Page last updated: 2024-10-19

inositol and Neoplasms

inositol has been researched along with Neoplasms in 31 studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"Inositol is an essential nutrient, obtained either by uptake from the environment or by de novo synthesis from glucose."2.82The paradoxical role of inositol in cancer: a consequence of the metabolic state of a tumor. ( Case, KC; Greenberg, ML; Schmidtke, MW, 2022)
"Cell expansion and metastasis are considered hallmarks of tumour progression."2.46Glycosidated phospholipids: uncoupling of signalling pathways at the plasma membrane. ( Danker, K; Reutter, W; Semini, G, 2010)
"A striking anticancer action of IP(6) was demonstrated in different experimental models."2.43Protection against cancer by dietary IP6 and inositol. ( Shamsuddin, AM; Vucenik, I, 2006)
"A striking anticancer effect of IP6 was demonstrated in different experimental models."2.42Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic. ( Shamsuddin, AM; Vucenik, I, 2003)
"Prostate cancer, the most prevalent non-cutaneous cancer in men, is associated with increased age."1.35The effect of dietary supplementation with limonene or myo-inositol on the induction of neoplasia and matrix metalloproteinase and plasminogen activator activities in accessory sex organs of male Lobund-Wistar rats. ( Lindgren, BR; Sinha, AA; Wilson, MJ, 2008)
"Multidrug-resistant (MDR) cancer cells have been shown to have an accumulation of glucosylceramide (GlcCer)."1.31Elevation of glucosylceramide in multidrug-resistant cancer cells and accumulation in cytoplasmic droplets. ( Aouali, N; Belhoussine, R; Levade, T; Manfait, M; Morjani, H; Veldman, RJ, 2001)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199014 (45.16)18.7374
1990's0 (0.00)18.2507
2000's6 (19.35)29.6817
2010's4 (12.90)24.3611
2020's7 (22.58)2.80

Authors

AuthorsStudies
Yuan, Q1
Wang, L1
Huang, J1
Zhao, W1
Wu, J1
Collins, NB1
Al Abosy, R1
Miller, BC1
Bi, K1
Zhao, Q1
Quigley, M1
Ishizuka, JJ1
Yates, KB1
Pope, HW1
Manguso, RT1
Shrestha, Y1
Wadsworth, M1
Hughes, T1
Shalek, AK1
Boehm, JS1
Hahn, WC1
Doench, JG1
Haining, WN1
Case, KC1
Schmidtke, MW1
Greenberg, ML1
Lu, Y1
Shi, Y1
Liu, Y1
Luo, Z1
Zhang, J1
Jiang, M1
Li, X1
Liu, X1
Guo, X1
Qin, B1
Yin, H1
Du, Y1
Qiu, Y1
Lou, Y1
Guan, G1
Luo, L1
You, J1
Salvagno, C1
Mandula, JK1
Rodriguez, PC1
Cubillos-Ruiz, JR1
Chen, Q1
Shen, L1
Li, S1
Yang, SX1
Song, CG1
Kuang, Y1
Liu, B1
Zhang, YX1
Zhang, MZ1
Zhang, CY1
Ding, G1
Qin, JC1
Bizzarri, M1
Dinicola, S1
Cucina, A1
Semini, G2
Hildmann, A1
von Haefen, C1
Danker, K2
Wilson, MJ1
Lindgren, BR1
Sinha, AA1
HERBST, WP1
BAGLEY, CE1
Reutter, W1
TATUM, EL1
RITCHEY, MG1
Serkova, NJ1
Brown, MS1
Cocco, L1
Manzoli, L1
Barnabei, O1
Gilmour, RS1
Martelli, AM1
EAGLE, H2
OYAMA, VI2
LEVY, M2
FREEMAN, A1
FREEMAN, AE1
AVIOLI, LV1
MCDONALD, JE1
SINGER, RA1
HENNEMAN, PH1
Vucenik, I2
Shamsuddin, AM2
SCHAEFER, AE1
COPELAND, DH1
SALMON, WD1
HALE, OM1
REBERT, AF1
Lembach, K2
Charalampous, FC3
Jariwalla, RJ1
Morjani, H1
Aouali, N1
Belhoussine, R1
Veldman, RJ1
Levade, T1
Manfait, M1
Trznadel, K1
Walasek, L1
Lutz, W1
NagaƄski, T1
Fajndt, S1
Warmsley, AM1
Phillips, B1
Pasternak, CA1
de Siebenthal, J1
Jenny, M1
Narumi, K1
Arita, M1
Kitagawa, M1
Kumazawa, A1
Tsumita, T1

