Page last updated: 2024-10-19

inositol and Hypothyroidism

inositol has been researched along with Hypothyroidism in 18 studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.

Research Excerpts

ExcerptRelevanceReference
"The beneficial effects obtained by myo-inositol in association with seleno-methionine in patients affected by subclinical hypothyroidism have been recently demonstrated."9.24Myo-inositol and selenium reduce the risk of developing overt hypothyroidism in patients with autoimmune thyroiditis. ( Antonelli, A; Benvenga, S; Di Bari, F; Fallahi, P; Ferrari, SM; Vita, R, 2017)
" Both metformin and myo-inositol were found to improve insulin sensitivity and to reduce thyrotropin levels in individuals with hypothyroidism."8.12Differences in levothyroxine action on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity between metformin- and myo-inositol-treated women with autoimmune subclinical hypothyroidism. ( Kowalcze, K; Krysiak, R; Okopień, B, 2022)
"The present study aims to evaluate the effect of myo-Inositol plus Selenium supplementation in patients affected by subclinical hypothyroidism."8.12Supplementation with myo-inositol and Selenium improves the clinical conditions and biochemical features of women with or at risk for subclinical hypothyroidism. ( Džupon, M; Jackuliak, P; Kužma, M; Payer, J; Vaňuga, P, 2022)
"The effects of hypothyroidism on the muscarinic cholinergic receptor-coupled inositol phospholipid hydrolysis in the adult rat brain were examined."7.68Hypothyroidism inhibits the formation of inositol phosphate in response to carbachol in the striatum of adult rat. ( Iriuchijima, T; Michimata, T; Mizuma, H; Mori, M; Murakami, M; Yamada, M, 1991)
"Myoinositol (Myo) is an isoform of inositol, a cyclic polyol with 6 hydroxyl groups."6.82Myoinositol in Autoimmune Thyroiditis. ( Antonelli, A; Balestri, E; Benvenga, S; Botrini, C; Elia, G; Fallahi, P; Ferrari, SM; Guarneri, F; Paparo, SR; Patrizio, A; Ragusa, F, 2022)
"Myo-inositol (Myo-Ins) plays an important role in thyroid function and autoimmunity."6.58Myo-inositol in autoimmune thyroiditis, and hypothyroidism. ( Antonelli, A; Caruso, C; Elia, G; Fallahi, P; Ferrari, SM; Guglielmi, G; Paparo, SR; Ragusa, F, 2018)
"The beneficial effects obtained by myo-inositol in association with seleno-methionine in patients affected by subclinical hypothyroidism have been recently demonstrated."5.24Myo-inositol and selenium reduce the risk of developing overt hypothyroidism in patients with autoimmune thyroiditis. ( Antonelli, A; Benvenga, S; Di Bari, F; Fallahi, P; Ferrari, SM; Vita, R, 2017)
" Both metformin and myo-inositol were found to improve insulin sensitivity and to reduce thyrotropin levels in individuals with hypothyroidism."4.12Differences in levothyroxine action on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity between metformin- and myo-inositol-treated women with autoimmune subclinical hypothyroidism. ( Kowalcze, K; Krysiak, R; Okopień, B, 2022)
"The present study aims to evaluate the effect of myo-Inositol plus Selenium supplementation in patients affected by subclinical hypothyroidism."4.12Supplementation with myo-inositol and Selenium improves the clinical conditions and biochemical features of women with or at risk for subclinical hypothyroidism. ( Džupon, M; Jackuliak, P; Kužma, M; Payer, J; Vaňuga, P, 2022)
"The effects of hypothyroidism on the muscarinic cholinergic receptor-coupled inositol phospholipid hydrolysis in the adult rat brain were examined."3.68Hypothyroidism inhibits the formation of inositol phosphate in response to carbachol in the striatum of adult rat. ( Iriuchijima, T; Michimata, T; Mizuma, H; Mori, M; Murakami, M; Yamada, M, 1991)
" There was a decrease in sensitivity to isoproterenol in spontaneously beating right atria, electrically driven left atria and field-stimulated vas deferens associated with hypothyroidism, with no change in maximum response."3.67Thyroid status and adrenergic receptor subtypes in the rat: comparison of receptor density and responsiveness. ( Abel, PW; Fox, AW; Johnson, RD; Juberg, EN; May, JM; Minneman, KP, 1985)
"Myoinositol (Myo) is an isoform of inositol, a cyclic polyol with 6 hydroxyl groups."2.82Myoinositol in Autoimmune Thyroiditis. ( Antonelli, A; Balestri, E; Benvenga, S; Botrini, C; Elia, G; Fallahi, P; Ferrari, SM; Guarneri, F; Paparo, SR; Patrizio, A; Ragusa, F, 2022)
"Myo-inositol (Myo-Ins) plays an important role in thyroid function and autoimmunity."2.58Myo-inositol in autoimmune thyroiditis, and hypothyroidism. ( Antonelli, A; Caruso, C; Elia, G; Fallahi, P; Ferrari, SM; Guglielmi, G; Paparo, SR; Ragusa, F, 2018)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19903 (16.67)18.7374
1990's4 (22.22)18.2507
2000's1 (5.56)29.6817
2010's7 (38.89)24.3611
2020's3 (16.67)2.80

