inositol and Disease Models, Animal studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

Excerpt	Relevance	Reference
" Maternal periconceptional supplementation with folic acid significantly reduces the risk of an NTD-affected pregnancy, but does not prevent all NTDs, and "folic acid non-responsive" NTDs continue to occur."	8.95	Inositol, neural tube closure and the prevention of neural tube defects. ( Copp, AJ; Greene, ND; Leung, KY, 2017)
" The effects of DCI-enriched Tartary buckwheat bran extract (TBBE) on superoxide anion generation, dynamin-related protein 1 (Drp1), mitofusin2 (Mfn2), inositol-requiring enzyme-1α (IRE1α) and Jun n-terminal kinase (JNK) activation and inflammation in the endothelium against lipotoxicity were investigated."	7.88	D-chiro-inositol enriched Fagopyrum tataricum (L.) Gaench extract alleviates mitochondrial malfunction and inhibits ER stress/JNK associated inflammation in the endothelium. ( Gao, C; Li, Y; Wang, M; Zhang, B, 2018)
"The purpose of this study was to induce experimental periodontitis in rats previously fed diets containing arginine silicate inositol (ASI) complex and examine the biochemical, immunological, and radiological effects."	7.83	Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis. ( Akdemir, F; Dundar, S; Eltas, A; Hakki, SS; Komorowski, J; Malkoc, S; Ozercan, IH; Sahin, K; Tuzcu, M; Uslu, MO, 2016)
"Myoinositol and D-chiroinositol improve insulin resistance in women with obesity and gestational diabetes and in postmenopausal women with metabolic syndrome."	7.83	The effect of combined inositol supplementation on maternal metabolic profile in pregnancies complicated by metabolic syndrome and obesity. ( Blackwell, SC; Facchinetti, F; Ferrari, F; Longo, M; Ontiveros, AE; Refuerzo, JS; Roberts, RP; Saade, MM; Sibai, BM, 2016)
"The aim of study was to search for new biomarkers with a magnetic resonance technique to identify the early stages of dementia, induced by D-galactose, and evaluate Simvastatin therapy."	7.81	Neuronal marker recovery after Simvastatin treatment in dementia in the rat brain: in vivo magnetic resonance study. ( Dubovický, M; Kašparová, S; Kucharská, J; Liptaj, T; Lipták, B; Sumbalová, Z; Szomolányi, P; Trattnig, S; Tušková, R; Uličná, O; Vančová, O, 2015)
" In this study, we investigated the metabolism in the thalamus to identify the changes that occur following Coriaria lactone (CL)-induced status epilepticus (SE) and to observe whether the epileptiform discharges could present a difference between the left and right thalami."	7.78	Longitudinal ¹H MRS assessment of the thalamus in a Coriaria lactone-induced rhesus monkey status epilepticus model. ( Gong, QY; Li, HX; Li, JM; Wang, L; Yang, ZY; Zhang, XY; Zhou, D, 2012)
"myo-Inositol is elevated in the Down syndrome (DS; trisomy 21) brain and may play a role in mental retardation."	7.70	Ts65Dn mouse, a Down syndrome model, exhibits elevated myo-inositol in selected brain regions and peripheral tissues. ( Galdzicki, Z; Rapoport, SI; Shetty, HU; Siarey, RJ; Stoll, J, 2000)
"The present study examined the effects of inositol on two animal models of depression: the Porsolt forced swim test, a behaviorally based model; and the reserpine-induced immobility model, a pharmacologically based model."	7.70	Inositol reduces depressive-like behaviors in two different animal models of depression. ( Belmaker, RH; Einat, H; Karbovski, H; Korik, J; Tsalah, D, 1999)
"Lens fiber swelling and related cataractous outgrowth positively correlated to the degree of lens bSMIT gene expression and intralenticular myo-inositol content."	7.70	A transgenic animal model of osmotic cataract. Part 1: over-expression of bovine Na+/myo-inositol cotransporter in lens fibers. ( Cammarata, PR; Chen, G; Kuszak, JR; Reeves, RE; Robinson, ML; Singh, I; Zhou, C, 1999)
"To develop and characterize a new model of galactose-induced cataract formation in young, 3- to 4-week-old Hartley guinea pigs."	7.69	Galactose-induced cataract formation in guinea pigs: morphologic changes and accumulation of galactitol. ( Bekhor, I; Kannan, R; Mackic, JB; McComb, JG; Ross-Cisneros, FN; Weiss, MH; Zlokovic, BV, 1994)
"Thus, the Li-pilocarpine seizure model may, despite its lack of face validity, be a biochemical marker for a model of mania treatment in animals."	6.44	Lithium-pilocarpine seizures as a model for lithium action in mania. ( Belmaker, RH; Bersudsky, Y, 2007)
" However, chronic use and overdose can lead to other severe adverse effects."	5.91	Nutraceutical combination ameliorates imiquimod-induced psoriasis in mice. ( Bhuvarahamurthy, S; Kalaiyazhagan, A; Meganathan, J; Ramamoorthy, R; Venugopal, B; Vijayapoopathi, S, 2023)
"Inositols were administered as mixture of myo-inositol and d-chiro-inositol in the drinking water."	5.56	Myo-inositol and d-chiro-inositol oral supplementation ameliorate cardiac dysfunction and remodeling in a mouse model of diet-induced obesity. ( Di Lascio, N; Faita, F; Forini, F; Kusmic, C; L'Abbate, S; Marchetti, S; Nicolini, G, 2020)
"Myoinositol-treated animals had significantly fewer demyelinating lesions than mannitol (2."	5.33	Myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats. ( Rojiani, AM; Schroeder, BM; Silver, SM; Sterns, RH, 2006)
"Myo-inositol is an important precursor in cellular second-messenger synthesis."	5.29	The effect of peripheral inositol injection on rat motor activity models of depression. ( Alpert, C; Belmaker, RH; Bersudsky, Y; Kofman, O; Vinnitsky, I, 1993)
" Maternal periconceptional supplementation with folic acid significantly reduces the risk of an NTD-affected pregnancy, but does not prevent all NTDs, and "folic acid non-responsive" NTDs continue to occur."	4.95	Inositol, neural tube closure and the prevention of neural tube defects. ( Copp, AJ; Greene, ND; Leung, KY, 2017)
"Clinical trials indicate that inositol may be effective in the treatment of patients with depression, panic disorder and obsessive compulsive disorder (OCD), but not in the treatment of patients with schizophrenia, Alzheimer's disease, ADHD or autism."	4.81	The effects of inositol treatment in animal models of psychiatric disorders. ( Belmaker, RH; Einat, H, 2001)
"Administration of 1000-1500 mg/day D-Chiro-Inositol (DCIns) or a combination of Myo-Inositol (MyoIns) and DCIns in their plasma molar ratio (40:1) for three or more months are among recommended treatments for metabolic syndrome and/or Polycystic Ovary Syndrome (PCOS)."	4.02	High Doses of D-Chiro-Inositol Alone Induce a PCO-Like Syndrome and Other Alterations in Mouse Ovaries. ( Bevilacqua, A; Di Emidio, G; Dragotto, J; Lucarelli, M; Monastra, G; Tatone, C, 2021)
" The effects of DCI-enriched Tartary buckwheat bran extract (TBBE) on superoxide anion generation, dynamin-related protein 1 (Drp1), mitofusin2 (Mfn2), inositol-requiring enzyme-1α (IRE1α) and Jun n-terminal kinase (JNK) activation and inflammation in the endothelium against lipotoxicity were investigated."	3.88	D-chiro-inositol enriched Fagopyrum tataricum (L.) Gaench extract alleviates mitochondrial malfunction and inhibits ER stress/JNK associated inflammation in the endothelium. ( Gao, C; Li, Y; Wang, M; Zhang, B, 2018)
"Increased levels of myo-inositol and monoacylglycerols, and decreased multiple lipid species in the gut-lymph triglyceride-rich lipoprotein fraction could be candidates for new biomarkers and/or involved in the progression of sepsis and gut ischemia-reperfusion pathobiology."	3.88	Altered Metabolic Profile of Triglyceride-Rich Lipoproteins in Gut-Lymph of Rodent Models of Sepsis and Gut Ischemia-Reperfusion Injury. ( Hickey, AJ; Hong, J; Nachkebia, S; Petzer, A; Phillips, AR; Tun, SM; Windsor, JA, 2018)
"Myoinositol and D-chiroinositol improve insulin resistance in women with obesity and gestational diabetes and in postmenopausal women with metabolic syndrome."	3.83	The effect of combined inositol supplementation on maternal metabolic profile in pregnancies complicated by metabolic syndrome and obesity. ( Blackwell, SC; Facchinetti, F; Ferrari, F; Longo, M; Ontiveros, AE; Refuerzo, JS; Roberts, RP; Saade, MM; Sibai, BM, 2016)
"The purpose of this study was to induce experimental periodontitis in rats previously fed diets containing arginine silicate inositol (ASI) complex and examine the biochemical, immunological, and radiological effects."	3.83	Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis. ( Akdemir, F; Dundar, S; Eltas, A; Hakki, SS; Komorowski, J; Malkoc, S; Ozercan, IH; Sahin, K; Tuzcu, M; Uslu, MO, 2016)
"The aim of study was to search for new biomarkers with a magnetic resonance technique to identify the early stages of dementia, induced by D-galactose, and evaluate Simvastatin therapy."	3.81	Neuronal marker recovery after Simvastatin treatment in dementia in the rat brain: in vivo magnetic resonance study. ( Dubovický, M; Kašparová, S; Kucharská, J; Liptaj, T; Lipták, B; Sumbalová, Z; Szomolányi, P; Trattnig, S; Tušková, R; Uličná, O; Vančová, O, 2015)
