Page last updated: 2024-10-19

inositol and Epilepsy, Tonic-Clonic

inositol has been researched along with Epilepsy, Tonic-Clonic in 4 studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Epilepsy, Tonic-Clonic: A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)

Research Excerpts

ExcerptRelevanceReference
"Valproate (VPA) interferes with mitochondrial metabolism causing hyperammonemia, thereby shifting the balance reaction of glutamine (Gln)/glutamate (Glu) toward Gln."3.75Valproate-induced metabolic changes in patients with epilepsy: assessment with H-MRS. ( Buechert, M; Garcia, M; Huppertz, HJ; Mader, I; Schumacher, M; Ziyeh, S, 2009)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's2 (50.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Garcia, M1
Huppertz, HJ1
Ziyeh, S1
Buechert, M1
Schumacher, M1
Mader, I1
Doelken, MT1
Mennecke, A1
Stadlbauer, A1
Kecskeméti, L1
Kasper, BS1
Struffert, T1
Doerfler, A1
Stefan, H1
Hammen, T1
Savic, I1
Osterman, Y1
Helms, G1
Kofman, O1
Sherman, WR1
Katz, V1
Belmaker, RH1

Other Studies

4 other studies available for inositol and Epilepsy, Tonic-Clonic

ArticleYear
Valproate-induced metabolic changes in patients with epilepsy: assessment with H-MRS.
    Epilepsia, 2009, Volume: 50, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Aspartic Acid; Choline; Creatine; Energy Metabolism; Epilepsies,

2009
Multi-voxel magnetic resonance spectroscopy at 3 T in patients with idiopathic generalised epilepsy.
    Seizure, 2010, Volume: 19, Issue:8

    Topics: Adolescent; Adult; Aspartic Acid; Basal Ganglia; Brain; Cerebral Cortex; Choline; Creatine; Epilepsy

2010
MRS shows syndrome differentiated metabolite changes in human-generalized epilepsies.
    NeuroImage, 2004, Volume: 21, Issue:1

    Topics: Adolescent; Adult; Aspartic Acid; Cerebellum; Cerebral Cortex; Choline; Creatine; Dominance, Cerebra

2004
Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures.
    Psychopharmacology, 1993, Volume: 110, Issue:1-2

    Topics: Animals; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Epilepsy, Tonic-Clonic; Injections, Int

1993