Authors

AuthorsStudies
Krysiak, R1
Kowalcze, K1
Okopień, B1
Paparo, SR2
Ferrari, SM3
Patrizio, A1
Elia, G2
Ragusa, F2
Botrini, C1
Balestri, E1
Guarneri, F1
Benvenga, S3
Antonelli, A3
Fallahi, P3
Payer, J3
Jackuliak, P3
Kužma, M3
Džupon, M3
Vaňuga, P3
Di Bari, F1
Vita, R1
Nordio, M2
Basciani, S2
Caruso, C1
Guglielmi, G1
Morgante, G1
Musacchio, MC1
Orvieto, R1
Massaro, MG1
De Leo, V1
Singh, S1
Rana, P1
Kumar, P1
Shankar, LR1
Khushu, S1
Sijens, PE1
Rödiger, LA1
Meiners, LC1
Lunsing, RJ1
Gupta, RK1
Bhatia, V1
Poptani, H1
Gujral, RB1
Pintor, A1
Fortuna, S1
Lorenzini, P1
Pascale, A1
Battaini, F1
Avellino, C1
Malvezzi Campeggi, L1
Salvati, S1
Iriuchijima, T2
Mizuma, H2
Michimata, T2
Ogiwara, T1
Yamada, M2
Murakami, M2
Mori, M2
Fox, AW1
Juberg, EN1
May, JM1
Johnson, RD1
Abel, PW1
Minneman, KP1
de Siebenthal, J1
Jenny, M1
Ishii, J1
Nakao, K1

Reviews

2 reviews available for inositol and Hypothyroidism

ArticleYear
Myoinositol in Autoimmune Thyroiditis.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Hashimoto Disease; Humans; Hydrogen Peroxide; Hypothyroidism; Inositol; Thyroiditis, Autoimmune; Thy

2022
Myo-inositol in autoimmune thyroiditis, and hypothyroidism.
    Reviews in endocrine & metabolic disorders, 2018, Volume: 19, Issue:4

    Topics: Animals; Chemokine CXCL10; Humans; Hypothyroidism; Inositol; Thyroiditis, Autoimmune; Thyrotropin

2018

Trials

2 trials available for inositol and Hypothyroidism

ArticleYear
Myo-inositol and selenium reduce the risk of developing overt hypothyroidism in patients with autoimmune thyroiditis.
    European review for medical and pharmacological sciences, 2017, Volume: 21, Issue:2 Suppl

    Topics: Autoantibodies; Chemokine CXCL10; Disease Progression; Drug Therapy, Combination; Female; Humans; Hy

2017
Myo-inositol plus selenium supplementation restores euthyroid state in Hashimoto's patients with subclinical hypothyroidism.
    European review for medical and pharmacological sciences, 2017, Volume: 21, Issue:2 Suppl

    Topics: Adult; Autoantibodies; Autoantigens; Drug Therapy, Combination; Female; Hashimoto Disease; Humans; H

2017

Other Studies

14 other studies available for inositol and Hypothyroidism

ArticleYear
Differences in levothyroxine action on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity between metformin- and myo-inositol-treated women with autoimmune subclinical hypothyroidism.
    Journal of clinical pharmacy and therapeutics, 2022, Volume: 47, Issue:10

    Topics: Autoimmunity; C-Reactive Protein; Female; Glucose; Hashimoto Disease; Humans; Hypothyroidism; Inosit

2022
Supplementation with myo-inositol and Selenium improves the clinical conditions and biochemical features of women with or at risk for subclinical hypothyroidism.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Dietary Supplements; Female; Humans; Hypothyroidism; Inositol; Male; Selenium; Thyrotropin

2022
Supplementation with myo-inositol and Selenium improves the clinical conditions and biochemical features of women with or at risk for subclinical hypothyroidism.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Dietary Supplements; Female; Humans; Hypothyroidism; Inositol; Male; Selenium; Thyrotropin