" The enzymatic activity of IMPase is inhibited by lithium, a drug used for the treatment of mood swings seen in bipolar disorder."	3.80	Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis. ( Gondo, Y; Hida, A; Iwayama, Y; Mishima, K; Murata, T; Ohba, H; Ohnishi, T; Watanabe, A; Yoshikawa, T, 2014)
" In this study, we investigated the metabolism in the thalamus to identify the changes that occur following Coriaria lactone (CL)-induced status epilepticus (SE) and to observe whether the epileptiform discharges could present a difference between the left and right thalami."	3.78	Longitudinal ¹H MRS assessment of the thalamus in a Coriaria lactone-induced rhesus monkey status epilepticus model. ( Gong, QY; Li, HX; Li, JM; Wang, L; Yang, ZY; Zhang, XY; Zhou, D, 2012)
"Valproic acid (VPA) is the most widely prescribed epilepsy treatment worldwide, but its mechanism of action remains unclear."	3.78	The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium. ( Bialer, M; Chang, P; Deranieh, RM; Dham, M; Greenberg, ML; Hoeller, O; Orabi, B; Shimshoni, JA; Walker, MC; Williams, RS; Yagen, B, 2012)
"The effect of inositol as an antidepressant was previously demonstrated in both animal models of depression-like behavior and in clinical trials."	3.71	The antidepressant activity of inositol in the forced swim test involves 5-HT(2) receptors. ( Belmaker, RH; Bourin, M; Clenet, F; Einat, H; Shaldubina, A, 2001)
"myo-Inositol is elevated in the Down syndrome (DS; trisomy 21) brain and may play a role in mental retardation."	3.70	Ts65Dn mouse, a Down syndrome model, exhibits elevated myo-inositol in selected brain regions and peripheral tissues. ( Galdzicki, Z; Rapoport, SI; Shetty, HU; Siarey, RJ; Stoll, J, 2000)
"The present study examined the effects of inositol on two animal models of depression: the Porsolt forced swim test, a behaviorally based model; and the reserpine-induced immobility model, a pharmacologically based model."	3.70	Inositol reduces depressive-like behaviors in two different animal models of depression. ( Belmaker, RH; Einat, H; Karbovski, H; Korik, J; Tsalah, D, 1999)
"Lens fiber swelling and related cataractous outgrowth positively correlated to the degree of lens bSMIT gene expression and intralenticular myo-inositol content."	3.70	A transgenic animal model of osmotic cataract. Part 1: over-expression of bovine Na+/myo-inositol cotransporter in lens fibers. ( Cammarata, PR; Chen, G; Kuszak, JR; Reeves, RE; Robinson, ML; Singh, I; Zhou, C, 1999)
"To develop and characterize a new model of galactose-induced cataract formation in young, 3- to 4-week-old Hartley guinea pigs."	3.69	Galactose-induced cataract formation in guinea pigs: morphologic changes and accumulation of galactitol. ( Bekhor, I; Kannan, R; Mackic, JB; McComb, JG; Ross-Cisneros, FN; Weiss, MH; Zlokovic, BV, 1994)
"Rats with portacaval shunts and humans with hepatic encephalopathy show severe myo-inositol depletion in the brain."	3.68	Decrease in cerebral inositols in rats and humans. ( Filippi, D; Lien, YH; Moats, RA; Ross, BD, 1993)
"Patients with type 2 diabetes mellitus (T2DM) have a higher incidence of cardiovascular (CV) events."	2.87	Effects of a Carob-Pod-Derived Sweetener on Glucose Metabolism. ( Badimon, L; Cubedo, J; Hernández-Mijares, A; Lambert, C; López-Bernal, S; Padró, T; Rocha, M; Vilahur, G, 2018)
"Mutants that have only exencephaly are fourfold more frequent than those that have spina bifida aperta with or without exencephaly."	2.46	An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure. ( Harris, MJ; Juriloff, DM, 2010)
"Thus, the Li-pilocarpine seizure model may, despite its lack of face validity, be a biochemical marker for a model of mania treatment in animals."	2.44	Lithium-pilocarpine seizures as a model for lithium action in mania. ( Belmaker, RH; Bersudsky, Y, 2007)
"A striking anticancer action of IP(6) was demonstrated in different experimental models."	2.43	Protection against cancer by dietary IP6 and inositol. ( Shamsuddin, AM; Vucenik, I, 2006)
"A striking anticancer effect of IP6 was demonstrated in different experimental models."	2.42	Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic. ( Shamsuddin, AM; Vucenik, I, 2003)
"Human hepatic encephalopathy (HE) is identified by a new noninvasive test, proton magnetic resonance spectroscopy (1H MRS) applied to the brain in a few minutes."	2.39	Proton magnetic resonance spectroscopy: the new gold standard for diagnosis of clinical and subclinical hepatic encephalopathy? ( Blüml, S; Danielsen, ER; Ross, BD, 1996)
" However, chronic use and overdose can lead to other severe adverse effects."	1.91	Nutraceutical combination ameliorates imiquimod-induced psoriasis in mice. ( Bhuvarahamurthy, S; Kalaiyazhagan, A; Meganathan, J; Ramamoorthy, R; Venugopal, B; Vijayapoopathi, S, 2023)
"Disease progression was investigated at 4 time points, from 9 to 18 months of age, and in 4 regions: cortex, hippocampus, striatum, and thalamus."	1.72	Spatio-temporal metabolic rewiring in the brain of TgF344-AD rat model of Alzheimer's disease. ( López-Gil, X; Muñoz-Moreno, E; Simões, RV; Soria, G; Tudela, R, 2022)
"The HFHFr diet induced severe NAFLD in terms of steatosis, hepatitis, and fibrosis."	1.72	The effects of the voglibose on non-alcoholic fatty liver disease in mice model. ( Bae, J; Cha, BS; Kang, ES; Lee, BW; Lee, JY; Lee, M; Lee, YH; Shin, E, 2022)
"Epilepsy is a severe neurological disease characterized by spontaneous recurrent seizures (SRS)."	1.72	Myo-Inositol Limits Kainic Acid-Induced Epileptogenesis in Rats. ( Burjanadze, M; Dashniani, M; Gamkrelidze, G; Kandashvili, M; Kokaia, M; Lagani, V; Lepsveridze, E; Lordkipanidze, T; Solomonia, R; Tsverava, L, 2022)
"Ulcerative colitis is a recrudescent intestinal inflammation coupled with diarrhea, weight loss, pus, and blood stool, which seriously impacts the quality of patient life."	1.62	Therapeutic role of d-pinitol on experimental colitis via activating Nrf2/ARE and PPAR-γ/NF-κB signaling pathways. ( Cai, J; Lin, Y; Su, J; Su, Z; Sun, Z; Wang, M; Wei, L; Wu, X; Wu, Y; Yi, X, 2021)
"Cardiac hypertrophy was produced in Sprague-Dawley rats by abdominal aortic constriction and treated with lisinopril (15 mg/kg) or pinitol (5, 10, and 20 mg/kg)."	1.62	Elucidation of the mechanism of action of pinitol against pressure overload-induced cardiac hypertrophy and fibrosis in an animal model of aortic stenosis. ( Feng, Z; Hu, X; L V, X; Zhu, Y, 2021)
"Pneumonia was induced in Sprague-Dawley rats by intratracheal administration of LPS (2 mg/kg)."	1.62	Pinitol attenuates LPS-induced pneumonia in experimental animals: Possible role via inhibition of the TLR-4 and NF-κB/IκBα signaling cascade pathway. ( Cao, K; Fan, Y; Feng, Z; Liu, J; Wang, J; Xu, H, 2021)
"Myo-inositol is a precursor of the membrane phospholipid, phosphatidylinositol (PI)."	1.62	Regulated inositol synthesis is critical for balanced metabolism and development in Drosophila melanogaster. ( Contreras, A; Eldon, ED; Klig, LS; Nguyen, LT; Rivera, MJ, 2021)
"Inositols were administered as mixture of myo-inositol and d-chiro-inositol in the drinking water."	1.56	Myo-inositol and d-chiro-inositol oral supplementation ameliorate cardiac dysfunction and remodeling in a mouse model of diet-induced obesity. ( Di Lascio, N; Faita, F; Forini, F; Kusmic, C; L'Abbate, S; Marchetti, S; Nicolini, G, 2020)
"Failure of Alzheimer's disease clinical trials to improve or stabilize cognition has led to the need for a better understanding of the driving forces behind cognitive decline in the presence of active disease processes."	1.56	Regional differences in Alzheimer's disease pathology confound behavioural rescue after amyloid-β attenuation. ( Bazzigaluppi, P; Beckett, TL; Hill, ME; Koletar, MM; McLaurin, J; Morrone, CD; Stefanovic, B, 2020)
"Myo-inositol is an abundant carbohydrate in the environment and in certain organs of the human body, especially the brain."	1.51	Myo-inositol utilization by Citrobacter koseri promotes brain infection. ( Jiang, L; Wang, J; Yang, P; Yuan, C, 2019)
"Lipopolysaccharide (LPS)-induced encephalopathy induces neuroinflammation."	1.51	Anti-inflammatory agent, OKN-007, reverses long-term neuroinflammatory responses in a rat encephalopathy model as assessed by multi-parametric MRI: implications for aging-associated neuroinflammation. ( Gulej, R; Lawrence, B; McKenzie, T; Morton, KA; Saunders, D; Smith, N; Towner, RA, 2019)
"Diabetic gastroparesis is a common complication of diabetes mellitus (DM) that is characterized by decreased serum insulin and insulin-like growth factor-1 (IGF-1)."	1.46	Impaired insulin/IGF-1 is responsible for diabetic gastroparesis by damaging myenteric cholinergic neurones and interstitial cells of Cajal. ( Han, K; Ji, F; Li, D; Sun, H; Sun, T; Wu, B; Yang, S; Zhang, G; Zhou, D, 2017)