Reviews

11 reviews available for inositol and Neoplasms

ArticleYear
The paradoxical role of inositol in cancer: a consequence of the metabolic state of a tumor.
    Cancer metastasis reviews, 2022, Volume: 41, Issue:2

    Topics: Cell Proliferation; Humans; Inositol; Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Prot

2022
Decoding endoplasmic reticulum stress signals in cancer cells and antitumor immunity.
    Trends in cancer, 2022, Volume: 8, Issue:11

    Topics: Endoplasmic Reticulum Stress; Endoribonucleases; Humans; Inositol; Neoplasms; Protein Serine-Threoni

2022
Emerging role of inositol monophosphatase in cancer.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 161

    Topics: 5'-Nucleotidase; Humans; Inositol; Inositol Phosphates; Neoplasms; Phosphoric Monoester Hydrolases

2023
Modulation of both Insulin Resistance and Cancer Growth by Inositol.
    Current pharmaceutical design, 2017, Volume: 23, Issue:34

    Topics: Animals; Blood Glucose; Growth Inhibitors; Humans; Inositol; Insulin Resistance; Neoplasms; Tumor Bu

2017
Glycosidated phospholipids - a promising group of anti-tumour lipids.
    Anti-cancer agents in medicinal chemistry, 2014, Volume: 14, Issue:4

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Adhesion; Cell Differentiation; Cell Movement; Cell

2014
Glycosidated phospholipids: uncoupling of signalling pathways at the plasma membrane.
    British journal of pharmacology, 2010, Volume: 160, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Membrane; Cell Movement; Cell Proliferation; Glycosides; Humans

2010
Quantitative analysis in magnetic resonance spectroscopy: from metabolic profiling to in vivo biomarkers.
    Bioanalysis, 2012, Volume: 4, Issue:3

    Topics: Biomarkers; Body Fluids; Humans; Inositol; Isotope Labeling; Magnetic Resonance Imaging; Magnetic Re

2012
Re-examination of the significance of nuclear localization of PLCbeta1 in the likelihood of its involvement in neoplastic cell growth.
    Advances in enzyme regulation, 2003, Volume: 43

    Topics: Animals; Cell Division; Cell Nucleus; Gene Expression Regulation, Neoplastic; Humans; Inositol; Isoe

2003
Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic.
    The Journal of nutrition, 2003, Volume: 133, Issue:11 Suppl 1

    Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Carcinogens; Colonic Neoplasms; Disease Mod

2003
Protection against cancer by dietary IP6 and inositol.
    Nutrition and cancer, 2006, Volume: 55, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic

2006
Rice-bran products: phytonutrients with potential applications in preventive and clinical medicine.
    Drugs under experimental and clinical research, 2001, Volume: 27, Issue:1

    Topics: Animals; Anticholesteremic Agents; Coumaric Acids; Dietary Fiber; Fatty Liver; Free Radical Scavenge

2001

Other Studies

20 other studies available for inositol and Neoplasms

ArticleYear
    Biomaterials science, 2021, Sep-28, Volume: 9, Issue:19

    Topics: Amides; Amino Acids; Cell Line, Tumor; Drug Carriers; Esters; Inositol; Nanoparticles; Neoplasms; Pa

2021
PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment.
    Journal for immunotherapy of cancer, 2022, Volume: 10, Issue:3

    Topics: Animals; Carcinogenesis; CD8-Positive T-Lymphocytes; Class I Phosphatidylinositol 3-Kinases; Disease

2022
A therapeutic DC vaccine with maintained immunological activity exhibits robust anti-tumor efficacy.
    Journal of controlled release : official journal of the Controlled Release Society, 2022, Volume: 349

    Topics: alpha-Tocopherol; Antigens, Neoplasm; Cancer Vaccines; Dendritic Cells; Endoribonucleases; Humans; I

2022
Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from
    Molecules (Basel, Switzerland), 2020, Mar-09, Volume: 25, Issue:5

    Topics: Aglaia; Alkaloids; Cell Proliferation; Hep G2 Cells; Humans; Inositol; Neoplasms; Triterpenes

2020
The effect of dietary supplementation with limonene or myo-inositol on the induction of neoplasia and matrix metalloproteinase and plasminogen activator activities in accessory sex organs of male Lobund-Wistar rats.
    Experimental and molecular pathology, 2008, Volume: 85, Issue:2

    Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Cyclohexenes; Dietary Supplements; Disease Mode

2008
Observations in the use of inositol in advanced malignancy of the genito-urinary tract.
    The Journal of urology, 1948, Volume: 59, Issue:4

    Topics: Inositol; Neoplasms; Urinary Tract; Urogenital Neoplasms; Urogenital System; Urologic Neoplasms

