inositol has been researched along with Liver Cirrhosis in 20 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recent in vivo studies using proton magnetic resonance (1H-MR) spectroscopy showed low levels of myo-inositol in the brain in hepatic encephalopathy; the pathogenetic relevance of this observation is unclear." | 7.69 | Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy. ( Bayer, S; Ernst, T; Gerok, W; Häussinger, D; Hennig, J; Langer, M; Laubenberger, J; vom Dahl, S, 1994) |
| " Combination of carotenoids and myo-inositol was found to prevent hepatocellular carcinoma development in patients with chronic viral hepatitis and cirrhosis." | 5.14 | Phytochemicals in hepatocellular cancer prevention. ( Nishino, H, 2009) |
| "In a double-blind study, overt hepatic encephalopathy (HE) and SCHE (defined with clinical and neuropsychiatric tests) were compared by means of H-1 MR spectroscopic criteria--reduction in cerebral myo-inositol (< 2 standard deviations [SDs] from normal) and choline (< 2 SDs from normal) with or without increased cerebral glutamine (> 1 SD from normal)--in 20 patients with cirrhosis." | 5.07 | Subclinical hepatic encephalopathy: proton MR spectroscopic abnormalities. ( Ernst, T; Jacobson, S; Korula, J; Kreis, R; Moats, RA; Ross, BD; Shonk, T; Villamil, F, 1994) |
| "Asymmetric dimethylarginine (ADMA) is an inhibitor of nitric oxide synthase that accumulates in liver disease and may contribute to hepatic encephalopathy (HE)." | 3.79 | Asymmetric dimethylarginine is strongly associated with cognitive dysfunction and brain MR spectroscopic abnormalities in cirrhosis. ( Ahluwalia, V; Bajaj, JS; Bouneva, I; Fuchs, M; Gilles, H; Heuman, DM; Kraft, KA; Luketic, V; Monteith, P; Noble, NA; Puri, P; Sanyal, AJ; Sterling, RK; Stravitz, RT; Wade, JB; White, MB, 2013) |
| " Significant decrease of myo-inositol in adults is probably due to cellular osmoregulation secondary to long-standing hyperammonemia." | 3.76 | Brain MR imaging and 1H-MR spectroscopy changes in patients with extrahepatic portal vein obstruction from early childhood to adulthood. ( Gupta, RK; Rathore, RK; Saksena, S; Saraswat, VA; Srivastava, A; Thomas, MA; Yadav, SK, 2010) |
| " Decreased myo-inositol and increased glutamine levels were noted to be the most sensitive spectroscopic markers for cirrhotic patients with hepatic encephalopathy (HE)." | 3.70 | Proton magnetic resonance spectroscopy (1H-MRS) findings for the brain in patients with liver cirrhosis reflect the hepatic functional reserve. ( Kim, ST; Lee, JH; Lee, YS; Lim, TH; Min, YI; Mun, CW; Seo, DW; Suh, DJ, 1999) |
| "Recent in vivo studies using proton magnetic resonance (1H-MR) spectroscopy showed low levels of myo-inositol in the brain in hepatic encephalopathy; the pathogenetic relevance of this observation is unclear." | 3.69 | Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy. ( Bayer, S; Ernst, T; Gerok, W; Häussinger, D; Hennig, J; Langer, M; Laubenberger, J; vom Dahl, S, 1994) |
| "Human hepatic encephalopathy (HE) is identified by a new noninvasive test, proton magnetic resonance spectroscopy (1H MRS) applied to the brain in a few minutes." | 2.39 | Proton magnetic resonance spectroscopy: the new gold standard for diagnosis of clinical and subclinical hepatic encephalopathy? ( Blüml, S; Danielsen, ER; Ross, BD, 1996) |