"Gaucher disease is an autosomal recessive disease, caused by a lack or functional deficiency of the lysosomal enzyme, glucocerebrosidase (GCase)."	1.42	Glucocerebrosidase deficiency and mitochondrial impairment in experimental Parkinson disease. ( Alvarez-Fischer, D; Andreas, H; Hirsch, EC; Höglinger, GU; Höllerhage, M; Lu, L; Noelker, C; Oertel, WH; Roscher, R; Sturn, A; Vulinovic, F, 2015)
"Atherosclerosis is a multifactorial and progressive disease commonly correlated with a high fat diet."	1.40	Serum metabonomic analysis of apoE(-/-) mice reveals progression axes for atherosclerosis based on NMR spectroscopy. ( Guo, J; Li, J; Li, X; Liu, Y; Wang, L; Wu, T; Yang, Y; Yuan, F; Zhang, Q; Zheng, L, 2014)
"Myo-inositol (mIns) is a marker of glial cells proliferation and has been shown to increase in early Alzheimer's disease (AD) pathology."	1.39	MICEST: a potential tool for non-invasive detection of molecular changes in Alzheimer's disease. ( Cai, K; Crescenzi, R; Hariharan, H; Haris, M; Kogan, F; Nath, K; Reddy, R; Singh, A, 2013)
"Phytic acid (PA) also acts as a natural antioxidant and may have numerous health benefits."	1.37	Green tea, phytic acid, and inositol in combination reduced the incidence of azoxymethane-induced colon tumors in Fisher 344 male rats. ( Davis, S; Khatiwada, J; Verghese, M; Williams, LL, 2011)
"Tumors were found to arise in the seminal vesicles and dorsal and anterior prostate lobes."	1.35	The effect of dietary supplementation with limonene or myo-inositol on the induction of neoplasia and matrix metalloproteinase and plasminogen activator activities in accessory sex organs of male Lobund-Wistar rats. ( Lindgren, BR; Sinha, AA; Wilson, MJ, 2008)
"Chronic inflammation is a well-recognized risk factor for the development of human cancer."	1.35	Inflammatory bowel disease: a model of chronic inflammation-induced cancer. ( Liao, J; Taboada, S; Yang, GY, 2009)
"Although hydrocephalus is usually considered a disorder of periventricular white matter, disturbance of gray matter is probably also involved."	1.35	Gray matter metabolism in acute and chronic hydrocephalus. ( Eyjolfsson, EM; Kondziella, D; Risa, O; Saether, O; Sonnewald, U, 2009)
"Prion diseases are fatal chronic neurodegenerative diseases."	1.34	MRI and MRS alterations in the preclinical phase of murine prion disease: association with neuropathological and behavioural changes. ( Anthony, DC; Blamire, AM; Broom, KA; Griffin, JL; Lowe, JP; Perry, VH; Scott, H; Sibson, NR; Styles, P, 2007)
"Myoinositol-treated animals had significantly fewer demyelinating lesions than mannitol (2."	1.33	Myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats. ( Rojiani, AM; Schroeder, BM; Silver, SM; Sterns, RH, 2006)
"Despite progress in defining a pathogenic role for amyloid beta protein (Abeta) in Alzheimer's disease, orally bioavailable compounds that prevent its effects on hippocampal synaptic plasticity and cognitive function have not yet emerged."	1.33	Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers. ( Cleary, JP; Hofmeister, J; Lesne, S; Mehta, T; O'Hare, E; Selkoe, DJ; Townsend, M; Walsh, DM, 2006)
"Pretreatment with pargyline attenuated the MPTP-induced clinical signs, MRI and MRS changes, and the histopathological and immunoreactivity alterations."	1.32	Proton magnetic resonance imaging and spectroscopy identify metabolic changes in the striatum in the MPTP feline model of parkinsonism. ( Hadjiconstantinou, M; Neff, NH; Podell, M; Smith, MA, 2003)
"Inositol is a simple polyol precursor in a second messenger system important in brain myo-insitol, the natural isomer, which has been found to be therapeutically effective in depression, panic disorder, and obsessive-compulsive disorder in double-blind controlled trials."	1.30	Epi-inositol and inositol depletion: two new treatment approaches in affective disorder. ( Belmaker, RH; Bersudsky, Y; Einat, H; Stahl, Z, 1999)
"Myo-inositol is an important precursor in cellular second-messenger synthesis."	1.29	The effect of peripheral inositol injection on rat motor activity models of depression. ( Alpert, C; Belmaker, RH; Bersudsky, Y; Kofman, O; Vinnitsky, I, 1993)
"myo-Inositol uptake was restored to normal in a time-dependent manner during recovery of islets at 5."	1.29	Insulin secretion, myo-inositol transport, and Na(+)-K(+)-ATPase in glucose-desensitized rat islets. ( Laychock, SG; Xia, M, 1993)
"myo-Inositol was found to be selectively elevated in the brain of the trisomy 16 mouse."	1.29	Brain accumulation of myo-inositol in the trisomy 16 mouse, an animal model of Down's syndrome. ( Acevedo, LD; Galdzicki, Z; Holloway, HW; Shetty, HU, 1996)
"Inositol was diminished in diabetes to 0."	1.28	Myocardial inositol and sodium in diabetes. ( Beyer-Mears, A; Fusilli, LD; Regan, TJ; Torres, R, 1992)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (6.75)	18.7374
1990's	18 (11.04)	18.2507
2000's	37 (22.70)	29.6817
2010's	72 (44.17)	24.3611
2020's	25 (15.34)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Ambroxol as a Novel Disease Modifying Treatment for Lewy Body Dementia[NCT04405596]	Phase 1/Phase 2	15 participants (Anticipated)	Interventional	2025-01-31	Not yet recruiting
Dietary Supplement N-acetylcysteine (NAC) as a Novel Complementary Medicine to Improve Cognitive Disfunction in Schizophrenia[NCT01885338]	Phase 1	26 participants (Actual)	Interventional	2013-06-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Therapeutic approaches employing natural compounds and derivatives for treating bipolar disorder: emphasis on experimental models of the manic phase. Metabolic brain disease, 2021, Volume: 36, Issue:7 Topics: Animals; Biological Products; Bipolar Disorder; Disease Models, Animal; Fatty Acids, Omega-3; Gallic	2021
Proton MRS in mild cognitive impairment. Journal of magnetic resonance imaging : JMRI, 2013, Volume: 37, Issue:4 Topics: Alzheimer Disease; Animals; Aspartic Acid; Biomarkers; Brain; Choline; Cognitive Dysfunction; Creati	2013
Cerebrovascular contributions to Alzheimer's disease pathophysiology and potential therapeutic interventions in mouse models. The European journal of neuroscience, 2013, Volume: 37, Issue:12 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cerebral Hemorrha	2013
Inositol, neural tube closure and the prevention of neural tube defects. Birth defects research, 2017, 01-30, Volume: 109, Issue:2 Topics: Animals; Clinical Trials as Topic; Dietary Supplements; Disease Models, Animal; Female; Folic Acid;	2017
An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure. Birth defects research. Part A, Clinical and molecular teratology, 2010, Volume: 88, Issue:8 Topics: Animals; Ciliary Motility Disorders; Disease Models, Animal; Epigenomics; Female; Folic Acid; Humans	2010
Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic. The Journal of nutrition, 2003, Volume: 133, Issue:11 Suppl 1 Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Carcinogens; Colonic Neoplasms; Disease Mod	2003
Protection against cancer by dietary IP6 and inositol. Nutrition and cancer, 2006, Volume: 55, Issue:2 Topics: Animals; Antineoplastic Agents; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic	2006
Lithium-pilocarpine seizures as a model for lithium action in mania. Neuroscience and biobehavioral reviews, 2007, Volume: 31, Issue:6 Topics: Animals; Antimanic Agents; Bipolar Disorder; Disease Models, Animal; Humans; Inositol; Limbic System	2007
The axonopathy of diabetic neuropathy. Diabetes, 1982, Volume: 31, Issue:4 Pt 1 Topics: Animals; Axons; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Edem	1982
Proton magnetic resonance spectroscopy: the new gold standard for diagnosis of clinical and subclinical hepatic encephalopathy? Digestive diseases (Basel, Switzerland), 1996, Volume: 14 Suppl 1 Topics: Animals; Astrocytes; Brain; Choline; Cognition Disorders; Disease Models, Animal; Glutamine; Hepatic	1996
What are the molecular mechanisms of neural tube defects? BioEssays : news and reviews in molecular, cellular and developmental biology, 1998, Volume: 20, Issue:1 Topics: Animals; Disease Models, Animal; Drug Resistance; Female; Folic Acid; Humans; Inositol; Mice; Mice,	1998
The effects of inositol treatment in animal models of psychiatric disorders. Journal of affective disorders, 2001, Volume: 62, Issue:1-2 Topics: Affect; Animals; Arousal; Depressive Disorder; Disease Models, Animal; Humans; Inositol; Mental Diso	2001
Metabolic abnormalities contributing to diabetic complications. II. Peripheral nerves. The American journal of clinical nutrition, 1976, Volume: 29, Issue:4 Topics: Animals; Axons; Cricetinae; Diabetes Mellitus; Diabetic Neuropathies; Disease Models, Animal; Glucos	1976