1948
Vitamin content of mouse epidermis during methylcholanthrene carcinogenesis; biotin, choline, inositol, rho-aminobenzoic acid, and pyridoxine.
    The Journal of biological chemistry, 1946, Volume: 163

    Topics: 4-Aminobenzoic Acid; Acids; Biotin; Carcinogenesis; Choline; Epidermis; Inositol; Methylcholanthrene

1946
Myo-inositol as an essential growth factor for normal and malignant human cells in tissue culture.
    Science (New York, N.Y.), 1956, May-11, Volume: 123, Issue:3202

    Topics: Inositol; Intercellular Signaling Peptides and Proteins; Neoplasms; Research Design; Tissue Culture

1956
Myo-Inositol as an essential growth factor for normal and malignant human cells in tissue culture.
    The Journal of biological chemistry, 1957, Volume: 226, Issue:1

    Topics: Carbohydrate Metabolism; Humans; Inositol; Intercellular Signaling Peptides and Proteins; Neoplasms

1957
A NEW ORAL ISOTOPIC TEST OF CALCIUM ABSORPTION.
    The Journal of clinical investigation, 1965, Volume: 44

    Topics: Adolescent; Bone Neoplasms; Calcinosis; Calcium; Calcium Isotopes; Ergocalciferols; Feces; Geriatric

1965
The influence of riboflavin, pyridoxine, inositol, and protein depletion- repletion upon the induction of neoplasms by choline deficiency.
    Cancer research, 1950, Volume: 10, Issue:12

    Topics: Choline Deficiency; Folic Acid; Humans; Inositol; Neoplasms; Pyridoxine; Riboflavin; Vitamin B Compl

1950
[Vitamins E and K and inositol in the treatment of tumors of corn induced by colchicine].
    Revue de pathologie comparee, 1951, Volume: 51, Issue:631

    Topics: Colchicine; Humans; Inositol; Neoplasms; Vitamin E; Vitamins; Zea mays

1951
Metabolic functions of myo-inositol. V. Utilization of glycine and serine in nucleotide and nucleic acid biosynthesis by inositol-deficient KB cells.
    The Journal of biological chemistry, 1967, Jun-10, Volume: 242, Issue:11

    Topics: Carbon Isotopes; Culture Techniques; Glycine; Humans; Inositol; Mouth Neoplasms; Neoplasms; Nucleic

1967
Metabolic functions of myo-inositol. VI. Impairment of amino acid transport in KB cells caused by inositol deficiency.
    The Journal of biological chemistry, 1967, Jun-10, Volume: 242, Issue:11

    Topics: Aminoisobutyric Acids; Carbon Isotopes; Culture Techniques; Glycine; Humans; Inositol; Kinetics; Mou

1967
Elevation of glucosylceramide in multidrug-resistant cancer cells and accumulation in cytoplasmic droplets.
    International journal of cancer, 2001, Oct-15, Volume: 94, Issue:2

    Topics: Cell Nucleus; Cytoplasm; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glucosy

2001
[Blood serum concentration and urinary excretion of myoinositol in patients with malignant tumors].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1977, Nov-14, Volume: 32, Issue:46

    Topics: Adult; Aged; Female; Humans; Inositol; Male; Middle Aged; Neoplasms

1977
The use of zonal centrifugation to study membrane formation during the life cycle of mammalian cells. Synthesis of 'marker' enzymes and other components of cellular organelles.
    The Biochemical journal, 1970, Volume: 120, Issue:4

    Topics: Cell Division; Cell Nucleus; Centrifugation, Zonal; Choline; Culture Techniques; Electron Transport

1970
[The hypercalcemias and their treatment].
    Schweizerische medizinische Wochenschrift, 1967, Dec-30, Volume: 97, Issue:52

    Topics: Adrenal Cortex Hormones; Edetic Acid; Female; Humans; Hypercalcemia; Hyperthyroidism; Hypothyroidism

1967
Gaschromatographic analysis of free myo- and scyllo-inositols in animal tissues.
    The Japanese journal of experimental medicine, 1969, Volume: 39, Issue:4

    Topics: Adrenal Glands; Animals; Aorta, Abdominal; Bone Marrow; Brain Chemistry; Cattle; Chromatography, Gas

1969
Metabolic functions of myo-inositol. VII. Role of inositol in the transport of alpha-aminoisobutyric acid in KB cells.
    The Journal of biological chemistry, 1969, Apr-10, Volume: 244, Issue:7

    Topics: Aminoisobutyric Acids; Biological Transport, Active; Carbon Isotopes; Culture Techniques; Depression

1969