| "Hyponatremia has a complex, non-linear relationship with brain Glx and mI, cognition and HRQOL." | 1.39 | Differential impact of hyponatremia and hepatic encephalopathy on health-related quality of life and brain metabolite abnormalities in cirrhosis. ( Ahluwalia, V; Bajaj, JS; Bouneva, I; Fuchs, M; Gilles, H; Heuman, DM; Kraft, KA; Luketic, V; Puri, P; Sanyal, AJ; Sterling, RK; Stravitz, RT; Thacker, L; Wade, JB, 2013) |
| "Minimal hepatic encephalopathy (MHE) is frequently diagnosed in patients with liver cirrhosis who do not show overt clinical cirrhosis-associated neurological deficits." | 1.33 | Chemical shift magnetic resonance spectroscopy of cingulate grey matter in patients with minimal hepatic encephalopathy. ( Graziadei, IW; Hinterhuber, H; Kugener, A; Marksteiner, J; Mattedi, M; Mechtcheriakov, S; Schocke, M; Vogel, W, 2005) |
| "6 patients with liver cirrhosis were included in this pilot study." | 1.33 | [Detection of subclinical and overt hepatic encephalopathy and treatment control after L-ornithine-L-aspartate medication by magnetic resonance spectroscopy ((1)H-MRS)]. ( Gregor, M; Hass, HG; Hösl, F; Kaiser, S; Nägele, T; Seeger, U, 2005) |
| "Hepatic encephalopathy is a common problem in cirrhosis." | 1.30 | Cerebral abnormalities in patients with cirrhosis detected by proton magnetic resonance spectroscopy and magnetic resonance imaging. ( Andus, T; Feuerbach, S; Fründ, R; Geissler, A; Held, P; Hollerbach, S; Holstege, A; Lock, G; Schölmerich, J, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (20.00) | 18.7374 |
| 1990's | 5 (25.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 6 (30.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chaganti, J | 1 |
| Zeng, G | 1 |
| Tun, N | 1 |
| Lockart, I | 1 |
| Abdelshaheed, C | 1 |
| Cysique, L | 1 |
| Montagnese, S | 1 |
| Brew, BJ | 1 |
| Danta, M | 1 |
| Zhao, SS | 1 |
| Li, NR | 1 |
| Zhao, WL | 1 |
| Liu, H | 1 |
| Ge, MX | 1 |
| Zhang, YX | 1 |
| Zhao, LY | 1 |
| You, XF | 1 |
| He, HW | 1 |
| Shao, RG | 1 |
| Ahluwalia, V | 2 |
| Wade, JB | 2 |
| Thacker, L | 1 |
| Kraft, KA | 2 |
| Sterling, RK | 2 |
| Stravitz, RT | 2 |
| Fuchs, M | 2 |
| Bouneva, I | 2 |
| Puri, P | 2 |
| Luketic, V | 2 |
| Sanyal, AJ | 2 |
| Gilles, H | 2 |
| Heuman, DM | 2 |
| Bajaj, JS | 2 |
| Razek, AA | 1 |
| Abdalla, A | 1 |
| Ezzat, A | 1 |
| Megahed, A | 1 |
| Barakat, T | 1 |
| Meng, LP | 1 |
| Chen, YC | 1 |
| Li, YH | 1 |
| Zhu, JS | 1 |
| Ye, JL | 1 |
| Nishino, H | 1 |
| Yadav, SK | 1 |
| Saksena, S | 1 |
| Srivastava, A | 2 |
| Saraswat, VA | 1 |
| Thomas, MA | 1 |
| Rathore, RK | 1 |
| Gupta, RK | 1 |
| GEPHARDT, MC | 1 |
| White, MB | 1 |
| Noble, NA | 1 |
| Monteith, P | 1 |
| GONZALEZ ALVAREZ, J | 2 |
| Shawcross, DL | 1 |
| Balata, S | 1 |
| Olde Damink, SW | 1 |
| Hayes, PC | 1 |
| Wardlaw, J | 1 |
| Marshall, I | 1 |
| Deutz, NE | 1 |
| Williams, R | 1 |
| Jalan, R | 1 |
| Mechtcheriakov, S | 1 |
| Schocke, M | 1 |
| Kugener, A | 1 |
| Graziadei, IW | 1 |
| Mattedi, M | 1 |
| Hinterhuber, H | 1 |