[Diabetic neuropathy--a review of pathological studies]. Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49 Suppl Topics: Adolescent; Adult; Aged; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Mo	1991
Pathogenesis of diabetic neuropathy: role of altered phosphoinositide metabolism. Critical reviews in neurobiology, 1989, Volume: 5, Issue:2 Topics: Animals; Diabetic Neuropathies; Disease Models, Animal; Humans; Inositol; Neural Conduction; Periphe	1989

Article	Year
Myo-inositol reduces β-catenin activation in colitis. World journal of gastroenterology, 2017, Jul-28, Volume: 23, Issue:28 Topics: Animals; beta Catenin; Biomarkers, Tumor; Biopsy; Cell Nucleus; Cell Proliferation; Colitis, Ulcerat	2017
Effects of a Carob-Pod-Derived Sweetener on Glucose Metabolism. Nutrients, 2018, Feb-27, Volume: 10, Issue:3 Topics: Adolescent; Adult; Aged; Animals; Beverages; Blood Glucose; Body Mass Index; Complement C4a; Diabete	2018

Article	Year
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49 Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr	2020
Phosphoproteomics analysis of diabetic cardiomyopathy in aging-accelerated mice and effects of D-pinitol. Proteomics. Clinical applications, 2022, Volume: 16, Issue:1 Topics: Aging; Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Disease Model	2022
Regulated inositol synthesis is critical for balanced metabolism and development in Drosophila melanogaster. Biology open, 2021, 10-15, Volume: 10, Issue:10 Topics: Animals; Diet, Carbohydrate Loading; Disease Models, Animal; Drosophila melanogaster; Inositol; Larv	2021
Myo-Inositol Limits Kainic Acid-Induced Epileptogenesis in Rats. International journal of molecular sciences, 2022, Jan-21, Volume: 23, Issue:3 Topics: Animals; Antinematodal Agents; Disease Models, Animal; Epilepsy; Inositol; Kainic Acid; Male; Memory	2022
PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment. Journal for immunotherapy of cancer, 2022, Volume: 10, Issue:3 Topics: Animals; Carcinogenesis; CD8-Positive T-Lymphocytes; Class I Phosphatidylinositol 3-Kinases; Disease	2022
Hypoxic Preconditioning Averts Sporadic Alzheimer's Disease-Like Phenotype in Rats: A Focus on Mitochondria. Antioxidants & redox signaling, 2022, Volume: 37, Issue:10-12 Topics: Alzheimer Disease; Animals; Disease Models, Animal; DNA, Mitochondrial; Glial Fibrillary Acidic Prot	2022
Dietary administration of D-chiro-inositol attenuates sex-specific metabolic imbalances in the 5xFAD mouse model of Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 150 Topics: Alzheimer Disease; Animals; Disease Models, Animal; Female; Humans; Inositol; Insulin; Insulin Resis	2022
The effects of the voglibose on non-alcoholic fatty liver disease in mice model. Scientific reports, 2022, 08-10, Volume: 12, Issue:1 Topics: Animals; Diet, High-Fat; Disease Models, Animal; Fructose; Glucose; Glycoside Hydrolase Inhibitors;	2022
Spatio-temporal metabolic rewiring in the brain of TgF344-AD rat model of Alzheimer's disease. Scientific reports, 2022, 10-10, Volume: 12, Issue:1 Topics: Alzheimer Disease; Animals; Brain; Choline; Creatine; Disease Models, Animal; Disease Progression; G	2022
Pharmacokinetics of International journal of molecular sciences, 2022, Sep-24, Volume: 23, Issue:19 Topics: Animals; Disease Models, Animal; Inositol; Lipids; Rats; Rats, Wistar; Water	2022
Nutraceutical combination ameliorates imiquimod-induced psoriasis in mice. Chemical biology & drug design, 2023, Volume: 102, Issue:6 Topics: Animals; Cannabidiol; Dietary Supplements; Disease Models, Animal; Erythema; Humans; Imiquimod; Inos	2023
A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding. Journal of thrombosis and haemostasis : JTH, 2019, Volume: 17, Issue:12 Topics: Allosteric Regulation; Animals; Anticoagulants; Blood Coagulation; Chlorides; Disease Models, Animal	2019
Profiles of brain oxidative damage, ventricular alterations, and neurochemical metabolites in the striatum of PINK1 knockout rats as functions of age and gender: Relevance to Parkinson disease. Free radical biology & medicine, 2019, 11-01, Volume: 143 Topics: Animals; Aspartic Acid; Biomarkers; Brain; Corpus Striatum; Disease Models, Animal; Female; Gene Kno	2019
Anti-inflammatory agent, OKN-007, reverses long-term neuroinflammatory responses in a rat encephalopathy model as assessed by multi-parametric MRI: implications for aging-associated neuroinflammation. GeroScience, 2019, Volume: 41, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Aspartic Acid; Benzenesulfonates; Brain Diseases; Cerebral Cortex	2019
The effects of myo-inositol and probiotic supplementation in a high-fat-fed preclinical model of glucose intolerance in pregnancy. The British journal of nutrition, 2020, 03-14, Volume: 123, Issue:5 Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes, Gestational; Diet, High-Fat; Dietary Supplements;	2020
Regional differences in Alzheimer's disease pathology confound behavioural rescue after amyloid-β attenuation. Brain : a journal of neurology, 2020, 01-01, Volume: 143, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Cognition; Disease Models, Anim	2020
Maternal Supplementation of Inositols, Fucoxanthin, and Hydroxytyrosol in Pregnant Murine Models of Hypertension. American journal of hypertension, 2020, 07-18, Volume: 33, Issue:7 Topics: Animals; Antioxidants; Dietary Supplements; Disease Models, Animal; Drug Evaluation, Preclinical; Dr	2020
Alpha-Glucosidase Inhibitor Voglibose Suppresses Azoxymethane-Induced Colonic Preneoplastic Lesions in Diabetic and Obese Mice. International journal of molecular sciences, 2020, Mar-23, Volume: 21, Issue:6 Topics: Animals; Antioxidants; Azoxymethane; Biomarkers; Biopsy; Cell Proliferation; Colonic Neoplasms; Cyto	2020
Myo-inositol and d-chiro-inositol oral supplementation ameliorate cardiac dysfunction and remodeling in a mouse model of diet-induced obesity. Pharmacological research, 2020, Volume: 159 Topics: Action Potentials; Administration, Oral; Animals; Arrhythmias, Cardiac; Diet, High-Fat; Dietary Supp	2020
D-Chiro-Inositol Treatment Affects Oocyte and Embryo Quality and Improves Glucose Intolerance in Both Aged Mice and Mouse Models of Polycystic Ovarian Syndrome. International journal of molecular sciences, 2020, Aug-22, Volume: 21, Issue:17 Topics: Aging; Animals; Blastocyst; Cumulus Cells; Dihydrotestosterone; Disease Models, Animal; Female; Gene	2020
Diet Alters Micronutrient Pathways in the Gut and Placenta that Regulate Fetal Growth and Development in Pregnant Mice. Reproductive sciences (Thousand Oaks, Calif.), 2021, Volume: 28, Issue:2 Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Caloric Restriction; Diet; Diet, H	2021
Pinitol attenuates LPS-induced pneumonia in experimental animals: Possible role via inhibition of the TLR-4 and NF-κB/IκBα signaling cascade pathway. Journal of biochemical and molecular toxicology, 2021, Volume: 35, Issue:1 Topics: Animals; Cytokines; Disease Models, Animal; Inositol; Lipopolysaccharides; Male; NF-kappa B; NF-Kapp	2021
Promising Anti-stroke Signature of Voglibose: Investigation through In- Silico Molecular Docking and Virtual Screening in In-Vivo Animal Studies. Current gene therapy, 2020, Volume: 20, Issue:3 Topics: Animals; Cerebrovascular Disorders; Computer Simulation; Diabetes Mellitus, Experimental; Diabetes M	2020
Neural tube defects: role of lithium carbonate exposure in embryonic neural development in a murine model. Pediatric research, 2021, Volume: 90, Issue:1 Topics: 5'-Nucleotidase; Animals; Central Nervous System; Disease Models, Animal; Female; Glycogen Synthase	2021
Elucidation of the mechanism of action of pinitol against pressure overload-induced cardiac hypertrophy and fibrosis in an animal model of aortic stenosis. Bioscience, biotechnology, and biochemistry, 2021, Feb-24, Volume: 85, Issue:3 Topics: Animals; Cardiomegaly; Disease Models, Animal; Gene Expression Profiling; Heart Function Tests; Inos	2021
Therapeutic role of d-pinitol on experimental colitis via activating Nrf2/ARE and PPAR-γ/NF-κB signaling pathways. Food & function, 2021, Mar-21, Volume: 12, Issue:6 Topics: Animals; Colitis; Dietary Supplements; Disease Models, Animal; Inositol; Male; Mice; Mice, Inbred BA	2021
High Doses of D-Chiro-Inositol Alone Induce a PCO-Like Syndrome and Other Alterations in Mouse Ovaries. International journal of molecular sciences, 2021, May-26, Volume: 22, Issue:11 Topics: Animals; Disease Models, Animal; Female; Humans; Inositol; Mice; Ovary; Polycystic Ovary Syndrome	2021
Protective Effect of Pinitol Against Inflammatory Mediators of Rheumatoid Arthritis via Inhibition of Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22). Medical science monitor : international medical journal of experimental and clinical research, 2017, Apr-21, Volume: 23 Topics: Animals; Antioxidants; Arthritis, Rheumatoid; Cytokines; Disease Models, Animal; Indomethacin; Infla	2017
