Page last updated: 2024-10-19

inositol and Glioma

inositol has been researched along with Glioma in 36 studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"We have examined the effects of phorbol esters on phosphatidylcholine (PtdCho) metabolism in the neuroblastoma-glioma hybrid cell line NG108-15."7.67Phosphatidylcholine biosynthesis in the neuroblastoma-glioma hybrid cell line NG108-15: stimulation by phorbol esters. ( Blusztajn, JK; Freese, A; Liscovitch, M; Wurtman, RJ, 1986)
" There are a number of metabolites that can be identified by standard brain proton MRS but only a few of them has a clinical significance in diagnosis of gliomas including N-acetylaspartate, choline, creatine, myo-inositol, lactate, and lipids."4.89Potential of MR spectroscopy for assessment of glioma grading. ( Bulik, M; Jancalek, R; Mechl, M; Skoch, A; Vanicek, J, 2013)
" MRS of normal brain parenchyma displays 4 main metabolites: N-acetyl aspartate (neuronal marker), creatine (cellular density marker), choline (membrane activity marker) and myoinositol (glial marker); pathological processes lead to variations of the level of these metabolites and/or the appearance of abnormal metabolites (lactate), following different patterns according to pathological process involved: glioma, meningioma, metastasis, bacterial or toxoplasmic abscess, radionecrosis."3.71[Contribution of magnetic resonance spectrometry to the diagnosis of intracranial tumors]. ( Confort-Gouny, S; Cozzone, PJ; Dufour, H; Galanaud, D; Le Fur, Y; Nicoli, F; Peragut, JC; Ranjeva, JP; Roche, P; Viout, P, 2002)
" In the present study, butyrate treatment caused decreases in thymidine incorporation in the early passages (45-60) of C6 glioma cells."3.70Alterations in Ca2+ signaling, and c-fos and nur77 expression are associated with sodium butyrate-induced differentiation of C6 glioma cell. ( Jang, TH; Sun, SH, 2000)
"Ketoconazole, cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate, and gossypol are reported inhibitors of the lipoxygenase (LO) and cytochrome P-450 enzyme systems and are potent blockers of swelling-activated efflux of organic osmolytes and volume-sensitive anion channels in C6 glioma cells."3.69Ketoconazole blocks organic osmolyte efflux independently of its effect on arachidonic acid conversion. ( Jackson, P; McManus, M; Serhan, C; Strange, K, 1994)
"C6 glioma cells accumulate the organic osmolyte inositol in response to chronic hypertonic stress."3.68Volume-sensitive anion channels mediate swelling-activated inositol and taurine efflux. ( Jackson, PS; Strange, K, 1993)
"Previous studies have shown that in the neuroblastoma x glioma hybrid cell line NG108-15 lithium is able to induce an increase in diacylglycerol levels."3.68Elevated phosphatidyl-CMP is not the source of diacylglycerol accumulation induced by lithium in NG108-15 cells. ( Brami, BA; Hauser, G; Leli, U, 1993)
"Endothelin (ET)-related peptides robustly stimulated [3H]-inositol phosphate (IP) formation in cultured cerebellar granule cells, astrocytes, and C6 glioma cells."3.68Endothelin-induced activation of phosphoinositide turnover, calcium mobilization, and transmitter release in cultured neurons and neurally related cell types. ( Chuang, DM; Lee, CY; Lin, WW, 1991)
"Phosphoinositide and inositol metabolism was compared in glioma (C6), neuroblastoma (N1E-115) and neuroblastoma X glioma hybrid (NG 108-15) cells."3.67Differences in the metabolism of inositol and phosphoinositides by cultured cells of neuronal and glial origin. ( Byers, DM; Cook, HW; Glanville, NT; Palmer, FB; Spence, MW, 1989)
"Accumulation of inositol phosphates in NG108-15 neuroblastoma x glioma hybrid cells, pre-labeled for 24h to equilibrium, was stimulated by bradykinin, guanosine 5'-O-(3-thiotriphosphate) and the diacylglycerol kinase inhibitor R59022."3.67Effects of bradykinin, GTP gamma S, R59022 and N-ethylmaleimide on inositol phosphate production in NG108-15 cells. ( Chiang, CF; Hauser, G, 1989)
"5-Hydroxytryptamine (serotonin or 5-HT) stimulated the incorporation of 32Pi into phosphatidylinositol (PI) but not into polyphosphoinositides in C6 glioma cells with an EC50 of 1."3.67Stimulation of phosphoinositide hydrolysis by serotonin in C6 glioma cells. ( Ananth, US; Hauser, G; Leli, U, 1987)
"We have examined the effects of phorbol esters on phosphatidylcholine (PtdCho) metabolism in the neuroblastoma-glioma hybrid cell line NG108-15."3.67Phosphatidylcholine biosynthesis in the neuroblastoma-glioma hybrid cell line NG108-15: stimulation by phorbol esters. ( Blusztajn, JK; Freese, A; Liscovitch, M; Wurtman, RJ, 1986)
"Most of the brain tumors were characterized by strongly reduced total N-acetylaspartyl compounds and marked increases of myo-inositol and choline-containing compounds, consistent with a lack of neuroaxonal tissue and a proliferation of glial cells."1.31Quantitative proton magnetic resonance spectroscopy of focal brain lesions. ( Dechent, P; Frahm, J; Hanefeld, F; Herms, J; Markakis, E; Maxton, C; Wilken, B, 2000)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19909 (25.00)18.7374
1990's11 (30.56)18.2507
2000's11 (30.56)29.6817
2010's3 (8.33)24.3611
2020's2 (5.56)2.80

