inositol and Glioma
inositol has been researched along with Glioma in 36 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have examined the effects of phorbol esters on phosphatidylcholine (PtdCho) metabolism in the neuroblastoma-glioma hybrid cell line NG108-15." | 7.67 | Phosphatidylcholine biosynthesis in the neuroblastoma-glioma hybrid cell line NG108-15: stimulation by phorbol esters. ( Blusztajn, JK; Freese, A; Liscovitch, M; Wurtman, RJ, 1986) |
| " There are a number of metabolites that can be identified by standard brain proton MRS but only a few of them has a clinical significance in diagnosis of gliomas including N-acetylaspartate, choline, creatine, myo-inositol, lactate, and lipids." | 4.89 | Potential of MR spectroscopy for assessment of glioma grading. ( Bulik, M; Jancalek, R; Mechl, M; Skoch, A; Vanicek, J, 2013) |
| " MRS of normal brain parenchyma displays 4 main metabolites: N-acetyl aspartate (neuronal marker), creatine (cellular density marker), choline (membrane activity marker) and myoinositol (glial marker); pathological processes lead to variations of the level of these metabolites and/or the appearance of abnormal metabolites (lactate), following different patterns according to pathological process involved: glioma, meningioma, metastasis, bacterial or toxoplasmic abscess, radionecrosis." | 3.71 | [Contribution of magnetic resonance spectrometry to the diagnosis of intracranial tumors]. ( Confort-Gouny, S; Cozzone, PJ; Dufour, H; Galanaud, D; Le Fur, Y; Nicoli, F; Peragut, JC; Ranjeva, JP; Roche, P; Viout, P, 2002) |
| " In the present study, butyrate treatment caused decreases in thymidine incorporation in the early passages (45-60) of C6 glioma cells." | 3.70 | Alterations in Ca2+ signaling, and c-fos and nur77 expression are associated with sodium butyrate-induced differentiation of C6 glioma cell. ( Jang, TH; Sun, SH, 2000) |
| "Ketoconazole, cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate, and gossypol are reported inhibitors of the lipoxygenase (LO) and cytochrome P-450 enzyme systems and are potent blockers of swelling-activated efflux of organic osmolytes and volume-sensitive anion channels in C6 glioma cells." | 3.69 | Ketoconazole blocks organic osmolyte efflux independently of its effect on arachidonic acid conversion. ( Jackson, P; McManus, M; Serhan, C; Strange, K, 1994) |
| "C6 glioma cells accumulate the organic osmolyte inositol in response to chronic hypertonic stress." | 3.68 | Volume-sensitive anion channels mediate swelling-activated inositol and taurine efflux. ( Jackson, PS; Strange, K, 1993) |
| "Previous studies have shown that in the neuroblastoma x glioma hybrid cell line NG108-15 lithium is able to induce an increase in diacylglycerol levels." | 3.68 | Elevated phosphatidyl-CMP is not the source of diacylglycerol accumulation induced by lithium in NG108-15 cells. ( Brami, BA; Hauser, G; Leli, U, 1993) |
