Page last updated: 2024-10-19

inositol and Mood Disorders

inositol has been researched along with Mood Disorders in 10 studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Mood Disorders: Those disorders that have a disturbance in mood as their predominant feature.

Research Excerpts

ExcerptRelevanceReference
"The "inositol depletion hypothesis" has been widely held to be the explanation for both the effect of lithium on brain function, apropos of its use in mood disorders, and on the impairment of development and induction of embryonic malformations in diverse organisms."3.72Phosphoinositide deficiency due to inositol depletion is not a mechanism of lithium action in brain. ( Berry, GT; Buccafusca, R; Eccleston, E; Greer, JJ, 2004)
"Valproic acid (VPA) is an antiepileptic drug with mood-stabilizing properties."2.42Search for a common mechanism of mood stabilizers. ( Agam, G; Harwood, AJ, 2003)
"Inositol was also effective for panic disorder in a double-blind, random-assignment, placebo-controlled crossover study of 21 patients, with 4 weeks in each phase (p = ."2.39Inositol treatment in psychiatry. ( Agam, G; Belmaker, RH; Benjamin, J; Bersudsky, Y; Kofman, O; Levine, J, 1995)
"Inositol is a simple polyol precursor in a second messenger system important in brain myo-insitol, the natural isomer, which has been found to be therapeutically effective in depression, panic disorder, and obsessive-compulsive disorder in double-blind controlled trials."1.30Epi-inositol and inositol depletion: two new treatment approaches in affective disorder. ( Belmaker, RH; Bersudsky, Y; Einat, H; Stahl, Z, 1999)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (20.00)18.2507
2000's7 (70.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hermens, DF1
Naismith, SL1
Chitty, KM1
Lee, RS1
Tickell, A1
Duffy, SL1
Paquola, C1
White, D1
Hickie, IB1
Lagopoulos, J1
Dickstein, DP2
Towbin, KE2
Van Der Veen, JW2
Rich, BA1
Brotman, MA1
Knopf, L2
Onelio, L1
Pine, DS2
Leibenluft, E2
Harwood, AJ2
Agam, G2
Nakagawa, S1
Koyama, T1
Berry, GT1
Buccafusca, R1
Greer, JJ1
Eccleston, E1
Kaplan, BJ1
Shannon, S1
Benjamin, J1
Levine, J1
Bersudsky, Y2
Kofman, O1
Belmaker, RH2
Einat, H1
Stahl, Z1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
1/2-MC4R Genotype and Pediatric Antipsychotic Drug- Induced Weight Gain[NCT01844700]Phase 414 participants (Actual)Interventional2013-07-31Terminated (stopped due to very slow recruitment, no sufficient results)
Inositol for Comorbid Anxiety in Children and Adolescents With Bipolar Disorder[NCT02811133]Phase 1/Phase 20 participants (Actual)Interventional2023-08-31Withdrawn (stopped due to Funding terminated)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Percent Weight Change Compared to Baseline Weight

(NCT01844700)
Timeframe: baseline to week 12

Interventionpercentage of weight change (Mean)
Ziprasidone11.58
Aripiprazole, Quetiapine, Risperidone5.66

BMI Percentile

(NCT01844700)
Timeframe: baseline to week 12

,
InterventionBMI percentile (Mean)
baselineweek 12 (n=1, n=2)
Aripiprazole, Quetiapine, Risperidone37.6762.5
Ziprasidone3259

BMI Z-scores

(NCT01844700)
Timeframe: baseline to week 12

,
InterventionBMI z-score (Mean)
baselineweek 12 (n=1, n=2)
Aripiprazole, Quetiapine, Risperidone-0.370.38
Ziprasidone-0.510.22

Weight Change

(NCT01844700)
Timeframe: baseline to week 12

,
Interventionlbs (Mean)
baselineweek 12 (n=1,2)
Aripiprazole, Quetiapine, Risperidone118.5141
Ziprasidone120.5151

Reviews

4 reviews available for inositol and Mood Disorders

ArticleYear
Search for a common mechanism of mood stabilizers.
    Biochemical pharmacology, 2003, Jul-15, Volume: 66, Issue:2

    Topics: Affect; Animals; Anticonvulsants; Antimanic Agents; Carbamazepine; Glycogen Synthase Kinase 3; Human

2003
[Mechanism and clinical effects of drugs for mood disorder].
    Ryoikibetsu shokogun shirizu, 2003, Issue:38

    Topics: Antidepressive Agents; Antimanic Agents; Biogenic Monoamines; Humans; Inositol; Lithium; Meta-Analys

2003
Neurodevelopment and mood stabilizers.
    Current molecular medicine, 2003, Volume: 3, Issue:5

    Topics: Glycogen Synthase Kinase 3; Humans; Inositol; Mood Disorders; Nervous System; Psychotropic Drugs

2003
Inositol treatment in psychiatry.
    Psychopharmacology bulletin, 1995, Volume: 31, Issue:1

    Topics: Clinical Trials as Topic; Humans; Inositol; Mood Disorders

1995

Trials

2 trials available for inositol and Mood Disorders

ArticleYear
Randomized double-blind placebo-controlled trial of lithium in youths with severe mood dysregulation.
    Journal of child and adolescent psychopharmacology, 2009, Volume: 19, Issue:1

    Topics: Adolescent; Antimanic Agents; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Bipolar

2009
Proton magnetic resonance spectroscopy in youth with severe mood dysregulation.
    Psychiatry research, 2008, May-30, Volume: 163, Issue:1

    Topics: Antimanic Agents; Arousal; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Bipolar Dis

2008

Other Studies

4 other studies available for inositol and Mood Disorders

ArticleYear
Cluster analysis reveals abnormal hippocampal neurometabolic profiles in young people with mood disorders.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2015, Volume: 25, Issue:6

    Topics: Adolescent; Adult; Aspartic Acid; Cluster Analysis; Creatine; Female; Glutamic Acid; Hippocampus; Hu

2015
Phosphoinositide deficiency due to inositol depletion is not a mechanism of lithium action in brain.
    Molecular genetics and metabolism, 2004, Volume: 82, Issue:1

    Topics: Animals; Brain; In Vitro Techniques; Inositol; Lithium; Mice; Mice, Knockout; Mood Disorders; Phosph

2004
Nutritional aspects of child and adolescent psychopharmacology.
    Pediatric annals, 2007, Volume: 36, Issue:9

    Topics: Adolescent; Child; Dietary Supplements; Drug Interactions; Food; Food-Drug Interactions; Humans; Ino

2007
Epi-inositol and inositol depletion: two new treatment approaches in affective disorder.
    Current psychiatry reports, 1999, Volume: 1, Issue:2

    Topics: Animals; Antimanic Agents; Blood-Brain Barrier; Brain Chemistry; Diet; Disease Models, Animal; Human

1999