Page last updated: 2024-10-19

inositol and Hyperglycemia, Postprandial

inositol has been researched along with Hyperglycemia, Postprandial in 78 studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Hyperglycemia, Postprandial: Abnormally high BLOOD GLUCOSE level after a meal.

Research Excerpts

ExcerptRelevanceReference
" Because it reflects the current status of hyperglycemia, urinary myo-inositol (UMI) may be useful."7.80The utility of urinary myo-inositol as a marker of glucose intolerance. ( Furusyo, N; Hayashi, J; Hayashi, T; Ihara, T; Ikezaki, H; Kainuma, M; Murata, M; Ogawa, E; Okada, K, 2014)
" The present experiment was designed to determine: 1) if hyperglycemia-induced membrane injury is associated with intracellular and/or extracellular lipid disturbances; 2) if supplemental myo-inositol therapy prevents hyperglycemia-induced embryopathy; 3) if a correlation exists between dietary myo-inositol, serum and tissue levels of myo-inositol, and conceptus development; and 4) the cellular content of arachidonic acid following myo-inositol supplementation."7.70Dietary myo-inositol therapy in hyperglycemia-induced embryopathy. ( Borenstein, M; Khandelwal, M; Reece, EA; Wu, YK, 1998)
"In many tissues, hyperglycemia alters the activities of the Na(+)-dependent myo-inositol (Na/MI) transporter, Na(+)-K(+)-ATPase, and protein kinase C (PKC)."7.69Hyperglycemia-induced changes in Na+/myo-inositol transport, Na(+)-K(+)-ATPase, and protein kinase C activity in proximal tubule cells. ( Cole, JA; Walker, RE; Yordy, MR, 1995)
" The current investigation was undertaken to assess the use of dietary myo-inositol supplementation as a pharmacologic prophylaxis to obviate the teratogenic effects of hyperglycemia in an in vivo study."7.69Dietary intake of myo-inositol and neural tube defects in offspring of diabetic rats. ( Borenstein, M; Khandelwal, M; Reece, EA; Wu, YK, 1997)
"myo-Inositol accumulation and incorporation into phosphoinositides was decreased in neuroblastoma cells chronically exposed to medium containing 30 mmol/L glucose or 30 mmol/L galactose."7.68Reversal of hyperglycemic-induced defects in myo-inositol metabolism and Na+/K+ pump activity in cultured neuroblastoma cells by normalizing glucose levels. ( Davidson, EP; Dunlap, JA; Stefani, MR; Yorek, MA, 1993)
"We have shown that myo-inositol in the cultured rat embryo is diminished whenever malformations are induced by hyperglycemia and that the malformations and reductions of tissue myo-inositol content are not corrected by aldose reductase inhibitors."7.68Uptake of myo-inositol by early-somite rat conceptus. Transport kinetics and effects of hyperglycemia. ( Freinkel, N; Garcia-Palmer, FJ; Weigensberg, MJ, 1990)
"We previously reported that a chronic supplementation with myo-inositol (MI) improved insulin sensitivity and reduced fat accretion in mice."3.81Abnormalities in myo-inositol metabolism associated with type 2 diabetes in mice fed a high-fat diet: benefits of a dietary myo-inositol supplementation. ( Croze, ML; Géloën, A; Soulage, CO, 2015)
"This study was designed to investigate the protective effects of d-Chiro-Inositol (DCI) enriched tartary buckwheat extract (DTBE) against high fructose (HF) diet-induced hyperglycemia and liver injury in mice."3.81Hypoglycemic and hepatoprotective effects of D-chiro-inositol-enriched tartary buckwheat extract in high fructose-fed mice. ( Guo, J; Hu, Y; Luo, Y; Ren, D; Yang, X; Zhao, Y, 2015)
" Because it reflects the current status of hyperglycemia, urinary myo-inositol (UMI) may be useful."3.80The utility of urinary myo-inositol as a marker of glucose intolerance. ( Furusyo, N; Hayashi, J; Hayashi, T; Ihara, T; Ikezaki, H; Kainuma, M; Murata, M; Ogawa, E; Okada, K, 2014)
"Peripheral hyperglycemia was associated with significant increases in brain sorbitol (7."3.74Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory. ( Chong, L; Diamond, DM; Hanna, S; Malone, JI; Mervis, RF; Park, CR; Saporta, S, 2008)
" The present experiment was designed to determine: 1) if hyperglycemia-induced membrane injury is associated with intracellular and/or extracellular lipid disturbances; 2) if supplemental myo-inositol therapy prevents hyperglycemia-induced embryopathy; 3) if a correlation exists between dietary myo-inositol, serum and tissue levels of myo-inositol, and conceptus development; and 4) the cellular content of arachidonic acid following myo-inositol supplementation."3.70Dietary myo-inositol therapy in hyperglycemia-induced embryopathy. ( Borenstein, M; Khandelwal, M; Reece, EA; Wu, YK, 1998)
"In many tissues, hyperglycemia alters the activities of the Na(+)-dependent myo-inositol (Na/MI) transporter, Na(+)-K(+)-ATPase, and protein kinase C (PKC)."3.69Hyperglycemia-induced changes in Na+/myo-inositol transport, Na(+)-K(+)-ATPase, and protein kinase C activity in proximal tubule cells. ( Cole, JA; Walker, RE; Yordy, MR, 1995)
