inositol has been researched along with Lung Neoplasms in 36 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this paper, we extended our work and examined the effects of I3C (70 or 30 micromol/g diet) and MI (56 micromol/g diet) against vinyl carbamate (VC)-induced lung adenocarcinoma by administering the agents from 1 week after the second of two injections of VC until termination of the study at week 18." | 7.76 | Inhibition of vinyl carbamate-induced pulmonary adenocarcinoma by indole-3-carbinol and myo-inositol in A/J mice. ( Hecht, SS; Kalscheuer, S; Kassie, F; Ma, L; Matise, I; Melkamu, T; Upadhyaya, P, 2010) |
| " In this paper, we extended our work and examined the effects of I3C (70 or 30 micromol/g diet) and MI (56 micromol/g diet) against vinyl carbamate (VC)-induced lung adenocarcinoma by administering the agents from 1 week after the second of two injections of VC until termination of the study at week 18." | 3.76 | Inhibition of vinyl carbamate-induced pulmonary adenocarcinoma by indole-3-carbinol and myo-inositol in A/J mice. ( Hecht, SS; Kalscheuer, S; Kassie, F; Ma, L; Matise, I; Melkamu, T; Upadhyaya, P, 2010) |
| " In the present study, the effects of myo-inositol and dexamethasone on benzo[a]pyrene (B[a]P)-induced pulmonary adenoma formation in female A/J mice was investigated." | 3.68 | Studies of chemopreventive effects of myo-inositol on benzo[a]pyrene-induced neoplasia of the lung and forestomach of female A/J mice. ( Estensen, RD; Wattenberg, LW, 1993) |
| "Myoinositol is an isomer of glucose that has chemopreventive activity in animal models of cancer." | 2.74 | The chemopreventive agent myoinositol inhibits Akt and extracellular signal-regulated kinase in bronchial lesions from heavy smokers. ( Dennis, PA; Gills, JJ; Han, W; Lam, S; Memmott, RM, 2009) |
| "myo-Inositol is a naturally occurring compound of particular interest because of its exceedingly low toxicity." | 2.39 | Chalcones, myo-inositol and other novel inhibitors of pulmonary carcinogenesis. ( Wattenberg, L, 1995) |
| "Lung cancer is the leading cause of cancer-related death in the United States, and 85 to 90% of lung cancer cases are associated with tobacco use." | 1.36 | The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis. ( Dennis, PA; Memmott, RM, 2010) |
| "Dietary myo-inositol is an effective inhibitor of lung tumor induction in mice, but no dose-response studies have been reported." | 1.31 | Dose-response study of myo-inositol as an inhibitor of lung tumorigenesis induced in A/J mice by benzo. ( Hecht, SS; Kenney, PM; Upadhyaya, P; Wang, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.56) | 18.7374 |
| 1990's | 6 (16.67) | 18.2507 |
| 2000's | 15 (41.67) | 29.6817 |
| 2010's | 9 (25.00) | 24.3611 |
| 2020's | 4 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Kassie, F | 5 |
| Bagherpoor, AJ | 1 |
| Kovacs, K | 1 |
| Seelig, D | 1 |
| Cui, Z | 1 |
| Mu, C | 1 |
| Wu, Z | 2 |
| Pan, S | 1 |
| Cheng, Z | 1 |
| Zhang, ZQ | 1 |
| Zhao, J | 1 |
| Xu, C | 1 |
| Bizzarri, M | 1 |
| Laganà, AS | 1 |
| Aragona, D | 1 |
| Unfer, V | 1 |
| Dai, C | 1 |
| Charlestin, V | 1 |
| Wang, M | 4 |
| Walker, ZT | 1 |
| Miranda-Vergara, MC | 1 |
| Facchine, BA | 1 |
| Wu, J | 1 |
| Kaliney, WJ | 1 |
| Dovichi, NJ | 1 |
| Li, J | 1 |
| Littlepage, LE | 1 |
| Khaodee, W | 1 |
| Inboot, N | 1 |
