Page last updated: 2024-10-19

inositol and Glucose Intolerance

inositol has been researched along with Glucose Intolerance in 24 studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Glucose Intolerance: A pathological state in which BLOOD GLUCOSE level is less than approximately 140 mg/100 ml of PLASMA at fasting, and above approximately 200 mg/100 ml plasma at 30-, 60-, or 90-minute during a GLUCOSE TOLERANCE TEST. This condition is seen frequently in DIABETES MELLITUS, but also occurs with other diseases and MALNUTRITION.

Research Excerpts

ExcerptRelevanceReference
" Because it reflects the current status of hyperglycemia, urinary myo-inositol (UMI) may be useful."7.80The utility of urinary myo-inositol as a marker of glucose intolerance. ( Furusyo, N; Hayashi, J; Hayashi, T; Ihara, T; Ikezaki, H; Kainuma, M; Murata, M; Ogawa, E; Okada, K, 2014)
" Myoinositol can be measured in urine and has been found to be elevated in patients with diabetes and glucose intolerance; it has thus proven useful as a marker for the early detection of these conditions."7.74Lucica MI urinary myoinositol kit: a new diagnostic test for diabetes mellitus and glucose intolerance. ( Kawazu, S; Yamakoshi, M, 2008)
"We measured urinary myo-inositol enzymatically before and 2 h after a 75-g oral glucose tolerance test in 564 volunteers, who were divided into four groups [normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes mellitus (DM)]."7.72A study of urinary myo-inositol as a sensitive marker of glucose intolerance. ( Katsura, Y; Kawazu, S; Kure, M; Matsuoka, T; Noritake, M; Sarashina, G; Shiomi, H; Takahashi, M; Tominaga, M; Tsuboi, I; Yamagata, F; Yamakoshi, M, 2004)
" We conclude that plasma levels of both pinitol and D-chiro-inositol are very responsive to pinitol ingestion, but insulin sensitivity does not increase after pinitol treatment in individuals with obesity and mild type 2 diabetes."5.09Effect of pinitol treatment on insulin action in subjects with insulin resistance. ( Christiansen, M; Davis, A; Hellerstein, MK; Horowitz, JF; Klein, S; Ostlund, RE, 2000)
" Because it reflects the current status of hyperglycemia, urinary myo-inositol (UMI) may be useful."3.80The utility of urinary myo-inositol as a marker of glucose intolerance. ( Furusyo, N; Hayashi, J; Hayashi, T; Ihara, T; Ikezaki, H; Kainuma, M; Murata, M; Ogawa, E; Okada, K, 2014)
" Myoinositol can be measured in urine and has been found to be elevated in patients with diabetes and glucose intolerance; it has thus proven useful as a marker for the early detection of these conditions."3.74Lucica MI urinary myoinositol kit: a new diagnostic test for diabetes mellitus and glucose intolerance. ( Kawazu, S; Yamakoshi, M, 2008)
"We measured urinary myo-inositol enzymatically before and 2 h after a 75-g oral glucose tolerance test in 564 volunteers, who were divided into four groups [normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes mellitus (DM)]."3.72A study of urinary myo-inositol as a sensitive marker of glucose intolerance. ( Katsura, Y; Kawazu, S; Kure, M; Matsuoka, T; Noritake, M; Sarashina, G; Shiomi, H; Takahashi, M; Tominaga, M; Tsuboi, I; Yamagata, F; Yamakoshi, M, 2004)
"Patients with type 2 diabetes mellitus (T2DM) have a higher incidence of cardiovascular (CV) events."2.87Effects of a Carob-Pod-Derived Sweetener on Glucose Metabolism. ( Badimon, L; Cubedo, J; Hernández-Mijares, A; Lambert, C; López-Bernal, S; Padró, T; Rocha, M; Vilahur, G, 2018)
"The increased prevalence of type 2 diabetes mellitus is a major concern for health providers."2.74Voglibose for prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese individuals with impaired glucose tolerance. ( Iwamoto, Y; Kaku, K; Kashiwagi, A; Kawamori, R; Shimamoto, K; Tajima, N, 2009)
"Since 1) dilated cardiomyopathy (DCM) causes chronic heart failure (CHF), and 2) augmentation of neurohumoral factors such as angiotensin II impairs glucose metabolism, we examined the rate of abnormal glucose metabolism in patients having both DCM and CHF and whether correction of the impairment of glucose metabolism would improve the pathophysiology of CHF in DCM patients."1.33Abnormal glucose tolerance contributes to the progression of chronic heart failure in patients with dilated cardiomyopathy. ( Asakura, M; Asanuma, H; Hashimura, K; Kanzaki, H; Kim, J; Kitakaze, M; Kokubo, Y; Komamura, K; Nakatani, S; Tomoike, H, 2006)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's11 (45.83)29.6817
2010's9 (37.50)24.3611
2020's4 (16.67)2.80

