inositol has been researched along with Glial Cell Tumors in 36 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have examined the effects of phorbol esters on phosphatidylcholine (PtdCho) metabolism in the neuroblastoma-glioma hybrid cell line NG108-15." | 7.67 | Phosphatidylcholine biosynthesis in the neuroblastoma-glioma hybrid cell line NG108-15: stimulation by phorbol esters. ( Blusztajn, JK; Freese, A; Liscovitch, M; Wurtman, RJ, 1986) |
| " There are a number of metabolites that can be identified by standard brain proton MRS but only a few of them has a clinical significance in diagnosis of gliomas including N-acetylaspartate, choline, creatine, myo-inositol, lactate, and lipids." | 4.89 | Potential of MR spectroscopy for assessment of glioma grading. ( Bulik, M; Jancalek, R; Mechl, M; Skoch, A; Vanicek, J, 2013) |
| " MRS of normal brain parenchyma displays 4 main metabolites: N-acetyl aspartate (neuronal marker), creatine (cellular density marker), choline (membrane activity marker) and myoinositol (glial marker); pathological processes lead to variations of the level of these metabolites and/or the appearance of abnormal metabolites (lactate), following different patterns according to pathological process involved: glioma, meningioma, metastasis, bacterial or toxoplasmic abscess, radionecrosis." | 3.71 | [Contribution of magnetic resonance spectrometry to the diagnosis of intracranial tumors]. ( Confort-Gouny, S; Cozzone, PJ; Dufour, H; Galanaud, D; Le Fur, Y; Nicoli, F; Peragut, JC; Ranjeva, JP; Roche, P; Viout, P, 2002) |
| " In the present study, butyrate treatment caused decreases in thymidine incorporation in the early passages (45-60) of C6 glioma cells." | 3.70 | Alterations in Ca2+ signaling, and c-fos and nur77 expression are associated with sodium butyrate-induced differentiation of C6 glioma cell. ( Jang, TH; Sun, SH, 2000) |
| "Ketoconazole, cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate, and gossypol are reported inhibitors of the lipoxygenase (LO) and cytochrome P-450 enzyme systems and are potent blockers of swelling-activated efflux of organic osmolytes and volume-sensitive anion channels in C6 glioma cells." | 3.69 | Ketoconazole blocks organic osmolyte efflux independently of its effect on arachidonic acid conversion. ( Jackson, P; McManus, M; Serhan, C; Strange, K, 1994) |
| "C6 glioma cells accumulate the organic osmolyte inositol in response to chronic hypertonic stress." | 3.68 | Volume-sensitive anion channels mediate swelling-activated inositol and taurine efflux. ( Jackson, PS; Strange, K, 1993) |
| "Previous studies have shown that in the neuroblastoma x glioma hybrid cell line NG108-15 lithium is able to induce an increase in diacylglycerol levels." | 3.68 | Elevated phosphatidyl-CMP is not the source of diacylglycerol accumulation induced by lithium in NG108-15 cells. ( Brami, BA; Hauser, G; Leli, U, 1993) |