" The current investigation was undertaken to assess the use of dietary myo-inositol supplementation as a pharmacologic prophylaxis to obviate the teratogenic effects of hyperglycemia in an in vivo study."3.69Dietary intake of myo-inositol and neural tube defects in offspring of diabetic rats. ( Borenstein, M; Khandelwal, M; Reece, EA; Wu, YK, 1997)
"myo-Inositol accumulation and incorporation into phosphoinositides was decreased in neuroblastoma cells chronically exposed to medium containing 30 mmol/L glucose or 30 mmol/L galactose."3.68Reversal of hyperglycemic-induced defects in myo-inositol metabolism and Na+/K+ pump activity in cultured neuroblastoma cells by normalizing glucose levels. ( Davidson, EP; Dunlap, JA; Stefani, MR; Yorek, MA, 1993)
"Since inositol (Ins) depletion appears to be an important mechanism of cell injury in diabetic glomerulopathy, we studied Ins transport in cultured rat mesangial cells during hyperglycemia."3.68Regulation of inositol transport by glucose and protein kinase C in mesangial cells. ( Crews, FT; Guzman, NJ, 1992)
"We have shown that myo-inositol in the cultured rat embryo is diminished whenever malformations are induced by hyperglycemia and that the malformations and reductions of tissue myo-inositol content are not corrected by aldose reductase inhibitors."3.68Uptake of myo-inositol by early-somite rat conceptus. Transport kinetics and effects of hyperglycemia. ( Freinkel, N; Garcia-Palmer, FJ; Weigensberg, MJ, 1990)
"Postprandial hyperglycemia and hyperlipidemia are considered risk factors for cardiovascular disease."2.72An alpha-glucosidase inhibitor, voglibose, reduces oxidative stress markers and soluble intercellular adhesion molecule 1 in obese type 2 diabetic patients. ( Aizawa-Abe, M; Kuzuya, H; Ogawa, Y; Satoh, N; Shimatsu, A; Suganami, T; Yamada, K, 2006)
"Postprandial hyperglycemia is frequently associated with visceral obesity which plays a key role in metabolic abnormalities such as dyslipidemia and hypertension."2.42[Pharmacological treatment of postprandial hyperglycemia in hypertensive patients with type 2 diabetes mellitus]. ( Yamada, K, 2003)
"The combination significantly reduced postprandial hyperglycemia after each meal."1.40The glycemic/metabolic responses to meal tolerance tests at breakfast, lunch and dinner, and effects of the mitiglinide/voglibose fixed-dose combination on postprandial profiles in Japanese patients with type 2 diabetes mellitus. ( Cho, KY; Nakamura, A; Nomoto, H; Ono, Y, 2014)
"Seventeen type 2 diabetes patients were given sitagliptin 50 mg/day or voglibose 0."1.39Comparison of glycemic variability in patients with type 2 diabetes given sitagliptin or voglibose: a continuous glucose monitoring-based pilot study. ( Ando, K; Morimoto, A; Nishimura, R; Sakamoto, M; Seo, C; Tsujino, D; Utsunomiya, K, 2013)
"The brain metabolites of 17 men with type 1 diabetes and 12 age-matched non-diabetic men (22-43 years old) were studied after an overnight fast (plasma glucose 9."1.35Hyperglycaemia is associated with changes in the regional concentrations of glucose and myo-inositol within the brain. ( Groop, PH; Heikkilä, O; Heikkinen, S; Lundbom, N; Mäkimattila, S; Timonen, M, 2009)
"A total of 21 inpatients with type 2 diabetes were recruited to a single-center, 2-period, crossover trial."1.33Effect of two alpha-glucosidase inhibitors, voglibose and acarbose, on postprandial hyperglycemia correlates with subjective abdominal symptoms. ( Fujisawa, T; Ikegami, H; Inoue, K; Kawabata, Y; Ogihara, T, 2005)
"However, the association between type 2 diabetes and oxidative stress in the pancreatic beta-cells has not been previously described."1.30Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes. ( Hiai, H; Ihara, Y; Ikeda, H; Odaka, H; Seino, Y; Tanaka, T; Toyokuni, S; Uchida, K; Yamada, Y, 1999)
"myo-Inositol uptake was restored to normal in a time-dependent manner during recovery of islets at 5."1.29Insulin secretion, myo-inositol transport, and Na(+)-K(+)-ATPase in glucose-desensitized rat islets. ( Laychock, SG; Xia, M, 1993)
"Both diabetic hyperglycemia and galactosemia caused the prolongation of peak latencies and in some cases a reduction in the amplitudes of oscillatory potentials on the b-wave."1.27The development of electroretinogram abnormalities and the possible role of polyol pathway activity in diabetic hyperglycemia and galactosemia. ( Fujimori, S; Hirata, Y; Okada, K; Segawa, M, 1988)

Research

Studies (78)

TimeframeStudies, this research(%)All Research%
pre-199014 (17.95)18.7374
1990's23 (29.49)18.2507
2000's16 (20.51)29.6817
2010's21 (26.92)24.3611
2020's4 (5.13)2.80