Authors

AuthorsStudies
Plows, JF1
Ramos Nieves, JM1
Budin, F1
Mace, K1
Reynolds, CM1
Vickers, MH1
Silva-Zolezzi, I1
Baker, PN1
Stanley, JL1
Takakado, M1
Takata, Y1
Yamagata, F3
Yaguchi, M1
Hiasa, G1
Sato, S1
Funada, JI1
Kawazu, S4
Osawa, H1
Pericuesta, E1
Laguna-Barraza, R1
Ramos-Ibeas, P1
Gutierrez-Arroyo, JL1
Navarro, JA1
Vera, K1
Sanjuan, C1
Baixeras, E1
de Fonseca, FR1
Gutierrez-Adan, A1
Asakura, M2
Kim, J2
Asanuma, H2
Hamasaki, T1
Tsukahara, K1
Higashino, Y1
Ishikawa, T1
Nakama, Y1
Koba, S1
Maruyama, Y1
Tsujimoto, M1
Himeno, H1
Ohkusa, T1
Fujino, S1
Shimizu, M1
Endo, T1
Yoda, S1
Muroya, T1
Murohara, T1
Ohte, N1
Suzuki, H1
Kohno, T1
Fukui, K1
Shiono, T1
Takase, H1
Uzui, H1
Nagai, Y1
Hashimoto, Y1
Ikeda, S1
Mizuno, S1
Tamita, K1
Fujita, M1
Satake, K1
Kinoshita, Y1
Nunohiro, T1
Sakagami, S1
Higaki, J1
Morii, I1
Sawada, R1
Hiasa, Y1
Shigemasa, T1
Nakahama, M1
Sata, M1
Doi, O1
Ueda, T1
Yamada, T1
Yamanouchi, T1
Yamaguchi, H1
Morita, Y1
Hayashi, H1
Kitakaze, M2
Lambert, C1
Cubedo, J1
Padró, T1
Vilahur, G1
López-Bernal, S1
Rocha, M1
Hernández-Mijares, A1
Badimon, L1
Donnarumma, M1
Marasca, C1
Palma, M1
Vastarella, M1
Annunziata, MC1
Fabbrocini, G1
Ortiz-Flores, AE1
Luque-Ramírez, M1
Escobar-Morreale, HF1
Moelands, SV1
Lucassen, PL1
Akkermans, RP1
De Grauw, WJ1
Van de Laar, FA1
Fried, PJ1
Pascual-Leone, A1
Bolo, NR1
Ikezaki, H1
Furusyo, N1
Okada, K1
Ihara, T1
Hayashi, T1
Ogawa, E1
Kainuma, M1
Murata, M1
Hayashi, J1
Kaku, K3
Yamakoshi, M2
Aoki, K1
Ito, Y1
Saito, K1
Shirakawa, J1
Togashi, Y1
Satoh, K1
Muraoka, T1
Shinoda, K1
Masuda, K1
Kimura, M1
Terauchi, Y1
Kawamori, R3
Tajima, N2
Iwamoto, Y2
Kashiwagi, A2
Shimamoto, K2
Scheen, AJ1
Shen, H1
Shao, M1
Cho, KW1
Wang, S1
Chen, Z1
Sheng, L1
Wang, T1
Liu, Y1
Rui, L1
Sarashina, G1
Noritake, M1
Takahashi, M1
Kure, M1
Katsura, Y1
Shiomi, H1
Tsuboi, I1
Tominaga, M1
Matsuoka, T1
Nakamura, J1
Nakatani, S1
Hashimura, K1
Komamura, K1
Kanzaki, H1
Kokubo, Y1
Tomoike, H1
Sundkvist, G1
Dahlin, LB1
Nilsson, H1
Eriksson, KF1
Lindgärde, F1
Rosén, I1
Lattimer, SA1
Sima, AA1
Sullivan, K1
Greene, DA1
Davis, A1
Christiansen, M1
Horowitz, JF1
Klein, S1
Hellerstein, MK1
Ostlund, RE1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Japan Working Group for the Assessment That the Alpha-glucosidase Inhibitor Blocks Cardiac Events in Patients With Myocardial Infarction and IGT[NCT00212017]3,000 participants (Actual)Interventional2005-04-30Terminated (stopped due to We obtained the final results due to the interim analysis.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for inositol and Glucose Intolerance

