inositol has been researched along with MS (Multiple Sclerosis) in 39 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Lower myo-inositol/creatine values, suggesting astrocytic damage, were consistently found within the NMO lesions when compared with healthy controls and patients with multiple sclerosis (MS), who showed at least 1 demyelinating lesion at the same cord level." | 7.79 | Low myo-inositol indicating astrocytic damage in a case series of neuromyelitis optica. ( Chard, D; Ciccarelli, O; De Vita, E; Kachramanoglou, C; Kapoor, R; Leary, S; Matthews, L; Miller, DH; Palace, J; Thomas, DL; Thompson, AJ; Toosy, AT; Wheeler-Kingshott, CA, 2013) |
| "Myo-inositol was given orally to nine multiple sclerosis patients and nine healthy control subjects." | 7.67 | The role of myo-inositol in multiple sclerosis. ( Hader, WJ; Hiscock, M; Logan, D; Warren, KG; Young, GB, 1986) |
| " This biochemical information can be processed and presented as density maps of several metabolites, among them N-acetylaspartate (marker of neuronal viability), choline (marker of membrane turnover), creatine (related to the energy state of the cells), myo-Inositol (exclusively found in astrocytes), lipids and lactate (observed in necrosis and other pathological processes) which mean relevant information in the context of brain tumors." | 4.85 | Proton magnetic resonance spectroscopy imaging in the study of human brain cancer. ( Celda, B; Martínez-Bisbal, MC, 2009) |
| " Lower myo-inositol/creatine values, suggesting astrocytic damage, were consistently found within the NMO lesions when compared with healthy controls and patients with multiple sclerosis (MS), who showed at least 1 demyelinating lesion at the same cord level." | 3.79 | Low myo-inositol indicating astrocytic damage in a case series of neuromyelitis optica. ( Chard, D; Ciccarelli, O; De Vita, E; Kachramanoglou, C; Kapoor, R; Leary, S; Matthews, L; Miller, DH; Palace, J; Thomas, DL; Thompson, AJ; Toosy, AT; Wheeler-Kingshott, CA, 2013) |
| "In the multiple sclerosis white matter lesions, N-acetylaspartate (NAA), choline (Cho), inositol (Ins), and creatine (Cr) peaks did not vary significantly over the entire period of the study in the untreated group." | 3.70 | 1H-MRS in patients with multiple sclerosis undergoing treatment with interferon beta-1a: results of a preliminary study. ( Alberti, A; Gallai, V; Gobbi, G; Orlacchio, A; Pelliccioli, GP; Presciutti, O; Sarchielli, P; Tarducci, R, 1998) |
| "Myo-inositol was given orally to nine multiple sclerosis patients and nine healthy control subjects." | 3.67 | The role of myo-inositol in multiple sclerosis. ( Hader, WJ; Hiscock, M; Logan, D; Warren, KG; Young, GB, 1986) |
| "Most of the brain tumors were characterized by strongly reduced total N-acetylaspartyl compounds and marked increases of myo-inositol and choline-containing compounds, consistent with a lack of neuroaxonal tissue and a proliferation of glial cells." | 1.31 | Quantitative proton magnetic resonance spectroscopy of focal brain lesions. ( Dechent, P; Frahm, J; Hanefeld, F; Herms, J; Markakis, E; Maxton, C; Wilken, B, 2000) |
| "The mechanisms behind the demyelination that is characteristic of multiple sclerosis (MS) are still poorly understood." | 1.30 | Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy. ( Bitsch, A; Brück, W; Bruhn, H; Frahm, J; Lassmann, H; Stringaris, A; Vougioukas, V, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (28.21) | 18.7374 |
| 1990's | 6 (15.38) | 18.2507 |
| 2000's | 13 (33.33) | 29.6817 |
| 2010's | 8 (20.51) | 24.3611 |
| 2020's | 1 (2.56) | 2.80 |
| Authors | Studies |
|---|---|
| Mueller, C | 1 |
| Baird, JF | 1 |
| Motl, RW | 1 |
| Hnilicová, P | 1 |
| Kantorová, E | 1 |
| Poláček, H | 1 |
| Grendár, M | 1 |