| "Endothelin (ET)-related peptides robustly stimulated [3H]-inositol phosphate (IP) formation in cultured cerebellar granule cells, astrocytes, and C6 glioma cells." | 3.68 | Endothelin-induced activation of phosphoinositide turnover, calcium mobilization, and transmitter release in cultured neurons and neurally related cell types. ( Chuang, DM; Lee, CY; Lin, WW, 1991) |
| "Phosphoinositide and inositol metabolism was compared in glioma (C6), neuroblastoma (N1E-115) and neuroblastoma X glioma hybrid (NG 108-15) cells." | 3.67 | Differences in the metabolism of inositol and phosphoinositides by cultured cells of neuronal and glial origin. ( Byers, DM; Cook, HW; Glanville, NT; Palmer, FB; Spence, MW, 1989) |
| "Accumulation of inositol phosphates in NG108-15 neuroblastoma x glioma hybrid cells, pre-labeled for 24h to equilibrium, was stimulated by bradykinin, guanosine 5'-O-(3-thiotriphosphate) and the diacylglycerol kinase inhibitor R59022." | 3.67 | Effects of bradykinin, GTP gamma S, R59022 and N-ethylmaleimide on inositol phosphate production in NG108-15 cells. ( Chiang, CF; Hauser, G, 1989) |
| "5-Hydroxytryptamine (serotonin or 5-HT) stimulated the incorporation of 32Pi into phosphatidylinositol (PI) but not into polyphosphoinositides in C6 glioma cells with an EC50 of 1." | 3.67 | Stimulation of phosphoinositide hydrolysis by serotonin in C6 glioma cells. ( Ananth, US; Hauser, G; Leli, U, 1987) |
| "We have examined the effects of phorbol esters on phosphatidylcholine (PtdCho) metabolism in the neuroblastoma-glioma hybrid cell line NG108-15." | 3.67 | Phosphatidylcholine biosynthesis in the neuroblastoma-glioma hybrid cell line NG108-15: stimulation by phorbol esters. ( Blusztajn, JK; Freese, A; Liscovitch, M; Wurtman, RJ, 1986) |
| "Most of the brain tumors were characterized by strongly reduced total N-acetylaspartyl compounds and marked increases of myo-inositol and choline-containing compounds, consistent with a lack of neuroaxonal tissue and a proliferation of glial cells." | 1.31 | Quantitative proton magnetic resonance spectroscopy of focal brain lesions. ( Dechent, P; Frahm, J; Hanefeld, F; Herms, J; Markakis, E; Maxton, C; Wilken, B, 2000) |
Research
Studies (36)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (25.00) | 18.7374 |
| 1990's | 11 (30.56) | 18.2507 |
| 2000's | 11 (30.56) | 29.6817 |
| 2010's | 3 (8.33) | 24.3611 |
| 2020's | 2 (5.56) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Autry, AW | 1 |
| Lafontaine, M | 1 |
| Jalbert, L | 1 |
| Phillips, E | 1 |
| Phillips, JJ | 1 |
| Villanueva-Meyer, J | 1 |
| Berger, MS | 1 |
| Chang, SM | 1 |
| Li, Y | 1 |
| Ruz, C | 1 |
| Alcantud, JL | 1 |
| Vives, F | 1 |
| Arrebola, F | 1 |
| Hardy, J | 1 |
| Lewis, PA | 1 |
| Manzoni, C | 1 |
| Duran, R | 1 |
| Nagashima, H | 1 |
| Sasayama, T | 1 |
| Tanaka, K | 1 |
| Kyotani, K | 1 |
| Sato, N | 1 |
| Maeyama, M | 1 |
| Kohta, M | 1 |
| Sakata, J | 1 |
| Yamamoto, Y | 1 |
| Hosoda, K | 1 |
| Itoh, T | 1 |
| Sasaki, R | 1 |
| Kohmura, E | 1 |
| Pascual-Castroviejo, I | 1 |
| Pascual-Pascual, SI | 1 |
