inositol has been researched along with Mood Disorders in 10 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Mood Disorders: Those disorders that have a disturbance in mood as their predominant feature.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The "inositol depletion hypothesis" has been widely held to be the explanation for both the effect of lithium on brain function, apropos of its use in mood disorders, and on the impairment of development and induction of embryonic malformations in diverse organisms." | 3.72 | Phosphoinositide deficiency due to inositol depletion is not a mechanism of lithium action in brain. ( Berry, GT; Buccafusca, R; Eccleston, E; Greer, JJ, 2004) |
| "Valproic acid (VPA) is an antiepileptic drug with mood-stabilizing properties." | 2.42 | Search for a common mechanism of mood stabilizers. ( Agam, G; Harwood, AJ, 2003) |
| "Inositol was also effective for panic disorder in a double-blind, random-assignment, placebo-controlled crossover study of 21 patients, with 4 weeks in each phase (p = ." | 2.39 | Inositol treatment in psychiatry. ( Agam, G; Belmaker, RH; Benjamin, J; Bersudsky, Y; Kofman, O; Levine, J, 1995) |
| "Inositol is a simple polyol precursor in a second messenger system important in brain myo-insitol, the natural isomer, which has been found to be therapeutically effective in depression, panic disorder, and obsessive-compulsive disorder in double-blind controlled trials." | 1.30 | Epi-inositol and inositol depletion: two new treatment approaches in affective disorder. ( Belmaker, RH; Bersudsky, Y; Einat, H; Stahl, Z, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 7 (70.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hermens, DF | 1 |
| Naismith, SL | 1 |
| Chitty, KM | 1 |
| Lee, RS | 1 |
| Tickell, A | 1 |
| Duffy, SL | 1 |
| Paquola, C | 1 |
| White, D | 1 |
| Hickie, IB | 1 |
| Lagopoulos, J | 1 |
| Dickstein, DP | 2 |
| Towbin, KE | 2 |
| Van Der Veen, JW | 2 |
| Rich, BA | 1 |
| Brotman, MA | 1 |
| Knopf, L | 2 |
| Onelio, L | 1 |
| Pine, DS | 2 |
| Leibenluft, E | 2 |
| Harwood, AJ | 2 |
| Agam, G | 2 |
| Nakagawa, S | 1 |
| Koyama, T | 1 |
| Berry, GT | 1 |
| Buccafusca, R | 1 |
| Greer, JJ | 1 |
| Eccleston, E | 1 |
| Kaplan, BJ | 1 |
| Shannon, S | 1 |
| Benjamin, J | 1 |
| Levine, J | 1 |
| Bersudsky, Y | 2 |
| Kofman, O | 1 |
| Belmaker, RH | 2 |
| Einat, H | 1 |
| Stahl, Z | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| 1/2-MC4R Genotype and Pediatric Antipsychotic Drug- Induced Weight Gain[NCT01844700] | Phase 4 | 14 participants (Actual) | Interventional | 2013-07-31 | Terminated (stopped due to very slow recruitment, no sufficient results) | ||
| Inositol for Comorbid Anxiety in Children and Adolescents With Bipolar Disorder[NCT02811133] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2023-08-31 | Withdrawn (stopped due to Funding terminated) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01844700)
Timeframe: baseline to week 12
| Intervention | percentage of weight change (Mean) |
|---|---|
| Ziprasidone | 11.58 |
| Aripiprazole, Quetiapine, Risperidone | 5.66 |
(NCT01844700)
Timeframe: baseline to week 12
| Intervention | BMI percentile (Mean) | |
|---|---|---|
| baseline | week 12 (n=1, n=2) | |
| Aripiprazole, Quetiapine, Risperidone | 37.67 | 62.5 |
| Ziprasidone | 32 | 59 |
(NCT01844700)
Timeframe: baseline to week 12
| Intervention | BMI z-score (Mean) | |
|---|---|---|
| baseline | week 12 (n=1, n=2) | |
| Aripiprazole, Quetiapine, Risperidone | -0.37 | 0.38 |
| Ziprasidone | -0.51 | 0.22 |
(NCT01844700)
Timeframe: baseline to week 12
| Intervention | lbs (Mean) | |
|---|---|---|
| baseline | week 12 (n=1,2) | |
| Aripiprazole, Quetiapine, Risperidone | 118.5 | 141 |
| Ziprasidone | 120.5 | 151 |
4 reviews available for inositol and Mood Disorders
| Article | Year |
|---|---|
Search for a common mechanism of mood stabilizers.
Topics: Affect; Animals; Anticonvulsants; Antimanic Agents; Carbamazepine; Glycogen Synthase Kinase 3; Human | 2003 |
[Mechanism and clinical effects of drugs for mood disorder].
Topics: Antidepressive Agents; Antimanic Agents; Biogenic Monoamines; Humans; Inositol; Lithium; Meta-Analys | 2003 |
Neurodevelopment and mood stabilizers.
Topics: Glycogen Synthase Kinase 3; Humans; Inositol; Mood Disorders; Nervous System; Psychotropic Drugs | 2003 |
Inositol treatment in psychiatry.
Topics: Clinical Trials as Topic; Humans; Inositol; Mood Disorders | 1995 |
2 trials available for inositol and Mood Disorders
| Article | Year |
|---|---|
Randomized double-blind placebo-controlled trial of lithium in youths with severe mood dysregulation.
Topics: Adolescent; Antimanic Agents; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Bipolar | 2009 |
Proton magnetic resonance spectroscopy in youth with severe mood dysregulation.
Topics: Antimanic Agents; Arousal; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Bipolar Dis | 2008 |
4 other studies available for inositol and Mood Disorders
| Article | Year |
|---|---|
Cluster analysis reveals abnormal hippocampal neurometabolic profiles in young people with mood disorders.
Topics: Adolescent; Adult; Aspartic Acid; Cluster Analysis; Creatine; Female; Glutamic Acid; Hippocampus; Hu | 2015 |
Phosphoinositide deficiency due to inositol depletion is not a mechanism of lithium action in brain.
Topics: Animals; Brain; In Vitro Techniques; Inositol; Lithium; Mice; Mice, Knockout; Mood Disorders; Phosph | 2004 |
Nutritional aspects of child and adolescent psychopharmacology.
Topics: Adolescent; Child; Dietary Supplements; Drug Interactions; Food; Food-Drug Interactions; Humans; Ino | 2007 |
Epi-inositol and inositol depletion: two new treatment approaches in affective disorder.
Topics: Animals; Antimanic Agents; Blood-Brain Barrier; Brain Chemistry; Diet; Disease Models, Animal; Human | 1999 |