Page last updated: 2024-10-19

inositol and Encephalopathy, Hepatic

inositol has been researched along with Encephalopathy, Hepatic in 44 studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Research Excerpts

ExcerptRelevanceReference
"This study was to investigate the effects of ammonia and manganese in the metabolism of minimal hepatic encephalopathy (MHE)."8.31The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study. ( Li, Y; Liu, XF; Lu, JJ; Qiang, JW; Yang, XY, 2023)
"Myo-inositol and glutamine levels in the brain were studied in vivo by 1H-MR spectroscopy in patients with hypo-osmolarity and hepatic encephalopathy."7.69Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy. ( Bayer, S; Ernst, T; Gerok, W; Häussinger, D; Hennig, J; Langer, M; Laubenberger, J; vom Dahl, S, 1994)
"Cerebral myo-inositol depletion is found in patients with hepatic encephalopathy and can be implicated in the pathogenesis of hepatic encephalopathy."7.69Scyllo-inositol depletion in hepatic encephalopathy. ( Lien, YH; Michaelis, T; Moats, RA; Ross, BD, 1994)
" An osmoregulatory response to the increase in brain glutamine may explain the decrease in brain myo-inositol; if this is the case, organic osmolytes may account for differences in the development of brain edema seen in acute or chronic liver failure."7.69Glutamine, myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: implications for ammonia-induced brain edema. ( Blei, AT; Cordoba, J; Gottstein, J, 1996)
"In a double-blind study, overt hepatic encephalopathy (HE) and SCHE (defined with clinical and neuropsychiatric tests) were compared by means of H-1 MR spectroscopic criteria--reduction in cerebral myo-inositol (< 2 standard deviations [SDs] from normal) and choline (< 2 SDs from normal) with or without increased cerebral glutamine (> 1 SD from normal)--in 20 patients with cirrhosis."5.07Subclinical hepatic encephalopathy: proton MR spectroscopic abnormalities. ( Ernst, T; Jacobson, S; Korula, J; Kreis, R; Moats, RA; Ross, BD; Shonk, T; Villamil, F, 1994)
"This study was to investigate the effects of ammonia and manganese in the metabolism of minimal hepatic encephalopathy (MHE)."4.31The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study. ( Li, Y; Liu, XF; Lu, JJ; Qiang, JW; Yang, XY, 2023)
"In hepatic encephalopathy (HE), osmotic stressors promoting brain edema result in a compensatory drop in the astrocyte metabolite myo-inositol (mI)."3.96Brain MR Spectroscopy Markers of Encephalopathy Due to Nonalcoholic Steatohepatitis. ( Cole, S; Csete, M; King, KS; Mena, E; Tran, TT; Wei, K, 2020)
"Compared with control dogs, dogs with hepatic encephalopathy had specific changes, which included significantly higher concentration relative to water of the glutamine-glutamate complex and significantly lower concentration of myoinositol."3.80In vivo proton magnetic resonance spectroscopy for the evaluation of hepatic encephalopathy in dogs. ( Beckman, K; Carrera, I; Dennler, M; Kircher, PR; Meier, D; Richter, H, 2014)
"Asymmetric dimethylarginine (ADMA) is an inhibitor of nitric oxide synthase that accumulates in liver disease and may contribute to hepatic encephalopathy (HE)."3.79Asymmetric dimethylarginine is strongly associated with cognitive dysfunction and brain MR spectroscopic abnormalities in cirrhosis. ( Ahluwalia, V; Bajaj, JS; Bouneva, I; Fuchs, M; Gilles, H; Heuman, DM; Kraft, KA; Luketic, V; Monteith, P; Noble, NA; Puri, P; Sanyal, AJ; Sterling, RK; Stravitz, RT; Wade, JB; White, MB, 2013)