| Velazquez-Fragua, R | 1 |
| Viaño, J | 1 |
| Bulik, M | 1 |
| Jancalek, R | 1 |
| Vanicek, J | 1 |
| Skoch, A | 1 |
| Mechl, M | 1 |
| Galanaud, D | 1 |
| Nicoli, F | 1 |
| Le Fur, Y | 1 |
| Roche, P | 1 |
| Confort-Gouny, S | 1 |
| Dufour, H | 1 |
| Ranjeva, JP | 1 |
| Peragut, JC | 1 |
| Viout, P | 1 |
| Cozzone, PJ | 1 |
| Simonetti, AW | 1 |
| Melssen, WJ | 1 |
| van der Graaf, M | 1 |
| Postma, GJ | 1 |
| Heerschap, A | 1 |
| Buydens, LM | 1 |
| McKnight, TR | 1 |
| Tong, ZY | 1 |
| Toshiaki, Y | 1 |
| Wang, YJ | 1 |
| Kim, JH | 1 |
| Chang, KH | 1 |
| Na, DG | 1 |
| Song, IC | 1 |
| Kwon, BJ | 1 |
| Han, MH | 1 |
| Kim, K | 1 |
| Hattingen, E | 1 |
| Raab, P | 1 |
| Franz, K | 1 |
| Zanella, FE | 1 |
| Lanfermann, H | 1 |
| Pilatus, U | 1 |
| Bulakbasi, N | 1 |
| Kocaoglu, M | 1 |
| Sanal, TH | 1 |
| Tayfun, C | 1 |
| Fujiwara, K | 1 |
| Iwado, E | 1 |
| Mills, GB | 1 |
| Sawaya, R | 1 |
| Kondo, S | 1 |
| Kondo, Y | 1 |
| Alimenti, A | 1 |
| Delavelle, J | 1 |
| Lazeyras, F | 1 |
| Yilmaz, H | 1 |
| Dietrich, PY | 1 |
| de Tribolet, N | 1 |
| Lövblad, KO | 1 |
| Poduslo, SE | 1 |
| Miller, K | 1 |
| Jang, Y | 1 |
| Hagberg, G | 1 |
| Burlina, AP | 1 |
| Mader, I | 1 |
| Roser, W | 1 |
| Radue, EW | 1 |
| Seelig, J | 1 |
| McManus, M | 1 |
| Serhan, C | 1 |
| Jackson, P | 1 |
| Strange, K | 3 |
| Gyngell, ML | 2 |
| Els, T | 1 |
| Hoehn-Berlage, M | 1 |
| Hossmann, KA | 1 |
| Jackson, PS | 1 |
| Brami, BA | 1 |
| Leli, U | 3 |
| Hauser, G | 4 |
| Sun, SH | 2 |
| Ou, HC | 1 |
| Jang, TH | 2 |
| Lin, LB | 1 |
| Huang, HM | 1 |
| Zwingmann, C | 1 |
| Brand, A | 1 |
| Richter-Landsberg, C | 1 |
| Leibfritz, D | 1 |
| Wilken, B | 1 |
| Dechent, P | 1 |
| Herms, J | 1 |
| Maxton, C | 1 |
| Markakis, E | 1 |
| Hanefeld, F | 1 |
| Frahm, J | 2 |
| Lin, WW | 2 |
| Chuang, DM | 2 |
| Lee, CY | 1 |
| Morrison, R | 1 |
| Heilig, CW | 1 |
| DiPietro, S | 1 |
| Gullans, SR | 1 |
| Carrithers, MD | 1 |
| Raman, VK | 1 |
| Masuda, S | 1 |
| Weyhenmeyer, JA | 1 |
| Glanville, NT | 1 |
| Byers, DM | 1 |
| Cook, HW | 1 |
| Spence, MW | 1 |
| Palmer, FB | 1 |
| Chiang, CF | 1 |
| Bruhn, H | 1 |
| Merboldt, KD | 1 |
| Hänicke, W | 1 |
| Sauter, R | 1 |
| Hamburger, C | 1 |
| Jackson, TR | 1 |
| Patterson, SI | 1 |
| Wong, YH | 1 |
| Hanley, MR | 1 |
| Ehrlich, YH | 1 |
| Snider, RM | 1 |
| Kornecki, E | 1 |
| Garfield, MG | 1 |
| Lenox, RH | 1 |
| Ananth, US | 1 |
| Liscovitch, M | 1 |
| Freese, A | 1 |
| Blusztajn, JK | 1 |
| Wurtman, RJ | 1 |
Reviews
3 reviews available for inositol and Glioma
| Article | Year |
|---|---|
[Corpus callosum tumor as the presenting symptom of neurofibromatosis type 1 in a patient and literature review].
Topics: Brain Neoplasms; Brain Stem Neoplasms; Cerebellar Neoplasms; Child, Preschool; Choline; Corpus Callo | 2012 |
Potential of MR spectroscopy for assessment of glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Inositol; Lactates; Lipid Metabol | 2013 |
Proton magnetic resonance spectroscopic evaluation of brain tumor metabolism.