D-chiro-inositol effectively attenuates cholestasis in bile duct ligated rats by improving bile acid secretion and attenuating oxidative stress. Acta pharmacologica Sinica, 2018, Volume: 39, Issue:2 Topics: Alanine Transaminase; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aspartate Am	2018
Novel therapeutic roles for surfactant-inositols and -phosphatidylglycerols in a neonatal piglet ARDS model: a translational study. American journal of physiology. Lung cellular and molecular physiology, 2018, 01-01, Volume: 314, Issue:1 Topics: Animals; Animals, Newborn; Apoptosis; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Anima	2018
Synthesis and preliminary in vivo evaluation of new [ Bioorganic & medicinal chemistry, 2017, 10-15, Volume: 25, Issue:20 Topics: Animals; Breast Neoplasms; Disease Models, Animal; Female; Fluorine Radioisotopes; Humans; Inositol;	2017
Impaired insulin/IGF-1 is responsible for diabetic gastroparesis by damaging myenteric cholinergic neurones and interstitial cells of Cajal. Bioscience reports, 2017, Oct-31, Volume: 37, Issue:5 Topics: Animals; Antigens, CD; Choline O-Acetyltransferase; Cholinergic Neurons; Diabetes Complications; Dis	2017
Investigating the efficacy of a combination Aβ-targeted treatment in a mouse model of Alzheimer's disease. Brain research, 2018, Jan-01, Volume: 1678 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Blood-Brain Barri	2018
Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol. International journal of cancer, 2018, 04-01, Volume: 142, Issue:7 Topics: Animals; Anticarcinogenic Agents; Disease Models, Animal; Humans; Inositol; Interleukin-6; Lung Neop	2018
D-chiro-inositol enriched Fagopyrum tataricum (L.) Gaench extract alleviates mitochondrial malfunction and inhibits ER stress/JNK associated inflammation in the endothelium. Journal of ethnopharmacology, 2018, Mar-25, Volume: 214 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Caspase 3; Cells, Cultured; Diet, High-Fat; Disease	2018
Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis. ACS infectious diseases, 2018, 05-11, Volume: 4, Issue:5 Topics: Animals; Bacterial Proteins; Binding Sites; Cysteine; Disease Models, Animal; Enzyme Activation; Fem	2018
Modulation of β-glucocerebrosidase increases α-synuclein secretion and exosome release in mouse models of Parkinson's disease. Human molecular genetics, 2018, 05-15, Volume: 27, Issue:10 Topics: alpha-Synuclein; Animals; Brain; Disease Models, Animal; Exosomes; Glucosylceramidase; Humans; Inosi	2018
Characterization of SNF472 pharmacokinetics and efficacy in uremic and non-uremic rats models of cardiovascular calcification. PloS one, 2018, Volume: 13, Issue:5 Topics: Animals; Calcinosis; Cardiovascular Diseases; Cholecalciferol; Disease Models, Animal; Disease Progr	2018
Altered Metabolic Profile of Triglyceride-Rich Lipoproteins in Gut-Lymph of Rodent Models of Sepsis and Gut Ischemia-Reperfusion Injury. Digestive diseases and sciences, 2018, Volume: 63, Issue:12 Topics: Animals; Biomarkers; Chromatography, Liquid; Chyle; Disease Models, Animal; Gastrointestinal Absorpt	2018
Myo-inositol and D-chiro-inositol (40:1) reverse histological and functional features of polycystic ovary syndrome in a mouse model. Journal of cellular physiology, 2019, Volume: 234, Issue:6 Topics: Animals; Body Weight; Disease Models, Animal; Female; Granulosa Cells; Inositol; Light; Male; Mice,	2019
Neuro-metabolite profiles of rodent models of psychiatric dysfunctions characterised by MR spectroscopy. Neuropharmacology, 2019, 03-01, Volume: 146 Topics: Anhedonia; Animals; Choline; Depression; Disease Models, Animal; Excitatory Amino Acid Antagonists;	2019
Development and biochemical characterization of a mouse model of Parkinson's disease bearing defective glucocerebrosidase activity. Neurobiology of disease, 2019, Volume: 124 Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Glucosylceramidase; Inositol; Male; Mice; Mice,	2019
In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling. The FEBS journal, 2019, Volume: 286, Issue:3 Topics: Animals; beta-Glucosidase; Brain; Cyclohexanols; Disease Models, Animal; Enzyme Assays; Glucosylcera	2019
Myoinositol CEST signal in animals with increased Iba-1 levels in response to an inflammatory challenge-Preliminary findings. PloS one, 2019, Volume: 14, Issue:2 Topics: Alzheimer Disease; Animals; Calcium-Binding Proteins; Disease Models, Animal; Female; Image Interpre	2019
Myo-inositol utilization by Citrobacter koseri promotes brain infection. Biochemical and biophysical research communications, 2019, 09-24, Volume: 517, Issue:3 Topics: Animals; Bacterial Proteins; Biological Transport; Brain; Citrobacter koseri; Disease Models, Animal	2019
Premature impairment of methylation pathway and cardiac metabolic dysfunction in fa/fa obese Zucker rats. Journal of proteome research, 2013, Apr-05, Volume: 12, Issue:4 Topics: Adipose Tissue, White; Age Factors; Animals; Betaine; Disease Models, Animal; Inositol; Liver; Magne	2013
Combination therapy in a transgenic model of Alzheimer's disease. Experimental neurology, 2013, Volume: 250 Topics: Alzheimer Disease; Animals; Behavior, Animal; Brain; Cognition; Disease Models, Animal; Drug Therapy	2013
Treatment effects in a transgenic mouse model of Alzheimer's disease: a magnetic resonance spectroscopy study after passive immunization. Neuroscience, 2014, Feb-14, Volume: 259 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Br	2014
Neuroinflammation and α-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction. Molecular genetics and metabolism, 2014, Volume: 111, Issue:2 Topics: alpha-Synuclein; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Evoked Potentials, Moto	2014
Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis. The Journal of biological chemistry, 2014, Apr-11, Volume: 289, Issue:15 Topics: Amino Acid Sequence; Animals; Behavior, Animal; Bipolar Disorder; Brain; Brain Diseases; Circadian R	2014
Multiple pathogenic proteins implicated in neuronopathic Gaucher disease mice. Human molecular genetics, 2014, Aug-01, Volume: 23, Issue:15 Topics: alpha-Synuclein; Amyloid beta-Protein Precursor; Animals; beta-Glucosidase; Cells, Cultured; Cerebra	2014
Rescue of cognitive-aging by administration of a neurogenic and/or neurotrophic compound. Neurobiology of aging, 2014, Volume: 35, Issue:9 Topics: Administration, Oral; Aging; Alzheimer Disease; Animals; Ciliary Neurotrophic Factor; Cognition Diso	2014
Inositoylated platelet-activating factor (Ino-C2-PAF) modulates dynamic lymphocyte-endothelial cell interactions and alleviates psoriasis-like skin inflammation in two complementary mouse models. The Journal of investigative dermatology, 2014, Volume: 134, Issue:10 Topics: Animals; Apoptosis; Cell Communication; Cells, Cultured; Disease Models, Animal; E-Selectin; Endothe	2014
Influence of an antidiabetic drug on biomechanical and histological parameters around implants in type 2 diabetic rats. Implant dentistry, 2014, Volume: 23, Issue:3 Topics: Alveolar Process; Animals; Biomechanical Phenomena; Dental Implants; Dental Stress Analysis; Diabete	2014
Insulin-mimicking bioactivities of acylated inositol glycans in several mouse models of diabetes with or without obesity. PloS one, 2014, Volume: 9, Issue:6 Topics: 3T3-L1 Cells; Adipocytes; Animal Feed; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dise	2014
Serum metabonomic analysis of apoE(-/-) mice reveals progression axes for atherosclerosis based on NMR spectroscopy. Molecular bioSystems, 2014, Volume: 10, Issue:12 Topics: Animals; Atherosclerosis; Biomarkers; Cholesterol, HDL; Cholesterol, LDL; Choline; Diet, High-Fat; D	2014
Longitudinal cerebral metabolic changes in pig-tailed macaques infected with the neurovirulent virus SIVsmmFGb. Journal of neurovirology, 2014, Volume: 20, Issue:6 Topics: Animals; Aspartic Acid; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Choline; Corpus Stri	2014
Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion. EMBO molecular medicine, 2015, Volume: 7, Issue:2 Topics: Animals; Anticonvulsants; Antitubercular Agents; Autophagy; Carbamazepine; Cell Line; Disease Models	2015
MRZ-99030 - A novel modulator of Aβ aggregation: II - Reversal of Aβ oligomer-induced deficits in long-term potentiation (LTP) and cognitive performance in rats and mice. Neuropharmacology, 2015, Volume: 92 Topics: Amyloid beta-Peptides; Animals; Calcium; Cognition Disorders; Conditioning, Operant; Culture Media,	2015
Neuronal marker recovery after Simvastatin treatment in dementia in the rat brain: in vivo magnetic resonance study. Behavioural brain research, 2015, May-01, Volume: 284 Topics: Animals; Aspartic Acid; Biomarkers; Brain; Dementia; Dipeptides; Disease Models, Animal; Galactose;	2015