" Significant decrease of myo-inositol in adults is probably due to cellular osmoregulation secondary to long-standing hyperammonemia."3.76Brain MR imaging and 1H-MR spectroscopy changes in patients with extrahepatic portal vein obstruction from early childhood to adulthood. ( Gupta, RK; Rathore, RK; Saksena, S; Saraswat, VA; Srivastava, A; Thomas, MA; Yadav, SK, 2010)
" Decreased myo-inositol and increased glutamine levels were noted to be the most sensitive spectroscopic markers for cirrhotic patients with hepatic encephalopathy (HE)."3.70Proton magnetic resonance spectroscopy (1H-MRS) findings for the brain in patients with liver cirrhosis reflect the hepatic functional reserve. ( Kim, ST; Lee, JH; Lee, YS; Lim, TH; Min, YI; Mun, CW; Seo, DW; Suh, DJ, 1999)
"Myo-inositol and glutamine levels in the brain were studied in vivo by 1H-MR spectroscopy in patients with hypo-osmolarity and hepatic encephalopathy."3.69Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy. ( Bayer, S; Ernst, T; Gerok, W; Häussinger, D; Hennig, J; Langer, M; Laubenberger, J; vom Dahl, S, 1994)
"Cerebral myo-inositol depletion is found in patients with hepatic encephalopathy and can be implicated in the pathogenesis of hepatic encephalopathy."3.69Scyllo-inositol depletion in hepatic encephalopathy. ( Lien, YH; Michaelis, T; Moats, RA; Ross, BD, 1994)
" An osmoregulatory response to the increase in brain glutamine may explain the decrease in brain myo-inositol; if this is the case, organic osmolytes may account for differences in the development of brain edema seen in acute or chronic liver failure."3.69Glutamine, myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: implications for ammonia-induced brain edema. ( Blei, AT; Cordoba, J; Gottstein, J, 1996)
"Rats with portacaval shunts and humans with hepatic encephalopathy show severe myo-inositol depletion in the brain."3.68Decrease in cerebral inositols in rats and humans. ( Filippi, D; Lien, YH; Moats, RA; Ross, BD, 1993)
"Minimal hepatic encephalopathy (MHE) is diagnosed when hepatic patients perform worse on psychometric tests compared to healthy controls."2.78Can Lactobacillus acidophilus improve minimal hepatic encephalopathy? A neurometabolite study using magnetic resonance spectroscopy. ( El Yamany, SA; Hamisa, MF; Hasan, AM; Soliman, HH; Ziada, DH, 2013)
"Human hepatic encephalopathy (HE) is identified by a new noninvasive test, proton magnetic resonance spectroscopy (1H MRS) applied to the brain in a few minutes."2.39Proton magnetic resonance spectroscopy: the new gold standard for diagnosis of clinical and subclinical hepatic encephalopathy? ( Blüml, S; Danielsen, ER; Ross, BD, 1996)
"In patients with hepatic encephalopathy, GABA+ levels in the cerebello-thalamo-cortical loop are significantly increased in the cerebellum and significantly decreased in the motor cortex."1.91J-difference GABA-edited MRS reveals altered cerebello-thalamo-cortical metabolism in patients with hepatic encephalopathy. ( Ahn, S; Butz, M; Füllenbach, ND; Häussinger, D; Jördens, MS; Ljimani, A; Oeltzschner, G; Schnitzler, A; Thiel, TA; Wilms, LM; Wittsack, HJ; Zöllner, HJ, 2023)
"The pathogenesis of hepatic encephalopathy (HE) is not fully understood yet."1.42Low visual cortex GABA levels in hepatic encephalopathy: links to blood ammonia, critical flicker frequency, and brain osmolytes. ( Baumgarten, TJ; Butz, M; Hoogenboom, N; Oeltzschner, G; Schnitzler, A; Wittsack, HJ, 2015)