| Bittšanský, M | 1 |
| Čierny, D | 1 |
| Sivák, Š | 1 |
| Zeleňák, K | 1 |
| Lehotský, J | 1 |
| Dobrota, D | 1 |
| Kurča, E | 1 |
| Ciccarelli, O | 2 |
| Thomas, DL | 1 |
| De Vita, E | 1 |
| Wheeler-Kingshott, CA | 1 |
| Kachramanoglou, C | 1 |
| Kapoor, R | 1 |
| Leary, S | 1 |
| Matthews, L | 1 |
| Palace, J | 1 |
| Chard, D | 2 |
| Miller, DH | 4 |
| Toosy, AT | 1 |
| Thompson, AJ | 4 |
| Tisell, A | 1 |
| Leinhard, OD | 1 |
| Warntjes, JB | 1 |
| Aalto, A | 1 |
| Smedby, Ö | 1 |
| Landtblom, AM | 2 |
| Lundberg, P | 1 |
| Llufriu, S | 1 |
| Kornak, J | 1 |
| Ratiney, H | 1 |
| Oh, J | 1 |
| Brenneman, D | 1 |
| Cree, BA | 1 |
| Sampat, M | 1 |
| Hauser, SL | 1 |
| Nelson, SJ | 1 |
| Pelletier, D | 2 |
| Datta, G | 1 |
| Violante, IR | 1 |
| Scott, G | 1 |
| Zimmerman, K | 1 |
| Santos-Ribeiro, A | 1 |
| Rabiner, EA | 1 |
| Gunn, RN | 1 |
| Malik, O | 1 |
| Nicholas, R | 1 |
| Matthews, PM | 1 |
| Kirov, II | 1 |
| Patil, V | 1 |
| Babb, JS | 1 |
| Rusinek, H | 1 |
| Herbert, J | 1 |
| Gonen, O | 1 |
| Martínez-Bisbal, MC | 1 |
| Celda, B | 1 |
| Brief, EE | 1 |
| Vavasour, IM | 1 |
| Laule, C | 1 |
| Li, DK | 2 |
| Mackay, AL | 1 |
| Hattingen, E | 1 |
| Magerkurth, J | 1 |
| Pilatus, U | 1 |
| Hübers, A | 1 |
| Wahl, M | 1 |
| Ziemann, U | 1 |
| Visser, F | 1 |
| Wattjes, MP | 3 |
| Pouwels, PJ | 2 |
| Linssen, WH | 1 |
| van Oosten, BW | 1 |
| Kapeller, P | 2 |
| Brex, PA | 2 |
| Dalton, C | 1 |
| Griffin, CM | 1 |
| McLean, MA | 3 |
| Parker, GJ | 2 |
| GARCIA-BUNUEL, L | 1 |
| GARCIA-BUNUEL, M | 1 |
| Fernando, KT | 1 |
| Chard, DT | 1 |
| MacManus, DG | 2 |
| Dalton, CM | 1 |
| Miszkiel, KA | 1 |
| Gordon, RM | 1 |
| Plant, GT | 1 |
| Kendi, AT | 1 |
| Tan, FU | 1 |
| Kendi, M | 1 |
| Yilmaz, S | 1 |
| Huvaj, S | 1 |
| Tellioğlu, S | 1 |
| Srinivasan, R | 1 |
| Sailasuta, N | 1 |
| Hurd, R | 1 |
| Nelson, S | 1 |
| Ropele, S | 1 |
| Enzinger, C | 1 |
| Lahousen, T | 1 |
| Strasser-Fuchs, S | 1 |
| Schmidt, R | 1 |
| Fazekas, F | 1 |
| Geurts, JJ | 1 |
| Reuling, IE | 1 |
| Vrenken, H | 1 |
| Uitdehaag, BM | 1 |
| Polman, CH | 1 |
| Castelijns, JA | 1 |
| Barkhof, F | 1 |
| Harzheim, M | 2 |
| Lutterbey, GG | 2 |
| Klotz, L | 1 |
| Schild, HH | 2 |
| Träber, F | 2 |
| Bogdanow, M | 1 |
| Holm, V | 2 |
| Koopmans, RA | 1 |
| Zhu, G | 1 |
| Allen, PS | 1 |
| Penn, A | 1 |
| Paty, DW | 1 |
| Sjöqvist, L | 1 |
| Söderfeldt, B | 1 |
| Nyland, H | 1 |
| Thuomas, KA | 1 |
| Tourbah, A | 1 |
| Stievenart, JL | 1 |
| Iba-Zizen, MT | 1 |
| Zannoli, G | 1 |
| Lyon-Caen, O | 1 |
| Cabanis, EA | 1 |
| Sarchielli, P | 1 |
| Presciutti, O | 1 |
| Tarducci, R | 1 |
| Gobbi, G | 1 |
| Alberti, A | 1 |
| Pelliccioli, GP | 1 |
| Orlacchio, A | 1 |
| Gallai, V | 1 |
| Falini, A | 1 |
| Calabrese, G | 1 |
| Filippi, M | 1 |
| Origgi, D | 1 |
| Lipari, S | 1 |
| Colombo, B | 1 |
| Comi, G | 1 |
| Scotti, G | 1 |
| Bitsch, A | 1 |
| Bruhn, H | 1 |
| Vougioukas, V | 1 |
| Stringaris, A | 1 |
| Lassmann, H | 1 |
| Frahm, J | 2 |
| Brück, W | 1 |
| Leary, SM | 1 |
| Barker, GJ | 2 |
| Wilken, B | 1 |
| Dechent, P | 1 |
| Herms, J | 1 |
| Maxton, C | 1 |
| Markakis, E | 1 |
| Hanefeld, F | 1 |
| Woermann, FG | 1 |
| Duncan, JS | 1 |
| Offner, H | 5 |
| Fog, T | 2 |
| Clausen, J | 5 |
| Raun, NE | 1 |
| Konat, G | 2 |
| Trznadel, K | 1 |
| Lutz, W | 1 |
| Young, GB | 1 |
| Hader, WJ | 1 |
| Hiscock, M | 1 |
| Warren, KG | 1 |
| Logan, D | 1 |
| Alling, C | 1 |
| Vanier, MT | 1 |
| Svennerholm, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Combination of 11C-MET PET and MRS in the Diagnosis of Glioma.[NCT03009318] | 100 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for inositol and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
Proton magnetic resonance spectroscopy imaging in the study of human brain cancer.