| Udomsom, S | 1 |
| Kumsaiyai, W | 1 |
| Cressey, R | 1 |
| Unver, N | 1 |
| Delgado, O | 1 |
| Zeleke, K | 1 |
| Cumpian, A | 1 |
| Tang, X | 1 |
| Caetano, MS | 1 |
| Wang, H | 1 |
| Katayama, H | 1 |
| Yu, H | 1 |
| Szabo, E | 4 |
| Wistuba, II | 1 |
| Moghaddam, SJ | 1 |
| Hanash, SM | 1 |
| Ostrin, EJ | 1 |
| Wang, Y | 2 |
| Zhang, Y | 1 |
| Chen, X | 1 |
| Hong, Y | 1 |
| An, YJ | 1 |
| Cho, HR | 1 |
| Kim, TM | 1 |
| Keam, B | 1 |
| Kim, JW | 1 |
| Wen, H | 1 |
| Park, CK | 1 |
| Lee, SH | 1 |
| Im, SA | 1 |
| Kim, JE | 1 |
| Choi, SH | 1 |
| Park, S | 1 |
| Lam, S | 4 |
| Mandrekar, SJ | 1 |
| Gesthalter, Y | 1 |
| Allen Ziegler, KL | 1 |
| Seisler, DK | 1 |
| Midthun, DE | 1 |
| Mao, JT | 1 |
| Aubry, MC | 1 |
| McWilliams, A | 3 |
| Sin, DD | 1 |
| Shaipanich, T | 1 |
| Liu, G | 2 |
| Johnson, E | 1 |
| Bild, A | 1 |
| Lenburg, ME | 2 |
| Ionescu, DN | 1 |
| Mayo, J | 1 |
| Yi, JE | 1 |
| Tazelaar, H | 1 |
| Harmsen, WS | 1 |
| Smith, J | 1 |
| Spira, AE | 1 |
| Beane, J | 1 |
| Limburg, PJ | 1 |
| Matise, I | 2 |
| Negia, M | 1 |
| Lahti, D | 1 |
| Pan, Y | 1 |
| Scherber, R | 1 |
| Upadhyaya, P | 6 |
| Hecht, SS | 7 |
| Han, W | 1 |
| Gills, JJ | 1 |
| Memmott, RM | 2 |
| Dennis, PA | 2 |
| Hatsukami, DK | 1 |
| Kalscheuer, S | 1 |
| Ma, L | 1 |
| Melkamu, T | 2 |
| Gustafson, AM | 1 |
| Soldi, R | 1 |
| Anderlind, C | 1 |
| Scholand, MB | 1 |
| Qian, J | 1 |
| Zhang, X | 1 |
| Cooper, K | 1 |
| Walker, D | 1 |
| Brody, J | 1 |
| Massion, PP | 1 |
| Bild, AH | 1 |
| Spira, A | 1 |
| Endalew, A | 1 |
| Luo, X | 1 |
| Bliss, RL | 1 |
| McIntee, EJ | 1 |
| Kenney, PM | 3 |
| Caine, GJ | 1 |
| Lip, GY | 1 |
| Estensen, RD | 4 |
| Jordan, MM | 1 |
| Wiedmann, TS | 2 |
| Galbraith, AR | 2 |
| Steele, VE | 3 |
| Wattenberg, LW | 4 |
| Witschi, H | 4 |
| Espiritu, I | 3 |
| Ly, M | 1 |
| Uyeminami, D | 2 |
| LeRiche, J | 1 |
| MacAulay, C | 1 |
| Wattenberg, L | 2 |
| Trushin, N | 1 |
| Agarwal, S | 1 |
| Rao, AV | 1 |
| Zimmerman, CL | 1 |
| Kelloff, GJ | 2 |
| Zhang, Z | 1 |
| Liu, Q | 1 |
| Lantry, LE | 1 |
| Anderson, MW | 1 |
| Wiseman, RW | 1 |
| Lubet, RA | 2 |
| You, M | 1 |
| Tate, AR | 1 |
| Foxall, PJ | 1 |
| Holmes, E | 1 |
| Moka, D | 1 |
| Spraul, M | 1 |
| Nicholson, JK | 1 |
| Lindon, JC | 1 |
| Gunning, WT | 1 |
| Kramer, PM | 1 |
| Pereira, MA | 1 |
| Suffia, M | 1 |
| Pinkerton, KE | 1 |
| French, FA | 1 |
| Vucenik, I | 1 |
| Tomazic, VJ | 1 |
| Fabian, D | 1 |
| Shamsuddin, AM | 1 |
| Pulverer, G | 1 |
| Beuth, J | 1 |
| Ko, HL | 1 |
| Yassin, A | 1 |
| Ohshima, Y | 1 |
| Roszkowski, K | 1 |
| Uhlenbruck, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Influence of Fluticasone Inhalation on Intermediate Markers of Carcinogenesis in the Bronchial Epithelium of a High Risk Population : A Double Blind Placebo-Controlled Randomised Phase II Study[NCT00407264] | Phase 2 | 90 participants | Interventional | 2002-02-28 | Completed | ||
| Immunohistochemical Analysis of Human Transbronchial Biopsy Specimens Collected in a Phase I Chemoprevention Trial of Myo-Inositol in Heavy Smokers Conducted Outside the Intramural NCI Program[NCT00342836] | Phase 1 | 20 participants | Interventional | 2005-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for inositol and Lung Neoplasms
| Article | Year |
|---|---|
Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers.