| Vogel, W | 1 |
| Marksteiner, J | 1 |
| Hass, HG | 1 |
| Nägele, T | 1 |
| Seeger, U | 1 |
| Hösl, F | 1 |
| Gregor, M | 1 |
| Kaiser, S | 1 |
| Häussinger, D | 1 |
| Laubenberger, J | 1 |
| vom Dahl, S | 1 |
| Ernst, T | 2 |
| Bayer, S | 1 |
| Langer, M | 1 |
| Gerok, W | 1 |
| Hennig, J | 1 |
| Ross, BD | 2 |
| Jacobson, S | 1 |
| Villamil, F | 1 |
| Korula, J | 1 |
| Kreis, R | 1 |
| Shonk, T | 1 |
| Moats, RA | 1 |
| Danielsen, ER | 1 |
| Blüml, S | 1 |
| Geissler, A | 1 |
| Lock, G | 1 |
| Fründ, R | 1 |
| Held, P | 1 |
| Hollerbach, S | 1 |
| Andus, T | 1 |
| Schölmerich, J | 1 |
| Feuerbach, S | 1 |
| Holstege, A | 1 |
| Lee, JH | 1 |
| Seo, DW | 1 |
| Lee, YS | 1 |
| Kim, ST | 1 |
| Mun, CW | 1 |
| Lim, TH | 1 |
| Min, YI | 1 |
| Suh, DJ | 1 |
| Pitkänen, E | 1 |
| Servo, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of Magnetic Resonance Imaging in Detection of Minimal Hepatic Encephalopathy[NCT04131205] | 40 participants (Anticipated) | Observational | 2019-06-01 | Recruiting | |||
| A Magnetic Resonance Spectroscopy Study of Neuropsychiatric Effects Associated With Cytokines[NCT00001547] | 150 participants | Observational | 1996-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for inositol and Liver Cirrhosis
| Article | Year |
|---|---|
Proton magnetic resonance spectroscopy: the new gold standard for diagnosis of clinical and subclinical hepatic encephalopathy?
Topics: Animals; Astrocytes; Brain; Choline; Cognition Disorders; Disease Models, Animal; Glutamine; Hepatic | 1996 |
4 trials available for inositol and Liver Cirrhosis
| Article | Year |
|---|---|
Minimal hepatic encephalopathy in children with liver cirrhosis: diffusion-weighted MR imaging and proton MR spectroscopy of the brain.
Topics: Adolescent; Child; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Female; Glutamic Acid; H | 2014 |
Phytochemicals in hepatocellular cancer prevention.
Topics: alpha-Tocopherol; Animals; Anticarcinogenic Agents; beta Carotene; Carcinoma, Hepatocellular; Carote | 2009 |
Low myo-inositol and high glutamine levels in brain are associated with neuropsychological deterioration after induced hyperammonemia.
Topics: Adult; Aged; Amino Acids; Ammonia; Basal Ganglia; Brain Chemistry; Choline; Creatinine; Female; Glut | 2004 |
Subclinical hepatic encephalopathy: proton MR spectroscopic abnormalities.
Topics: Adult; Brain Chemistry; Choline; Double-Blind Method; Female; Glutamine; Hepatic Encephalopathy; Hum | 1994 |
15 other studies available for inositol and Liver Cirrhosis
| Article | Year |
|---|---|
Novel magnetic resonance KTRANS measurement of blood-brain barrier permeability correlated with covert HE.
Topics: Blood-Brain Barrier; Brain; Choline; Glutamine; Hepatic Encephalopathy; Humans; Inositol; Liver Cirr | 2023 |
D-chiro-inositol effectively attenuates cholestasis in bile duct ligated rats by improving bile acid secretion and attenuating oxidative stress.
Topics: Alanine Transaminase; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aspartate Am | 2018 |
Differential impact of hyponatremia and hepatic encephalopathy on health-related quality of life and brain metabolite abnormalities in cirrhosis.
