inositol has been researched along with Multiple Sclerosis in 39 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Lower myo-inositol/creatine values, suggesting astrocytic damage, were consistently found within the NMO lesions when compared with healthy controls and patients with multiple sclerosis (MS), who showed at least 1 demyelinating lesion at the same cord level." | 7.79 | Low myo-inositol indicating astrocytic damage in a case series of neuromyelitis optica. ( Chard, D; Ciccarelli, O; De Vita, E; Kachramanoglou, C; Kapoor, R; Leary, S; Matthews, L; Miller, DH; Palace, J; Thomas, DL; Thompson, AJ; Toosy, AT; Wheeler-Kingshott, CA, 2013) |
| "Myo-inositol was given orally to nine multiple sclerosis patients and nine healthy control subjects." | 7.67 | The role of myo-inositol in multiple sclerosis. ( Hader, WJ; Hiscock, M; Logan, D; Warren, KG; Young, GB, 1986) |
| " This biochemical information can be processed and presented as density maps of several metabolites, among them N-acetylaspartate (marker of neuronal viability), choline (marker of membrane turnover), creatine (related to the energy state of the cells), myo-Inositol (exclusively found in astrocytes), lipids and lactate (observed in necrosis and other pathological processes) which mean relevant information in the context of brain tumors." | 4.85 | Proton magnetic resonance spectroscopy imaging in the study of human brain cancer. ( Celda, B; Martínez-Bisbal, MC, 2009) |
| " Lower myo-inositol/creatine values, suggesting astrocytic damage, were consistently found within the NMO lesions when compared with healthy controls and patients with multiple sclerosis (MS), who showed at least 1 demyelinating lesion at the same cord level." | 3.79 | Low myo-inositol indicating astrocytic damage in a case series of neuromyelitis optica. ( Chard, D; Ciccarelli, O; De Vita, E; Kachramanoglou, C; Kapoor, R; Leary, S; Matthews, L; Miller, DH; Palace, J; Thomas, DL; Thompson, AJ; Toosy, AT; Wheeler-Kingshott, CA, 2013) |
| "In the multiple sclerosis white matter lesions, N-acetylaspartate (NAA), choline (Cho), inositol (Ins), and creatine (Cr) peaks did not vary significantly over the entire period of the study in the untreated group." | 3.70 | 1H-MRS in patients with multiple sclerosis undergoing treatment with interferon beta-1a: results of a preliminary study. ( Alberti, A; Gallai, V; Gobbi, G; Orlacchio, A; Pelliccioli, GP; Presciutti, O; Sarchielli, P; Tarducci, R, 1998) |
| "Myo-inositol was given orally to nine multiple sclerosis patients and nine healthy control subjects." | 3.67 | The role of myo-inositol in multiple sclerosis. ( Hader, WJ; Hiscock, M; Logan, D; Warren, KG; Young, GB, 1986) |
| "Most of the brain tumors were characterized by strongly reduced total N-acetylaspartyl compounds and marked increases of myo-inositol and choline-containing compounds, consistent with a lack of neuroaxonal tissue and a proliferation of glial cells." | 1.31 | Quantitative proton magnetic resonance spectroscopy of focal brain lesions. ( Dechent, P; Frahm, J; Hanefeld, F; Herms, J; Markakis, E; Maxton, C; Wilken, B, 2000) |
| "The mechanisms behind the demyelination that is characteristic of multiple sclerosis (MS) are still poorly understood." | 1.30 | Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy. ( Bitsch, A; Brück, W; Bruhn, H; Frahm, J; Lassmann, H; Stringaris, A; Vougioukas, V, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (28.21) | 18.7374 |
| 1990's | 6 (15.38) | 18.2507 |
| 2000's | 13 (33.33) | 29.6817 |
| 2010's | 8 (20.51) | 24.3611 |
| 2020's | 1 (2.56) | 2.80 |
| Authors | Studies |
|---|---|
| Mueller, C | 1 |
| Baird, JF | 1 |
| Motl, RW | 1 |
| Hnilicová, P | 1 |
| Kantorová, E | 1 |
| Poláček, H | 1 |
| Grendár, M | 1 |