Topics: Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Glioblastoma; Humans; In | 2009 |
[Biochemical and clinical aspects of myoinositol].
Topics: Animals; Biological Transport, Active; Cell Membrane; Diabetes Mellitus; Fatty Liver; Guinea Pigs; H | 1976 |
2 trials available for inositol and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
High field MR imaging and 1H-MR spectroscopy in clinically isolated syndromes suggestive of multiple sclerosis: correlation between metabolic alterations and diagnostic MR imaging criteria.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Diagnosis, Differential; | 2008 |
Quantitative analysis of short echo time (1)H-MRSI of cerebral gray and white matter.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Calibration; Cerebrospinal Fluid; Choline; Creatine; D | 2000 |
35 other studies available for inositol and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
Whole-Brain Metabolic Abnormalities Are Associated With Mobility in Older Adults With Multiple Sclerosis.
Topics: Aged; Aspartic Acid; Brain; Brain Diseases; Choline; Creatine; Humans; Inositol; Magnetic Resonance | 2022 |
Altered hypothalamic metabolism in early multiple sclerosis - MR spectroscopy study.
Topics: Adult; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Hypothalamus; Ino | 2019 |
Low myo-inositol indicating astrocytic damage in a case series of neuromyelitis optica.
Topics: Adult; Astrocytes; Biomarkers; Cervical Vertebrae; Diagnosis, Differential; Female; Humans; Inositol | 2013 |
Increased concentrations of glutamate and glutamine in normal-appearing white matter of patients with multiple sclerosis and normal MR imaging brain scans.
Topics: Adult; Aged; Aspartic Acid; Brain; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Inos | 2013 |
Magnetic resonance spectroscopy markers of disease progression in multiple sclerosis.
Topics: Adult; Aspartic Acid; Atrophy; Biomarkers; Case-Control Studies; Disability Evaluation; Disease Prog | 2014 |
Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis.
Topics: Adult; Aged; Brain; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Mu | 2017 |
MR spectroscopy indicates diffuse multiple sclerosis activity during remission.
Topics: Adult; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; Inositol; Magnetic Resonan | 2009 |
Proton MRS of large multiple sclerosis lesions reveals subtle changes in metabolite T(1) and area.
Topics: Aspartic Acid; Choline; Humans; Inositol; Magnetic Resonance Spectroscopy; Multiple Sclerosis; Proto | 2010 |
Combined (1)H and (31)P spectroscopy provides new insights into the pathobiochemistry of brain damage in multiple sclerosis.
Topics: Adult; Brain; Case-Control Studies; Female; Glycerylphosphorylcholine; Humans; Inositol; Magnetic Re | 2011 |
Tumefactive multiple sclerosis lesions under fingolimod treatment.
Topics: Aspartic Acid; Brain; Choline; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; I | 2012 |
Quantitative 1H MRS imaging 14 years after presenting with a clinically isolated syndrome suggestive of multiple sclerosis.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Inositol; Magnetic Resonance Spectro | 2002 |
CEREBROSPINAL FLUID LEVELS OF FREE MYOINOSITOL IN SOME NEUROLOGICAL DISORDERS.
Topics: Biochemical Phenomena; Biochemistry; Cerebrospinal Fluid; Child; Dementia; Diabetic Neuropathies; Ge | 1965 |
Elevated white matter myo-inositol in clinically isolated syndromes suggestive of multiple sclerosis.
Topics: Adolescent; Adult; Aspartic Acid; Biomarkers; Brain; Creatine; Female; Humans; Inositol; Magnetic Re | 2004 |
MR spectroscopy of cervical spinal cord in patients with multiple sclerosis.
Topics: Adult; Aspartic Acid; Case-Control Studies; Cervical Vertebrae; Choline; Creatine; Female; Humans; I | 2004 |
Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T.
