Page last updated: 2024-10-19

inositol and Liver Steatosis

inositol has been researched along with Liver Steatosis in 36 studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Research Excerpts

ExcerptRelevanceReference
"d- chiro-Inositol (DCI) is a biologically active component found in tartary buckwheat, which can reduce hyperglycemia and ameliorate insulin resistance."7.91d- chiro-Inositol Ameliorates High Fat Diet-Induced Hepatic Steatosis and Insulin Resistance via PKCε-PI3K/AKT Pathway. ( Cheng, F; Ge, X; Han, L; Li, Y; Pan, C; Wang, M; Xiao, Y; Yan, S; Zhang, Y, 2019)
"We have previously shown that dietary inositol hexakisphosphate (IP6) and myo-inositol prevent fatty liver in rats fed a casein-based diet containing 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane (DDT)."7.74Dietary inositol hexakisphosphate, but not myo-inositol, clearly improves hypercholesterolemia in rats fed casein-type amino acid mixtures and 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane. ( Katayama, T; Okazaki, Y, 2008)
"The activities of pathways for the biosynthesis of hippurate, urea and pyrimidines in hepatocytes isolated from lean livers were compared with those from three sources of fatty liver: a) the genetically obese Zucker rat, b) Sprague-Dawley rats fed a diet deficient in choline and inositol, and c) Sprague-Dawley rats fed a diet supplemented with orotic acid."7.67Biosynthesis of hippurate, urea and pyrimidines in the fatty liver: studies with rats fed orotic acid or a diet deficient in choline and inositol, and with genetically obese (Zucker) rats. ( Maswoswe, SM; Tremblay, GC, 1989)
" The dose-response relationship between feed intake, liver hemorrhagic score and liver lipid content was again demonstrated."5.25Effect of inositol, lecithin, vitamins (B12 with choline and E), and iodinated casein on induced fatty liver-hemorrhagic syndrome in laying chickens. ( Polin, D; Wolford, JH, 1975)
"d- chiro-Inositol (DCI) is a biologically active component found in tartary buckwheat, which can reduce hyperglycemia and ameliorate insulin resistance."3.91d- chiro-Inositol Ameliorates High Fat Diet-Induced Hepatic Steatosis and Insulin Resistance via PKCε-PI3K/AKT Pathway. ( Cheng, F; Ge, X; Han, L; Li, Y; Pan, C; Wang, M; Xiao, Y; Yan, S; Zhang, Y, 2019)
"This study was designed to investigate the protective effects of d-Chiro-Inositol (DCI) enriched tartary buckwheat extract (DTBE) against high fructose (HF) diet-induced hyperglycemia and liver injury in mice."3.81Hypoglycemic and hepatoprotective effects of D-chiro-inositol-enriched tartary buckwheat extract in high fructose-fed mice. ( Guo, J; Hu, Y; Luo, Y; Ren, D; Yang, X; Zhao, Y, 2015)
"We have previously shown that dietary inositol hexakisphosphate (IP6) and myo-inositol prevent fatty liver in rats fed a casein-based diet containing 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane (DDT)."3.74Dietary inositol hexakisphosphate, but not myo-inositol, clearly improves hypercholesterolemia in rats fed casein-type amino acid mixtures and 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane. ( Katayama, T; Okazaki, Y, 2008)
"The activities of pathways for the biosynthesis of hippurate, urea and pyrimidines in hepatocytes isolated from lean livers were compared with those from three sources of fatty liver: a) the genetically obese Zucker rat, b) Sprague-Dawley rats fed a diet deficient in choline and inositol, and c) Sprague-Dawley rats fed a diet supplemented with orotic acid."3.67Biosynthesis of hippurate, urea and pyrimidines in the fatty liver: studies with rats fed orotic acid or a diet deficient in choline and inositol, and with genetically obese (Zucker) rats. ( Maswoswe, SM; Tremblay, GC, 1989)
"Myo-inositol is a necessary component of the phospholipid phosphatidyl-inositol, which is an important membrane constituent."1.27Inositol as a lipotropic agent in dairy cattle diets. ( Emery, RS; Gerloff, BJ; Herdt, TH; Wells, WW, 1984)
" The dose-response relationship between feed intake, liver hemorrhagic score and liver lipid content was again demonstrated."1.25Effect of inositol, lecithin, vitamins (B12 with choline and E), and iodinated casein on induced fatty liver-hemorrhagic syndrome in laying chickens. ( Polin, D; Wolford, JH, 1975)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199028 (77.78)18.7374
1990's1 (2.78)18.2507
2000's2 (5.56)29.6817
2010's4 (11.11)24.3611
2020's1 (2.78)2.80

