inositol has been researched along with Epilepsy in 22 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Inositols have proved effective in many disorders; hence, in the current study, we tested potential antiepileptic properties of scyllo-inositol (SCI)-one of the most common commercially available inositols-in zebrafish larvae with pentylenetetrazol-induced seizures." | 8.31 | Antiepileptic Properties of Scyllo-Inositol on Pentylenetetrazol-Induced Seizures. ( Antonowski, T; Juranek, J; Podlasz, P; Wiśniewski, K; Wojtkiewicz, J, 2023) |
| "The effects of seizures on brain lipid metabolism and some recent studies from our laboratory are described in this chapter." | 6.37 | The accumulation of free arachidonic acid, diacylglycerols, prostaglandins, and lipoxygenase reaction products in the brain during experimental epilepsy. ( Bazan, NG; Birkle, DL; Reddy, TS; Tang, W, 1986) |
| "Epilepsy is one of the most devastating neurological diseases and despite significant efforts there is no cure available." | 5.51 | Long-Term Effects of Myoinositol on Behavioural Seizures and Biochemical Changes Evoked by Kainic Acid Induced Epileptogenesis. ( Gamkrelidze, G; Kandashvili, M; Kokaia, M; Lepsveridze, E; Lortkipanidze, T; Margvelani, G; Solomonia, R; Tsverava, L, 2019) |
| " Inositols have proved effective in many disorders; hence, in the current study, we tested potential antiepileptic properties of scyllo-inositol (SCI)-one of the most common commercially available inositols-in zebrafish larvae with pentylenetetrazol-induced seizures." | 4.31 | Antiepileptic Properties of Scyllo-Inositol on Pentylenetetrazol-Induced Seizures. ( Antonowski, T; Juranek, J; Podlasz, P; Wiśniewski, K; Wojtkiewicz, J, 2023) |
| "Valproic acid (VPA) is the most widely prescribed epilepsy treatment worldwide, but its mechanism of action remains unclear." | 3.78 | The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium. ( Bialer, M; Chang, P; Deranieh, RM; Dham, M; Greenberg, ML; Hoeller, O; Orabi, B; Shimshoni, JA; Walker, MC; Williams, RS; Yagen, B, 2012) |
| "Compared with normal gray matter, hypothalamic hamartomas were hyperintense on T2-weighted images (93%), hypointense on T1-weighted images (74%), and had reduced N-acetylaspartate and increased myoinositol content shown by MR spectroscopy." | 3.72 | MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: analysis of 72 cases. ( Berkovic, SF; Coleman, LT; Freeman, JL; Harvey, AS; Jackson, GD; Kean, MJ; Rosenfeld, JV; Wellard, RM, 2004) |
| "The effects of seizures on brain lipid metabolism and some recent studies from our laboratory are described in this chapter." | 2.37 | The accumulation of free arachidonic acid, diacylglycerols, prostaglandins, and lipoxygenase reaction products in the brain during experimental epilepsy. ( Bazan, NG; Birkle, DL; Reddy, TS; Tang, W, 1986) |
| "Epilepsy is a severe neurological disease characterized by spontaneous recurrent seizures (SRS)." | 1.72 | Myo-Inositol Limits Kainic Acid-Induced Epileptogenesis in Rats. ( Burjanadze, M; Dashniani, M; Gamkrelidze, G; Kandashvili, M; Kokaia, M; Lagani, V; Lepsveridze, E; Lordkipanidze, T; Solomonia, R; Tsverava, L, 2022) |
| "Epilepsy is one of the most widespread neurological diseases characterized by spontaneous recurrent seizures." | 1.51 | Concentration- and time-dependent effects of myo-inositol on evoked epileptic afterdischarge in the hippocampus in vivo. ( Bilanishvili, IG; Gamkrelidze, GN; Kandashvili, M; Kokaia, M; Lordkipanidze, T; Nanobashvili, ZI; Solomonia, RO, 2019) |
| "Epilepsy is one of the most devastating neurological diseases and despite significant efforts there is no cure available." | 1.51 | Long-Term Effects of Myoinositol on Behavioural Seizures and Biochemical Changes Evoked by Kainic Acid Induced Epileptogenesis. ( Gamkrelidze, G; Kandashvili, M; Kokaia, M; Lepsveridze, E; Lortkipanidze, T; Margvelani, G; Solomonia, R; Tsverava, L, 2019) |