Authors

AuthorsStudies
Mukherjee, S1
Chakraborty, M1
Haubner, J1
Ernst, G1
DePasquale, M1
Carpenter, D1
Barrow, JC1
Chakraborty, A1
Hedrington, MS1
Davis, SN1
Shah, P2
Chavda, V2
Patel, S1
Bhadada, S2
Ashraf, GM1
Patel, SS1
Baldassarre, MPA1
Di Tomo, P1
Centorame, G1
Pandolfi, A1
Di Pietro, N1
Consoli, A1
Formoso, G1
Kaneko, K1
Satake, C1
Izumi, T1
Tanaka, M1
Yamamoto, J1
Asai, Y1
Sawada, S1
Imai, J1
Yamada, T1
Katagiri, H1
Ono, Y3
Kameda, H1
Cho, KY2
Seo, C1
Sakamoto, M1
Nishimura, R1
Tsujino, D1
Ando, K1
Morimoto, A1
Utsunomiya, K1
Hernández-Mijares, A2
Bañuls, C2
Peris, JE1
Monzó, N2
Jover, A1
Bellod, L1
Victor, VM2
Rocha, M2
Nakamura, A2
Nomoto, H2
Lee, BH1
Lee, CC1
Wu, SC1
Ikezaki, H1
Furusyo, N1
Okada, K3
Ihara, T1
Hayashi, T1
Ogawa, E1
Kainuma, M1
Murata, M1
Hayashi, J1
Kobayashi, K1
Yokoh, H1
Sato, Y2
Takemoto, M1
Uchida, D1
Kanatsuka, A1
Kuribayashi, N1
Terano, T1
Hashimoto, N1
Sakurai, K1
Hanaoka, H1
Ishikawa, K1
Onishi, S1
Yokote, K1
Osonoi, T1
Saito, M1
Tamasawa, A1
Ishida, H1
Osonoi, Y1
Kamoshima, H1
Croze, ML1
Géloën, A1
Soulage, CO1
Rovira-Llopis, S1
Falcón, R1
Veses, S1
Hu, Y1
Zhao, Y1
Ren, D1
Guo, J1
Luo, Y1
Yang, X1
Matsumoto, Y1
Ishii, M1
Sekimizu, K1
Chukwuma, CI1
Ibrahim, MA1
Islam, MS1
Hirasawa, Y1
Matsui, Y1
Ohtsu, S1
Yamane, K1
Toyoshi, T1
Kyuki, K1
Sakai, T1
Feng, Y1
Nagamatsu, T1
Koh, N1
Sakamoto, S1
Chino, F1
Malone, JI1
Hanna, S1
Saporta, S1
Mervis, RF1
Park, CR1
Chong, L1
Diamond, DM1
Heikkilä, O1
Lundbom, N1
Timonen, M1
Groop, PH1
Heikkinen, S1
Mäkimattila, S1
Sivakumar, S2
Subramanian, SP2
Abe, M1
Maruyama, T1
Maruyama, N1
Matsumoto, K1
Palsamy, P1
Shen, H1
Shao, M1
Cho, KW1
Wang, S1
Chen, Z1
Sheng, L1
Wang, T1
Liu, Y1
Rui, L1
Standl, E1
Schnell, O1
Inoue, M1
Odaka, H2
Watanabe, K1
Kawamori, R1
Eriksson, UJ1
Cederberg, J1
Wentzel, P1
Yamada, K2
Fujisawa, T1
Ikegami, H1
Inoue, K1
Kawabata, Y1
Ogihara, T1
Nakamura, J1
Yamazaki, H1
Philbrick, W1
Zawalich, KC2
Zawalich, WS2
Liao, Y1
Takashima, S1
Zhao, H1
Asano, Y1
Shintani, Y1
Minamino, T1
Kim, J1
Fujita, M1
Hori, M1
Kitakaze, M1
Satoh, N1
Shimatsu, A1
Aizawa-Abe, M1
Suganami, T1
Kuzuya, H1
Ogawa, Y1
Yamazaki, K1
Inoue, T1
Yasuda, N1
Nagakura, T1
Takenaka, O1
Clark, R1
Saeki, T1
Tanaka, I1
Tomlinson, DR1
Mayer, JH1
Greene, DA5
Cole, JA1
Walker, RE1
Yordy, MR1
Sima, AA1
Stevens, MJ2
Feldman, EL1
Killen, PD2
Henry, DN2
Thomas, T1
Dananberg, J1
Lattimer, SA1
Thomas, TP1
Xia, M1
Laychock, SG1
Yorek, MA1
Dunlap, JA1
Stefani, MR1
Davidson, EP1
Gruetter, R1
Garwood, M1
Uğurbil, K1
Seaquist, ER1
Reece, EA2
Khandelwal, M2
Wu, YK2
Borenstein, M2
Iwamoto, Y1
Mooradian, AD1
Thurman, JE1
Ihara, Y1
Toyokuni, S1
Uchida, K1
Tanaka, T1
Ikeda, H1
Hiai, H1
Seino, Y1
Yamada, Y1
Fonteles, MC1
Almeida, MQ1
Larner, J1
Anderson, JW1
Winegrad, AI3
Simmons, DA1
Edwardson, JM1
Dean, PM1
McCaleb, ML1
Sredy, J1
Guzman, NJ1
Crews, FT1
Hod, M2
Star, S2
Passonneau, JV1
Unterman, TG2
Freinkel, N3
Hotta, N1
Sakamoto, N1
Hashimoto, M1
Akazawa, S1
Akazawa, M1
Akashi, M1
Yamamoto, H1
Maeda, Y1
Yamaguchi, Y1
Yamasaki, H1
Tahara, D1
Nakanishi, T1
Shulman, GI1
Rossetti, L1
Moller, DE1
Moses, AC1
Passonneau, J1
Weigensberg, MJ1
Garcia-Palmer, FJ1
Sinclair, SH1
Nesler, CL1
Schwartz, SS1
Legan, E1
Balabolkin, MI1
Islambekov, RR1
Mascardo, RN1
Segawa, M1
Hirata, Y1
Fujimori, S1
Varma, SD1
Kinoshita, JH1
Lewin, LM1
Szeinberg, A1
Lepkifker, E1
Prockop, LD1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of Quercetin in Type 2 Diabetes: Impact on Glucose Tolerance and Postprandial Endothelial Function.[NCT01839344]Phase 219 participants (Actual)Interventional2013-05-31Completed
Inhibition of Intestinal Glucose Absorption by the Bioflavonoid Quercetin in the Obese and in Obese Type 2 Diabetics[NCT00065676]Phase 224 participants (Actual)Interventional2010-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

