in myo-inositol metabolism and Na+/K+ pump activity in cultured neuroblastoma cells by normalizing glucose levels.
Topics: Animals; Biological Transport; Blood Glucose; Galactose; Glucose; Hyperglycemia; Inositol; Neuroblas | 1993 |
Elevated phosphatidyl-CMP is not the source of diacylglycerol accumulation induced by lithium in NG108-15 cells.
Topics: Animals; Bradykinin; Cytidine Monophosphate; Diglycerides; Glioma; Hybrid Cells; Inositol; Lithium; | 1993 |
Lithium enhances muscarinic receptor-stimulated CDP-diacylglycerol formation in inositol-depleted SK-N-SH neuroblastoma cells.
Topics: Atropine; Carbachol; Cytidine Diphosphate Diglycerides; Humans; Inositol; Kinetics; Lithium; Neurobl | 1993 |
Modulation of basal nitric oxide-dependent cyclic-GMP production by ambient glucose, myo-inositol, and protein kinase C in SH-SY5Y human neuroblastoma cells.
Topics: Base Sequence; Cholinergic Fibers; Cyclic GMP; Diabetic Neuropathies; Glucose; Humans; Inositol; Mod | 1996 |
In vitro accumulation of glucocerebroside in neuroblastoma cells: a model for study of Gaucher disease pathobiology.
Topics: alpha-Mannosidase; beta-Galactosidase; beta-Glucosidase; Cell Line; Gaucher Disease; Glucosylceramid | 1996 |
Studies of inositol phosphate export from neuronal tissue in vitro.
Topics: Animals; Carbachol; Cerebral Cortex; Hippocampus; Humans; In Vitro Techniques; Inositol; Inositol 1, | 1997 |
Differentiated human NT2-N neurons possess a high intracellular content of myo-inositol.
Topics: Antineoplastic Agents; Astrocytoma; Biological Transport; Cell Differentiation; Cells, Cultured; Hum | 1999 |
Cilostazol, a cyclic AMP phosphodiesterase inhibitor, stimulates nitric oxide production and sodium potassium adenosine triphosphatase activity in SH-SY5Y human neuroblastoma cells.
Topics: Cilostazol; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dexamethasone; Humans; Inositol; Isoqu | 1999 |
Lithium activates the c-Jun NH2-terminal kinases in vitro and in the CNS in vivo.
Topics: Animals; Antimanic Agents; Cells, Cultured; DNA; Enzyme Activation; Enzyme Inhibitors; Frontal Lobe; | 1999 |
Suppressive effect of carbachol on forskolin-stimulated neurite outgrowth in human neuroblastoma NB-OK1 cells.
Topics: Atropine; Calcium; Calcium Channel Blockers; Carbachol; Cell Line; Colforsin; Cyclic AMP; Drug Inter | 1992 |
L-fucose is a potent inhibitor of myo-inositol transport and metabolism in cultured neuroblastoma cells.
Topics: Animals; Binding, Competitive; Biological Transport; Fucose; Glucose; Inositol; Membrane Potentials; | 1992 |
Phosphoinositide turnover in human neuroblastoma cells (SK-N-BE).
Topics: Atropine; Carbachol; Cell Line; Humans; Inositol; Inositol Phosphates; Kinetics; Neuroblastoma; Phos | 1991 |
The aminosteroid U-73122 inhibits muscarinic receptor sequestration and phosphoinositide hydrolysis in SK-N-SH neuroblastoma cells. A role for Gp in receptor compartmentation.
Topics: Alprostadil; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Down-Regulation; En | 1991 |
Restoration of Na(+)-K+ pump activity and resting membrane potential by myo-inositol supplementation in neuroblastoma cells chronically exposed to glucose or galactose.
Topics: Animals; Biological Transport, Active; Cell Membrane; Culture Media; Dose-Response Relationship, Dru | 1991 |
Resting membrane potential in 41A3 mouse neuroblastoma cells. Effect of increased glucose and galactose concentrations.
Topics: Animals; Galactose; Glucose; Indicators and Reagents; Inositol; Kinetics; Membrane Potentials; Mice; | 1991 |
Trans-hydroxyl group configuration on carbons 2 and 3 of glucose. Responsible for acute inhibition of myo-inositol transport?
Topics: 3-O-Methylglucose; Animals; Biological Transport; Carbohydrate Conformation; Cell Line; Cytochalasin | 1991 |
Accumulation and metabolism of Ins(1,4,5)P3 and Ins(1,3,4,5)P4 in muscarinic-receptor-stimulated SH-SY5Y neuroblastoma cells.
Topics: Animals; Carbachol; Cell Line; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics | 1991 |
Effect of fructose supplementation on sorbitol accumulation and myo-inositol metabolism in cultured neuroblastoma cells exposed to increased glucose concentrations.
Topics: Aldehyde Reductase; Animals; Biological Transport; Cell Line; Cycloheximide; Fructose; Glucose; Inos | 1990 |
Retinoic acid rapidly decreases phosphatidylinositol turnover during neuroblastoma cell differentiation.
