Page last updated: 2024-10-19

inositol and Huntington Disease

inositol has been researched along with Huntington Disease in 4 studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sturrock, A1
Laule, C1
Wyper, K1
Milner, RA1
Decolongon, J1
Dar Santos, R1
Coleman, AJ1
Carter, K1
Creighton, S1
Bechtel, N1
Bohlen, S1
Reilmann, R1
Johnson, HJ1
Hayden, MR1
Tabrizi, SJ1
Mackay, AL1
Leavitt, BR1
Graham, SF1
Kumar, PK1
Bjorndahl, T1
Han, B1
Yilmaz, A1
Sherman, E1
Bahado-Singh, RO1
Wishart, D1
Mann, D1
Green, BD1
Sarkar, S2
Rubinsztein, DC2
Krishna, G1
Imarisio, S1
Saiki, S1
O'Kane, CJ1

Reviews

1 review available for inositol and Huntington Disease

ArticleYear
Huntington's disease: degradation of mutant huntingtin by autophagy.
    The FEBS journal, 2008, Volume: 275, Issue:17

    Topics: Autophagy; Humans; Huntingtin Protein; Huntington Disease; Inositol; Lithium Compounds; Mutation; Ne

2008

Other Studies

3 other studies available for inositol and Huntington Disease

ArticleYear
A longitudinal study of magnetic resonance spectroscopy Huntington's disease biomarkers.
    Movement disorders : official journal of the Movement Disorder Society, 2015, Volume: 30, Issue:3

    Topics: Adult; Analysis of Variance; Aspartic Acid; Biomarkers; Brain; Cross-Sectional Studies; Female; Huma

2015
Metabolic signatures of Huntington's disease (HD): (1)H NMR analysis of the polar metabolome in post-mortem human brain.
    Biochimica et biophysica acta, 2016, Volume: 1862, Issue:9

    Topics: Brain; Case-Control Studies; Corpus Striatum; Frontal Lobe; Humans; Huntington Disease; Inositol; Le

2016
A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.
    Human molecular genetics, 2008, Jan-15, Volume: 17, Issue:2

    Topics: Animals; Autophagy; Chlorocebus aethiops; COS Cells; Disease Models, Animal; Drosophila; Drosophila

2008