| Bittšanský, M | 1 |
| Čierny, D | 1 |
| Sivák, Š | 1 |
| Zeleňák, K | 1 |
| Lehotský, J | 1 |
| Dobrota, D | 1 |
| Kurča, E | 1 |
| Ciccarelli, O | 2 |
| Thomas, DL | 1 |
| De Vita, E | 1 |
| Wheeler-Kingshott, CA | 1 |
| Kachramanoglou, C | 1 |
| Kapoor, R | 1 |
| Leary, S | 1 |
| Matthews, L | 1 |
| Palace, J | 1 |
| Chard, D | 2 |
| Miller, DH | 4 |
| Toosy, AT | 1 |
| Thompson, AJ | 4 |
| Tisell, A | 1 |
| Leinhard, OD | 1 |
| Warntjes, JB | 1 |
| Aalto, A | 1 |
| Smedby, Ö | 1 |
| Landtblom, AM | 2 |
| Lundberg, P | 1 |
| Llufriu, S | 1 |
| Kornak, J | 1 |
| Ratiney, H | 1 |
| Oh, J | 1 |
| Brenneman, D | 1 |
| Cree, BA | 1 |
| Sampat, M | 1 |
| Hauser, SL | 1 |
| Nelson, SJ | 1 |
| Pelletier, D | 2 |
| Datta, G | 1 |
| Violante, IR | 1 |
| Scott, G | 1 |
| Zimmerman, K | 1 |
| Santos-Ribeiro, A | 1 |
| Rabiner, EA | 1 |
| Gunn, RN | 1 |
| Malik, O | 1 |
| Nicholas, R | 1 |
| Matthews, PM | 1 |
| Kirov, II | 1 |
| Patil, V | 1 |
| Babb, JS | 1 |
| Rusinek, H | 1 |
| Herbert, J | 1 |
| Gonen, O | 1 |
| Martínez-Bisbal, MC | 1 |
| Celda, B | 1 |
| Brief, EE | 1 |
| Vavasour, IM | 1 |
| Laule, C | 1 |
| Li, DK | 2 |
| Mackay, AL | 1 |
| Hattingen, E | 1 |
| Magerkurth, J | 1 |
| Pilatus, U | 1 |
| Hübers, A | 1 |
| Wahl, M | 1 |
| Ziemann, U | 1 |
| Visser, F | 1 |
| Wattjes, MP | 3 |
| Pouwels, PJ | 2 |
| Linssen, WH | 1 |
| van Oosten, BW | 1 |
| Kapeller, P | 2 |
| Brex, PA | 2 |
| Dalton, C | 1 |
| Griffin, CM | 1 |
| McLean, MA | 3 |
| Parker, GJ | 2 |
| GARCIA-BUNUEL, L | 1 |
| GARCIA-BUNUEL, M | 1 |
| Fernando, KT | 1 |
| Chard, DT | 1 |
| MacManus, DG | 2 |
| Dalton, CM | 1 |
| Miszkiel, KA | 1 |
| Gordon, RM | 1 |
| Plant, GT | 1 |
| Kendi, AT | 1 |
| Tan, FU | 1 |
| Kendi, M | 1 |
| Yilmaz, S | 1 |
| Huvaj, S | 1 |
| Tellioğlu, S | 1 |
| Srinivasan, R | 1 |
| Sailasuta, N | 1 |
| Hurd, R | 1 |
| Nelson, S | 1 |
| Ropele, S | 1 |
| Enzinger, C | 1 |
| Lahousen, T | 1 |
| Strasser-Fuchs, S | 1 |
| Schmidt, R | 1 |
| Fazekas, F | 1 |
| Geurts, JJ | 1 |
| Reuling, IE | 1 |
| Vrenken, H | 1 |
| Uitdehaag, BM | 1 |
| Polman, CH | 1 |
| Castelijns, JA | 1 |
| Barkhof, F | 1 |
| Harzheim, M | 2 |
| Lutterbey, GG | 2 |
| Klotz, L | 1 |
| Schild, HH | 2 |
| Träber, F | 2 |
| Bogdanow, M | 1 |
| Holm, V | 2 |
| Koopmans, RA | 1 |
| Zhu, G | 1 |
| Allen, PS | 1 |
| Penn, A | 1 |
| Paty, DW | 1 |
| Sjöqvist, L | 1 |
| Söderfeldt, B | 1 |
| Nyland, H | 1 |
| Thuomas, KA | 1 |
| Tourbah, A | 1 |
| Stievenart, JL | 1 |
| Iba-Zizen, MT | 1 |
| Zannoli, G | 1 |
| Lyon-Caen, O | 1 |
| Cabanis, EA | 1 |
| Sarchielli, P | 1 |
| Presciutti, O | 1 |
| Tarducci, R | 1 |
| Gobbi, G | 1 |
| Alberti, A | 1 |
| Pelliccioli, GP | 1 |
| Orlacchio, A | 1 |
| Gallai, V | 1 |
| Falini, A | 1 |
| Calabrese, G | 1 |
| Filippi, M | 1 |
| Origgi, D | 1 |
| Lipari, S | 1 |
| Colombo, B | 1 |
| Comi, G | 1 |
| Scotti, G | 1 |
| Bitsch, A | 1 |
| Bruhn, H | 1 |
| Vougioukas, V | 1 |
| Stringaris, A | 1 |
| Lassmann, H | 1 |
| Frahm, J | 2 |
| Brück, W | 1 |
| Leary, SM | 1 |
| Barker, GJ | 2 |
| Wilken, B | 1 |
| Dechent, P | 1 |
| Herms, J | 1 |
| Maxton, C | 1 |
| Markakis, E | 1 |
| Hanefeld, F | 1 |
| Woermann, FG | 1 |
| Duncan, JS | 1 |
| Offner, H | 5 |
| Fog, T | 2 |
| Clausen, J | 5 |
| Raun, NE | 1 |
| Konat, G | 2 |
| Trznadel, K | 1 |
| Lutz, W | 1 |
| Young, GB | 1 |
| Hader, WJ | 1 |
| Hiscock, M | 1 |
| Warren, KG | 1 |
| Logan, D | 1 |
| Alling, C | 1 |
| Vanier, MT | 1 |
| Svennerholm, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Combination of 11C-MET PET and MRS in the Diagnosis of Glioma.[NCT03009318] | 100 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for inositol and Multiple Sclerosis
| Article | Year |
|---|---|
Proton magnetic resonance spectroscopy imaging in the study of human brain cancer.