Topics: Alanine; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glutamic Acid; Glutamine; Humans | 2004 |
Other Studies
33 other studies available for inositol and Glioma
| Article | Year |
|---|---|
Spectroscopic imaging of D-2-hydroxyglutarate and other metabolites in pre-surgical patients with IDH-mutant lower-grade gliomas.
Topics: Brain Neoplasms; Glioma; Glutarates; Humans; Inositol; Isocitrate Dehydrogenase; Magnetic Resonance | 2022 |
Seventy-Two-Hour LRRK2 Kinase Activity Inhibition Increases Lysosomal GBA Expression in H4, a Human Neuroglioma Cell Line.
Topics: Cell Line; Cell Line, Tumor; Enzyme Inhibitors; Glioma; Glucosylceramidase; Humans; Inositol; Leucin | 2022 |
Myo-inositol concentration in MR spectroscopy for differentiating high grade glioma from primary central nervous system lymphoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Brain Neoplasms; Glioma; Humans; Imag | 2018 |
[Contribution of magnetic resonance spectrometry to the diagnosis of intracranial tumors].
Topics: Aspartic Acid; Biomarkers; Brain Abscess; Brain Neoplasms; Choline; Computer Graphics; Creatine; Dia | 2002 |
A chemometric approach for brain tumor classification using magnetic resonance imaging and spectroscopy.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Cerebrospinal Fluid; Choline; Creatine; Disc | 2003 |
Proton magnetic resonance spectroscopy of normal human brain and glioma: a quantitative in vivo study.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Glioma; Glycine; Humans; Inositol; Magnetic | 2005 |
3T 1H-MR spectroscopy in grading of cerebral gliomas: comparison of short and intermediate echo time sequences.
Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Echo-Planar Imaging; Female; Glioma; | 2006 |
Myo-inositol: a marker of reactive astrogliosis in glial tumors?
Topics: Adolescent; Adult; Biomarkers; Brain Neoplasms; Female; Glioma; Humans; Image Interpretation, Comput | 2008 |
Dysembryoplastic neuroepithelial tumors: proton MR spectroscopy, diffusion and perfusion characteristics.
Topics: Adolescent; Adult; Blood Flow Velocity; Choline; Creatine; Diagnosis, Differential; Diffusion Magnet | 2007 |
Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Cycle; Cell Line, Tumor; Cell Survival; Colony-For | 2007 |
Monovoxel 1H magnetic resonance spectroscopy in the progression of gliomas.
Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Disease Progression; Female; Glioma; | 2007 |
Comparison of lipids and lipid metabolism in a human glioma cell line, its clone, and oligodendroglia.
Topics: Acetates; Acetic Acid; Cell Line; Choline; Chromatography, Thin Layer; Clone Cells; Glioma; Glycolip | 1983 |
In vivo proton MR spectroscopy of human gliomas: definition of metabolic coordinates for multi-dimensional classification.
Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Cluster Analysis; Creatine; Discriminan | 1995 |
Ketoconazole blocks organic osmolyte efflux independently of its effect on arachidonic acid conversion.
Topics: Animals; Anions; Arachidonic Acid; Brain Neoplasms; Chromatography, High Pressure Liquid; Eicosanoid | 1994 |
Proton MR spectroscopy of experimental brain tumors in vivo.
Topics: Animals; Aspartic Acid; Blood Glucose; Brain Edema; Brain Neoplasms; Caudate Nucleus; Cell Line; Cho | 1994 |
Volume-sensitive anion channels mediate swelling-activated inositol and taurine efflux.
Topics: Animals; Biological Transport; Cell Line; Chloride Channels; Chlorides; Fatty Acids, Nonesterified; | 1993 |
Elevated phosphatidyl-CMP is not the source of diacylglycerol accumulation induced by lithium in NG108-15 cells.
Topics: Animals; Bradykinin; Cytidine Monophosphate; Diglycerides; Glioma; Hybrid Cells; Inositol; Lithium; | 1993 |
Altered phospholipid metabolism in sodium butyrate-induced differentiation of C6 glioma cells.