Authors

AuthorsStudies
Yang, Q1
Zhang, Y2
Li, L1
Li, J1
Li, Y2
Han, L2
Wang, M2
Liu, X1
Green, RM1
Cheng, F1
Xiao, Y1
Pan, C1
Ge, X1
Yan, S1
Hu, Y1
Zhao, Y1
Ren, D1
Guo, J1
Luo, Y1
Yang, X1
Okazaki, Y1
Katayama, T1
EILERT, ML1
DRAGSTEDT, LR1
Elphick, LM1
Pawolleck, N1
Guschina, IA1
Chaieb, L1
Eikel, D1
Nau, H1
Harwood, JL1
Plant, NJ1
Williams, RS1
LEVY, M1
TSAMBOULAS, N1
MARGARONIS, K1
KRIKELIS, J1
WOOD, JD1
CATOLLA-CAVALCANTI, A1
CATOLLA CAVALCANTI, A1
LEVIS, F1
Gerloff, BJ1
Herdt, TH1
Emery, RS1
Wells, WW4
Jariwalla, RJ1
Wolford, JH2
Polin, D1
Burton, LE3
Hoover, GA1
Nicolosi, RJ1
Corey, JE1
el Lozy, M1
Hayes, KC1
Trznadel, K1
Lutz, W1
Pearce, J1
Leclerc, J1
Maswoswe, SM1
Tremblay, GC1
Laird, RD1
Drill, VA1
Hasan, SH5
Nakagawa, Y2
Nishigaki, I2
Yagi, K6
Hamilton, PB1
Garlich, JD1
Murphy, D1
Beckmann, R1
Petith, M1
Filippini, L1
Kotaki, A5
Okumura, M1
Okuyama, S1
Neuman, M1
Cachin, M1
Galian, P1
Charbonnier, A1
Pergola, F1
Sakurai, T1
Kobayashi, M1
Pisi, E1
Bianchi, FB1
Nigro, F1

Reviews

3 reviews available for inositol and Liver Steatosis

ArticleYear
Rice-bran products: phytonutrients with potential applications in preventive and clinical medicine.
    Drugs under experimental and clinical research, 2001, Volume: 27, Issue:1

    Topics: Animals; Anticholesteremic Agents; Coumaric Acids; Dietary Fiber; Fatty Liver; Free Radical Scavenge

2001
[Biochemical and clinical aspects of myoinositol].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1976, Oct-25, Volume: 31, Issue:43

    Topics: Animals; Biological Transport, Active; Cell Membrane; Diabetes Mellitus; Fatty Liver; Guinea Pigs; H

1976
[Inosite: recent experimental and clinical findigs. Review of the literature and therapeutic experience].
    Die Medizinische Welt, 1970, Jan-24, Volume: 4

    Topics: Animals; Bacteria; Cattle; Central Nervous System; Dogs; Fatty Liver; Female; Humans; Hyperlipidemia

1970

Other Studies

33 other studies available for inositol and Liver Steatosis

ArticleYear
D-
    Food & function, 2022, Jul-04, Volume: 13, Issue:13

    Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Body Weight; Diet, High-Fat; Fatty Liver; Gluco

2022
MicroRNAs: Unfolding the Link Between Inositol-Requiring Enzyme 1α and Fatty Liver.
    Hepatology (Baltimore, Md.), 2019, Volume: 69, Issue:6

    Topics: Endoribonucleases; Fatty Liver; Humans; Inositol; Liver; MicroRNAs; Protein Serine-Threonine Kinases

2019
d- chiro-Inositol Ameliorates High Fat Diet-Induced Hepatic Steatosis and Insulin Resistance via PKCε-PI3K/AKT Pathway.
    Journal of agricultural and food chemistry, 2019, May-29, Volume: 67, Issue:21

    Topics: Animals; Diet, High-Fat; Fatty Liver; Hep G2 Cells; Hepatocytes; Humans; Hypoglycemic Agents; Inosit

2019
Hypoglycemic and hepatoprotective effects of D-chiro-inositol-enriched tartary buckwheat extract in high fructose-fed mice.
    Food & function, 2015, Volume: 6, Issue:12

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Glucose; C-Reactive Protein; Chemi

2015
Dietary inositol hexakisphosphate, but not myo-inositol, clearly improves hypercholesterolemia in rats fed casein-type amino acid mixtures and 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane.
    Nutrition research (New York, N.Y.), 2008, Volume: 28, Issue:10

    Topics: Animals; Caseins; Cholesterol; DDT; Fatty Liver; Hypercholesterolemia; Inositol; Male; Phospholipids