| "Endothelin (ET)-related peptides robustly stimulated [3H]-inositol phosphate (IP) formation in cultured cerebellar granule cells, astrocytes, and C6 glioma cells." | 3.68 | Endothelin-induced activation of phosphoinositide turnover, calcium mobilization, and transmitter release in cultured neurons and neurally related cell types. ( Chuang, DM; Lee, CY; Lin, WW, 1991) |
| "Phosphoinositide and inositol metabolism was compared in glioma (C6), neuroblastoma (N1E-115) and neuroblastoma X glioma hybrid (NG 108-15) cells." | 3.67 | Differences in the metabolism of inositol and phosphoinositides by cultured cells of neuronal and glial origin. ( Byers, DM; Cook, HW; Glanville, NT; Palmer, FB; Spence, MW, 1989) |
| "Accumulation of inositol phosphates in NG108-15 neuroblastoma x glioma hybrid cells, pre-labeled for 24h to equilibrium, was stimulated by bradykinin, guanosine 5'-O-(3-thiotriphosphate) and the diacylglycerol kinase inhibitor R59022." | 3.67 | Effects of bradykinin, GTP gamma S, R59022 and N-ethylmaleimide on inositol phosphate production in NG108-15 cells. ( Chiang, CF; Hauser, G, 1989) |
| "5-Hydroxytryptamine (serotonin or 5-HT) stimulated the incorporation of 32Pi into phosphatidylinositol (PI) but not into polyphosphoinositides in C6 glioma cells with an EC50 of 1." | 3.67 | Stimulation of phosphoinositide hydrolysis by serotonin in C6 glioma cells. ( Ananth, US; Hauser, G; Leli, U, 1987) |
| "We have examined the effects of phorbol esters on phosphatidylcholine (PtdCho) metabolism in the neuroblastoma-glioma hybrid cell line NG108-15." | 3.67 | Phosphatidylcholine biosynthesis in the neuroblastoma-glioma hybrid cell line NG108-15: stimulation by phorbol esters. ( Blusztajn, JK; Freese, A; Liscovitch, M; Wurtman, RJ, 1986) |
| "Most of the brain tumors were characterized by strongly reduced total N-acetylaspartyl compounds and marked increases of myo-inositol and choline-containing compounds, consistent with a lack of neuroaxonal tissue and a proliferation of glial cells." | 1.31 | Quantitative proton magnetic resonance spectroscopy of focal brain lesions. ( Dechent, P; Frahm, J; Hanefeld, F; Herms, J; Markakis, E; Maxton, C; Wilken, B, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (25.00) | 18.7374 |
| 1990's | 11 (30.56) | 18.2507 |
| 2000's | 11 (30.56) | 29.6817 |
| 2010's | 3 (8.33) | 24.3611 |
| 2020's | 2 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Autry, AW | 1 |
| Lafontaine, M | 1 |
| Jalbert, L | 1 |
| Phillips, E | 1 |
| Phillips, JJ | 1 |
| Villanueva-Meyer, J | 1 |
| Berger, MS | 1 |
| Chang, SM | 1 |
| Li, Y | 1 |
| Ruz, C | 1 |
| Alcantud, JL | 1 |
| Vives, F | 1 |
| Arrebola, F | 1 |
| Hardy, J | 1 |
| Lewis, PA | 1 |
| Manzoni, C | 1 |
| Duran, R | 1 |
| Nagashima, H | 1 |
| Sasayama, T | 1 |
| Tanaka, K | 1 |
| Kyotani, K | 1 |
| Sato, N | 1 |
| Maeyama, M | 1 |
| Kohta, M | 1 |
| Sakata, J | 1 |
| Yamamoto, Y | 1 |
| Hosoda, K | 1 |
| Itoh, T | 1 |
| Sasaki, R | 1 |
| Kohmura, E | 1 |
| Pascual-Castroviejo, I | 1 |
| Pascual-Pascual, SI | 1 |
| Velazquez-Fragua, R | 1 |