Topics: Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Glioblastoma; Humans; In | 2009 |
[Biochemical and clinical aspects of myoinositol].
Topics: Animals; Biological Transport, Active; Cell Membrane; Diabetes Mellitus; Fatty Liver; Guinea Pigs; H | 1976 |
2 trials available for inositol and Multiple Sclerosis
| Article | Year |
|---|---|
High field MR imaging and 1H-MR spectroscopy in clinically isolated syndromes suggestive of multiple sclerosis: correlation between metabolic alterations and diagnostic MR imaging criteria.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Diagnosis, Differential; | 2008 |
Quantitative analysis of short echo time (1)H-MRSI of cerebral gray and white matter.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Calibration; Cerebrospinal Fluid; Choline; Creatine; D | 2000 |
35 other studies available for inositol and Multiple Sclerosis
| Article | Year |
|---|---|
Whole-Brain Metabolic Abnormalities Are Associated With Mobility in Older Adults With Multiple Sclerosis.
Topics: Aged; Aspartic Acid; Brain; Brain Diseases; Choline; Creatine; Humans; Inositol; Magnetic Resonance | 2022 |
Altered hypothalamic metabolism in early multiple sclerosis - MR spectroscopy study.
Topics: Adult; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Hypothalamus; Ino | 2019 |
Low myo-inositol indicating astrocytic damage in a case series of neuromyelitis optica.
Topics: Adult; Astrocytes; Biomarkers; Cervical Vertebrae; Diagnosis, Differential; Female; Humans; Inositol | 2013 |
Increased concentrations of glutamate and glutamine in normal-appearing white matter of patients with multiple sclerosis and normal MR imaging brain scans.
Topics: Adult; Aged; Aspartic Acid; Brain; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Inos | 2013 |
Magnetic resonance spectroscopy markers of disease progression in multiple sclerosis.
Topics: Adult; Aspartic Acid; Atrophy; Biomarkers; Case-Control Studies; Disability Evaluation; Disease Prog | 2014 |
Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis.
Topics: Adult; Aged; Brain; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Mu | 2017 |
MR spectroscopy indicates diffuse multiple sclerosis activity during remission.
Topics: Adult; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; Inositol; Magnetic Resonan | 2009 |
Proton MRS of large multiple sclerosis lesions reveals subtle changes in metabolite T(1) and area.
Topics: Aspartic Acid; Choline; Humans; Inositol; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Proto | 2010 |
Combined (1)H and (31)P spectroscopy provides new insights into the pathobiochemistry of brain damage in multiple sclerosis.
Topics: Adult; Brain; Case-Control Studies; Female; Glycerylphosphorylcholine; Humans; Inositol; Magnetic Re | 2011 |
Tumefactive multiple sclerosis lesions under fingolimod treatment.
Topics: Aspartic Acid; Brain; Choline; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; I | 2012 |
Quantitative 1H MRS imaging 14 years after presenting with a clinically isolated syndrome suggestive of multiple sclerosis.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Inositol; Magnetic Resonance Spectro | 2002 |
CEREBROSPINAL FLUID LEVELS OF FREE MYOINOSITOL IN SOME NEUROLOGICAL DISORDERS.
Topics: Biochemical Phenomena; Biochemistry; Cerebrospinal Fluid; Child; Dementia; Diabetic Neuropathies; Ge | 1965 |
Elevated white matter myo-inositol in clinically isolated syndromes suggestive of multiple sclerosis.
Topics: Adolescent; Adult; Aspartic Acid; Biomarkers; Brain; Creatine; Female; Humans; Inositol; Magnetic Re | 2004 |
MR spectroscopy of cervical spinal cord in patients with multiple sclerosis.
Topics: Adult; Aspartic Acid; Case-Control Studies; Cervical Vertebrae; Choline; Creatine; Female; Humans; I | 2004 |
Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T.