2008
Lipotropic action of lipocaic; a study of the effect of oral and parenteral lipocaic and oral inositol on the dietary fatty liver of the white rat.
    The American journal of physiology, 1946, Volume: 147

    Topics: Animals; Fats; Fatty Liver; Inositol; Lipid Metabolism; Lipotropic Agents; Pancreas; Pancreatic Extr

1946
Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds.
    Disease models & mechanisms, 2012, Volume: 5, Issue:2

    Topics: Cell Line; Dictyostelium; Fatty Acids; Fatty Liver; Hepatocytes; Humans; Inositol; Kinetics; Lipid M

2012
[Effect of choline and inositol on metabolic disorders found in animals with various types of steatosis].
    Archives des sciences physiologiques, 1957, Volume: 11, Issue:3

    Topics: Animals; Choline; Fatty Liver; Inositol; Metabolic Diseases

1957
[The prevention of lipophanerosis of the liver by lipotropic substances].
    Gastroenterologia, 1958, Volume: 90, Issue:6

    Topics: Biomedical Research; Choline; Fatty Liver; Inositol; Lipotropic Agents; Liver; Methionine

1958
THE EFFECT OF COLD EXPOSURE ON PLASMA AND LIVER CHOLESTEROL LEVELS IN RATS FED VARIOUS DIETS.
    Canadian journal of physiology and pharmacology, 1964, Volume: 42

    Topics: Biochemical Phenomena; Biochemistry; Body Weight; Cholesterol; Choline; Choline Deficiency; Cold Tem

1964
[Hepatic steatosis due to phosphorus; lipotropic action of choline and of combined choline-inositol].
    Minerva medica, 1950, Nov-03, Volume: 41, Issue:56

    Topics: Choline; Fatty Liver; Humans; Inositol; Lipotropic Agents; Phosphorus

1950
[Steatosis of the liver due to phosphorus. I. Lipotropic action of pantothenic acid and of its combination with meso-inositol].
    Archivio per le scienze mediche, 1950, Volume: 90, Issue:6

    Topics: Adipose Tissue; Fatty Liver; Inositol; Lipotropic Agents; Pantothenic Acid; Phosphorus; Phosphorus,

1950
Inositol as a lipotropic agent in dairy cattle diets.
    Journal of animal science, 1984, Volume: 59, Issue:3

    Topics: Animals; Cattle; Cattle Diseases; Fatty Liver; Female; Food, Fortified; Inositol; Insulin; Liver; Pr

1984
Effect of inositol, lecithin, vitamins (B12 with choline and E), and iodinated casein on induced fatty liver-hemorrhagic syndrome in laying chickens.
    Poultry science, 1975, Volume: 54, Issue:4

    Topics: Animal Feed; Animals; Caseins; Chickens; Choline; Eggs; Fatty Liver; Female; Hemorrhage; Inositol; I

1975
myo-Inositol deficiency: studies on the mechanism of lactation-dependent fatty liver formation in the rat.
    The Journal of nutrition, 1979, Volume: 109, Issue:8

    Topics: Animals; Fatty Liver; Female; Inositol; Lactation; Lipids; Liver; Microsomes, Liver; Palmitic Acids;

1979
Characterization of the lactation-dependent fatty liver in myo-inositol deficient rats.
    The Journal of nutrition, 1977, Volume: 107, Issue:10

    Topics: Animals; Cholesterol; Cholesterol Esters; Fatty Liver; Female; Inositol; Lactation; Lipid Metabolism

1977
Inositol deficiency in the gerbil: altered hepatic lipid metabolism and triglyceride secretion.
    The Journal of nutrition, 1978, Volume: 108, Issue:10

    Topics: Animals; Cholesterol; Cocos; Dietary Carbohydrates; Dietary Fats; Fatty Liver; Gerbillinae; Inositol

1978
myo-Inositol metabolism during lactation and development in the rat. The prevention of lactation-induced fatty liver by dietary myo-inositol.
    The Journal of nutrition, 1976, Volume: 106, Issue:11

    Topics: Amniotic Fluid; Animals; Body Weight; Disaccharides; Fatty Liver; Female; Galactose; Inositol; Lacta

1976
The effects of choline and inositol on hepatic lipid metabolism and the incidence of the fatty liver and kidney syndrome in broilers.
    British poultry science, 1975, Volume: 16, Issue:6

    Topics: Animal Feed; Animals; ATP Citrate (pro-S)-Lyase; Chickens; Choline; Dietary Proteins; Fatty Liver; I