"Hyponatremia (HN) and hepatic encephalopathy (HE) together can impair health-related quality of life (HRQOL) and cognition in cirrhosis."1.39Differential impact of hyponatremia and hepatic encephalopathy on health-related quality of life and brain metabolite abnormalities in cirrhosis. ( Ahluwalia, V; Bajaj, JS; Bouneva, I; Fuchs, M; Gilles, H; Heuman, DM; Kraft, KA; Luketic, V; Puri, P; Sanyal, AJ; Sterling, RK; Stravitz, RT; Thacker, L; Wade, JB, 2013)
"Acute-on-chronic liver failure (ACLF), acute liver failure (ALF) and chronic liver disease (CLD) are common forms of liver failure and present with similar clinical profiles."1.35In vivo 1H magnetic resonance spectroscopy-derived metabolite variations between acute-on-chronic liver failure and acute liver failure. ( Gupta, RK; Nath, K; Radha Krishna, Y; Saraswat, VA; Thomas, MA; Verma, A, 2008)
"Minimal hepatic encephalopathy (MHE) is frequently diagnosed in patients with liver cirrhosis who do not show overt clinical cirrhosis-associated neurological deficits."1.33Chemical shift magnetic resonance spectroscopy of cingulate grey matter in patients with minimal hepatic encephalopathy. ( Graziadei, IW; Hinterhuber, H; Kugener, A; Marksteiner, J; Mattedi, M; Mechtcheriakov, S; Schocke, M; Vogel, W, 2005)
"6 patients with liver cirrhosis were included in this pilot study."1.33[Detection of subclinical and overt hepatic encephalopathy and treatment control after L-ornithine-L-aspartate medication by magnetic resonance spectroscopy ((1)H-MRS)]. ( Gregor, M; Hass, HG; Hösl, F; Kaiser, S; Nägele, T; Seeger, U, 2005)
"Myo-inositol levels were strongly decreased already at 3h after treatment with NH4Cl; other intracellular osmolytes, such as hypotaurine and choline-containing compounds were also decreased, along with a concomitant increase of both the total concentration and the amount of newly synthesized glutamine, alanine, and glutathione."1.33Ammonia toxicity under hyponatremic conditions in astrocytes: de novo synthesis of amino acids for the osmoregulatory response. ( Leibfritz, D; Zwingmann, C, 2005)
"Episodic hepatic encephalopathy has been described in patients with portal vein thrombosis, but it is not known if these patients develop minimal hepatic encephalopathy."1.33Noncirrhotic portal vein thrombosis exhibits neuropsychological and MR changes consistent with minimal hepatic encephalopathy. ( Alonso, J; Bosch, J; Córdoba, J; García-Pagán, JC; Mínguez, B; Rovira, A; Turnes, J, 2006)
"Six patients, who underwent TIPS for treatment of portal hypertension, were examined by MRS I week before and 1 week after TIPS."1.31Proton MR spectroscopy of the brain in patients treated with TIPS. ( Hamuro, M; Higashida, M; Kaminou, T; Matsuoka, T; Nakamura, K; Yamada, R, 2000)
"Hepatic encephalopathy is a common problem in cirrhosis."1.30Cerebral abnormalities in patients with cirrhosis detected by proton magnetic resonance spectroscopy and magnetic resonance imaging. ( Andus, T; Feuerbach, S; Fründ, R; Geissler, A; Held, P; Hollerbach, S; Holstege, A; Lock, G; Schölmerich, J, 1997)
"Also, patients with Wilson disease and portosystemic shunting had lower myo-inositol-creatine ratios than did patients with Wilson disease and no portosystemic shunting (P < ."1.30Differentiation between portal-systemic encephalopathy and neurodegenerative disorders in patients with Wilson disease: H-1 MR spectroscopy. ( Hoogenraad, TU; Mali, WP; Van Den Heuvel, AG; Van der Grond, J; Van Rooij, LG; Van Wassenaer-van Hall, HN, 1997)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's18 (40.91)18.2507
2000's10 (22.73)29.6817
2010's11 (25.00)24.3611
2020's5 (11.36)2.80