13 reviews available for inositol and Hyperglycemia, Postprandial

ArticleYear
Considerations when using alpha-glucosidase inhibitors in the treatment of type 2 diabetes.
    Expert opinion on pharmacotherapy, 2019, Volume: 20, Issue:18

    Topics: 1-Deoxynojirimycin; Acarbose; Aged; Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type

2019
Alpha-glucosidase inhibitors 2012 - cardiovascular considerations and trial evaluation.
    Diabetes & vascular disease research, 2012, Volume: 9, Issue:3

    Topics: 1-Deoxynojirimycin; Acarbose; Cardiovascular Diseases; Diabetes Complications; Glycoside Hydrolase I

2012
[alpha-Glucosidase inhibitor, its structure and mechanism of antidiabetic action].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 9

    Topics: Acarbose; Animals; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glycoside Hydrolase Inhibitors; Hum

2002
[Combination therapy with insulin and alpha-glucosidase inhibitor].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 9

    Topics: Acarbose; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Drug Thera

2002
Congenital malformations in offspring of diabetic mothers--animal and human studies.
    Reviews in endocrine & metabolic disorders, 2003, Volume: 4, Issue:1

    Topics: Animals; Arachidonic Acid; Congenital Abnormalities; Diabetes Complications; Female; Gene Expression

2003
[Pharmacological treatment of postprandial hyperglycemia in hypertensive patients with type 2 diabetes mellitus].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61, Issue:7

    Topics: Acarbose; Cyclohexanes; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 2; Enzyme

2003
[Effects of voglibose, alpha-glucosidase inhibitor in treatment of impaired glucose tolerance].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 2

    Topics: Animals; Carbohydrate Metabolism; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glucose Intolerance;

2005
Defects of axonal transport in diabetes mellitus--a possible contribution to the aetiology of diabetic neuropathy.
    Journal of autonomic pharmacology, 1984, Volume: 4, Issue:1

    Topics: Animals; Axonal Transport; Body Temperature; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dia

1984
Aldose reductase inhibitors: an approach to the treatment of diabetic nerve damage.
    Diabetes/metabolism reviews, 1993, Volume: 9, Issue:3

    Topics: Aldehyde Reductase; Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Neuropathi

1993
[Management of postprandial hyperglycemia].
    Nihon rinsho. Japanese journal of clinical medicine, 1997, Volume: 55 Suppl

    Topics: Acarbose; Diabetes Mellitus, Type 2; Diet, Diabetic; Exercise Therapy; Humans; Hyperglycemia; Hypogl

1997
Drug therapy of postprandial hyperglycaemia.
    Drugs, 1999, Volume: 57, Issue:1

    Topics: 1-Deoxynojirimycin; Acarbose; Amyloid; Carbamates; Diabetes Mellitus; Enzyme Inhibitors; Glucosamine

1999
Metabolic abnormalities contributing to diabetic complications. II. Peripheral nerves.
    The American journal of clinical nutrition, 1976, Volume: 29, Issue:4

    Topics: Animals; Axons; Cricetinae; Diabetes Mellitus; Diabetic Neuropathies; Disease Models, Animal; Glucos

1976
Acute and chronic complications of diabetes mellitus in older patients.
    The American journal of medicine, 1986, May-16, Volume: 80, Issue:5A

    Topics: Adult; Aged; Aging; Blood Pressure; Diabetes Complications; Diabetes Mellitus; Diabetic Coma; Diabet

1986

Trials

10 trials available for inositol and Hyperglycemia, Postprandial

ArticleYear
Mitiglinide/voglibose fixed-dose combination improves postprandial glycemic excursions in Japanese patients with type 2 diabetes mellitus.
    Expert opinion on pharmacotherapy, 2013, Volume: 14, Issue:4

