inositol has been researched along with Hypertension in 34 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, our knowledge regarding the effects of G6PD deficiency on pathogenesis of vascular diseases caused by factors, like angiotensin II (Ang-II), which stimulate synthesis of inflammatory cytokines and vascular inflammation, is lacking." | 8.12 | Mediterranean G6PD variant rats are protected from Angiotensin II-induced hypertension and kidney damage, but not from inflammation and arterial stiffness. ( D'Addiaro, C; De Miguel, C; Gupte, R; Gupte, SA; Matsumura, S; Miano, JM; Slivano, OJ; Stier, C, 2022) |
| "Inositols (INOs) supplementation during pregnancy, specifically the combination of myo-inositol (MI) and D-chiro-inositol (DCI), has been reported to improve vascular parameters in women with gestational diabetes mellitus." | 7.91 | Vascular and metabolic profiles in offspring born to pregnant mice with metabolic syndrome treated with inositols. ( Alrais, M; Blackwell, SC; Facchinetti, F; Ferrari, F; Longo, M; Refuerzo, JS; Sibai, BM; Tamayo, EH, 2019) |
| "To determine the blood concentrations of myo-inositol, glucose and zinc before, during and after normal pregnancy." | 7.73 | Myo-inositol, glucose and zinc concentrations determined in the preconceptional period, during and after pregnancy. ( Groenen, PM; Merkus, HM; Peer, PG; Roes, EM; Steegers, EA; Steegers-Theunissen, RP, 2006) |
| "Myo-inositol and D-chiro-inositol are capable of improving the ovarian function and metabolism of polycystic ovary syndrome (PCOS) patients." | 5.19 | Comparison between effects of myo-inositol and D-chiro-inositol on ovarian function and metabolic factors in women with PCOS. ( Barbaro, L; Laganà, AS; Pizzo, A, 2014) |
| " However, our knowledge regarding the effects of G6PD deficiency on pathogenesis of vascular diseases caused by factors, like angiotensin II (Ang-II), which stimulate synthesis of inflammatory cytokines and vascular inflammation, is lacking." | 4.12 | Mediterranean G6PD variant rats are protected from Angiotensin II-induced hypertension and kidney damage, but not from inflammation and arterial stiffness. ( D'Addiaro, C; De Miguel, C; Gupte, R; Gupte, SA; Matsumura, S; Miano, JM; Slivano, OJ; Stier, C, 2022) |
| "Inositols (INOs) supplementation during pregnancy, specifically the combination of myo-inositol (MI) and D-chiro-inositol (DCI), has been reported to improve vascular parameters in women with gestational diabetes mellitus." | 3.91 | Vascular and metabolic profiles in offspring born to pregnant mice with metabolic syndrome treated with inositols. ( Alrais, M; Blackwell, SC; Facchinetti, F; Ferrari, F; Longo, M; Refuerzo, JS; Sibai, BM; Tamayo, EH, 2019) |
| "To determine the blood concentrations of myo-inositol, glucose and zinc before, during and after normal pregnancy." | 3.73 | Myo-inositol, glucose and zinc concentrations determined in the preconceptional period, during and after pregnancy. ( Groenen, PM; Merkus, HM; Peer, PG; Roes, EM; Steegers, EA; Steegers-Theunissen, RP, 2006) |
| "In this study, cognitively intact chronic hypertensive older patients had a higher white matter myoinositol/creatine ratio compared with healthy older subjects, suggesting that myoinositol may be a sensitive marker of the effects of chronic hypertension on the brain." | 3.71 | Proton magnetic resonance spectroscopy reveals similar white matter biochemical changes in patients with chronic hypertension and early Alzheimer's disease. ( Benedetti, C; Catani, M; Cherubini, A; Howard, R; Mariani, E; Mecocci, P; Metastasio, A; Pelliccioli, GP; Senin, U; Tarducci, R, 2002) |