Topics: Acute Disease; Adult; Brain; Choline; Chronic Disease; Female; Glutamic Acid; Humans; Inositol; Magn | 2005 |
Discrimination of white matter lesions and multiple sclerosis plaques by short echo quantitative 1H-magnetic resonance spectroscopy.
Topics: Adult; Aged; Analysis of Variance; Aspartic Acid; Brain; Case-Control Studies; Creatine; Female; Fou | 2005 |
MR spectroscopic evidence for thalamic and hippocampal, but not cortical, damage in multiple sclerosis.
Topics: Adult; Aged; Aspartic Acid; Cerebral Cortex; Female; Hippocampus; Humans; Inositol; Magnetic Resonan | 2006 |
Axonal damage but no increased glial cell activity in the normal-appearing white matter of patients with clinically isolated syndromes suggestive of multiple sclerosis using high-field magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Axons; Brain; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Ino | 2007 |
Kinetic studies on changes in the redox state of in vitro incubation of peripheral blood from multiple sclerosis patients under partial anaerobic conditions.
Topics: Anaerobiosis; Humans; Inositol; Magnesium; Multiple Sclerosis; Oxidation-Reduction | 1981 |
Magnetic resonance spectroscopy of multiple sclerosis: in-vivo detection of myelin breakdown products.
Topics: Adult; Choline; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis | 1993 |
Proton MR spectroscopy and MR imaging in acute and chronic multiple sclerosis--ringlike appearances in acute plaques.
Topics: Adult; Aged; Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Female; Humans; Inositol | 1996 |
In vivo localized NMR proton spectroscopy of normal appearing white matter in patients with multiple sclerosis.
Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Brain Diseases; Choline; Clinical Trials as Topic | 1996 |
1H-MRS in patients with multiple sclerosis undergoing treatment with interferon beta-1a: results of a preliminary study.
Topics: Adult; Brain; Choline; Creatinine; Disability Evaluation; Humans; Inositol; Interferon-beta; Magneti | 1998 |
Benign versus secondary-progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Disease Progression; Female; Follow-Up Studies; Huma | 1998 |
Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy.
Topics: Adult; Aspartic Acid; Axons; Biopsy, Needle; Blood-Brain Barrier; Brain; Cell Division; Choline; Dem | 1999 |
A (1)H magnetic resonance spectroscopy study of aging in parietal white matter: implications for trials in multiple sclerosis.
Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; I | 2000 |
Quantitative proton magnetic resonance spectroscopy of focal brain lesions.
Topics: Adolescent; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Abscess; Brain Diseases; Brain Neoplasms; | 2000 |
Correlation between incorporation of myo-(2-3H)inositol into the phosphatidylinositol of lymphocytes and disability degree, stage and duration of multiple sclerosis.
Topics: Adult; Antigens; Disability Evaluation; Female; Humans; Inositol; Lectins; Lymphocytes; Male; Measle | 1975 |
Lymphocyte stimulation in multiple sclerosis patients untreated and treated with transfer factor. Long-term studies on the effect of different stimulants on myo-(2-3H)inositol incorporation into phosphatidylinositol of lymphocytes.
Topics: Adult; Antigens, Viral; Female; Humans; Inositol; Lectins; Lipopolysaccharides; Lymphocyte Activatio | 1977 |
Inositol in multiple sclerosis.
Topics: Humans; In Vitro Techniques; Inositol; Multiple Sclerosis | 1978 |
The role of myo-inositol in multiple sclerosis.
Topics: Adult; Evoked Potentials, Visual; Female; Humans; Inositol; Male; Multiple Sclerosis; Reaction Time; | 1986 |
Letter: Inhibition of lymphocyte response to stimulants induced by unsaturated fatty acids and prostaglandins.
Topics: Adolescent; Adult; Arachidonic Acids; Fatty Acids, Unsaturated; Humans; Inositol; Linoleic Acids; Ly | 1974 |
Letter: Inhibition of lymphocyte response to stimulants induced by unsaturated fatty acids and prostaglandins in multiple sclerosis.
Topics: Fatty Acids, Unsaturated; Humans; Inositol; Lectins; Lymphocyte Activation; Multiple Sclerosis; Pros | 1974 |
Lipid alterations in apparently normal white matter in multiple sclerosis.
Topics: Adult; Aged; Brain; Cerebrosides; Cholesterol; Choline; Fatty Acids; Female; Humans; Inositol; Lipid | 1971 |
Effect of phytohemagglutinin, basic protein and measles antigen on myo-(2-3H)inositol incorporation into phosphatidylinositol of lymphocytes from patients with multiple sclerosis.
Topics: Adult; Antigens, Viral; Biological Assay; Cells, Cultured; Female; Hemagglutination Inhibition Tests | 1974 |