Authors

AuthorsStudies
Zöllner, HJ1
Thiel, TA1
Füllenbach, ND1
Jördens, MS1
Ahn, S1
Wilms, LM1
Ljimani, A1
Häussinger, D2
Butz, M2
Wittsack, HJ2
Schnitzler, A2
Oeltzschner, G2
Chaganti, J1
Zeng, G1
Tun, N1
Lockart, I1
Abdelshaheed, C1
Cysique, L1
Montagnese, S1
Brew, BJ1
Danta, M1
Liu, XF1
Lu, JJ1
Li, Y1
Yang, XY1
Qiang, JW1
Tran, TT1
Wei, K1
Cole, S1
Mena, E1
Csete, M1
King, KS1
Asaki, Y1
Murofushi, Y1
Yasukawa, K1
Hara, M1
Takanashi, JI1
Ciarlariello, VB1
Fujino, MVT1
Almeida, MD1
Barsottini, OGP1
Pedroso, JL1
Ahluwalia, V2
Wade, JB2
Thacker, L1
Kraft, KA2
Sterling, RK2
Stravitz, RT2
Fuchs, M2
Bouneva, I2
Puri, P2
Luketic, V2
Sanyal, AJ2
Gilles, H2
Heuman, DM2
Bajaj, JS2
Ziada, DH1
Soliman, HH1
El Yamany, SA1
Hamisa, MF1
Hasan, AM1
Razek, AA1
Abdalla, A1
Ezzat, A1
Megahed, A1
Barakat, T1
Carrera, I1
Kircher, PR1
Meier, D1
Richter, H1
Beckman, K1
Dennler, M1
Meng, LP1
Chen, YC1
Li, YH1
Zhu, JS1
Ye, JL1
Baumgarten, TJ1
Hoogenboom, N1
Singhal, A1
Nagarajan, R1
Kumar, R1
Huda, A1
Gupta, RK5
Thomas, MA4
Yadav, SK1
Saksena, S2
Srivastava, A2
Saraswat, VA4
Rathore, RK1
Herman-Sucharska, I1
Grzybek, M1
Grochowska, A1
Karcz, P1
Urbanik, A1
Bokemeyer, M1
Ding, XQ1
Goldbecker, A1
Raab, P1
Heeren, M1
Arvanitis, D1
Tillmann, HL1
Lanfermann, H1
Weissenborn, K1
White, MB1
Noble, NA1
Monteith, P1
Zwingmann, C2
Chatauret, N1
Rose, C1
Leibfritz, D2
Butterworth, RF1
Mechtcheriakov, S1
Schocke, M1
Kugener, A1
Graziadei, IW1
Mattedi, M1
Hinterhuber, H1
Vogel, W1
Marksteiner, J1
Hass, HG1
Nägele, T1
Seeger, U2
Hösl, F1
Gregor, M2
Kaiser, S2
Mínguez, B1
García-Pagán, JC1
Bosch, J1
Turnes, J1
Alonso, J1
Rovira, A1
Córdoba, J3
Rai, V1
Rathore, RS1
Purwar, A1
Kumar, M1
Verma, A1
Radha Krishna, Y1
Nath, K1
Norenberg, MD1
Bender, AS1
Danielsen, ER2
Michaelis, T2
Ross, BD8
Laubenberger, J2
vom Dahl, S1
Ernst, T2
Bayer, S2
Langer, M2
Gerok, W1
Hennig, J2
Jacobson, S1
Villamil, F1
Korula, J1
Kreis, R4
Shonk, T1
Moats, RA3
Lien, YH2
Filippi, D1
Poptani, H1
Dhiman, RK1
Kohli, A1
Gujral, RB1
Naik, SR1
Gottstein, J1
Blei, AT1
Blüml, S1
Geissler, A1
Lock, G1
Fründ, R1
Held, P1
Hollerbach, S1
Andus, T1
Schölmerich, J1
Feuerbach, S1
Holstege, A1
Van Den Heuvel, AG1
Van der Grond, J1
Van Rooij, LG1
Van Wassenaer-van Hall, HN1
Hoogenraad, TU1
Mali, WP1
Thiel, T1
Gruetter, R1
Weisdorf, SA1
Rajanayagan, V1
Terpstra, M1
Merkle, H1
Truwit, CL1
Garwood, M1
Nyberg, SL1
Uğurbil, K1
Lee, JH1
Seo, DW1
Lee, YS1
Kim, ST1
Mun, CW1
Lim, TH1
Min, YI1
Suh, DJ1
Naegele, T1
Grodd, W1
Viebahn, R1
Klose, U1
Seitz, D1
Mader, I1
Mayer, J1
Lauchart, W1
Voigt, K1
Hamuro, M1
Nakamura, K1
Matsuoka, T1
Kaminou, T1
Higashida, M1
Yamada, R1
Farrow, NA1
Ackerman, Z1
Farrow, N2

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Role of Magnetic Resonance Imaging in Detection of Minimal Hepatic Encephalopathy[NCT04131205]40 participants (Anticipated)Observational2019-06-01Recruiting
A Magnetic Resonance Spectroscopy Study of Neuropsychiatric Effects Associated With Cytokines[NCT00001547]150 participants Observational1996-06-30Completed
A Phase 2a Study to Evaluate the Safety and Tolerability of OCR-002 (Ornithine Phenylacetate) in the Treatment of Patients With Acute Liver Failure/Severe Acute Liver Injury[NCT01548690]Phase 247 participants (Actual)Interventional2012-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Ammonia

To evaluate the effect of OCR-002 on ammonia levels in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: Baseline and 72 Hours

InterventionPercent Change (Mean)
Maximum Dose Level 3.33 g/24h41.2
Maximum Dose Level 6.65 g/24h16.6
Maximum Dose Level 10 g/24h41.8
Maximum Dose Level 20g/24h38.4