Topics: Animals; Anticarcinogenic Agents; Budesonide; Clinical Trials as Topic; Cysteine; Humans; Inositol; | 2009 |
Chalcones, myo-inositol and other novel inhibitors of pulmonary carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Chalcone; Chalcones; Dexamethasone; Female; Inositol; Lung Neoplas | 1995 |
3 trials available for inositol and Lung Neoplasms
| Article | Year |
|---|---|
A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia.
Topics: Aged; Biomarkers, Tumor; Biopsy; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoscopy; Chemopreventio | 2016 |
The chemopreventive agent myoinositol inhibits Akt and extracellular signal-regulated kinase in bronchial lesions from heavy smokers.
Topics: Adult; Aged; Antineoplastic Agents; Bronchial Diseases; Cell Line; Cell Proliferation; Extracellular | 2009 |
A phase I study of myo-inositol for lung cancer chemoprevention.
Topics: Adult; Aged; Blood Pressure; Body Weight; Chemoprevention; Dose-Response Relationship, Drug; Female; | 2006 |
31 other studies available for inositol and Lung Neoplasms
| Article | Year |
|---|---|
Combinatory lung tumor inhibition by myo-inositol and iloprost/rapamycin: association with immunomodulation.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Iloprost; Immunomodulation; Inositol; Lung Neoplasms; | 2022 |
The sodium/myo-inositol co-transporter SLC5A3 promotes non-small cell lung cancer cell growth.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Heat-Shock Proteins; Humans; Inositol; Lung Neoplasms; Mice | 2022 |
Inositol and pulmonary function. Could myo-inositol treatment downregulate inflammation and cytokine release syndrome in SARS-CoV-2?
Topics: Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Cytokine Release Syndrom | 2020 |
Aquaporin-7 Regulates the Response to Cellular Stress in Breast Cancer.
Topics: Adipocytes; Animals; Aquaporins; Breast Neoplasms; Carbohydrate Metabolism; Cell Movement; Female; G | 2020 |
Glucosidase II beta subunit (GluIIβ) plays a role in autophagy and apoptosis regulation in lung carcinoma cells in a p53-dependent manner.
Topics: alpha-Glucosidases; Apoptosis; Autophagy; Blotting, Western; Calcium-Binding Proteins; Cell Cycle; C | 2017 |
Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol.
Topics: Animals; Anticarcinogenic Agents; Disease Models, Animal; Humans; Inositol; Interleukin-6; Lung Neop | 2018 |
[Combined treatment with myo-inositol and luteolin selectively suppresses growth of human lung cancer A549 cells possibly by suppressing activation of PDK1 and Akt].
Topics: A549 Cells; Cell Movement; Cell Proliferation; Cell Survival; Humans; Inositol; Lung Neoplasms; Lute | 2018 |
An NMR metabolomics approach for the diagnosis of leptomeningeal carcinomatosis in lung adenocarcinoma cancer patients.
Topics: Adenocarcinoma; Alanine; Area Under Curve; Biomarkers, Tumor; Case-Control Studies; Citric Acid; Cre | 2015 |
Combinations of N-Acetyl-S-(N-2-Phenethylthiocarbamoyl)-L-Cysteine and myo-inositol inhibit tobacco carcinogen-induced lung adenocarcinoma in mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; bcl-Associated Death Protei | 2008 |
Inhibition of vinyl carbamate-induced pulmonary adenocarcinoma by indole-3-carbinol and myo-inositol in A/J mice.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Caspase 3; Cell Prol | 2010 |
The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis.
Topics: Animals; Carcinogens; Humans; Indoles; Inositol; Intracellular Signaling Peptides and Proteins; Lung | 2010 |
Airway PI3K pathway activation is an early and reversible event in lung cancer development.