| Viaño, J | 1 |
| Bulik, M | 1 |
| Jancalek, R | 1 |
| Vanicek, J | 1 |
| Skoch, A | 1 |
| Mechl, M | 1 |
| Galanaud, D | 1 |
| Nicoli, F | 1 |
| Le Fur, Y | 1 |
| Roche, P | 1 |
| Confort-Gouny, S | 1 |
| Dufour, H | 1 |
| Ranjeva, JP | 1 |
| Peragut, JC | 1 |
| Viout, P | 1 |
| Cozzone, PJ | 1 |
| Simonetti, AW | 1 |
| Melssen, WJ | 1 |
| van der Graaf, M | 1 |
| Postma, GJ | 1 |
| Heerschap, A | 1 |
| Buydens, LM | 1 |
| McKnight, TR | 1 |
| Tong, ZY | 1 |
| Toshiaki, Y | 1 |
| Wang, YJ | 1 |
| Kim, JH | 1 |
| Chang, KH | 1 |
| Na, DG | 1 |
| Song, IC | 1 |
| Kwon, BJ | 1 |
| Han, MH | 1 |
| Kim, K | 1 |
| Hattingen, E | 1 |
| Raab, P | 1 |
| Franz, K | 1 |
| Zanella, FE | 1 |
| Lanfermann, H | 1 |
| Pilatus, U | 1 |
| Bulakbasi, N | 1 |
| Kocaoglu, M | 1 |
| Sanal, TH | 1 |
| Tayfun, C | 1 |
| Fujiwara, K | 1 |
| Iwado, E | 1 |
| Mills, GB | 1 |
| Sawaya, R | 1 |
| Kondo, S | 1 |
| Kondo, Y | 1 |
| Alimenti, A | 1 |
| Delavelle, J | 1 |
| Lazeyras, F | 1 |
| Yilmaz, H | 1 |
| Dietrich, PY | 1 |
| de Tribolet, N | 1 |
| Lövblad, KO | 1 |
| Poduslo, SE | 1 |
| Miller, K | 1 |
| Jang, Y | 1 |
| Hagberg, G | 1 |
| Burlina, AP | 1 |
| Mader, I | 1 |
| Roser, W | 1 |
| Radue, EW | 1 |
| Seelig, J | 1 |
| McManus, M | 1 |
| Serhan, C | 1 |
| Jackson, P | 1 |
| Strange, K | 3 |
| Gyngell, ML | 2 |
| Els, T | 1 |
| Hoehn-Berlage, M | 1 |
| Hossmann, KA | 1 |
| Jackson, PS | 1 |
| Brami, BA | 1 |
| Leli, U | 3 |
| Hauser, G | 4 |
| Sun, SH | 2 |
| Ou, HC | 1 |
| Jang, TH | 2 |
| Lin, LB | 1 |
| Huang, HM | 1 |
| Zwingmann, C | 1 |
| Brand, A | 1 |
| Richter-Landsberg, C | 1 |
| Leibfritz, D | 1 |
| Wilken, B | 1 |
| Dechent, P | 1 |
| Herms, J | 1 |
| Maxton, C | 1 |
| Markakis, E | 1 |
| Hanefeld, F | 1 |
| Frahm, J | 2 |
| Lin, WW | 2 |
| Chuang, DM | 2 |
| Lee, CY | 1 |
| Morrison, R | 1 |
| Heilig, CW | 1 |
| DiPietro, S | 1 |
| Gullans, SR | 1 |
| Carrithers, MD | 1 |
| Raman, VK | 1 |
| Masuda, S | 1 |
| Weyhenmeyer, JA | 1 |
| Glanville, NT | 1 |
| Byers, DM | 1 |
| Cook, HW | 1 |
| Spence, MW | 1 |
| Palmer, FB | 1 |
| Chiang, CF | 1 |
| Bruhn, H | 1 |
| Merboldt, KD | 1 |
| Hänicke, W | 1 |
| Sauter, R | 1 |
| Hamburger, C | 1 |
| Jackson, TR | 1 |
| Patterson, SI | 1 |
| Wong, YH | 1 |
| Hanley, MR | 1 |
| Ehrlich, YH | 1 |
| Snider, RM | 1 |
| Kornecki, E | 1 |
| Garfield, MG | 1 |
| Lenox, RH | 1 |
| Ananth, US | 1 |
| Liscovitch, M | 1 |
| Freese, A | 1 |
| Blusztajn, JK | 1 |
| Wurtman, RJ | 1 |
3 reviews available for inositol and Glial Cell Tumors
| Article | Year |
|---|---|
[Corpus callosum tumor as the presenting symptom of neurofibromatosis type 1 in a patient and literature review].
Topics: Brain Neoplasms; Brain Stem Neoplasms; Cerebellar Neoplasms; Child, Preschool; Choline; Corpus Callo | 2012 |
Potential of MR spectroscopy for assessment of glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Inositol; Lactates; Lipid Metabol | 2013 |
Proton magnetic resonance spectroscopic evaluation of brain tumor metabolism.