Measurement of OCR-002 Plasma Concentration

To evaluate the steady state pharmacokinetic and pharmacodynamic profile of OCR-002 in patients with impaired and intact renal function using urinary phenylacetylglutamine (PAGN) as a surrogate marker (NCT01548690)
Timeframe: 24 Hours after last infusion

Interventionmicrograms per millileter (Mean)
Maximum Dose Level 3.33 g/24h65.6
Maximum Dose Level 6.65 g/24h32.2
Maximum Dose Level 10 g/24h33.4
Maximum Dose Level 20g/24h104.9

Neurological Function Measured by the Orientation Log (O-log)

The orientation log focuses on orientation to place, time, and circumstance. There are 10 items on the orientation log, which are scored 0-3. A spontaneous correct response is awarded 3 points. A spontaneous response that is lacking or incorrect, but a correct response is provided following a logical cue is awarded 2 points. A score of 1 is given if spontaneous and cued responses are lacking or incorrect, but a correct response is provided in a recognition format. A score of 0 is given if the spontaneous, cued, or recognition format does not generate a correct answer. Scores from the 10 items are summed and the final score ranges from 0 to 30. (NCT01548690)
Timeframe: 30 Days

Interventionunits on a scale (Mean)
Maximum Dose Level 3.33 g/24h23.8
Maximum Dose Level 6.65 g/24h24.0
Maximum Dose Level 10 g/24h24.0
Maximum Dose Level 20g/24h24.0

Neurological Function Measured by the West Haven Criteria (WHC) for Hepatic Encephalopathy

The West Haven Criteria (WHC) for Hepatic Encephalopathy measures the severity of encephalopathy and patient's level of consciousness. The scale ranges from 0 to 4; a minimum score of 0 represents a better outcome, and a maximum total score of 4 represents a worse outcome. A score of 0 corresponds to normal consciousness and behavior and normal neurological examination. A score of 1 corresponds to mild lack of awareness, shortened attention span, and impaired addition or subtraction; mild asterixis or tremor. A score of 2 corresponds to lethargy, disorientated or inappropriate behavior, obvious asterixis; slurred speech. A score of 3 corresponds to somnolent but arousable, gross disorientation or bizarre behavior, muscle rigidity and clonus; hyperreflexia. A score of 4 corresponds to coma and decerebrate posturing. (NCT01548690)
Timeframe: 120 hours from start of infusion

Interventionunits on a scale (Mean)
Maximum Dose Level 3.33 g/24h2.4
Maximum Dose Level 6.65 g/24h3.2
Maximum Dose Level 10 g/24h1.6
Maximum Dose Level 20g/24h1.8

Number of Participants That do Not Tolerate the Administered Dose and Had Grade 3 or 4 Treatment Emergent Adverse Events as a Measure of Safety and Tolerability

To evaluate the safety and tolerability of OCR-002 in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: 30 Days

InterventionParticipants (Count of Participants)
Maximum Dose Level 3.33 g/24h0
Maximum Dose Level 6.65 g/24h0
Maximum Dose Level 10 g/24h0
Maximum Dose Level 20g/24h0

Reviews

1 review available for inositol and Encephalopathy, Hepatic

ArticleYear
Proton magnetic resonance spectroscopy: the new gold standard for diagnosis of clinical and subclinical hepatic encephalopathy?
    Digestive diseases (Basel, Switzerland), 1996, Volume: 14 Suppl 1

    Topics: Animals; Astrocytes; Brain; Choline; Cognition Disorders; Disease Models, Animal; Glutamine; Hepatic

1996

Trials

3 trials available for inositol and Encephalopathy, Hepatic

ArticleYear
Can Lactobacillus acidophilus improve minimal hepatic encephalopathy? A neurometabolite study using magnetic resonance spectroscopy.
    Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology, 2013, Volume: 14, Issue:3

    Topics: Adult; Ammonia; Brain; Choline; Creatinine; Female; Gastrointestinal Agents; Gastrointestinal Tract;

2013
Minimal hepatic encephalopathy in children with liver cirrhosis: diffusion-weighted MR imaging and proton MR spectroscopy of the brain.
    Neuroradiology, 2014, Volume: 56, Issue:10

    Topics: Adolescent; Child; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Female; Glutamic Acid; H