Topics: Adult; Aged; Bronchi; Cohort Studies; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Gene E | 2010 |
Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protocols; Be | 2010 |
Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination.
Topics: Animals; Antineoplastic Agents; Carcinogenicity Tests; Cell Transformation, Neoplastic; Cysteine; Di | 2002 |
Dietary prevention of carcinogenesis in smokers.
Topics: Anticarcinogenic Agents; Humans; Inositol; Isothiocyanates; Lung Neoplasms; Smoking; Vegetables | 2002 |
Effect of chemopreventive agents on separate stages of progression of benzo[alpha]pyrene induced lung tumors in A/J mice.
Topics: Adenoma; Aerosols; Animals; Anti-Inflammatory Agents; Benzo(a)pyrene; Budesonide; Carcinogens; Disea | 2004 |
The effects of dietary myoinositol on lung tumor development in tobacco smoke-exposed mice.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Diet; Dose-Response Relationship, Drug; | 2004 |
Studies of chemopreventive effects of myo-inositol on benzo[a]pyrene-induced neoplasia of the lung and forestomach of female A/J mice.
Topics: Adenoma; Animals; Benzo(a)pyrene; Dexamethasone; Drug Screening Assays, Antitumor; Drug Therapy, Com | 1993 |
Chemopreventive effects of myo-inositol and dexamethasone on benzo[a]pyrene and 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone-induced pulmonary carcinogenesis in female A/J mice.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Dexamethasone; Drug Screenin | 1996 |
Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Benzo(a)pyrene; Butylated Hydroxyanisole; Carotenoid | 1999 |
Chemoprevention of tobacco smoke-induced lung tumors in A/J strain mice with dietary myo-inositol and dexamethasone.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Atmosphere Exposure Chambers; Body Weight; Chemopreventi | 1999 |
Chemoprevention of pulmonary carcinogenesis by brief exposures to aerosolized budesonide or beclomethasone dipropionate and by the combination of aerosolized budesonide and dietary myo-inositol.
Topics: Adenoma; Administration, Oral; Aerosols; Animals; Anticarcinogenic Agents; Beclomethasone; Benzo(a)p | 2000 |
A germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo-inositol and chemotherapeutic agents taxol or adriamycin.
Topics: Alleles; Animals; Anticarcinogenic Agents; Dexamethasone; Doxorubicin; Genes, p53; Germ-Line Mutatio | 2000 |
Distinction between normal and renal cell carcinoma kidney cortical biopsy samples using pattern recognition of (1)H magic angle spinning (MAS) NMR spectra.
Topics: Amino Acids; Biopsy; Carcinoma, Renal Cell; Discriminant Analysis; Glucose; Humans; Hydrogen; Inosit | 2000 |
Successful and not so successful chemoprevention of tobacco smoke-induced lung tumors.
Topics: Animals; Anticarcinogenic Agents; Aspirin; Chemoprevention; Cyclohexenes; Dexamethasone; Diet; Disea | 2000 |
Chemoprevention of vinyl carbamate-induced lung tumors in strain A mice.
Topics: Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Chemoprevention; Dexamethaso | 2000 |
Dose-response study of myo-inositol as an inhibitor of lung tumorigenesis induced in A/J mice by benzo.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Diet; Dose-Response Rela | 2001 |
Expression of cyclin D1/2 in the lungs of strain A/J mice fed chemopreventive agents.
Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Aspirin; Blotting, Western; Cell Nucleus; Cyclin D | 2002 |
The influence of nutritional factors on pulmonary adenomas in mice.
Topics: Adenoma; Animals; Body Weight; Choline; Inositol; Lung Neoplasms; Mice; Mice, Inbred Strains; Niacin | 1977 |
Antitumor activity of phytic acid (inositol hexaphosphate) in murine transplanted and metastatic fibrosarcoma, a pilot study.
Topics: Animals; Drug Synergism; Fibrosarcoma; Germ-Free Life; Injections, Intraperitoneal; Inositol; Lung N | 1992 |
Glycoprotein modifications of sarcoma L-1 tumor cells by tunicamycin, swainsonine, bromoconduritol or 1-desoxynojirimycin treatment inhibits their metastatic lung colonization in Balb/c-mice.
Topics: 1-Deoxynojirimycin; Alkaloids; Animals; Carbohydrates; Cyclohexenes; Glucosamine; Glycoproteins; Ino | 1988 |