| "Postprandial hyperglycemia is frequently associated with visceral obesity which plays a key role in metabolic abnormalities such as dyslipidemia and hypertension." | 2.42 | [Pharmacological treatment of postprandial hyperglycemia in hypertensive patients with type 2 diabetes mellitus]. ( Yamada, K, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (67.65) | 18.7374 |
| 1990's | 1 (2.94) | 18.2507 |
| 2000's | 4 (11.76) | 29.6817 |
| 2010's | 3 (8.82) | 24.3611 |
| 2020's | 3 (8.82) | 2.80 |
| Authors | Studies |
|---|---|
| Matsumura, S | 1 |
| D'Addiaro, C | 1 |
| Slivano, OJ | 1 |
| De Miguel, C | 1 |
| Stier, C | 1 |
| Gupte, R | 1 |
| Miano, JM | 1 |
| Gupte, SA | 1 |
| Menichini, D | 1 |
| Alrais, M | 2 |
| Liu, C | 1 |
| Xia, Y | 1 |
| Blackwell, SC | 2 |
| Facchinetti, F | 2 |
| Sibai, BM | 2 |
| Longo, M | 2 |
| Hashemi Tari, S | 1 |
| Sohouli, MH | 1 |
| Lari, A | 1 |
| Fatahi, S | 1 |
| Rahideh, ST | 1 |
| Tamayo, EH | 1 |
| Ferrari, F | 1 |
| Refuerzo, JS | 1 |
| Pizzo, A | 1 |
| Laganà, AS | 1 |
| Barbaro, L | 1 |
| Chang, HH | 1 |
| Chao, HN | 1 |
| Walker, CS | 1 |
| Choong, SY | 1 |
| Phillips, A | 1 |
| Loomes, KM | 1 |
| Catani, M | 1 |
| Mecocci, P | 1 |
| Tarducci, R | 1 |
| Howard, R | 1 |
| Pelliccioli, GP | 1 |
| Mariani, E | 1 |
| Metastasio, A | 1 |
| Benedetti, C | 1 |
| Senin, U | 1 |
| Cherubini, A | 1 |
| Yamada, K | 1 |
| BOYD, LJ | 1 |
| LOMBARDI, AA | 1 |
| SVIGALS, CS | 1 |
| CARERE-COMES, O | 1 |
| SAVELLI, G | 1 |
| SODO, D | 1 |
| BERNSTEIN, LM | 1 |
| IVY, AC | 1 |
| MENEGHINI, P | 1 |
| AVANZI, G | 1 |
| STROBBIA, R | 1 |
| DONATELLI, L | 1 |
| SPIGLIATI, P | 1 |
| ZABBAN, M | 1 |
| SELLERI, R | 1 |
| BARBARO FORLEO, G | 2 |
| SERPI, L | 2 |
| BARICALLA, A | 1 |
| Groenen, PM | 1 |
| Roes, EM | 1 |
| Peer, PG | 1 |
| Merkus, HM | 1 |
| Steegers, EA | 1 |
| Steegers-Theunissen, RP | 1 |
| Nitkunan, A | 1 |
| Charlton, RA | 1 |
| McIntyre, DJ | 1 |
| Barrick, TR | 1 |
| Howe, FA | 1 |
| Markus, HS | 1 |
| Russo-Marie, F | 1 |
| Duval, D | 1 |
| Felix, G | 1 |
| Otrzonsek, G | 1 |
| Windsheimer, F | 1 |
| Schneider, B | 1 |
| Jaillard, J | 1 |
| Krämer, KD | 2 |
| Ghabussi, P | 2 |
| Hochrein, H | 2 |
| Schnicke, M | 1 |
| Olschowka, U | 1 |
| Rezori, R | 1 |
| Lehmann, HU | 1 |
| Hotta, N | 1 |
| Sano, T | 1 |
| Minenko, A | 1 |
| Gabrysiak, B | 1 |
| Oehme, P | 1 |
| Resink, TJ | 1 |
| Scott-Burden, T | 1 |
| Baur, U | 1 |
| Bühler, FR | 1 |
| Buck, SH | 1 |
| Nabika, T | 1 |
| Lovenberg, W | 1 |
| Heagerty, AM | 1 |
| Ollerenshaw, JD | 1 |
| Swales, JD | 1 |
| Ortega Mata, R | 1 |
| Guglielmi, G | 1 |
| Barlattani, M | 1 |
| Wardemann, H | 1 |
| Hesseling, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Inositols on Insulin Resistance in Children With Obesity (ONIRICO Trial)[NCT05701813] | 56 participants (Anticipated) | Interventional | 2023-02-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for inositol and Hypertension
| Article | Year |
|---|---|
The effect of inositol supplementation on blood pressure: A systematic review and meta-analysis of randomized-controlled trials.