2014
Subclinical hepatic encephalopathy: proton MR spectroscopic abnormalities.
    Radiology, 1994, Volume: 193, Issue:2

    Topics: Adult; Brain Chemistry; Choline; Double-Blind Method; Female; Glutamine; Hepatic Encephalopathy; Hum

1994

Other Studies

40 other studies available for inositol and Encephalopathy, Hepatic

ArticleYear
J-difference GABA-edited MRS reveals altered cerebello-thalamo-cortical metabolism in patients with hepatic encephalopathy.
    Metabolic brain disease, 2023, Volume: 38, Issue:4

    Topics: Ammonia; Cerebellum; Choline; gamma-Aminobutyric Acid; Glutamine; Hepatic Encephalopathy; Humans; In

2023
Novel magnetic resonance KTRANS measurement of blood-brain barrier permeability correlated with covert HE.
    Hepatology communications, 2023, 04-01, Volume: 7, Issue:4

    Topics: Blood-Brain Barrier; Brain; Choline; Glutamine; Hepatic Encephalopathy; Humans; Inositol; Liver Cirr

2023
The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study.
    PloS one, 2023, Volume: 18, Issue:8

    Topics: Alanine; Ammonia; Animals; Arginine; Brain; Citrulline; gamma-Aminobutyric Acid; Glutamic Acid; Glut

2023
Brain MR Spectroscopy Markers of Encephalopathy Due to Nonalcoholic Steatohepatitis.
    Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2020, Volume: 30, Issue:5

    Topics: Aged; Biomarkers; Brain; Brain Edema; Female; Glutamine; Hepatic Encephalopathy; Humans; Inositol; M

2020
Neurochemistry of hyponatremic encephalopathy evaluated by MR spectroscopy.
    Brain & development, 2020, Volume: 42, Issue:10

    Topics: Aspartic Acid; Child; Creatine; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans; Hyponatrem

2020
Teaching Video NeuroImages: Hepatic myelopathy: An unusual neurologic complication of hepatic encephalopathy.
    Neurology, 2019, 07-16, Volume: 93, Issue:3

    Topics: Choline; Gait Disorders, Neurologic; Globus Pallidus; Glutamic Acid; Glutamine; Hepatic Encephalopat

2019
Differential impact of hyponatremia and hepatic encephalopathy on health-related quality of life and brain metabolite abnormalities in cirrhosis.
    Journal of hepatology, 2013, Volume: 59, Issue:3

    Topics: Brain; Cognition; Cognition Disorders; Diuretics; Female; Glutamic Acid; Glutamine; Hepatic Encephal

2013
In vivo proton magnetic resonance spectroscopy for the evaluation of hepatic encephalopathy in dogs.
    American journal of veterinary research, 2014, Volume: 75, Issue:9

    Topics: Animals; Brain; Case-Control Studies; Dog Diseases; Dogs; Female; Glutamic Acid; Glutamine; Hepatic

2014
Viability assessment of magnetic resonance spectroscopy for the detection of minimal hepatic encephalopathy severity.
    European journal of radiology, 2015, Volume: 84, Issue:10

    Topics: Adult; Aspartic Acid; Basal Ganglia; Brain; Cognition; Creatine; Female; Glutamic Acid; Glutamine; G

2015
Low visual cortex GABA levels in hepatic encephalopathy: links to blood ammonia, critical flicker frequency, and brain osmolytes.
    Metabolic brain disease, 2015, Volume: 30, Issue:6

    Topics: Ammonia; Brain Chemistry; Creatine; Female; Flicker Fusion; gamma-Aminobutyric Acid; Glutamine; Glyc

2015
Magnetic resonance T2-relaxometry and 2D L-correlated spectroscopy in patients with minimal hepatic encephalopathy.
    Journal of magnetic resonance imaging : JMRI, 2009, Volume: 30, Issue:5

    Topics: Adult; Aged; Brain; Choline; Creatine; Female; Hepatic Encephalopathy; Humans; Inositol; Liver; Magn

2009
Brain MR imaging and 1H-MR spectroscopy changes in patients with extrahepatic portal vein obstruction from early childhood to adulthood.
    AJNR. American journal of neuroradiology, 2010, Volume: 31, Issue:7

    Topics: Adolescent; Adult; Age Factors; Ammonia; Basal Ganglia; Child; Female; Hepatic Encephalopathy; Human