    Topics: Blood Glucose; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Combinations; Female; H

2013
A single acute dose of pinitol from a naturally-occurring food ingredient decreases hyperglycaemia and circulating insulin levels in healthy subjects.
    Food chemistry, 2013, Nov-15, Volume: 141, Issue:2

    Topics: Adult; Beverages; Blood Glucose; Down-Regulation; Female; Humans; Hyperglycemia; Inositol; Insulin;

2013
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin compared with α-glucosidase inhibitor in Japanese patients with type 2 diabetes inadequately controlled on sulfonylurea alone (SUCCESS-2): a multicenter, randomized, open-label, non-i
    Diabetes, obesity & metabolism, 2014, Volume: 16, Issue:8

    Topics: 1-Deoxynojirimycin; Aged; alpha-Glucosidases; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inh

2014
Effects of sitagliptin or mitiglinide as an add-on to acarbose on daily blood glucose fluctuations measured by 72 h subcutaneous continuous glucose monitoring in Japanese patients with type 2 diabetes: a prospective randomized study.
    Expert opinion on pharmacotherapy, 2014, Volume: 15, Issue:10

    Topics: Acarbose; Aged; Asian People; Blood Glucose; Diabetes Mellitus, Type 2; Drug Substitution; Drug Ther

2014
Glycemic/metabolic responses to identical meal tolerance tests at breakfast, lunch and dinner in Japanese patients with type 2 diabetes mellitus treated with a dipeptidyl peptidase-4 inhibitor and the effects of adding a mitiglinide/voglibose fixed-dose c
    Expert opinion on pharmacotherapy, 2014, Volume: 15, Issue:13

    Topics: Aged; Blood Glucose; Breakfast; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug

2014
Chronic consumption of an inositol-enriched carob extract improves postprandial glycaemia and insulin sensitivity in healthy subjects: A randomized controlled trial.
    Clinical nutrition (Edinburgh, Scotland), 2016, Volume: 35, Issue:3

    Topics: Adult; Blood Glucose; Dietary Supplements; Double-Blind Method; Fabaceae; Female; Fruit; Humans; Hyp

2016
Improvement in medication compliance and glycemic control with voglibose oral disintegrating tablet.
    The Tohoku journal of experimental medicine, 2008, Volume: 216, Issue:3

    Topics: Administration, Oral; Aged; Female; Glycated Hemoglobin; Humans; Hyperglycemia; Hypoglycemic Agents;

2008
Combination therapy with mitiglinide and voglibose improves glycemic control in type 2 diabetic patients on hemodialysis.
    Expert opinion on pharmacotherapy, 2010, Volume: 11, Issue:2

    Topics: Aged; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hyperglycemia; Hypoglycemia; H

2010
Tighter control of postprandial hyperglycemia with mitiglinide/voglibose fixed-dose combination in Japanese patients with type 2 diabetes mellitus.
    Expert opinion on pharmacotherapy, 2012, Volume: 13, Issue:16

    Topics: Aged; Asian People; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Drug Combinations;

2012
An alpha-glucosidase inhibitor, voglibose, reduces oxidative stress markers and soluble intercellular adhesion molecule 1 in obese type 2 diabetic patients.
    Metabolism: clinical and experimental, 2006, Volume: 55, Issue:6

    Topics: Adult; Biomarkers; Diabetes Mellitus, Type 2; Female; Glycoside Hydrolase Inhibitors; Humans; Hyperg

2006

Other Studies

55 other studies available for inositol and Hyperglycemia, Postprandial

ArticleYear
The IP6K Inhibitor LI-2242 Ameliorates Diet-Induced Obesity, Hyperglycemia, and Hepatic Steatosis in Mice by Improving Cell Metabolism and Insulin Signaling.
    Biomolecules, 2023, 05-20, Volume: 13, Issue:5

    Topics: Animals; Diet; Diphosphates; Hyperglycemia; Inositol; Insulin; Insulin Resistance; Lipid Metabolism;

2023
Promising Anti-stroke Signature of Voglibose: Investigation through In- Silico Molecular Docking and Virtual Screening in In-Vivo Animal Studies.
    Current gene therapy, 2020, Volume: 20, Issue:3

    Topics: Animals; Cerebrovascular Disorders; Computer Simulation; Diabetes Mellitus, Experimental; Diabetes M

2020
Pre-exposure of voglibose exerts cerebroprotective effects through attenuating activation of the polyol pathway and inflammation.
    The European journal of neuroscience, 2021, Volume: 53, Issue:8

    Topics: Animals; Hyperglycemia; Inflammation; Inositol; Male; Polymers; Rats

2021
Myoinositol Reduces Inflammation and Oxidative Stress in Human Endothelial Cells Exposed In Vivo to Chronic Hyperglycemia.
    Nutrients, 2021, Jun-27, Volume: 13, Issue:7

    Topics: Adult; Antioxidants; Cell Adhesion; Cell Adhesion Molecules; Diabetes, Gestational; Female; Human Um

2021
Enhancement of postprandial endogenous insulin secretion rather than exogenous insulin injection ameliorated insulin antibody-induced unstable diabetes: a case report.
    BMC endocrine disorders, 2019, Jan-08, Volume: 19, Issue:1

    Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Drug Therapy, Combination; Gl

2019
Comparison of glycemic variability in patients with type 2 diabetes given sitagliptin or voglibose: a continuous glucose monitoring-based pilot study.
    Diabetes technology & therapeutics, 2013, Volume: 15, Issue:5

    Topics: Aged; Asian People; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Drug Combinations; Fe

2013
The glycemic/metabolic responses to meal tolerance tests at breakfast, lunch and dinner, and effects of the mitiglinide/voglibose fixed-dose combination on postprandial profiles in Japanese patients with type 2 diabetes mellitus.
    Expert opinion on pharmacotherapy, 2014, Volume: 15, Issue:3

    Topics: Aged; Blood Glucose; Breakfast; C-Reactive Protein; Diabetes Mellitus, Type 2; Drug Combinations; Fa

2014
Ice plant (Mesembryanthemum crystallinum) improves hyperglycaemia and memory impairments in a Wistar rat model of streptozotocin-induced diabetes.
    Journal of the science of food and agriculture, 2014, Volume: 94, Issue:11

    Topics: Acetylcholinesterase; Animals; Avoidance Learning; Blood Glucose; Brain; Cholinesterase Inhibitors;

2014
The utility of urinary myo-inositol as a marker of glucose intolerance.
    Diabetes research and clinical practice, 2014, Volume: 103, Issue:1

    Topics: Adult; Aged; Biomarkers; Blood Glucose; Cross-Sectional Studies; Female; Glucose Intolerance; Glucos

2014
Abnormalities in myo-inositol metabolism associated with type 2 diabetes in mice fed a high-fat diet: benefits of a dietary myo-inositol supplementation.
    The British journal of nutrition, 2015, Jun-28, Volume: 113, Issue:12

    Topics: Adipokines; Adipose Tissue, White; Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Dietary Suppl

2015
Hypoglycemic and hepatoprotective effects of D-chiro-inositol-enriched tartary buckwheat extract in high fructose-fed mice.
    Food & function, 2015, Volume: 6, Issue:12

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Glucose; C-Reactive Protein; Chemi

2015
An in vivo invertebrate evaluation system for identifying substances that suppress sucrose-induced postprandial hyperglycemia.
    Scientific reports, 2016, 05-19, Volume: 6

    Topics: Acarbose; Animals; Bombyx; Dietary Sucrose; Disease Models, Animal; Glucose; Glycoside Hydrolase Inh

2016
Myo-inositol inhibits intestinal glucose absorption and promotes muscle glucose uptake: a dual approach study.
    Journal of physiology and biochemistry, 2016, Volume: 72, Issue:4

    Topics: Administration, Oral; Animals; Biological Transport; Blood Glucose; Carbohydrate Metabolism; Diabete

2016
Involvement of hyperglycemia in deposition of aggregated protein in glomeruli of diabetic mice.
    European journal of pharmacology, 2008, Dec-28, Volume: 601, Issue:1-3

    Topics: Animals; Blood Glucose; Diabetes Mellitus; Glucose; Glycated Hemoglobin; Glycated Serum Albumin; Gly

2008
Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory.
    Pediatric diabetes, 2008, Volume: 9, Issue:6

    Topics: Animals; Brain Chemistry; Cerebral Cortex; Dendrites; Dendritic Spines; Diabetes Mellitus, Experimen

2008
Hyperglycaemia is associated with changes in the regional concentrations of glucose and myo-inositol within the brain.
    Diabetologia, 2009, Volume: 52, Issue:3

    Topics: Adult; Blood Glucose; Blood Pressure; Body Mass Index; Brain; C-Reactive Protein; Cholesterol, HDL;

2009
Pancreatic tissue protective nature of D-Pinitol studied in streptozotocin-mediated oxidative stress in experimental diabetic rats.
    European journal of pharmacology, 2009, Nov-10, Volume: 622, Issue:1-3

    Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Hyperglycemia; Inositol; Insulin-Secreting C

2009
Impact of D-pinitol on the attenuation of proinflammatory cytokines, hyperglycemia-mediated oxidative stress and protection of kidney tissue ultrastructure in streptozotocin-induced diabetic rats.
    Chemico-biological interactions, 2010, Oct-06, Volume: 188, Issue:1

    Topics: Animals; Cytokines; Diabetes Mellitus, Experimental; Hyperglycemia; Inositol; Kidney; Microscopy, El

2010
Herbal constituent sequoyitol improves hyperglycemia and glucose intolerance by targeting hepatocytes, adipocytes, and β-cells.
    American journal of physiology. Endocrinology and metabolism, 2012, Apr-15, Volume: 302, Issue:8

    Topics: Adipocytes, White; Animals; Cell Line; Cells, Cultured; Diabetes Mellitus, Experimental; Female; Glu

2012
Effect of two alpha-glucosidase inhibitors, voglibose and acarbose, on postprandial hyperglycemia correlates with subjective abdominal symptoms.
    Metabolism: clinical and experimental, 2005, Volume: 54, Issue:3