Topics: Cell Differentiation; Deoxyglucose; Glycerol; Humans; Inositol; Inositol Phosphates; Neuroblastoma; | 1990 |
Inositol metabolism during neuroblastoma B50 cell differentiation: effects of differentiating agents on inositol uptake.
Topics: Amiloride; Animals; Biological Transport; Bucladesine; Calcium; Cell Differentiation; Cytochalasin B | 1990 |
Inhibition of inositol 1,4,5-trisphosphate metabolism in permeabilised SH-SY5Y human neuroblastoma cells by a phosphorothioate-containing analogue of inositol 1,4,5-trisphosphate.
Topics: Animals; Carbachol; Cell Line; Cell Membrane; Cell Membrane Permeability; Electric Stimulation; Guan | 1990 |
Effect of angiotensin II and III on inositol polyphosphate production in differentiated NG108-15 hybrid cells.
Topics: Angiotensin II; Angiotensin III; Animals; Cell Differentiation; Cell Line; Glioma; Hybrid Cells; Ino | 1990 |
Differences in the metabolism of inositol and phosphoinositides by cultured cells of neuronal and glial origin.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Glioma; Hybrid Cells; Inositol; Neuroblastoma; Neuroglia; | 1989 |
Effect of galactose and glucose levels and sorbinil treatment on myo-inositol metabolism and Na+-K+ pump activity in cultured neuroblastoma cells.
Topics: Aldehyde Reductase; Animals; Cell Line; Galactose; Glucose; Imidazoles; Imidazolidines; Inositol; Mi | 1989 |
Effects of bradykinin, GTP gamma S, R59022 and N-ethylmaleimide on inositol phosphate production in NG108-15 cells.
Topics: Animals; Bradykinin; Cell Line; Drug Interactions; Ethylmaleimide; Glioma; Guanosine 5'-O-(3-Thiotri | 1989 |
Bradykinin stimulation of inositol phosphate and calcium responses in insensitive to pertussis toxin in NG115-401L neuronal cells.
Topics: Adenosine Diphosphate Ribose; Alprostadil; Animals; Bradykinin; Cell Line; Cyclic AMP; Glioma; Inosi | 1987 |
Modulation of neuronal signal transduction systems by extracellular ATP.
Topics: Adenosine Triphosphate; Aequorin; Alprostadil; Aminoquinolines; Calcium; Cyclic AMP; Cyclic GMP; Flu | 1988 |
Effect of increased glucose levels on Na+/K+-pump activity in cultured neuroblastoma cells.
Topics: Aldehyde Reductase; Animals; Cell Line; Glucose; Imidazoles; Imidazolidines; Inositol; Mice; Neurobl | 1988 |
Bradykinin analogues: differential agonist and antagonist activities suggesting multiple receptors.
Topics: Animals; Bradykinin; Cells, Cultured; Inositol; Mice; Neuroblastoma; Phosphatidylinositols; Receptor | 1988 |
Neurotensin stimulates inositol phospholipid metabolism and calcium mobilization in murine neuroblastoma clone N1E-115.
Topics: Animals; Calcium; Cell Line; Clone Cells; Cyclic GMP; Inositol; Inositol Phosphates; Mice; Neuroblas | 1986 |
myo-Inositol metabolism in 41A3 neuroblastoma cells: effects of high glucose and sorbitol levels.
Topics: Animals; Cell Division; Cell Line; Choline; Ethanolamine; Ethanolamines; Glucose; Inositol; Kinetics | 1987 |
The influence of insulin and sorbinil on myoinositol uptake in peripheral nerve from normal and diabetic rats and a neuroblastoma cell line (N1E-115).
Topics: Aldehyde Reductase; Animals; Cell Line; Diabetes Mellitus, Experimental; Femoral Nerve; Glucose; Imi | 1988 |
Cell cycle dependence of inositol phosphate levels in neuroblastoma cells.
Topics: Animals; Cell Cycle; Cell Line; DNA Replication; Inositol; Inositol Phosphates; Kinetics; Neuroblast | 1988 |
Acute changes in myo-inositol uptake and 22Na+ flux in murine neuroblastoma cells (N1E-115) following insulin.
Topics: Animals; Biological Transport; Cell Line; Glucose; Inositol; Insulin; Mice; Neuroblastoma; Sodium; T | 1987 |
Effect of sorbinil on myo-inositol metabolism in cultured neuroblastoma cells exposed to increased glucose levels.
Topics: Animals; Cell Line; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Kinetics; Mice; Neurobl | 1988 |
Myoinositol uptake by four cultured mammalian cell lines.
Topics: Animals; Biological Transport, Active; Cattle; Cell Line; Endothelium; Humans; Inositol; Kinetics; L | 1986 |
Phosphatidylcholine biosynthesis in the neuroblastoma-glioma hybrid cell line NG108-15: stimulation by phorbol esters.
Topics: Animals; Cell Line; Choline; Ethanolamine; Ethanolamines; Glioma; Inositol; Neuroblastoma; Phorbol E | 1986 |