¹H- and ¹³C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996), 2015, Volume: 122, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Br	2015
Myo-inositol is a promising treatment for the prevention of ovarian hyperstimulation syndrome (OHSS): an animal study. Archives of gynecology and obstetrics, 2015, Volume: 292, Issue:5 Topics: Animals; Cyclooxygenase 1; Disease Models, Animal; Estradiol; Female; Inositol; Membrane Proteins; O	2015
Myo-inositol improves the host's ability to eliminate balofloxacin-resistant Escherichia coli. Scientific reports, 2015, Jun-01, Volume: 5 Topics: Adaptation, Biological; Animals; Anti-Bacterial Agents; Biomarkers; Computational Biology; Disease M	2015
A 1H-NMR-Based Metabonomic Study on the Anti-Depressive Effect of the Total Alkaloid of Corydalis Rhizoma. Molecules (Basel, Switzerland), 2015, May-29, Volume: 20, Issue:6 Topics: Alkaloids; Amino Acids; Animals; Antidepressive Agents; Biomarkers; Blood Glucose; Corydalis; Depres	2015
Glucocerebrosidase deficiency and mitochondrial impairment in experimental Parkinson disease. Journal of the neurological sciences, 2015, Sep-15, Volume: 356, Issue:1-2 Topics: 1-Deoxynojirimycin; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cell Count; Cells,	2015
QIAD assay for quantitating a compound's efficacy in elimination of toxic Aβ oligomers. Scientific reports, 2015, Sep-23, Volume: 5 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Carrier Proteins; Catechin; Disease Models, Anima	2015
Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy. Diabetes, 2016, Volume: 65, Issue:1 Topics: Animals; Carnitine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal;	2016
D-Pinitol Protects Against Carbon Tetrachloride-Induced Hepatotoxicity in Rats. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2015, Volume: 34, Issue:4 Topics: Animals; Antioxidants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models,	2015
CNS-accessible Inhibitor of Glucosylceramide Synthase for Substrate Reduction Therapy of Neuronopathic Gaucher Disease. Molecular therapy : the journal of the American Society of Gene Therapy, 2016, Volume: 24, Issue:6 Topics: Administration, Oral; Animals; Carbamates; Central Nervous System; Disease Models, Animal; Enzyme In	2016
An in vivo invertebrate evaluation system for identifying substances that suppress sucrose-induced postprandial hyperglycemia. Scientific reports, 2016, 05-19, Volume: 6 Topics: Acarbose; Animals; Bombyx; Dietary Sucrose; Disease Models, Animal; Glucose; Glycoside Hydrolase Inh	2016
Delineating pathological pathways in a chemically induced mouse model of Gaucher disease. The Journal of pathology, 2016, Volume: 239, Issue:4 Topics: Animals; Disease Models, Animal; Gaucher Disease; Gene Expression Profiling; Inositol; Mice	2016
The effect of combined inositol supplementation on maternal metabolic profile in pregnancies complicated by metabolic syndrome and obesity. American journal of obstetrics and gynecology, 2016, Volume: 215, Issue:4 Topics: Animals; Biomarkers; Blood Glucose; Dietary Supplements; Disease Models, Animal; Female; Gastric Inh	2016
Effects of hypotension and/or hypocapnia during sevoflurane anesthesia on perfusion and metabolites in the developing brain of piglets-a blinded randomized study. Paediatric anaesthesia, 2016, Volume: 26, Issue:9 Topics: Anesthetics, Inhalation; Animals; Aspartic Acid; Brain; Choline; Disease Models, Animal; Female; Hyp	2016
Chronic psychosocial stress in mice leads to changes in brain functional connectivity and metabolite levels comparable to human depression. NeuroImage, 2016, Nov-15, Volume: 142 Topics: Amygdala; Animals; Behavior, Animal; Connectome; Depression; Diffusion Tensor Imaging; Disease Model	2016
Identification of Modifier Genes in a Mouse Model of Gaucher Disease. Cell reports, 2016, 09-06, Volume: 16, Issue:10 Topics: Animals; Base Sequence; Disease Models, Animal; Gaucher Disease; Genes, Modifier; Genome-Wide Associ	2016
Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis. Drug design, development and therapy, 2016, Volume: 10 Topics: Animals; Arginine; Diet; Disease Models, Animal; Drug Combinations; Female; Gingiva; Inositol; Ligat	2016
The Effects of Myo-Inositol and B and D Vitamin Supplementation in the db/+ Mouse Model of Gestational Diabetes Mellitus. Nutrients, 2017, Feb-15, Volume: 9, Issue:2 Topics: Adipose Tissue; Animals; Diabetes Mellitus, Experimental; Diabetes, Gestational; Dietary Supplements	2017
The effect of dietary supplementation with limonene or myo-inositol on the induction of neoplasia and matrix metalloproteinase and plasminogen activator activities in accessory sex organs of male Lobund-Wistar rats. Experimental and molecular pathology, 2008, Volume: 85, Issue:2 Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Cyclohexenes; Dietary Supplements; Disease Mode	2008
D-chiro-inositol-enriched tartary buckwheat bran extract lowers the blood glucose level in KK-Ay mice. Journal of agricultural and food chemistry, 2008, Nov-12, Volume: 56, Issue:21 Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dietary Fiber; Disease Models, Animal; Fagopyrum;	2008
Gray matter metabolism in acute and chronic hydrocephalus. Neuroscience, 2009, Mar-17, Volume: 159, Issue:2 Topics: Analysis of Variance; Animals; Aspartic Acid; Brain; Brain Chemistry; Brain Mapping; Creatine; Disea	2009
Inflammatory bowel disease: a model of chronic inflammation-induced cancer. Methods in molecular biology (Clifton, N.J.), 2009, Volume: 511 Topics: Animals; Antineoplastic Agents; Antioxidants; Cell Transformation, Neoplastic; Colorectal Neoplasms;	2009
Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature, 2009, Jun-25, Volume: 459, Issue:7250 Topics: Animals; Calcineurin; Calcium-Binding Proteins; Catechols; Cells, Cultured; Disease Models, Animal;	2009
In vivo proton magnetic resonance spectroscopy reveals region specific metabolic responses to SIV infection in the macaque brain. BMC neuroscience, 2009, Jun-22, Volume: 10 Topics: Animals; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Disease Models, Animal; Female; Ino	2009
Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism. Neurotoxicology, 2009, Volume: 30, Issue:6 Topics: alpha-Synuclein; Analysis of Variance; Animals; Cell Differentiation; Disease Models, Animal; Dose-R	2009
Magnetic resonance spectroscopy of regional brain metabolite markers in FALS mice and the effects of dietary creatine supplementation. The European journal of neuroscience, 2009, Volume: 30, Issue:11 Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Biomarkers; Brain; Creatine; Disease Models,	2009
Desipramine attenuates forced swim test-induced behavioral and neurochemical alterations in mice: an in vivo(1)H-MRS study at 9.4T. Brain research, 2010, Aug-12, Volume: 1348 Topics: Animals; Behavior, Animal; Brain Chemistry; Choline; Creatine; Desipramine; Disease Models, Animal;	2010
Accumulation and distribution of α-synuclein and ubiquitin in the CNS of Gaucher disease mouse models. Molecular genetics and metabolism, 2011, Volume: 102, Issue:4 Topics: Age Factors; alpha-Synuclein; Animals; beta-Glucosidase; Brain; Disease Models, Animal; Gaucher Dise	2011
Green tea, phytic acid, and inositol in combination reduced the incidence of azoxymethane-induced colon tumors in Fisher 344 male rats. Journal of medicinal food, 2011, Volume: 14, Issue:11 Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protoco	2011
The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium. Disease models & mechanisms, 2012, Volume: 5, Issue:1 Topics: Animals; Anticonvulsants; Dictyostelium; Disease Models, Animal; Dose-Response Relationship, Drug; E	2012
N-acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development. Biological psychiatry, 2012, Jun-01, Volume: 71, Issue:11 Topics: Acetylcysteine; Alanine; Animals; Aspartic Acid; Cerebral Cortex; Disease Models, Animal; Free Radic	2012
In vivo uptake of β-amyloid by non-plaque associated microglia. Current Alzheimer research, 2012, Volume: 9, Issue:8 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Enzyme-Linked Immu	2012
Longitudinal ¹H MRS assessment of the thalamus in a Coriaria lactone-induced rhesus monkey status epilepticus model. NMR in biomedicine, 2012, Volume: 25, Issue:10 Topics: Animals; Creatinine; Disease Models, Animal; Glutamic Acid; Inositol; Lactones; Macaca mulatta; Magn	2012
Imaging brain neuronal activity using functionalized magnetonanoparticles and MRI. Brain topography, 2012, Volume: 25, Issue:4 Topics: Afferent Pathways; Animals; Brain; Brain Mapping; Convulsants; Dextrans; Disease Models, Animal; Ele	2012
