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inositol and Leukodystrophy, Globoid Cell

inositol has been researched along with Leukodystrophy, Globoid Cell in 3 studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Leukodystrophy, Globoid Cell: An autosomal recessive metabolic disorder caused by a deficiency of GALACTOSYLCERAMIDASE leading to intralysosomal accumulation of galactolipids such as GALACTOSYLCERAMIDES and PSYCHOSINE. It is characterized by demyelination associated with large multinucleated globoid cells, predominantly involving the white matter of the central nervous system. The loss of MYELIN disrupts normal conduction of nerve impulses.

Research Excerpts

ExcerptRelevanceReference
"Krabbe disease (globoid cell leukodystrophy [GLD]) is an autosomal recessive lysosomal disorder affecting the central and peripheral nervous system."2.71Proton MRS profile of cerebral metabolic abnormalities in Krabbe disease. ( Brockmann, K; Dechent, P; Frahm, J; Hanefeld, F; Rusch, O; Wilken, B, 2003)
"We present a case of infantile onset Krabbe disease with prolonged survival, initial intracranial optic nerves and optic chiasm hypertrophy, and serial changes on cranial magnetic resonance imaging and magnetic resonance spectroscopy."1.38Prolonged survival and serial magnetic resonance imaging/magnetic resonance spectroscopy changes in infantile Krabbe disease. ( Bunge, M; Mhanni, AA; Ryner, L; Salman, MS; Udow, S, 2012)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Udow, S1
Bunge, M1
Ryner, L1
Mhanni, AA1
Salman, MS1
Brockmann, K1
Dechent, P1
Wilken, B1
Rusch, O1
Frahm, J1
Hanefeld, F1
Vanier, MT1
Svennerholm, L1

Trials

1 trial available for inositol and Leukodystrophy, Globoid Cell

ArticleYear
Proton MRS profile of cerebral metabolic abnormalities in Krabbe disease.
    Neurology, 2003, Mar-11, Volume: 60, Issue:5

    Topics: Adult; Aspartic Acid; Basal Ganglia; Brain; Child; Child, Preschool; Choline; Creatinine; Dipeptides

2003

Other Studies

2 other studies available for inositol and Leukodystrophy, Globoid Cell

ArticleYear
Prolonged survival and serial magnetic resonance imaging/magnetic resonance spectroscopy changes in infantile Krabbe disease.
    Pediatric neurology, 2012, Volume: 47, Issue:4

    Topics: Anticonvulsants; Aspartic Acid; Brain Chemistry; Choline; Combined Modality Therapy; Creatine; DNA M

2012
Chemical pathology of Krabbe's disease. I. Lipid composition and fatty acid patterns of phosphoglycerides in brain.
    Acta paediatrica Scandinavica, 1974, Volume: 63, Issue:4

    Topics: Brain Chemistry; Cerebral Cortex; Cerebrosides; Child, Preschool; Cholesterol; Choline; Ethanolamine

1974