| "We present a case of infantile onset Krabbe disease with prolonged survival, initial intracranial optic nerves and optic chiasm hypertrophy, and serial changes on cranial magnetic resonance imaging and magnetic resonance spectroscopy." | 1.38 | Prolonged survival and serial magnetic resonance imaging/magnetic resonance spectroscopy changes in infantile Krabbe disease. ( Bunge, M; Mhanni, AA; Ryner, L; Salman, MS; Udow, S, 2012) |
| "Intracranial arachnoid cysts (ACs) are usually asymptomatic, benign developmental anomalies." | 1.35 | Single-voxel magnetic resonance spectroscopy of brain tissue adjacent to arachnoid cysts of epileptic patients. ( Ozcan, C; Ozisik, HI; Sarac, K, 2008) |
| "Myo-inositol was found to be lower while taking VPA, although no relationship between the change in metabolite concentration, VPA dose or seizure control was observed." | 1.34 | The effect of sodium valproate on proton MRS visible neurochemical concentrations. ( Barker, GJ; Duncan, JS; McLean, MA; Simister, RJ, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 11 (50.00) | 29.6817 |
| 2010's | 6 (27.27) | 24.3611 |
| 2020's | 3 (13.64) | 2.80 |
| Authors | Studies |
|---|---|
| Kandashvili, M | 3 |
| Gamkrelidze, G | 2 |
| Tsverava, L | 2 |
| Lordkipanidze, T | 2 |
| Lepsveridze, E | 2 |
| Lagani, V | 1 |
| Burjanadze, M | 1 |
| Dashniani, M | 1 |
| Kokaia, M | 3 |
| Solomonia, R | 2 |
| Cai, J | 1 |
| Li, X | 2 |
| Wu, S | 1 |
| Tian, Y | 1 |
| Zhang, Y | 1 |
| Wei, Z | 1 |
| Jin, Z | 1 |
| Chen, X | 1 |
| Chen, WX | 1 |
| Gamkrelidze, GN | 1 |
| Nanobashvili, ZI | 1 |
| Bilanishvili, IG | 1 |
| Solomonia, RO | 1 |
| Barta, H | 1 |
| Jermendy, A | 1 |
| Kolossvary, M | 1 |
| Kozak, LR | 1 |
| Lakatos, A | 1 |
| Meder, U | 1 |
| Szabo, M | 1 |
| Rudas, G | 1 |
| Margvelani, G | 1 |
| Lortkipanidze, T | 1 |
| Tschampa, HJ | 1 |
| Urbach, H | 1 |
| Träber, F | 1 |
| Sprinkart, AM | 1 |
| Greschus, S | 1 |
| Malter, MP | 1 |
| Surges, R | 1 |
| Gieseke, J | 1 |
| Block, W | 1 |
| Ozisik, HI | 1 |
| Sarac, K | 1 |
| Ozcan, C | 1 |
| Terbach, N | 1 |
| Williams, RS | 2 |
| Chang, P | 1 |
| Orabi, B | 1 |
| Deranieh, RM | 1 |
| Dham, M | 1 |
| Hoeller, O | 1 |
| Shimshoni, JA | 1 |
| Yagen, B | 1 |
| Bialer, M | 1 |
| Greenberg, ML | 1 |
| Walker, MC | 1 |
| Udow, S | 1 |
| Bunge, M | 1 |
| Ryner, L | 1 |
| Mhanni, AA | 1 |
| Salman, MS | 1 |
| Ziyeh, S | 1 |
| Thiel, T | 1 |
| Spreer, J | 1 |
| Klisch, J | 1 |
| Schumacher, M | 1 |
| Freeman, JL | 1 |
| Coleman, LT | 1 |
| Wellard, RM | 2 |
| Kean, MJ | 1 |
| Rosenfeld, JV | 1 |
| Jackson, GD | 2 |
| Berkovic, SF | 1 |
| Harvey, AS | 1 |
| Briellmann, RS | 1 |
| Musto, A | 1 |
| Bazan, NG | 2 |
| Simister, RJ | 1 |
| McLean, MA | 3 |
| Barker, GJ | 3 |
| Duncan, JS | 3 |
| Zhvaniia, MG | 1 |
| Solomoniia, RO | 1 |
| Bikashvili, TZ | 1 |
| Kotariia, NT | 1 |
| Chkhikvishvili, TsG | 1 |
| Kiladze, MT | 1 |
| Nozadze, MB | 1 |
| Dzhaparidze, ND | 1 |
| Stanimirovic, DB | 1 |
| Bacic, F | 1 |
| Uematsu, S | 1 |
| Spatz, M | 1 |
| Woermann, FG | 2 |
| Mizuno, S | 1 |
| Takahashi, Y | 1 |
| Kato, Z | 1 |
| Goto, H | 1 |
| Kondo, N | 1 |
| Hoshi, H | 1 |
| Bartlett, PA | 1 |
| Birkle, DL | 1 |
| Tang, W | 1 |
| Reddy, TS | 1 |
| Wiśniewski, K | 1 |
| Antonowski, T | 1 |
| Juranek, J | 1 |
| Podlasz, P | 1 |
| Wojtkiewicz, J | 1 |
4 reviews available for inositol and Epilepsy
| Article | Year |
|---|---|
Assessing the causal association between human blood metabolites and the risk of epilepsy.
Topics: Epilepsy; Genome-Wide Association Study; Humans; Inositol; Mendelian Randomization Analysis; Polymor | 2022 |
Structure-function studies for the panacea, valproic acid.