1975
Fatty liver induced by methionine supplementation of low protein diet: effect of inositol supply.
    The Journal of nutrition, 1991, Volume: 121, Issue:7

    Topics: Animals; Dietary Proteins; Fatty Liver; Inositol; Methionine; Rats

1991
Biosynthesis of hippurate, urea and pyrimidines in the fatty liver: studies with rats fed orotic acid or a diet deficient in choline and inositol, and with genetically obese (Zucker) rats.
    The Journal of nutrition, 1989, Volume: 119, Issue:2

    Topics: Ammonium Chloride; Animals; Benzoates; Choline Deficiency; Diet; Fatty Liver; Gluconeogenesis; Hippu

1989
Lipotropic activity of inositol and chlortetracycline alone and in various combinations of choline, vitamin B 12 and folic acid. Activity of three liver extracts with assays for these substances.
    Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 194, Issue:1

    Topics: Animals; Body Weight; Cattle; Chlortetracycline; Choline; Dietary Fats; Drug Combinations; Fatty Liv

1971
Studies on myoinositol. 8. The incorporation of 3 H-myoinositol into phosphatidyl-inositol of fatty liver.
    The Journal of vitaminology, 1971, Sep-10, Volume: 17, Issue:3

    Topics: Animals; Chromatography; Fatty Liver; Inositol; Lipids; Lipoproteins; Liver; Male; Microsomes, Liver

1971
Failure of vitamin supplementation to alter the fatty liver syndrome caused by aflatoxin.
    Poultry science, 1972, Volume: 51, Issue:2

    Topics: Aflatoxins; Animals; Aspergillus flavus; Chickens; Choline; Fatty Liver; Female; Inositol; Lipids; L

1972
Effect of diet on fatty liver-hemorrhagic syndrome incidence in laying chickens.
    Poultry science, 1972, Volume: 51, Issue:6

    Topics: Animals; Body Weight; Chickens; Choline; Cobalt; Diet; Fatty Liver; Female; Hemorrhage; Inositol; Li

1972
[Therapy of hepatic steatosis].
    Minerva medica, 1972, Apr-25, Volume: 63, Issue:31

    Topics: Diet Therapy; Fatty Liver; Humans; Inositol; Liver Extracts; Nicotinic Acids; Prognosis; Tolbutamide

1972
Studies on myoinositol. VI. Effect of myoinositol on plasma lipoprotein metabolism of rats suffering from fatty liver.
    The Journal of vitaminology, 1970, Jun-10, Volume: 16, Issue:2

    Topics: Acetates; Animals; Body Weight; Carbon Isotopes; Cholesterol; Fatty Liver; Inositol; Leucine; Lipopr

1970
Studies on myoinositol. V. Effect of myoinositol on the prevention of fatty liver induced by orotic acid.
    The Journal of vitaminology, 1970, Mar-10, Volume: 16, Issue:1

    Topics: Animals; Choline; Fatty Liver; Injections, Subcutaneous; Inositol; Lipid Metabolism; Liver; Male; Mu

1970
Retardation of microsomal protein synthesis in rat liver due to induction of Handler's experimental fatty liver.
    The Journal of vitaminology, 1970, Mar-10, Volume: 16, Issue:1

    Topics: Animals; Choline; Fatty Liver; Injections, Subcutaneous; Inositol; Leucine; Male; Microsomes, Liver;

1970
Studies on myoinositol. VII. Removal of deposited fats from dietary fatty liver.
    The Journal of vitaminology, 1970, Jun-10, Volume: 17, Issue:2

    Topics: Animals; Cholesterol; Cytoplasm; Diet; Endoplasmic Reticulum; Fatty Liver; Inositol; Lipids; Lipopro

1970
[Treatment of hyperlipemia and steatosis by high doses of meso-insitol hexanicotinate].
    Semaine therapeutique, 1968, Volume: 44, Issue:10

    Topics: Adult; Fatty Liver; Humans; Hyperlipidemias; Inositol; Middle Aged; Nicotinic Acids

1968
Studies on myoinositol. IV. Effect of myoinositol on the cholesterol metabolism of rats suffering from experimental fatty liver.
    The Journal of vitaminology, 1968, Jun-10, Volume: 14, Issue:2

    Topics: Acetates; Adipose Tissue; Animals; Carbon Isotopes; Cholesterol; Choline; Fatty Liver; Inositol; Lip

1968
[Considerations on the therapy of hepatic steatosis].
    Minerva medica, 1969, Aug-29, Volume: 60, Issue:69

    Topics: Adult; Aged; Alcoholism; Choline; Colitis, Ulcerative; Diabetes Complications; Fatty Liver; Gout; He

1969