Topics: Brain; Cognition; Cognition Disorders; Diuretics; Female; Glutamic Acid; Glutamine; Hepatic Encephal | 2013 |
Viability assessment of magnetic resonance spectroscopy for the detection of minimal hepatic encephalopathy severity.
Topics: Adult; Aspartic Acid; Basal Ganglia; Brain; Cognition; Creatine; Female; Glutamic Acid; Glutamine; G | 2015 |
Brain MR imaging and 1H-MR spectroscopy changes in patients with extrahepatic portal vein obstruction from early childhood to adulthood.
Topics: Adolescent; Adult; Age Factors; Ammonia; Basal Ganglia; Child; Female; Hepatic Encephalopathy; Human | 2010 |
Xanthomatous biliary cirrhosis; lipid levels while receiving inositol.
Topics: Blood; Humans; Inositol; Lipids; Liver Cirrhosis; Liver Cirrhosis, Biliary; Xanthomatosis | 1947 |
Asymmetric dimethylarginine is strongly associated with cognitive dysfunction and brain MR spectroscopic abnormalities in cirrhosis.
Topics: Adult; Arginine; Aspartic Acid; Biomarkers; Brain; Cognition Disorders; Cross-Sectional Studies; Fem | 2013 |
[Electrophoresis on paper. V. Effect of cholineinositol on blood lipids and proteins].
Topics: Arteriosclerosis; Blood Proteins; Cholesterol; Choline; Diabetes Mellitus; Electrophoresis; Humans; | 1955 |
[Electrophoresis on paper. V. Effect of cholineinositol on blood lipids and proteins].
Topics: Arteriosclerosis; Blood Proteins; Cholesterol; Choline; Diabetes Mellitus; Electrophoresis; Humans; | 1955 |
[Electrophoresis on paper. V. Effect of cholineinositol on blood lipids and proteins].
Topics: Arteriosclerosis; Blood Proteins; Cholesterol; Choline; Diabetes Mellitus; Electrophoresis; Humans; | 1955 |
[Electrophoresis on paper. V. Effect of cholineinositol on blood lipids and proteins].
Topics: Arteriosclerosis; Blood Proteins; Cholesterol; Choline; Diabetes Mellitus; Electrophoresis; Humans; | 1955 |
Chemical shift magnetic resonance spectroscopy of cingulate grey matter in patients with minimal hepatic encephalopathy.
Topics: Aspartic Acid; Cerebral Cortex; Choline; Creatinine; Female; Glutamic Acid; Glutamine; Gyrus Cinguli | 2005 |
[Detection of subclinical and overt hepatic encephalopathy and treatment control after L-ornithine-L-aspartate medication by magnetic resonance spectroscopy ((1)H-MRS)].
Topics: Adult; Ammonia; Brain; Choline; Combined Modality Therapy; Creatinine; Diet, Protein-Restricted; Dip | 2005 |
Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Brain Chemistry; Brain Diseases; Female; Glutamine; | 1994 |
Cerebral abnormalities in patients with cirrhosis detected by proton magnetic resonance spectroscopy and magnetic resonance imaging.
Topics: Adult; Aged; Aspartic Acid; Brain; Choline; Female; Glutamic Acid; Hepatic Encephalopathy; Humans; I | 1997 |
Proton magnetic resonance spectroscopy (1H-MRS) findings for the brain in patients with liver cirrhosis reflect the hepatic functional reserve.
Topics: Adult; Aged; Aspartic Acid; Basal Ganglia; Brain; Choline; Creatinine; Energy Metabolism; Female; Gl | 1999 |
Lipotropic products.
Topics: Choline; Humans; Inositol; Lipotropic Agents; Liver Cirrhosis | 1973 |
Polyol oxidoreductase activity in human blood serum during acute hepatitis.
Topics: Acute Disease; Alcohol Oxidoreductases; Aspartate Aminotransferases; Carbohydrates; Electrophoresis; | 1971 |