Authors

AuthorsStudies
Autry, AW1
Lafontaine, M1
Jalbert, L1
Phillips, E1
Phillips, JJ1
Villanueva-Meyer, J1
Berger, MS1
Chang, SM1
Li, Y1
Ruz, C1
Alcantud, JL1
Vives, F1
Arrebola, F1
Hardy, J1
Lewis, PA1
Manzoni, C1
Duran, R1
Nagashima, H1
Sasayama, T1
Tanaka, K1
Kyotani, K1
Sato, N1
Maeyama, M1
Kohta, M1
Sakata, J1
Yamamoto, Y1
Hosoda, K1
Itoh, T1
Sasaki, R1
Kohmura, E1
Pascual-Castroviejo, I1
Pascual-Pascual, SI1
Velazquez-Fragua, R1
Viaño, J1
Bulik, M1
Jancalek, R1
Vanicek, J1
Skoch, A1
Mechl, M1
Galanaud, D1
Nicoli, F1
Le Fur, Y1
Roche, P1
Confort-Gouny, S1
Dufour, H1
Ranjeva, JP1
Peragut, JC1
Viout, P1
Cozzone, PJ1
Simonetti, AW1
Melssen, WJ1
van der Graaf, M1
Postma, GJ1
Heerschap, A1
Buydens, LM1
McKnight, TR1
Tong, ZY1
Toshiaki, Y1
Wang, YJ1
Kim, JH1
Chang, KH1
Na, DG1
Song, IC1
Kwon, BJ1
Han, MH1
Kim, K1
Hattingen, E1
Raab, P1
Franz, K1
Zanella, FE1
Lanfermann, H1
Pilatus, U1
Bulakbasi, N1
Kocaoglu, M1
Sanal, TH1
Tayfun, C1
Fujiwara, K1
Iwado, E1
Mills, GB1
Sawaya, R1
Kondo, S1
Kondo, Y1
Alimenti, A1
Delavelle, J1
Lazeyras, F1
Yilmaz, H1
Dietrich, PY1
de Tribolet, N1
Lövblad, KO1
Poduslo, SE1
Miller, K1
Jang, Y1
Hagberg, G1
Burlina, AP1
Mader, I1
Roser, W1
Radue, EW1
Seelig, J1
McManus, M1
Serhan, C1
Jackson, P1
Strange, K3
Gyngell, ML2
Els, T1
Hoehn-Berlage, M1
Hossmann, KA1
Jackson, PS1
Brami, BA1
Leli, U3
Hauser, G4
Sun, SH2
Ou, HC1
Jang, TH2
Lin, LB1
Huang, HM1
Zwingmann, C1
Brand, A1
Richter-Landsberg, C1
Leibfritz, D1
Wilken, B1
Dechent, P1
Herms, J1
Maxton, C1
Markakis, E1
Hanefeld, F1
Frahm, J2
Lin, WW2
Chuang, DM2
Lee, CY1
Morrison, R1
Heilig, CW1
DiPietro, S1
Gullans, SR1
Carrithers, MD1
Raman, VK1
Masuda, S1
Weyhenmeyer, JA1
Glanville, NT1
Byers, DM1
Cook, HW1
Spence, MW1
Palmer, FB1
Chiang, CF1
Bruhn, H1
Merboldt, KD1
Hänicke, W1
Sauter, R1
Hamburger, C1
Jackson, TR1
Patterson, SI1
Wong, YH1
Hanley, MR1
Ehrlich, YH1
Snider, RM1
Kornecki, E1
Garfield, MG1
Lenox, RH1
Ananth, US1
Liscovitch, M1
Freese, A1
Blusztajn, JK1
Wurtman, RJ1