Topics: Blood Pressure; Dietary Supplements; Humans; Hypertension; Inositol; Randomized Controlled Trials as | 2021 |
[Pharmacological treatment of postprandial hyperglycemia in hypertensive patients with type 2 diabetes mellitus].
Topics: Acarbose; Cyclohexanes; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 2; Enzyme | 2003 |
5 trials available for inositol and Hypertension
| Article | Year |
|---|---|
Comparison between effects of myo-inositol and D-chiro-inositol on ovarian function and metabolic factors in women with PCOS.
Topics: Adolescent; Adult; Amenorrhea; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follicl | 2014 |
[Long-term antihypertensive therapy with Etozoline].
Topics: Adult; Drug Evaluation; Female; Humans; Hypertension; Inositol; Male; Mefruside; Middle Aged; Reserp | 1980 |
[Antihypertensive combination-therapy with inositol nicotinate in essential hypertension].
Topics: Adult; Aged; Blood Pressure; Cholesterol; Clinical Trials as Topic; Drug Therapy, Combination; Femal | 1977 |
[Mild and medium severe hypertension. Treatment of mild and medium severe hypertension with bendigon mite].
Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Drug Combinations; Drug Evaluation; Female; Humans | 1979 |
[Dose-effect comparison of antihypertensive combinations with and without alpha-methyldopa].
Topics: Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Dose-Response Relationship, | 1975 |
27 other studies available for inositol and Hypertension
| Article | Year |
|---|---|
Mediterranean G6PD variant rats are protected from Angiotensin II-induced hypertension and kidney damage, but not from inflammation and arterial stiffness.
Topics: Actins; Angiotensin II; Animals; Glucosephosphate Dehydrogenase Deficiency; Humans; Hypertension; In | 2022 |
Maternal Supplementation of Inositols, Fucoxanthin, and Hydroxytyrosol in Pregnant Murine Models of Hypertension.
Topics: Animals; Antioxidants; Dietary Supplements; Disease Models, Animal; Drug Evaluation, Preclinical; Dr | 2020 |
Vascular and metabolic profiles in offspring born to pregnant mice with metabolic syndrome treated with inositols.
Topics: Animals; Biomarkers; Drug Administration Schedule; Female; Hypertension; Inositol; Male; Metabolic S | 2019 |
Renal depletion of myo-inositol is associated with its increased degradation in animal models of metabolic disease.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Hypertension; Inositol; Inositol O | 2015 |
Proton magnetic resonance spectroscopy reveals similar white matter biochemical changes in patients with chronic hypertension and early Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Choline; Chronic Disease; Creatine | 2002 |
The use of hexa-nitro-mesoinositol in renal hypertension.
Topics: Hexosaminidase A; Hypertension; Hypertension, Renal; Inositol | 1952 |
[Nitroadenol therapy of arterial hypertension and especially of hypertensive myocardiosclerosis].
Topics: Adenosine Triphosphate; Cardiomyopathies; Disease; Heart Diseases; Humans; Hypertension; Inositol; M | 1954 |
Inositol and mannitol hexanitrates in hypertension management.
Topics: Disease Management; Hypertension; Inositol; Mannitol; Nitrites | 1955 |
[INDIRECT FIBRINOLYTIC AND ANTICOAGULANT TREATMENT OF THROMBOSIS].
Topics: Anticoagulants; Arteriosclerosis Obliterans; Arteritis; Coronary Disease; Diabetic Angiopathies; Eth | 1964 |
[Clinical and experimental research on hexanitromesoinositol in arterial hypertension and vascular spasm].