Inhibition of amyloid-beta peptide aggregation rescues the autophagic deficits in the TgCRND8 mouse model of Alzheimer disease. Biochimica et biophysica acta, 2012, Volume: 1822, Issue:10 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autophagy; Brain; Disease Models, Animal; Inosito	2012
Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice. Behavioural brain research, 2012, Nov-01, Volume: 235, Issue:1 Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Cholin	2012
Altered neurochemical profile in the McGill-R-Thy1-APP rat model of Alzheimer's disease: a longitudinal in vivo 1 H MRS study. Journal of neurochemistry, 2012, Volume: 123, Issue:4 Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Choline; Cre	2012
MICEST: a potential tool for non-invasive detection of molecular changes in Alzheimer's disease. Journal of neuroscience methods, 2013, Jan-15, Volume: 212, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Brain Mapping	2013
Cerebral blood flow and metabolic changes in hippocampal regions of a modified rat model with chronic cerebral hypoperfusion. Acta neurologica Belgica, 2013, Volume: 113, Issue:3 Topics: Animals; Aspartic Acid; Cerebrovascular Circulation; Creatine; Disease Models, Animal; Hippocampus;	2013
Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination. Carcinogenesis, 2002, Volume: 23, Issue:9 Topics: Animals; Antineoplastic Agents; Carcinogenicity Tests; Cell Transformation, Neoplastic; Cysteine; Di	2002
Long-term therapeutic effects of voglibose, a potent intestinal alpha-glucosidase inhibitor, in spontaneous diabetic GK rats. Diabetes research and clinical practice, 2003, Volume: 59, Issue:2 Topics: Alkaline Phosphatase; Animals; Blood Glucose; Blotting, Northern; Blotting, Western; Body Weight; Di	2003
Proton magnetic resonance imaging and spectroscopy identify metabolic changes in the striatum in the MPTP feline model of parkinsonism. Experimental neurology, 2003, Volume: 179, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Aspartic Acid; Brain; Cats; Choline; Corpus S	2003
Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol. Human molecular genetics, 2004, Jan-01, Volume: 13, Issue:1 Topics: Animals; Blotting, Western; Disease Models, Animal; Embryo, Mammalian; Gene Expression Regulation, E	2004
Phenotype of the neural tube defect mouse model bent tail is not sensitive to maternal folinic acid, myo-inositol, or zinc supplementation. Birth defects research. Part A, Clinical and molecular teratology, 2003, Volume: 67, Issue:12 Topics: Animals; Diet; Disease Models, Animal; DNA; Embryo Loss; Female; Genotype; Inositol; Leucovorin; Lit	2003
Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia. Brain research, 2004, Feb-27, Volume: 999, Issue:1 Topics: Animals; Brain Edema; Disease Models, Animal; Glutamine; Hepatic Encephalopathy; Hypothermia, Induce	2004
Comparison of voglibose and nateglinide for their acute effects on insulin secretion and free fatty acid levels in OLETF rat portal blood after sucrose loading. Endocrine, 2004, Volume: 23, Issue:1 Topics: Animals; Area Under Curve; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Type 2; Disease Models, A	2004
A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDS. BMC neuroscience, 2004, Mar-05, Volume: 5 Topics: Acute Disease; AIDS Dementia Complex; Animals; Aspartic Acid; Brain; Choline; Chronic Disease; Creat	2004
Relationships between astrogliosis and 1H MR spectroscopic measures of brain choline/creatine and myo-inositol/creatine in a primate model. AJNR. American journal of neuroradiology, 2005, Volume: 26, Issue:4 Topics: Animals; Choline; Creatine; Disease Models, Animal; Glial Fibrillary Acidic Protein; Gliosis; Hydrog	2005
High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease. The Journal of biological chemistry, 2005, Dec-30, Volume: 280, Issue:52 Topics: Aging; Animals; Aspartic Acid; Brain; Cerebellum; Cerebral Cortex; Creatine; Disease Models, Animal;	2005
Myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats. Journal of neuropathology and experimental neurology, 2006, Volume: 65, Issue:1 Topics: Animals; Arginine Vasopressin; Behavior, Animal; Blood Glucose; Brain; Demyelinating Diseases; Disea	2006
D-pinitol regulates Th1/Th2 balance via suppressing Th2 immune response in ovalbumin-induced asthma. FEBS letters, 2007, Jan-09, Volume: 581, Issue:1 Topics: Animals; Asthma; Cytokines; Disease Models, Animal; Eosinophils; Female; GATA3 Transcription Factor;	2007
Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers. Annals of neurology, 2006, Volume: 60, Issue:6 Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Disease Models, Anim	2006
Postnatal biochemical changes in rat lens: an important factor in cataract models. Current eye research, 2007, Volume: 32, Issue:2 Topics: Amino Acids; Animals; Cataract; Crystallins; Disease Models, Animal; Energy Metabolism; Inositol; Le	2007
MRI and MRS alterations in the preclinical phase of murine prion disease: association with neuropathological and behavioural changes. Neurobiology of disease, 2007, Volume: 26, Issue:3 Topics: Animals; Aspartic Acid; Astrocytes; Body Water; Brain; Choline; Creatine; Diffusion; Disease Models,	2007
Time course of early metabolic changes following diffuse traumatic brain injury in rats as detected by (1)H NMR spectroscopy. Journal of neurotrauma, 2007, Volume: 24, Issue:6 Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Chemistry; Brain Injuries; Creatine; Diffuse Axona	2007
A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. Human molecular genetics, 2008, Jan-15, Volume: 17, Issue:2 Topics: Animals; Autophagy; Chlorocebus aethiops; COS Cells; Disease Models, Animal; Drosophila; Drosophila	2008
Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder. Molecular psychiatry, 2009, Volume: 14, Issue:3 Topics: Adult; Analysis of Variance; Animals; Antimanic Agents; Aspartic Acid; Bipolar Disorder; Case-Contro	2009
Metabolic markers of neuronal injury correlate with SIV CNS disease severity and inoculum in the macaque model of neuroAIDS. Magnetic resonance in medicine, 2008, Volume: 59, Issue:3 Topics: AIDS Dementia Complex; Analysis of Variance; Animals; Aspartic Acid; Choline; Creatine; Disease Mode	2008
Dependence of reversibility and progression of mouse neuronopathic Gaucher disease on acid beta-glucosidase residual activity levels. Molecular genetics and metabolism, 2008, Volume: 94, Issue:2 Topics: Animals; Central Nervous System; Cytokines; Disease Models, Animal; Disease Progression; Female; Gau	2008
Distribution of conduritol B epoxide in the animal model for Gaucher's disease (Gaucher mouse). Biochimica et biophysica acta, 1981, Jan-07, Volume: 672, Issue:1 Topics: Animals; beta-Glucosidase; Blood-Brain Barrier; Disease Models, Animal; Gaucher Disease; Glucosidase	1981
The Gaucher mouse. Progress in clinical and biological research, 1982, Volume: 95 Topics: Acid Phosphatase; Animals; beta-Glucosidase; Brain; Cerebrosides; Disease Models, Animal; Galactosyl	1982
Liposomes in Gaucher type I disease: use in enzyme therapy and the creation of an animal model. Progress in clinical and biological research, 1982, Volume: 95 Topics: Adult; Animals; beta-Glucosidase; Disease Models, Animal; Female; Gaucher Disease; Glucosidases; Glu	1982
Polyinositol interrelationships in skeletal muscle under the duress of burn trauma. Burns : journal of the International Society for Burn Injuries, 1994, Volume: 20, Issue:3 Topics: Animals; Burns; Disease Models, Animal; Inositol; Male; Mice; Muscles; Phosphatidylinositols; Signal	1994
Galactose-induced cataract formation in guinea pigs: morphologic changes and accumulation of galactitol. Investigative ophthalmology & visual science, 1994, Volume: 35, Issue:3 Topics: Animals; Cataract; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; Galactitol;	1994
Decrease in cerebral inositols in rats and humans. The Biochemical journal, 1993, Oct-01, Volume: 295 ( Pt 1) Topics: Animals; Brain Chemistry; Disease Models, Animal; Hepatic Encephalopathy; Humans; Inositol; Magnetic	1993
The effect of peripheral inositol injection on rat motor activity models of depression. Israel journal of medical sciences, 1993, Volume: 29, Issue:9 Topics: Amphetamine; Analysis of Variance; Animals; Apomorphine; Depression; Disease Models, Animal; Drug Sy	1993
Multivariate influence of polyinositols on IP3 in diaphragm: individually applied matrix and vectorial analysis of trauma from small and large body surface area burn groups. Methods and findings in experimental and clinical pharmacology, 1993, Volume: 15, Issue:8 Topics: Analysis of Variance; Animals; Body Surface Area; Burns; Diaphragm; Disease Models, Animal; Inositol	1993
Insulin secretion, myo-inositol transport, and Na(+)-K(+)-ATPase in glucose-desensitized rat islets. Diabetes, 1993, Volume: 42, Issue:10 Topics: Animals; Arginine; Biological Transport; Carbachol; Cells, Cultured; Disease Models, Animal; Dose-Re	1993