Reviews

3 reviews available for inositol and Glioma

ArticleYear
[Corpus callosum tumor as the presenting symptom of neurofibromatosis type 1 in a patient and literature review].
    Revista de neurologia, 2012, Nov-01, Volume: 55, Issue:9

    Topics: Brain Neoplasms; Brain Stem Neoplasms; Cerebellar Neoplasms; Child, Preschool; Choline; Corpus Callo

2012
Potential of MR spectroscopy for assessment of glioma grading.
    Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:2

    Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Inositol; Lactates; Lipid Metabol

2013
Proton magnetic resonance spectroscopic evaluation of brain tumor metabolism.
    Seminars in oncology, 2004, Volume: 31, Issue:5

    Topics: Alanine; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glutamic Acid; Glutamine; Humans

2004

Other Studies

33 other studies available for inositol and Glioma

ArticleYear
Spectroscopic imaging of D-2-hydroxyglutarate and other metabolites in pre-surgical patients with IDH-mutant lower-grade gliomas.
    Journal of neuro-oncology, 2022, Volume: 159, Issue:1

    Topics: Brain Neoplasms; Glioma; Glutarates; Humans; Inositol; Isocitrate Dehydrogenase; Magnetic Resonance

2022
Seventy-Two-Hour LRRK2 Kinase Activity Inhibition Increases Lysosomal GBA Expression in H4, a Human Neuroglioma Cell Line.
    International journal of molecular sciences, 2022, Jun-22, Volume: 23, Issue:13

    Topics: Cell Line; Cell Line, Tumor; Enzyme Inhibitors; Glioma; Glucosylceramidase; Humans; Inositol; Leucin

2022
Myo-inositol concentration in MR spectroscopy for differentiating high grade glioma from primary central nervous system lymphoma.
    Journal of neuro-oncology, 2018, Volume: 136, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Brain Neoplasms; Glioma; Humans; Imag

2018
[Contribution of magnetic resonance spectrometry to the diagnosis of intracranial tumors].
    Annales de medecine interne, 2002, Volume: 153, Issue:8

    Topics: Aspartic Acid; Biomarkers; Brain Abscess; Brain Neoplasms; Choline; Computer Graphics; Creatine; Dia

2002
A chemometric approach for brain tumor classification using magnetic resonance imaging and spectroscopy.
    Analytical chemistry, 2003, Oct-15, Volume: 75, Issue:20

    Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Cerebrospinal Fluid; Choline; Creatine; Disc

2003
Proton magnetic resonance spectroscopy of normal human brain and glioma: a quantitative in vivo study.
    Chinese medical journal, 2005, Aug-05, Volume: 118, Issue:15

    Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Glioma; Glycine; Humans; Inositol; Magnetic

2005
3T 1H-MR spectroscopy in grading of cerebral gliomas: comparison of short and intermediate echo time sequences.
    AJNR. American journal of neuroradiology, 2006, Volume: 27, Issue:7

    Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Echo-Planar Imaging; Female; Glioma;

2006
Myo-inositol: a marker of reactive astrogliosis in glial tumors?
    NMR in biomedicine, 2008, Volume: 21, Issue:3

    Topics: Adolescent; Adult; Biomarkers; Brain Neoplasms; Female; Glioma; Humans; Image Interpretation, Comput

2008
Dysembryoplastic neuroepithelial tumors: proton MR spectroscopy, diffusion and perfusion characteristics.
    Neuroradiology, 2007, Volume: 49, Issue:10

    Topics: Adolescent; Adult; Blood Flow Velocity; Choline; Creatine; Diagnosis, Differential; Diffusion Magnet

2007
Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy.
    International journal of oncology, 2007, Volume: 31, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Cycle; Cell Line, Tumor; Cell Survival; Colony-For

2007
Monovoxel 1H magnetic resonance spectroscopy in the progression of gliomas.
    European neurology, 2007, Volume: 58, Issue:4

    Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Disease Progression; Female; Glioma;

2007
Comparison of lipids and lipid metabolism in a human glioma cell line, its clone, and oligodendroglia.
    Cancer research, 1983, Volume: 43, Issue:3

    Topics: Acetates; Acetic Acid; Cell Line; Choline; Chromatography, Thin Layer; Clone Cells; Glioma; Glycolip

1983
In vivo proton MR spectroscopy of human gliomas: definition of metabolic coordinates for multi-dimensional classification.
    Magnetic resonance in medicine, 1995, Volume: 34, Issue:2

    Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Cluster Analysis; Creatine; Discriminan

1995
Ketoconazole blocks organic osmolyte efflux independently of its effect on arachidonic acid conversion.
    The American journal of physiology, 1994, Volume: 267, Issue:1 Pt 1

    Topics: Animals; Anions; Arachidonic Acid; Brain Neoplasms; Chromatography, High Pressure Liquid; Eicosanoid

1994
Proton MR spectroscopy of experimental brain tumors in vivo.
    Acta neurochirurgica. Supplementum, 1994, Volume: 60

    Topics: Animals; Aspartic Acid; Blood Glucose; Brain Edema; Brain Neoplasms; Caudate Nucleus; Cell Line; Cho

1994
Volume-sensitive anion channels mediate swelling-activated inositol and taurine efflux.
    The American journal of physiology, 1993, Volume: 265, Issue:6 Pt 1

    Topics: Animals; Biological Transport; Cell Line; Chloride Channels; Chlorides; Fatty Acids, Nonesterified;

1993
Elevated phosphatidyl-CMP is not the source of diacylglycerol accumulation induced by lithium in NG108-15 cells.
    Journal of neurochemistry, 1993, Volume: 60, Issue:3

    Topics: Animals; Bradykinin; Cytidine Monophosphate; Diglycerides; Glioma; Hybrid Cells; Inositol; Lithium;

1993
Altered phospholipid metabolism in sodium butyrate-induced differentiation of C6 glioma cells.
    Lipids, 1997, Volume: 32, Issue:3

    Topics: Acylation; Animals; Arachidonic Acid; Butyrates; Butyric Acid; Calcium; Chloroform; Glioma; Glutamat

1997
Multinuclear NMR spectroscopy studies on NH4Cl-induced metabolic alterations and detoxification processes in primary astrocytes and glioma cells.
    Developmental neuroscience, 1998, Volume: 20, Issue:4-5

    Topics: Amino Acids; Ammonium Chloride; Animals; Astrocytes; Energy Metabolism; Enzyme Inhibitors; Glioma; G

1998
Quantitative proton magnetic resonance spectroscopy of focal brain lesions.
    Pediatric neurology, 2000, Volume: 23, Issue:1

    Topics: Adolescent; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Abscess; Brain Diseases; Brain Neoplasms;

2000
Alterations in Ca2+ signaling, and c-fos and nur77 expression are associated with sodium butyrate-induced differentiation of C6 glioma cell.
    The Chinese journal of physiology, 2000, Dec-31, Volume: 43, Issue:4