Topics: Alanine; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glutamic Acid; Glutamine; Humans | 2004 |
33 other studies available for inositol and Glial Cell Tumors
| Article | Year |
|---|---|
Spectroscopic imaging of D-2-hydroxyglutarate and other metabolites in pre-surgical patients with IDH-mutant lower-grade gliomas.
Topics: Brain Neoplasms; Glioma; Glutarates; Humans; Inositol; Isocitrate Dehydrogenase; Magnetic Resonance | 2022 |
Seventy-Two-Hour LRRK2 Kinase Activity Inhibition Increases Lysosomal GBA Expression in H4, a Human Neuroglioma Cell Line.
Topics: Cell Line; Cell Line, Tumor; Enzyme Inhibitors; Glioma; Glucosylceramidase; Humans; Inositol; Leucin | 2022 |
Myo-inositol concentration in MR spectroscopy for differentiating high grade glioma from primary central nervous system lymphoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Brain Neoplasms; Glioma; Humans; Imag | 2018 |
[Contribution of magnetic resonance spectrometry to the diagnosis of intracranial tumors].
Topics: Aspartic Acid; Biomarkers; Brain Abscess; Brain Neoplasms; Choline; Computer Graphics; Creatine; Dia | 2002 |
A chemometric approach for brain tumor classification using magnetic resonance imaging and spectroscopy.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Cerebrospinal Fluid; Choline; Creatine; Disc | 2003 |
Proton magnetic resonance spectroscopy of normal human brain and glioma: a quantitative in vivo study.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Glioma; Glycine; Humans; Inositol; Magnetic | 2005 |
3T 1H-MR spectroscopy in grading of cerebral gliomas: comparison of short and intermediate echo time sequences.
Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Echo-Planar Imaging; Female; Glioma; | 2006 |
Myo-inositol: a marker of reactive astrogliosis in glial tumors?
Topics: Adolescent; Adult; Biomarkers; Brain Neoplasms; Female; Glioma; Humans; Image Interpretation, Comput | 2008 |
Dysembryoplastic neuroepithelial tumors: proton MR spectroscopy, diffusion and perfusion characteristics.
Topics: Adolescent; Adult; Blood Flow Velocity; Choline; Creatine; Diagnosis, Differential; Diffusion Magnet | 2007 |
Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Cycle; Cell Line, Tumor; Cell Survival; Colony-For | 2007 |
Monovoxel 1H magnetic resonance spectroscopy in the progression of gliomas.
Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Disease Progression; Female; Glioma; | 2007 |
Comparison of lipids and lipid metabolism in a human glioma cell line, its clone, and oligodendroglia.
Topics: Acetates; Acetic Acid; Cell Line; Choline; Chromatography, Thin Layer; Clone Cells; Glioma; Glycolip | 1983 |
In vivo proton MR spectroscopy of human gliomas: definition of metabolic coordinates for multi-dimensional classification.
Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Cluster Analysis; Creatine; Discriminan | 1995 |
Ketoconazole blocks organic osmolyte efflux independently of its effect on arachidonic acid conversion.
Topics: Animals; Anions; Arachidonic Acid; Brain Neoplasms; Chromatography, High Pressure Liquid; Eicosanoid | 1994 |
Proton MR spectroscopy of experimental brain tumors in vivo.
Topics: Animals; Aspartic Acid; Blood Glucose; Brain Edema; Brain Neoplasms; Caudate Nucleus; Cell Line; Cho | 1994 |
Volume-sensitive anion channels mediate swelling-activated inositol and taurine efflux.
Topics: Animals; Biological Transport; Cell Line; Chloride Channels; Chlorides; Fatty Acids, Nonesterified; | 1993 |
Elevated phosphatidyl-CMP is not the source of diacylglycerol accumulation induced by lithium in NG108-15 cells.
Topics: Animals; Bradykinin; Cytidine Monophosphate; Diglycerides; Glioma; Hybrid Cells; Inositol; Lithium; | 1993 |
Altered phospholipid metabolism in sodium butyrate-induced differentiation of C6 glioma cells.