Topics: Acylation; Animals; Arachidonic Acid; Butyrates; Butyric Acid; Calcium; Chloroform; Glioma; Glutamat | 1997 |
Multinuclear NMR spectroscopy studies on NH4Cl-induced metabolic alterations and detoxification processes in primary astrocytes and glioma cells.
Topics: Amino Acids; Ammonium Chloride; Animals; Astrocytes; Energy Metabolism; Enzyme Inhibitors; Glioma; G | 1998 |
Quantitative proton magnetic resonance spectroscopy of focal brain lesions.
Topics: Adolescent; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Abscess; Brain Diseases; Brain Neoplasms; | 2000 |
Alterations in Ca2+ signaling, and c-fos and nur77 expression are associated with sodium butyrate-induced differentiation of C6 glioma cell.
Topics: Adenosine Triphosphate; Animals; Butyrates; Calcium; Calcium Signaling; Cell Differentiation; Chelat | 2000 |
Potentiation by Ca2+ ionophores and inhibition by extracellular KCl of endothelin-induced phosphoinositide turnover in C6 glioma cells.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcimycin; Calcium; Dose-Response Relations | 1992 |
Endothelin-induced activation of phosphoinositide turnover, calcium mobilization, and transmitter release in cultured neurons and neurally related cell types.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Endothelins; Glioma; Inositol; Neurons | 1991 |
Upregulation of inositol transport mediates inositol accumulation in hyperosmolar brain cells.
Topics: Animals; Biological Transport; Brain; Cell Line; Cell Membrane; Glioma; Inositol; Kinetics; Magnetic | 1991 |
Effect of angiotensin II and III on inositol polyphosphate production in differentiated NG108-15 hybrid cells.
Topics: Angiotensin II; Angiotensin III; Animals; Cell Differentiation; Cell Line; Glioma; Hybrid Cells; Ino | 1990 |
Differences in the metabolism of inositol and phosphoinositides by cultured cells of neuronal and glial origin.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Glioma; Hybrid Cells; Inositol; Neuroblastoma; Neuroglia; | 1989 |
Effects of bradykinin, GTP gamma S, R59022 and N-ethylmaleimide on inositol phosphate production in NG108-15 cells.
Topics: Animals; Bradykinin; Cell Line; Drug Interactions; Ethylmaleimide; Glioma; Guanosine 5'-O-(3-Thiotri | 1989 |
Noninvasive differentiation of tumors with use of localized H-1 MR spectroscopy in vivo: initial experience in patients with cerebral tumors.
Topics: Adult; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Cysts; | 1989 |
Bradykinin stimulation of inositol phosphate and calcium responses in insensitive to pertussis toxin in NG115-401L neuronal cells.
Topics: Adenosine Diphosphate Ribose; Alprostadil; Animals; Bradykinin; Cell Line; Cyclic AMP; Glioma; Inosi | 1987 |
Modulation of neuronal signal transduction systems by extracellular ATP.
Topics: Adenosine Triphosphate; Aequorin; Alprostadil; Aminoquinolines; Calcium; Cyclic AMP; Cyclic GMP; Flu | 1988 |
Chlorpromazine induces accumulation of inositol phosphates in C6 glioma cells.
Topics: Animals; Cell Line; Chlorpromazine; Desipramine; Glioma; Inositol; Inositol Phosphates; Lysophosphol | 1986 |
Stimulation of phosphoinositide hydrolysis by serotonin in C6 glioma cells.
Topics: Animals; Cell Line; Glioma; Hydrolysis; Inositol; Inositol Phosphates; Ketanserin; Lithium; Phosphat | 1987 |
Phosphatidylcholine biosynthesis in the neuroblastoma-glioma hybrid cell line NG108-15: stimulation by phorbol esters.
Topics: Animals; Cell Line; Choline; Ethanolamine; Ethanolamines; Glioma; Inositol; Neuroblastoma; Phorbol E | 1986 |