Topics: Blood Pressure; Blood Pressure Determination; Humans; Hypertension; Inositol; Spasm; Vascular Diseas | 1950 |
[Nicotinic hexaester of m-inositol (esantene), new synthetic hypotensive drug with prolonged action].
Topics: Blood Pressure; Humans; Hypertension; Hypotension; Inositol | 1951 |
[Arterial hypertension; treatment with a new nitroderivative compound].
Topics: Humans; Hypertension; Inositol | 1951 |
[Arterial hypertension; treatment with a new nitroderivative preparation].
Topics: Hypertension; Inositol | 1951 |
[Effect of nicotinic hexa-ester of m-inosite (Exantene) in menopausal hypertension].
Topics: Climacteric; Female; Hexosaminidase A; Humans; Hypertension; Inositol; Menopause; Niacin; Nicotinic | 1952 |
Myo-inositol, glucose and zinc concentrations determined in the preconceptional period, during and after pregnancy.
Topics: Adult; Blood Glucose; Erythrocytes; Female; Humans; Hypertension; Inositol; Linear Models; Longitudi | 2006 |
Diffusion tensor imaging and MR spectroscopy in hypertension and presumed cerebral small vessel disease.
Topics: Aged; Aspartic Acid; Brain Diseases; Brain Ischemia; Case-Control Studies; Cerebrovascular Circulati | 2008 |
Dexamethasone-induced inhibition of prostaglandin production dose not result from a direct action on phospholipase activities but is mediated through a steroid-inducible factor.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Dexamethasone; Hypertension; Inositol | 1982 |
[Clinical experimentation with tensid (apropos of 60 cases)].
Topics: Adult; Aged; Diuretics; Drug Combinations; Drug Evaluation; Female; Humans; Hypertension; Inositol; | 1976 |
[Risk factors of developing diabetic complications].
Topics: Animals; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetic Retinopathy; Female; Glycoprotei | 1991 |
Decreased SP-stimulated diesteratic hydrolysis of inositol phospholipids in adrenal medulla slices from spontaneously hypertensive rats.
Topics: Adrenal Medulla; Animals; Hydrolysis; Hypertension; Inositol; Male; Phosphates; Phosphatidic Acids; | 1988 |
Increased proliferation fate and phosphoinositide turnover in cultured smooth muscle cells from spontaneously hypertensive rats.
Topics: Animals; Cell Division; Cells, Cultured; Hypertension; Inositol; Inositol Phosphates; Male; Muscle, | 1987 |
Mn++-stimulated 3H-inositol incorporation in cultured vascular smooth muscle cells: deficiency in cells from spontaneously hypertensive rats.
Topics: Animals; Cells, Cultured; Hypertension; Inositol; Manganese; Muscle, Smooth, Vascular; Phosphatidyli | 1985 |
Abnormal vascular phosphoinositide hydrolysis in the spontaneously hypertensive rat.
Topics: Aging; Animals; Hydrolysis; Hypertension; Inositol; Male; Muscle, Smooth, Vascular; Phosphatidylinos | 1986 |
[Treatment of arterial hypertension with a new preparation, Bay Mc 4540 (Bendigon)].
Topics: Adult; Aged; Diuretics; Drug Combinations; Female; Furans; Humans; Hypertension; Inositol; Male; Mid | 1973 |
[Clinico-therapeutic controls of the antihypertensive drugs and compounds effective on the regulation of the regional circulation].
Topics: Aged; Antihypertensive Agents; Blood Circulation; Blood Pressure; Female; Humans; Hypertension; Inos | 1971 |
[Clinical studies with a new antihypertensive agent, Bendigon].
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Diuretics; Drug Combinations; Drug Synergism; | 1970 |
[Clinical tests with a new antihypertensive combination (Bendigon)].
Topics: Adult; Aged; Antihypertensive Agents; Diuretics; Drug Combinations; Drug Synergism; Evaluation Studi | 1970 |