Topics: Acylation; Animals; Arachidonic Acid; Butyrates; Butyric Acid; Calcium; Chloroform; Glioma; Glutamat | 1997 |
Multinuclear NMR spectroscopy studies on NH4Cl-induced metabolic alterations and detoxification processes in primary astrocytes and glioma cells.
Topics: Amino Acids; Ammonium Chloride; Animals; Astrocytes; Energy Metabolism; Enzyme Inhibitors; Glioma; G | 1998 |
Quantitative proton magnetic resonance spectroscopy of focal brain lesions.
Topics: Adolescent; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Abscess; Brain Diseases; Brain Neoplasms; | 2000 |
Alterations in Ca2+ signaling, and c-fos and nur77 expression are associated with sodium butyrate-induced differentiation of C6 glioma cell.
Topics: Adenosine Triphosphate; Animals; Butyrates; Calcium; Calcium Signaling; Cell Differentiation; Chelat | 2000 |
Potentiation by Ca2+ ionophores and inhibition by extracellular KCl of endothelin-induced phosphoinositide turnover in C6 glioma cells.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcimycin; Calcium; Dose-Response Relations | 1992 |
Endothelin-induced activation of phosphoinositide turnover, calcium mobilization, and transmitter release in cultured neurons and neurally related cell types.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Endothelins; Glioma; Inositol; Neurons | 1991 |
Upregulation of inositol transport mediates inositol accumulation in hyperosmolar brain cells.
Topics: Animals; Biological Transport; Brain; Cell Line; Cell Membrane; Glioma; Inositol; Kinetics; Magnetic | 1991 |
Effect of angiotensin II and III on inositol polyphosphate production in differentiated NG108-15 hybrid cells.
Topics: Angiotensin II; Angiotensin III; Animals; Cell Differentiation; Cell Line; Glioma; Hybrid Cells; Ino | 1990 |
Differences in the metabolism of inositol and phosphoinositides by cultured cells of neuronal and glial origin.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Glioma; Hybrid Cells; Inositol; Neuroblastoma; Neuroglia; | 1989 |
Effects of bradykinin, GTP gamma S, R59022 and N-ethylmaleimide on inositol phosphate production in NG108-15 cells.
Topics: Animals; Bradykinin; Cell Line; Drug Interactions; Ethylmaleimide; Glioma; Guanosine 5'-O-(3-Thiotri | 1989 |
Noninvasive differentiation of tumors with use of localized H-1 MR spectroscopy in vivo: initial experience in patients with cerebral tumors.
Topics: Adult; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Cysts; | 1989 |
Bradykinin stimulation of inositol phosphate and calcium responses in insensitive to pertussis toxin in NG115-401L neuronal cells.
Topics: Adenosine Diphosphate Ribose; Alprostadil; Animals; Bradykinin; Cell Line; Cyclic AMP; Glioma; Inosi | 1987 |
Modulation of neuronal signal transduction systems by extracellular ATP.
Topics: Adenosine Triphosphate; Aequorin; Alprostadil; Aminoquinolines; Calcium; Cyclic AMP; Cyclic GMP; Flu | 1988 |
Chlorpromazine induces accumulation of inositol phosphates in C6 glioma cells.
Topics: Animals; Cell Line; Chlorpromazine; Desipramine; Glioma; Inositol; Inositol Phosphates; Lysophosphol | 1986 |
Stimulation of phosphoinositide hydrolysis by serotonin in C6 glioma cells.
Topics: Animals; Cell Line; Glioma; Hydrolysis; Inositol; Inositol Phosphates; Ketanserin; Lithium; Phosphat | 1987 |
Phosphatidylcholine biosynthesis in the neuroblastoma-glioma hybrid cell line NG108-15: stimulation by phorbol esters.
Topics: Animals; Cell Line; Choline; Ethanolamine; Ethanolamines; Glioma; Inositol; Neuroblastoma; Phorbol E | 1986 |