    Topics: Acarbose; Aged; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Fem

2005
Acute and chronic effects of glucose and carbachol on insulin secretion and phospholipase C activation: studies with diazoxide and atropine.
    American journal of physiology. Endocrinology and metabolism, 2006, Volume: 290, Issue:1

    Topics: Animals; Atropine; Carbachol; Colforsin; Diazoxide; Enzyme Activation; Glucose; Hyperglycemia; In Vi

2006
Control of plasma glucose with alpha-glucosidase inhibitor attenuates oxidative stress and slows the progression of heart failure in mice.
    Cardiovascular research, 2006, Apr-01, Volume: 70, Issue:1

    Topics: Acetophenones; Animals; Blotting, Western; Body Weight; Cells, Cultured; Disease Progression; Echoca

2006
Comparison of efficacies of a dipeptidyl peptidase IV inhibitor and alpha-glucosidase inhibitors in oral carbohydrate and meal tolerance tests and the effects of their combination in mice.
    Journal of pharmacological sciences, 2007, Volume: 104, Issue:1

    Topics: Acarbose; Administration, Oral; Animals; Area Under Curve; Blood Glucose; Carbohydrate Metabolism; D

2007
Metabolic abnormalities in diabetic peripheral nerve: relation to impaired function.
    Metabolism: clinical and experimental, 1983, Volume: 32, Issue:7 Suppl 1

    Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Energy Metabolism; Female; Gluc

1983
Hyperglycemia-induced changes in Na+/myo-inositol transport, Na(+)-K(+)-ATPase, and protein kinase C activity in proximal tubule cells.
    Diabetes, 1995, Volume: 44, Issue:4

    Topics: Biological Transport; Cell Membrane; Cells, Cultured; Cytosol; Humans; Hyperglycemia; In Vitro Techn

1995
Aldose reductase gene expression and osmotic dysregulation in cultured human retinal pigment epithelial cells.
    The American journal of physiology, 1993, Volume: 265, Issue:3 Pt 1

    Topics: Aldehyde Reductase; Blood Glucose; Cell Line; Fructose; Gene Expression; Glucose; Humans; Hyperglyce

1993
Insulin secretion, myo-inositol transport, and Na(+)-K(+)-ATPase in glucose-desensitized rat islets.
    Diabetes, 1993, Volume: 42, Issue:10

    Topics: Animals; Arginine; Biological Transport; Carbachol; Cells, Cultured; Disease Models, Animal; Dose-Re

1993
Reversal of hyperglycemic-induced defects in myo-inositol metabolism and Na+/K+ pump activity in cultured neuroblastoma cells by normalizing glucose levels.
    Metabolism: clinical and experimental, 1993, Volume: 42, Issue:9

    Topics: Animals; Biological Transport; Blood Glucose; Galactose; Glucose; Hyperglycemia; Inositol; Neuroblas

1993
Observation of resolved glucose signals in 1H NMR spectra of the human brain at 4 Tesla.
    Magnetic resonance in medicine, 1996, Volume: 36, Issue:1

    Topics: Blood Glucose; Body Water; Brain; Carbon Isotopes; Creatine; Glucose; Humans; Hydrogen; Hyperglycemi

1996
Dietary intake of myo-inositol and neural tube defects in offspring of diabetic rats.
    American journal of obstetrics and gynecology, 1997, Volume: 176, Issue:3

    Topics: Animals; Diabetes Mellitus, Experimental; Embryonic and Fetal Development; Female; Hyperglycemia; In

1997
Dietary myo-inositol therapy in hyperglycemia-induced embryopathy.
    Teratology, 1998, Volume: 57, Issue:2

    Topics: Animals; Arachidonic Acid; Blood Glucose; Diabetes Mellitus, Experimental; Embryo, Mammalian; Embryo

1998
Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.
    Diabetes, 1999, Volume: 48, Issue:4

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Blood Glucose; Deoxyguanosine; Diabetes Mellitus, T

1999
Antihyperglycemic effects of 3-O-methyl-D-chiro-inositol and D-chiro-inositol associated with manganese in streptozotocin diabetic rats.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2000, Volume: 32, Issue:4

    Topics: Animals; Blood Glucose; Chlorides; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Femal

2000
Diabetic polyneuropathy: the importance of insulin deficiency, hyperglycemia and alterations in myoinositol metabolism in its pathogenesis.
    The New England journal of medicine, 1976, Dec-16, Volume: 295, Issue:25

    Topics: Acute Disease; Animals; Demyelinating Diseases; Diabetes Mellitus, Experimental; Diabetic Neuropathi

1976
Mechanisms in rabbit aorta for hyperglycaemia-induced alterations in angiotensin II and norepinephrine effects.
    Diabetologia, 1992, Volume: 35, Issue:8

    Topics: Angiotensin II; Animals; Aorta; Glucose; Hyperglycemia; Inositol; Kinetics; Male; Muscle, Smooth, Va

1992
Inhibition of alloxan-induced hyperglycaemia by compounds of similar molecular structure.
    Biochemical pharmacology, 1992, Dec-01, Volume: 44, Issue:11

    Topics: Allantoin; Alloxan; Animals; Barbiturates; Blood Glucose; Caffeine; Ethosuximide; Hyperglycemia; Ino