Topics: Acute Disease; Adult; Brain; Choline; Chronic Disease; Female; Glutamic Acid; Humans; Inositol; Magn | 2005 |
Discrimination of white matter lesions and multiple sclerosis plaques by short echo quantitative 1H-magnetic resonance spectroscopy.
Topics: Adult; Aged; Analysis of Variance; Aspartic Acid; Brain; Case-Control Studies; Creatine; Female; Fou | 2005 |
MR spectroscopic evidence for thalamic and hippocampal, but not cortical, damage in multiple sclerosis.
Topics: Adult; Aged; Aspartic Acid; Cerebral Cortex; Female; Hippocampus; Humans; Inositol; Magnetic Resonan | 2006 |
Axonal damage but no increased glial cell activity in the normal-appearing white matter of patients with clinically isolated syndromes suggestive of multiple sclerosis using high-field magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Axons; Brain; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Ino | 2007 |
Kinetic studies on changes in the redox state of in vitro incubation of peripheral blood from multiple sclerosis patients under partial anaerobic conditions.
Topics: Anaerobiosis; Humans; Inositol; Magnesium; Multiple Sclerosis; Oxidation-Reduction | 1981 |
Magnetic resonance spectroscopy of multiple sclerosis: in-vivo detection of myelin breakdown products.
Topics: Adult; Choline; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis | 1993 |
Proton MR spectroscopy and MR imaging in acute and chronic multiple sclerosis--ringlike appearances in acute plaques.
Topics: Adult; Aged; Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Female; Humans; Inositol | 1996 |
In vivo localized NMR proton spectroscopy of normal appearing white matter in patients with multiple sclerosis.
Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Brain Diseases; Choline; Clinical Trials as Topic | 1996 |
1H-MRS in patients with multiple sclerosis undergoing treatment with interferon beta-1a: results of a preliminary study.
Topics: Adult; Brain; Choline; Creatinine; Disability Evaluation; Humans; Inositol; Interferon-beta; Magneti | 1998 |
Benign versus secondary-progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Disease Progression; Female; Follow-Up Studies; Huma | 1998 |
Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy.
Topics: Adult; Aspartic Acid; Axons; Biopsy, Needle; Blood-Brain Barrier; Brain; Cell Division; Choline; Dem | 1999 |
A (1)H magnetic resonance spectroscopy study of aging in parietal white matter: implications for trials in multiple sclerosis.
Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; I | 2000 |
Quantitative proton magnetic resonance spectroscopy of focal brain lesions.
Topics: Adolescent; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Abscess; Brain Diseases; Brain Neoplasms; | 2000 |
Correlation between incorporation of myo-(2-3H)inositol into the phosphatidylinositol of lymphocytes and disability degree, stage and duration of multiple sclerosis.
Topics: Adult; Antigens; Disability Evaluation; Female; Humans; Inositol; Lectins; Lymphocytes; Male; Measle | 1975 |
Lymphocyte stimulation in multiple sclerosis patients untreated and treated with transfer factor. Long-term studies on the effect of different stimulants on myo-(2-3H)inositol incorporation into phosphatidylinositol of lymphocytes.
Topics: Adult; Antigens, Viral; Female; Humans; Inositol; Lectins; Lipopolysaccharides; Lymphocyte Activatio | 1977 |
Inositol in multiple sclerosis.
Topics: Humans; In Vitro Techniques; Inositol; Multiple Sclerosis | 1978 |
The role of myo-inositol in multiple sclerosis.
Topics: Adult; Evoked Potentials, Visual; Female; Humans; Inositol; Male; Multiple Sclerosis; Reaction Time; | 1986 |
Letter: Inhibition of lymphocyte response to stimulants induced by unsaturated fatty acids and prostaglandins.
Topics: Adolescent; Adult; Arachidonic Acids; Fatty Acids, Unsaturated; Humans; Inositol; Linoleic Acids; Ly | 1974 |
Letter: Inhibition of lymphocyte response to stimulants induced by unsaturated fatty acids and prostaglandins in multiple sclerosis.
Topics: Fatty Acids, Unsaturated; Humans; Inositol; Lectins; Lymphocyte Activation; Multiple Sclerosis; Pros | 1974 |
Lipid alterations in apparently normal white matter in multiple sclerosis.
Topics: Adult; Aged; Brain; Cerebrosides; Cholesterol; Choline; Fatty Acids; Female; Humans; Inositol; Lipid | 1971 |
Effect of phytohemagglutinin, basic protein and measles antigen on myo-(2-3H)inositol incorporation into phosphatidylinositol of lymphocytes from patients with multiple sclerosis.
Topics: Adult; Antigens, Viral; Biological Assay; Cells, Cultured; Female; Hemagglutination Inhibition Tests | 1974 |