ArticleYear
Pharmacotherapeutic management of comorbid polycystic ovary syndrome and diabetes.
    Expert opinion on pharmacotherapy, 2018, Volume: 19, Issue:17

    Topics: Animals; Diabetes Mellitus; Female; Glucose Intolerance; Humans; Inositol; Insulin; Insulin Resistan

2018
Alpha-glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk of developing type 2 diabetes mellitus.
    The Cochrane database of systematic reviews, 2018, 12-28, Volume: 12

    Topics: Acarbose; Blood Glucose; Cause of Death; Diabetes Mellitus, Type 2; Diet; Exercise; Fasting; Glucose

2018
Efficacy of voglibose in type 2 diabetes.
    Expert opinion on pharmacotherapy, 2014, Volume: 15, Issue:8

    Topics: Atherosclerosis; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Drug Therapy, Combination; Glucos

2014
[Detection of glucose intolerance by urinary myo-inositol].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 2

    Topics: Biomarkers; Gas Chromatography-Mass Spectrometry; Glucose Intolerance; Humans; Inositol; Mass Screen

2005
[Effects of voglibose, alpha-glucosidase inhibitor in treatment of impaired glucose tolerance].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 2

    Topics: Animals; Carbohydrate Metabolism; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glucose Intolerance;

2005

Trials

7 trials available for inositol and Glucose Intolerance

ArticleYear
Does Treatment of Impaired Glucose Tolerance Improve Cardiovascular Outcomes in Patients with Previous Myocardial Infarction?
    Cardiovascular drugs and therapy, 2017, Volume: 31, Issue:4

    Topics: Aged; Cardiovascular Diseases; Female; Glucose Intolerance; Glycoside Hydrolase Inhibitors; Humans;

2017
Effects of a Carob-Pod-Derived Sweetener on Glucose Metabolism.
    Nutrients, 2018, Feb-27, Volume: 10, Issue:3

    Topics: Adolescent; Adult; Aged; Animals; Beverages; Blood Glucose; Body Mass Index; Complement C4a; Diabete

2018
Comparison of pre- versus post-meal administration of voglibose in men with or without impaired glucose tolerance.
    Diabetes research and clinical practice, 2009, Volume: 83, Issue:2

    Topics: Adult; Area Under Curve; Blood Glucose; Cross-Over Studies; Drug Administration Schedule; Eating; Gl

2009
Voglibose for prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese individuals with impaired glucose tolerance.
    Lancet (London, England), 2009, May-09, Volume: 373, Issue:9675

    Topics: Administration, Oral; Analysis of Variance; Diabetes Mellitus, Type 2; Disease Progression; Double-B

2009
[Alpha-glucosidase inhibitor for the prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese subjects with impaired glucose tolerance].
    Nihon rinsho. Japanese journal of clinical medicine, 2009, Volume: 67, Issue:9

    Topics: Asian People; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Disease Progression; Enzyme Inhibi

2009
[Evidence demonstrating the effect of voglibose for the prevention of type 2 diabetes mellitus: a randomised double-blind trial in Japanese subjects with inpaired glucose tolerance].
    Nihon rinsho. Japanese journal of clinical medicine, 2011, Volume: 69 Suppl 1

    Topics: Adult; Aged; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucose Intolerance; Humans; Hy

2011
Effect of pinitol treatment on insulin action in subjects with insulin resistance.
    Diabetes care, 2000, Volume: 23, Issue:7