Topics: Animals; Anticonvulsants; Bipolar Disorder; Epilepsy; gamma-Aminobutyric Acid; Glycogen Synthase Kin | 2009 |
Seizure-associated abnormalities in epilepsy: evidence from MR imaging.
Topics: Adult; Aspartic Acid; Atrophy; Brain; Brain Diseases; Brain Edema; Choline; Creatine; Diffusion Magn | 2005 |
The accumulation of free arachidonic acid, diacylglycerols, prostaglandins, and lipoxygenase reaction products in the brain during experimental epilepsy.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Biomechanical Phenomena; Brain; Diglycerides; Epilepsy | 1986 |
2 trials available for inositol and Epilepsy
| Article | Year |
|---|---|
Quantitative analysis of short echo time (1)H-MRSI of cerebral gray and white matter.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Calibration; Cerebrospinal Fluid; Choline; Creatine; D | 2000 |
Quantitative short echo time proton magnetic resonance spectroscopic imaging study of malformations of cortical development causing epilepsy.
Topics: Adult; Analysis of Variance; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Dipeptides; Epilepsy | 2001 |
16 other studies available for inositol and Epilepsy
| Article | Year |
|---|---|
Myo-Inositol Limits Kainic Acid-Induced Epileptogenesis in Rats.
Topics: Animals; Antinematodal Agents; Disease Models, Animal; Epilepsy; Inositol; Kainic Acid; Male; Memory | 2022 |
Concentration- and time-dependent effects of myo-inositol on evoked epileptic afterdischarge in the hippocampus in vivo.
Topics: Anticonvulsants; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy; Hipp | 2019 |
Prognostic value of early, conventional proton magnetic resonance spectroscopy in cooled asphyxiated infants.
Topics: Aspartic Acid; Brain; Creatine; Epilepsy; Female; Hearing Loss; Hospital Mortality; Humans; Hypother | 2018 |
Long-Term Effects of Myoinositol on Behavioural Seizures and Biochemical Changes Evoked by Kainic Acid Induced Epileptogenesis.
Topics: Animals; Behavior, Animal; Epilepsy; Inositol; Kainic Acid; Seizures; Time Factors | 2019 |
Proton magnetic resonance spectroscopy in focal cortical dysplasia at 3T.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Child, Preschool; Choline; Creatine; Drug Resistant E | 2015 |
Single-voxel magnetic resonance spectroscopy of brain tissue adjacent to arachnoid cysts of epileptic patients.
Topics: Adolescent; Adult; Arachnoid Cysts; Aspartic Acid; Brain; Brain Mapping; Child; Choline; Creatine; E | 2008 |
The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium.
Topics: Animals; Anticonvulsants; Dictyostelium; Disease Models, Animal; Dose-Response Relationship, Drug; E | 2012 |
Prolonged survival and serial magnetic resonance imaging/magnetic resonance spectroscopy changes in infantile Krabbe disease.
Topics: Anticonvulsants; Aspartic Acid; Brain Chemistry; Choline; Combined Modality Therapy; Creatine; DNA M | 2012 |
Valproate-induced encephalopathy: assessment with MR imaging and 1H MR spectroscopy.
Topics: Adult; Anticonvulsants; Aspartic Acid; Brain; Brain Diseases, Metabolic; Choline; Creatine; Epilepsy | 2002 |
MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: analysis of 72 cases.
Topics: Adolescent; Adult; Aspartic Acid; Cell Count; Cerebral Cortex; Child; Child, Preschool; Dominance, C | 2004 |
Diacylglycerol kinase epsilon modulates rapid kindling epileptogenesis.
Topics: Animals; Diacylglycerol Kinase; Disease Susceptibility; Electric Stimulation; Electrodes, Implanted; | 2006 |
The effect of sodium valproate on proton MRS visible neurochemical concentrations.
Topics: Adolescent; Adult; Algorithms; Anticonvulsants; Brain Chemistry; Dipeptides; Epilepsy; Female; Gluta | 2007 |
[The influence of myo-inositol on the ultrastructure of hippocampal CA1 area in kainate treated rats].
Topics: Animals; Anticonvulsants; Astrocytes; Epilepsy; Hippocampus; Inositol; Kainic Acid; Male; Neurons; O | 2007 |
Profile of prostaglandins induced by endothelin-1 in human brain capillary endothelium.
Topics: Analysis of Variance; Capillaries; Cell Line; Dexamethasone; Endothelin Receptor Antagonists; Endoth | 1993 |
Magnetic resonance spectroscopy of tubers in patients with tuberous sclerosis.
Topics: Adult; Age Factors; Aspartic Acid; Case-Control Studies; Child; Child, Preschool; Creatine; Disease | 2000 |
Antiepileptic Properties of Scyllo-Inositol on Pentylenetetrazol-Induced Seizures.
Topics: Animals; Anticonvulsants; Epilepsy; Larva; Pentylenetetrazole; Seizures; Zebrafish | 2023 |