2010
[Myoinositol trends in HMRS brain spectrum of patients with hepatic encephalopathy].
    Przeglad lekarski, 2010, Volume: 67, Issue:4

    Topics: Ammonia; Biomarkers; Choline; Creatine; Hepatic Encephalopathy; Humans; Inositol; Liver; Magnetic Re

2010
Evidence for neuroinflammation and neuroprotection in HCV infection-associated encephalopathy.
    Gut, 2011, Volume: 60, Issue:3

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Mapping; Case-Control Studies; Choline; Cognition Disorders

2011
Asymmetric dimethylarginine is strongly associated with cognitive dysfunction and brain MR spectroscopic abnormalities in cirrhosis.
    Journal of hepatology, 2013, Volume: 58, Issue:1

    Topics: Adult; Arginine; Aspartic Acid; Biomarkers; Brain; Cognition Disorders; Cross-Sectional Studies; Fem

2013
Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia.
    Brain research, 2004, Feb-27, Volume: 999, Issue:1

    Topics: Animals; Brain Edema; Disease Models, Animal; Glutamine; Hepatic Encephalopathy; Hypothermia, Induce

2004
Chemical shift magnetic resonance spectroscopy of cingulate grey matter in patients with minimal hepatic encephalopathy.
    Neuroradiology, 2005, Volume: 47, Issue:1

    Topics: Aspartic Acid; Cerebral Cortex; Choline; Creatinine; Female; Glutamic Acid; Glutamine; Gyrus Cinguli

2005
[Detection of subclinical and overt hepatic encephalopathy and treatment control after L-ornithine-L-aspartate medication by magnetic resonance spectroscopy ((1)H-MRS)].
    Zeitschrift fur Gastroenterologie, 2005, Volume: 43, Issue:4

    Topics: Adult; Ammonia; Brain; Choline; Combined Modality Therapy; Creatinine; Diet, Protein-Restricted; Dip

2005
Ammonia toxicity under hyponatremic conditions in astrocytes: de novo synthesis of amino acids for the osmoregulatory response.
    Neurochemistry international, 2005, Volume: 47, Issue:1-2

    Topics: Alanine; Amino Acids; Ammonia; Ammonium Chloride; Animals; Animals, Newborn; Astrocytes; Brain Edema

2005
Noncirrhotic portal vein thrombosis exhibits neuropsychological and MR changes consistent with minimal hepatic encephalopathy.
    Hepatology (Baltimore, Md.), 2006, Volume: 43, Issue:4

    Topics: Administration, Oral; Adult; Ammonia; Attention; Body Water; Brain; Case-Control Studies; Female; Gl

2006
Cerebral diffusion tensor imaging and in vivo proton magnetic resonance spectroscopy in patients with fulminant hepatic failure.
    Journal of gastroenterology and hepatology, 2008, Volume: 23, Issue:7 Pt 2

    Topics: Adolescent; Adult; Anisotropy; Aspartic Acid; Biomarkers; Case-Control Studies; Cerebrovascular Circ

2008
In vivo 1H magnetic resonance spectroscopy-derived metabolite variations between acute-on-chronic liver failure and acute liver failure.
    Liver international : official journal of the International Association for the Study of the Liver, 2008, Volume: 28, Issue:8

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Case-Control Studies; Choline; Chronic Disease; Creat

2008
Astrocyte swelling in liver failure: role of glutamine and benzodiazepines.
    Acta neurochirurgica. Supplementum, 1994, Volume: 60

    Topics: Ammonia; Animals; Animals, Newborn; Astrocytes; Brain Edema; Cells, Cultured; Cerebral Cortex; Chlor

1994
Three methods of calibration in quantitative proton MR spectroscopy.
    Journal of magnetic resonance. Series B, 1995, Volume: 106, Issue:3

    Topics: Adult; Aspartic Acid; Body Water; Brain; Brain Chemistry; Brain Injuries; Calibration; Choline; Crea

1995
Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy.
    Gastroenterology, 1994, Volume: 107, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Brain Chemistry; Brain Diseases; Female; Glutamine;

1994
Scyllo-inositol depletion in hepatic encephalopathy.
    Life sciences, 1994, Volume: 54, Issue:20

    Topics: Autopsy; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Hepatic Encephalopathy; Human