2022
Supplementation with myo-inositol and Selenium improves the clinical conditions and biochemical features of women with or at risk for subclinical hypothyroidism.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Dietary Supplements; Female; Humans; Hypothyroidism; Inositol; Male; Selenium; Thyrotropin

2022
Supplementation with myo-inositol and Selenium improves the clinical conditions and biochemical features of women with or at risk for subclinical hypothyroidism.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Dietary Supplements; Female; Humans; Hypothyroidism; Inositol; Male; Selenium; Thyrotropin

2022
Evaluation of thyroid nodule characteristics in subclinical hypothyroid patients under a myo-inositol plus selenium treatment.
    European review for medical and pharmacological sciences, 2018, Volume: 22, Issue:7

    Topics: Adult; Antioxidants; Drug Therapy, Combination; Female; Humans; Hypothyroidism; Inositol; Male; Midd

2018
Alterations in thyroid function among the different polycystic ovary syndrome phenotypes.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2013, Volume: 29, Issue:11

    Topics: Adult; Body Mass Index; Drug Therapy, Combination; Female; Hospitals, University; Humans; Hypoglycem

2013
Hippocampal Neurometabolite Changes in Hypothyroidism: An In Vivo (1) H Magnetic Resonance Spectroscopy Study Before and After Thyroxine Treatment.
    Journal of neuroendocrinology, 2016, Volume: 28, Issue:9

    Topics: Adult; Female; Glutamic Acid; Hippocampus; Humans; Hypothyroidism; Inositol; Male; Proton Magnetic R

2016
(Soft) capsules of wisdom: preventing myo-inositol malabsorption caused by coffee.
    Expert opinion on drug delivery, 2012, Volume: 9, Issue:10

    Topics: Biological Availability; Capsules; Coffee; Female; Gelatin; Gels; Humans; Hypothyroidism; Inositol;

2012
1H magnetic resonance spectroscopy in monocarboxylate transporter 8 gene deficiency.
    The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:5

    Topics: Aspartic Acid; Brain; Choline; Genotype; Humans; Hypothyroidism; Infant; Inositol; Magnetic Resonanc

2008
Brain metabolite changes on in vivo proton magnetic resonance spectroscopy in children with congenital hypothyroidism.
    The Journal of pediatrics, 1995, Volume: 126, Issue:3

    Topics: Adolescent; Brain; Child; Choline; Congenital Hypothyroidism; Creatine; Humans; Hypothyroidism; Inos

1995
Influences of hypothyroidism on lipid composition and inositol lipid-linked receptors responsiveness and protein kinase C (PKC) activity in the cerebral cortex of Lewis rats.
    Neurochemical research, 1996, Volume: 21, Issue:5

    Topics: Animals; Carbachol; Cerebral Cortex; Cycloleucine; Hypothyroidism; Inositol; Inositol Phosphates; Ma

1996
Thyroid hormone affects the hydrolysis of inositol phospholipids in the rat hypothalamus.
    Neuroscience letters, 1992, Jan-06, Volume: 134, Issue:2

    Topics: Animals; Chlorides; Hydrolysis; Hypothalamus; Hypothyroidism; In Vitro Techniques; Inositol; Inosito

1992
Hypothyroidism inhibits the formation of inositol phosphate in response to carbachol in the striatum of adult rat.
    Research communications in chemical pathology and pharmacology, 1991, Volume: 73, Issue:2

    Topics: Animals; Atropine; Binding Sites; Carbachol; Cell Membrane; Cerebral Cortex; Corpus Striatum; Hippoc

1991
Thyroid status and adrenergic receptor subtypes in the rat: comparison of receptor density and responsiveness.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:3

    Topics: Animals; Cerebral Cortex; Ethanolamines; Heart; Heart Rate; Hyperthyroidism; Hypothyroidism; In Vitr

1985
[The hypercalcemias and their treatment].
    Schweizerische medizinische Wochenschrift, 1967, Dec-30, Volume: 97, Issue:52

    Topics: Adrenal Cortex Hormones; Edetic Acid; Female; Humans; Hypercalcemia; Hyperthyroidism; Hypothyroidism

1967
Analysis of the human erythrocyte lipid in various functional conditions of the thyroid.
    The Tohoku journal of experimental medicine, 1968, Volume: 94, Issue:2

    Topics: Centrifugation; Cerebrosides; Cholesterol; Chromatography, Thin Layer; Densitometry; Erythrocytes; H

1968