    Topics: Adenosine Triphosphate; Animals; Butyrates; Calcium; Calcium Signaling; Cell Differentiation; Chelat

2000
Potentiation by Ca2+ ionophores and inhibition by extracellular KCl of endothelin-induced phosphoinositide turnover in C6 glioma cells.
    Neurochemistry international, 1992, Volume: 21, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcimycin; Calcium; Dose-Response Relations

1992
Endothelin-induced activation of phosphoinositide turnover, calcium mobilization, and transmitter release in cultured neurons and neurally related cell types.
    Journal of cardiovascular pharmacology, 1991, Volume: 17 Suppl 7

    Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Endothelins; Glioma; Inositol; Neurons

1991
Upregulation of inositol transport mediates inositol accumulation in hyperosmolar brain cells.
    The American journal of physiology, 1991, Volume: 260, Issue:4 Pt 1

    Topics: Animals; Biological Transport; Brain; Cell Line; Cell Membrane; Glioma; Inositol; Kinetics; Magnetic

1991
Effect of angiotensin II and III on inositol polyphosphate production in differentiated NG108-15 hybrid cells.
    Biochemical and biophysical research communications, 1990, Mar-30, Volume: 167, Issue:3

    Topics: Angiotensin II; Angiotensin III; Animals; Cell Differentiation; Cell Line; Glioma; Hybrid Cells; Ino

1990
Differences in the metabolism of inositol and phosphoinositides by cultured cells of neuronal and glial origin.
    Biochimica et biophysica acta, 1989, Aug-08, Volume: 1004, Issue:2

    Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Glioma; Hybrid Cells; Inositol; Neuroblastoma; Neuroglia;

1989
Effects of bradykinin, GTP gamma S, R59022 and N-ethylmaleimide on inositol phosphate production in NG108-15 cells.
    Biochemical and biophysical research communications, 1989, Nov-30, Volume: 165, Issue:1

    Topics: Animals; Bradykinin; Cell Line; Drug Interactions; Ethylmaleimide; Glioma; Guanosine 5'-O-(3-Thiotri

1989
Noninvasive differentiation of tumors with use of localized H-1 MR spectroscopy in vivo: initial experience in patients with cerebral tumors.
    Radiology, 1989, Volume: 172, Issue:2

    Topics: Adult; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Cysts;

1989
Bradykinin stimulation of inositol phosphate and calcium responses in insensitive to pertussis toxin in NG115-401L neuronal cells.
    Biochemical and biophysical research communications, 1987, Oct-14, Volume: 148, Issue:1

    Topics: Adenosine Diphosphate Ribose; Alprostadil; Animals; Bradykinin; Cell Line; Cyclic AMP; Glioma; Inosi

1987
Modulation of neuronal signal transduction systems by extracellular ATP.
    Journal of neurochemistry, 1988, Volume: 50, Issue:1

    Topics: Adenosine Triphosphate; Aequorin; Alprostadil; Aminoquinolines; Calcium; Cyclic AMP; Cyclic GMP; Flu

1988
Chlorpromazine induces accumulation of inositol phosphates in C6 glioma cells.
    Biochemical and biophysical research communications, 1986, Mar-13, Volume: 135, Issue:2

    Topics: Animals; Cell Line; Chlorpromazine; Desipramine; Glioma; Inositol; Inositol Phosphates; Lysophosphol

1986
Stimulation of phosphoinositide hydrolysis by serotonin in C6 glioma cells.
    Journal of neurochemistry, 1987, Volume: 48, Issue:1

    Topics: Animals; Cell Line; Glioma; Hydrolysis; Inositol; Inositol Phosphates; Ketanserin; Lithium; Phosphat

1987
Phosphatidylcholine biosynthesis in the neuroblastoma-glioma hybrid cell line NG108-15: stimulation by phorbol esters.
    Journal of neurochemistry, 1986, Volume: 47, Issue:6

    Topics: Animals; Cell Line; Choline; Ethanolamine; Ethanolamines; Glioma; Inositol; Neuroblastoma; Phorbol E

1986