1994
Decrease in cerebral inositols in rats and humans.
    The Biochemical journal, 1993, Oct-01, Volume: 295 ( Pt 1)

    Topics: Animals; Brain Chemistry; Disease Models, Animal; Hepatic Encephalopathy; Humans; Inositol; Magnetic

1993
Magnetic resonance imaging and localized in vivo proton spectroscopy in patients with fulminant hepatic failure.
    The American journal of gastroenterology, 1993, Volume: 88, Issue:5

    Topics: Adult; Atrophy; Brain; Cerebral Cortex; Female; Glutamine; Hepatic Encephalopathy; Humans; Inositol;

1993
Glutamine, myo-inositol, and brain edema in acute liver failure.
    Hepatology (Baltimore, Md.), 1996, Volume: 23, Issue:5

    Topics: Brain; Brain Edema; Glutamine; Hepatic Encephalopathy; Humans; Inositol

1996
Glutamine, myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: implications for ammonia-induced brain edema.
    Hepatology (Baltimore, Md.), 1996, Volume: 24, Issue:4

    Topics: Ammonia; Animals; Blood Pressure; Body Water; Body Weight; Brain; Brain Edema; Cerebral Cortex; Glut

1996
Cerebral abnormalities in patients with cirrhosis detected by proton magnetic resonance spectroscopy and magnetic resonance imaging.
    Hepatology (Baltimore, Md.), 1997, Volume: 25, Issue:1

    Topics: Adult; Aged; Aspartic Acid; Brain; Choline; Female; Glutamic Acid; Hepatic Encephalopathy; Humans; I

1997
Differentiation between portal-systemic encephalopathy and neurodegenerative disorders in patients with Wilson disease: H-1 MR spectroscopy.
    Radiology, 1997, Volume: 203, Issue:2

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Diseases; Choline; Creatinine; Diagnosis, Differential; Fem

1997
[Clinical uses of proton magnetic resonance spectroscopy of the brain].
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1998, Volume: 168, Issue:6

    Topics: AIDS Dementia Complex; Alzheimer Disease; Animals; Aspartic Acid; Brain; Brain Diseases; Brain Disea

1998
Resolution improvements in in vivo 1H NMR spectra with increased magnetic field strength.
    Journal of magnetic resonance (San Diego, Calif. : 1997), 1998, Volume: 135, Issue:1

    Topics: Adult; Amino Acids; Animals; Brain Chemistry; Dogs; Hepatic Encephalopathy; Humans; Image Processing

1998
Proton magnetic resonance spectroscopy (1H-MRS) findings for the brain in patients with liver cirrhosis reflect the hepatic functional reserve.
    The American journal of gastroenterology, 1999, Volume: 94, Issue:8

    Topics: Adult; Aged; Aspartic Acid; Basal Ganglia; Brain; Choline; Creatinine; Energy Metabolism; Female; Gl

1999
MR imaging and (1)H spectroscopy of brain metabolites in hepatic encephalopathy: time-course of renormalization after liver transplantation.
    Radiology, 2000, Volume: 216, Issue:3

    Topics: Adult; Basal Ganglia; Choline; Creatine; Energy Metabolism; Female; Glutamic Acid; Glutamine; Hepati

2000
Proton MR spectroscopy of the brain in patients treated with TIPS.
    Acta radiologica (Stockholm, Sweden : 1987), 2000, Volume: 41, Issue:6

    Topics: Adult; Aged; Brain Chemistry; Female; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans; Hype

2000
Metabolic disorders of the brain in chronic hepatic encephalopathy detected with H-1 MR spectroscopy.
    Radiology, 1992, Volume: 182, Issue:1

    Topics: Aspartic Acid; Brain; Choline; Female; Glucose; Glutamates; Glutamic Acid; Glutamine; Hepatic Enceph

1992
Localized 1H NMR spectroscopy in patients with chronic hepatic encephalopathy. Analysis of changes in cerebral glutamine, choline and inositols.
    NMR in biomedicine, 1991, Volume: 4, Issue:2

    Topics: Aged; Brain; Choline; Chronic Disease; Data Interpretation, Statistical; Electronic Data Processing;

1991
Diagnosis of hepatic encephalopathy by proton magnetic resonance spectroscopy.
    Lancet (London, England), 1990, Sep-08, Volume: 336, Issue:8715

    Topics: Aged; Female; Glutamine; Hepatic Encephalopathy; Humans; Inositol; Magnetic Resonance Spectroscopy;

1990