    Topics: Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucose Cl

2000

Other Studies

12 other studies available for inositol and Glucose Intolerance

ArticleYear
The effects of myo-inositol and probiotic supplementation in a high-fat-fed preclinical model of glucose intolerance in pregnancy.
    The British journal of nutrition, 2020, 03-14, Volume: 123, Issue:5

    Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes, Gestational; Diet, High-Fat; Dietary Supplements;

2020
Simple and non-invasive screening method for diabetes based on myoinositol levels in urine samples collected at home.
    BMJ open diabetes research & care, 2020, Volume: 8, Issue:1

    Topics: Adult; Aged; Blood Glucose; Creatinine; Diabetes Mellitus, Type 2; Diagnostic Tests, Routine; Fastin

2020
D-Chiro-Inositol Treatment Affects Oocyte and Embryo Quality and Improves Glucose Intolerance in Both Aged Mice and Mouse Models of Polycystic Ovarian Syndrome.
    International journal of molecular sciences, 2020, Aug-22, Volume: 21, Issue:17

    Topics: Aging; Animals; Blastocyst; Cumulus Cells; Dihydrotestosterone; Disease Models, Animal; Female; Gene

2020
An oral supplementation based on myo-inositol, folic acid and liposomal magnesium may act synergistically with antibiotic therapy and can improve metabolic profile in patients affected by Hidradenitis suppurativa: our experience.
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2020, Volume: 155, Issue:6

    Topics: Administration, Cutaneous; Administration, Oral; Anti-Bacterial Agents; Clindamycin; Dietary Supplem

2020
Diabetes and the link between neuroplasticity and glutamate in the aging human motor cortex.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2019, Volume: 130, Issue:9

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Creatine; Diabetes Mellitus, Type 2; Female; Glucose;

2019
The utility of urinary myo-inositol as a marker of glucose intolerance.
    Diabetes research and clinical practice, 2014, Volume: 103, Issue:1

    Topics: Adult; Aged; Biomarkers; Blood Glucose; Cross-Sectional Studies; Female; Glucose Intolerance; Glucos

2014
Lucica MI urinary myoinositol kit: a new diagnostic test for diabetes mellitus and glucose intolerance.
    Molecular diagnosis & therapy, 2008, Volume: 12, Issue:3

    Topics: Clinical Trials as Topic; Diabetes Mellitus; Glucose Intolerance; Glucose Tolerance Test; Humans; In

2008
Voglibose for prevention of type 2 diabetes mellitus.
    Lancet (London, England), 2009, May-09, Volume: 373, Issue:9675

    Topics: Diabetes Mellitus, Type 2; Glucose Intolerance; Humans; Hypoglycemic Agents; Inositol; Life Style; P

2009
Herbal constituent sequoyitol improves hyperglycemia and glucose intolerance by targeting hepatocytes, adipocytes, and β-cells.
    American journal of physiology. Endocrinology and metabolism, 2012, Apr-15, Volume: 302, Issue:8

    Topics: Adipocytes, White; Animals; Cell Line; Cells, Cultured; Diabetes Mellitus, Experimental; Female; Glu

2012
A study of urinary myo-inositol as a sensitive marker of glucose intolerance.
    Clinica chimica acta; international journal of clinical chemistry, 2004, Volume: 344, Issue:1-2

    Topics: Adult; Age Factors; Biomarkers; Case-Control Studies; Female; Glucose Intolerance; Humans; Inositol;

2004
Abnormal glucose tolerance contributes to the progression of chronic heart failure in patients with dilated cardiomyopathy.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2006, Volume: 29, Issue:10

    Topics: Cardiomyopathy, Dilated; Chronic Disease; Disease Progression; Echocardiography; Female; Glucose Int

2006
Sorbitol and myo-inositol levels and morphology of sural nerve in relation to peripheral nerve function and clinical neuropathy in men with diabetic, impaired, and normal glucose tolerance.
    Diabetic medicine : a journal of the British Diabetic Association, 2000, Volume: 17, Issue:4

    Topics: Diabetes Mellitus, Type 1; Diabetic Neuropathies; Glucose Intolerance; Glucose Tolerance Test; Human

2000