1992
Metabolic abnormalities of the hyperglycemic obese Zucker rat.
    Metabolism: clinical and experimental, 1992, Volume: 41, Issue:5

    Topics: Animals; Fructose; Glucose; Glycosuria; Hyperglycemia; Inositol; Male; Obesity; Rats; Rats, Zucker;

1992
Regulation of inositol transport by glucose and protein kinase C in mesangial cells.
    Kidney international, 1992, Volume: 42, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Biological Transport, Active; Cel

1992
Understanding diabetic neuropathy.
    Lancet (London, England), 1991, Dec-14, Volume: 338, Issue:8781

    Topics: Diabetic Neuropathies; Humans; Hyperglycemia; Inositol; Nerve Growth Factors; Peripheral Nerves; Tim

1991
Effect of hyperglycemia on sorbitol and myo-inositol content of cultured rat conceptus: prevention of dysmorphogenesis with aldose reductase inhibitors and myo-inositol.
    Journal of perinatal medicine, 1991, Volume: 19 Suppl 1

    Topics: Aldehyde Reductase; Animals; Blood; Congenital Abnormalities; Culture Media; Culture Techniques; Fem

1991
[Abnormal metabolism of polyol pathway and diabetic complications].
    Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49 Suppl

    Topics: Diabetes Mellitus; Glucose; Humans; Hyperglycemia; Inositol; NADP; Osmotic Pressure; Polymers

1991
Effects of hyperglycaemia on sorbitol and myo-inositol contents of cultured embryos: treatment with aldose reductase inhibitor and myo-inositol supplementation.
    Diabetologia, 1990, Volume: 33, Issue:10

    Topics: Aldehyde Reductase; Animals; Embryo, Mammalian; Embryonic and Fetal Development; Female; Fetal Disea

1990
Chronic in vivo hyperglycemia impairs phosphoinositide hydrolysis and insulin release in isolated perifused rat islets.
    Endocrinology, 1990, Volume: 126, Issue:1

    Topics: Animals; Blood Glucose; Chronic Disease; Glucose; Hydrolysis; Hyperglycemia; In Vitro Techniques; In

1990
Advances in the diagnosis and pathogenesis of diabetes mellitus and its complications.
    Comprehensive therapy, 1990, Volume: 16, Issue:7

    Topics: Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Dia

1990
Glucose-induced dysmorphogenesis in the cultured rat conceptus: prevention by supplementation with myo-inositol.
    Israel journal of medical sciences, 1990, Volume: 26, Issue:10

    Topics: Animals; Congenital Abnormalities; Culture Media; Culture Techniques; Disease Models, Animal; Embryo

1990
Uptake of myo-inositol by early-somite rat conceptus. Transport kinetics and effects of hyperglycemia.
    Diabetes, 1990, Volume: 39, Issue:5

    Topics: Animals; Biological Transport; Congenital Abnormalities; Culture Techniques; DNA; Embryo, Mammalian;

1990
Retinopathy in the pregnant diabetic.
    Clinical obstetrics and gynecology, 1985, Volume: 28, Issue:3

    Topics: Adult; Blood Flow Velocity; Diabetic Angiopathies; Diabetic Retinopathy; Enzymes; Female; Fluorescei

1985
Effects of streptozotocin-induced hyperglycemia on agonist-stimulated phosphatidylinositol turnover in rat aorta.
    Life sciences, 1989, Volume: 45, Issue:5

    Topics: Animals; Aorta, Thoracic; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Hyperglycemia

1989
[Diabetic polyneuropathy].
    Klinicheskaia meditsina, 1989, Volume: 67, Issue:4

    Topics: Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Humans; Hyperglycemia; Inositol; P

1989
Banting lecture 1986. Does a common mechanism induce the diverse complications of diabetes?
    Diabetes, 1987, Volume: 36, Issue:3

    Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Ne

1987
The effects of hyperglycemia on the directed migration of wounded endothelial cell monolayers.
    Metabolism: clinical and experimental, 1988, Volume: 37, Issue:4

    Topics: Animals; Cattle; Cell Movement; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vasc

1988
The development of electroretinogram abnormalities and the possible role of polyol pathway activity in diabetic hyperglycemia and galactosemia.
    Metabolism: clinical and experimental, 1988, Volume: 37, Issue:5

    Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Electroretinography; Galactitol; Galactosemias;

1988
The absence of cataracts in mice with congenital hyperglycemia.
    Experimental eye research, 1974, Volume: 19, Issue:6

    Topics: Alcohol Oxidoreductases; Animals; Cataract; Diabetes Mellitus; Diet; Fructose; Galactitol; Galactose

1974
Gas chromatography measurement of myo-inositol in human blood, cerebrospinal fluid and seminal fluid.
    Clinica chimica acta; international journal of clinical chemistry, 1973, May-30, Volume: 45, Issue:4

    Topics: Adult; Aged; Child, Preschool; Chromatography, Gas; Chromatography, Ion Exchange; Creatine Kinase; D

1973
Hyperglycemia, polyol accumulation, and increased intracranial pressure.
    Archives of neurology, 1971, Volume: 25, Issue:2

    Topics: Animals; Brain; Brain Edema; Cerebrospinal Fluid Proteins; Diabetic Ketoacidosis; Disease Models, An

1971