Brain accumulation of myo-inositol in the trisomy 16 mouse, an animal model of Down's syndrome. The Biochemical journal, 1996, Jan-01, Volume: 313 ( Pt 1) Topics: Animals; Brain; Diploidy; Disease Models, Animal; Down Syndrome; Female; Homeostasis; Humans; Inosit	1996
Effect of inositol treatment on the behavior of rhesus monkeys: preliminary results. Progress in neuro-psychopharmacology & biological psychiatry, 1998, Volume: 22, Issue:6 Topics: Animals; Behavior, Animal; Disease Models, Animal; Inositol; Macaca mulatta; Memory; Motor Activity;	1998
A transgenic animal model of osmotic cataract. Part 1: over-expression of bovine Na+/myo-inositol cotransporter in lens fibers. Investigative ophthalmology & visual science, 1999, Volume: 40, Issue:8 Topics: Animals; Carrier Proteins; Cataract; Cell Differentiation; Chromatography, Ion Exchange; Disease Mod	1999
Inositol reduces depressive-like behaviors in two different animal models of depression. Psychopharmacology, 1999, Volume: 144, Issue:2 Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Drug Evaluatio	1999
Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment. Neuroreport, 2000, Feb-28, Volume: 11, Issue:3 Topics: Animals; Aspartic Acid; Brain; Choline; Creatine; Disease Models, Animal; Down Syndrome; Female; Ino	2000
Ts65Dn mouse, a Down syndrome model, exhibits elevated myo-inositol in selected brain regions and peripheral tissues. Neurochemical research, 2000, Volume: 25, Issue:4 Topics: Animals; Brain; Brain Stem; Cerebellum; Disease Models, Animal; Down Syndrome; Female; Frontal Lobe;	2000
Epi-inositol and inositol depletion: two new treatment approaches in affective disorder. Current psychiatry reports, 1999, Volume: 1, Issue:2 Topics: Animals; Antimanic Agents; Blood-Brain Barrier; Brain Chemistry; Diet; Disease Models, Animal; Human	1999
The antidepressant activity of inositol in the forced swim test involves 5-HT(2) receptors. Behavioural brain research, 2001, Jan-08, Volume: 118, Issue:1 Topics: Animals; Antidepressive Agents; Benzylamines; Depression; Disease Models, Animal; Drug Interactions;	2001
Successful and not so successful chemoprevention of tobacco smoke-induced lung tumors. Experimental lung research, 2000, Volume: 26, Issue:8 Topics: Animals; Anticarcinogenic Agents; Aspirin; Chemoprevention; Cyclohexenes; Dexamethasone; Diet; Disea	2000
Chemoprevention of vinyl carbamate-induced lung tumors in strain A mice. Experimental lung research, 2000, Volume: 26, Issue:8 Topics: Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Chemoprevention; Dexamethaso	2000
The Gaucher mouse: additional biochemical alterations. Journal of neurochemistry, 1979, Volume: 32, Issue:3 Topics: Acid Phosphatase; Animals; Brain; Cerebrosides; Disease Models, Animal; Gangliosides; Gaucher Diseas	1979
The Gaucher mouse. Biochemical and biophysical research communications, 1975, Nov-03, Volume: 67, Issue:1 Topics: Animals; Brain; Ceramides; Disease Models, Animal; Gaucher Disease; Glucosidases; Glycoside Hydrolas	1975
In vivo formation of polyphosphoinositide isomers and association with progression of murine polycystic kidney disease. Experimental and molecular pathology, 1992, Volume: 57, Issue:1 Topics: Animals; Cell Division; Chromatography, High Pressure Liquid; Disease Models, Animal; Epithelium; In	1992
Myocardial inositol and sodium in diabetes. International journal of cardiology, 1992, Volume: 37, Issue:3 Topics: Animals; Biopsy; Body Fluid Compartments; Chromatography, Gas; Diabetes Mellitus, Experimental; Dise	1992
Retinal polyol and myo-inositol in galactosemic dogs given an aldose-reductase inhibitor. Investigative ophthalmology & visual science, 1991, Volume: 32, Issue:13 Topics: Aldehyde Reductase; Alloxan; Animals; Chromatography, Gas; Diabetes Mellitus, Experimental; Disease	1991
Glucose-induced dysmorphogenesis in the cultured rat conceptus: prevention by supplementation with myo-inositol. Israel journal of medical sciences, 1990, Volume: 26, Issue:10 Topics: Animals; Congenital Abnormalities; Culture Media; Culture Techniques; Disease Models, Animal; Embryo	1990
Experimental chronic hypoxic neuropathy: relevance to diabetic neuropathy. The American journal of physiology, 1986, Volume: 250, Issue:1 Pt 1 Topics: Animals; Diabetic Neuropathies; Disease Models, Animal; Electrophysiology; Glycated Hemoglobin; Hexo	1986
Experimental studies on pathogenesis and progression of uremic neuropathy in rats. II. Is plasma myoinositol a uremic neurotoxin? Bulletin of the Osaka Medical School, 1986, Volume: 32, Issue:2 Topics: Animals; Disease Models, Animal; Inositol; Kidney Failure, Chronic; Male; Nervous System Diseases; N	1986
Hyperglycemia, polyol accumulation, and increased intracranial pressure. Archives of neurology, 1971, Volume: 25, Issue:2 Topics: Animals; Brain; Brain Edema; Cerebrospinal Fluid Proteins; Diabetic Ketoacidosis; Disease Models, An	1971

inositol and Disease Models, Animal

Research Excerpts

Research

Studies (163)

Authors

Clinical Trials (2)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Abrams, RPM	1
Yasgar, A	1
Teramoto, T	1
Lee, MH	1
Dorjsuren, D	1
Eastman, RT	1
Malik, N	1
Zakharov, AV	1
Li, W	1
Bachani, M	1
Brimacombe, K	1
Steiner, JP	1
Hall, MD	1
Balasubramanian, A	1
Jadhav, A	1
Padmanabhan, R	1
Simeonov, A	1
Nath, A	1
Li, XL	1
Yu, F	1
Fu, CL	1
Yu, X	1
Xu, M	1
Cheng, M	1
Rivera, MJ	1
Contreras, A	1
Nguyen, LT	1
Eldon, ED	1
Klig, LS	1
Kandashvili, M	1
Gamkrelidze, G	1
Tsverava, L	1
Lordkipanidze, T	1
Lepsveridze, E	1
Lagani, V	1
Burjanadze, M	1
Dashniani, M	1
Kokaia, M	1
Solomonia, R	1
Collins, NB	1
Al Abosy, R	1
Miller, BC	1
Bi, K	1
Zhao, Q	1
Quigley, M	1
Ishizuka, JJ	1
Yates, KB	1
Pope, HW	1
Manguso, RT	1
Shrestha, Y	1
Wadsworth, M	1
Hughes, T	1
Shalek, AK	1
Boehm, JS	1
Hahn, WC	1
Doench, JG	1
Haining, WN	1
Correia, SC	1
Alves, MG	1
Oliveira, PF	1
Casadesus, G	1
LaManna, J	1
Perry, G	1
Moreira, PI	1
López-Gambero, AJ	1
Pacheco-Sánchez, B	1
Rosell-Valle, C	1
Medina-Vera, D	1
Navarro, JA	2
Fernández-Arjona, MDM	1
de Ceglia, M	1
Sanjuan, C	2
Simon, V	1
Cota, D	1
Rivera, P	1
Rodríguez de Fonseca, F	1
Suárez, J	1
Bae, J	1
Lee, JY	1
Shin, E	1
Lee, M	1
Lee, YH	1
Lee, BW	1
Kang, ES	1
Cha, BS	1
Muñoz-Moreno, E	1
Simões, RV	1
Tudela, R	1
López-Gil, X	1
Soria, G	1
Antonowski, T	1
Osowski, A	1
Szczesny, D	1
Szablińska-Piernik, J	1
Juśkiewicz, J	1
Lahuta, L	1
Rynkiewicz, A	1
Wojtkiewicz, J	1
Vijayapoopathi, S	1
Ramamoorthy, R	1
Meganathan, J	1
Kalaiyazhagan, A	1
Bhuvarahamurthy, S	1
Venugopal, B	1
Al-Horani, RA	1
Abdelfadiel, EI	1
Afosah, DK	1
Morla, S	1
Sistla, JC	1
Mohammed, B	1
Martin, EJ	1
Sakagami, M	1
Brophy, DF	1
Desai, UR	1
Ren, X	1
Hinchie, A	1
Swomley, A	1
Powell, DK	1
Butterfield, DA	1
Towner, RA	1
Saunders, D	1
Smith, N	1
Gulej, R	1
McKenzie, T	1
Lawrence, B	1
Morton, KA	1
Plows, JF	2
Ramos Nieves, JM	1
Budin, F	2
Mace, K	2
Reynolds, CM	1
Vickers, MH	2
Silva-Zolezzi, I	2
Baker, PN	2
Stanley, JL	2
Morrone, CD	1
Bazzigaluppi, P	1
Beckett, TL	1
Hill, ME	1
Koletar, MM	1
Stefanovic, B	2
McLaurin, J	5
Menichini, D	1
Alrais, M	1
Liu, C	1
Xia, Y	1
Blackwell, SC	2
Facchinetti, F	2
Sibai, BM	2
Longo, M	2
Kato, J	1
Shirakami, Y	1
Mizutani, T	1
Kubota, M	1
Sakai, H	1
Ibuka, T	1
Shimizu, M	1
L'Abbate, S	1
Nicolini, G	1
Forini, F	1
Marchetti, S	1
Di Lascio, N	1
Faita, F	1
Kusmic, C	1
Pericuesta, E	1
Laguna-Barraza, R	1
Ramos-Ibeas, P	1
Gutierrez-Arroyo, JL	1
Vera, K	1
Baixeras, E	1
de Fonseca, FR	1
Gutierrez-Adan, A	1
Palladino, E	1
Van Mieghem, T	1
Connor, KL	1
Fan, Y	1
Wang, J	3
Feng, Z	2
Cao, K	1
Xu, H	2
Liu, J	1
Shah, P	1
Chavda, V	1
Patel, S	1
Bhadada, S	1
Ashraf, GM	1
Li, S	1
Luo, D	1
Yue, H	1
Lyu, J	1
Yang, Y	2
Gao, T	1
Liu, Y	2
Qin, J	1
Wang, X	1
Guan, Z	1
Wang, F	1
Zhang, F	1
Niu, B	1
Zhang, T	1
Zhong, R	1
Guo, J	2
Hu, X	1
Zhu, Y	1
L V, X	1
Lin, Y	1
Wu, Y	2
Su, J	1
Wang, M	4
Wu, X	1
Su, Z	1
Yi, X	1
Wei, L	1
Cai, J	1
Sun, Z	1
Bevilacqua, A	2
Dragotto, J	2
Lucarelli, M	1
Di Emidio, G	1
Monastra, G	1
Tatone, C	1
Recart, VM	1
Spohr, L	1
Soares, MSP	1
Luduvico, KP	1
Stefanello, FM	1
Spanevello, RM	1
Zheng, K	1
Zhao, Z	1
Lin, N	1
Xu, Y	1
Zhang, W	3
Zhao, SS	1
Li, NR	1
Zhao, WL	1
Liu, H	1
Ge, MX	1
Zhang, YX	1
Zhao, LY	1
You, XF	1
He, HW	1
Shao, RG	1
Bradford, EM	1
Thompson, CA	1
Goretsky, T	1
Yang, GY	2
Rodriguez, LM	1
Li, L	1
Barrett, TA	1
Spengler, D	1
Winoto-Morbach, S	1
Kupsch, S	1
Vock, C	1
Blöchle, K	1
Frank, S	1
Rintz, N	1
Diekötter, M	1
Janga, H	1
Weckmann, M	1
Fuchs, S	1
Schromm, AB	1
Fehrenbach, H	1
Schütze, S	1
Krause, MF	1
Collet, C	1
Schmitt, S	1
Maskali, F	1
Clément, A	1
Chrétien, F	1
Karcher, G	1
Marie, PY	1
Poussier, S	1
Lamandé-Langle, S	1
Yang, S	1
Wu, B	1
Sun, H	1
Sun, T	1
Han, K	1
Li, D	2
Ji, F	1
Zhang, G	1
Zhou, D	2
Liu, M	2
Jevtic, S	1
Markham-Coultes, K	1
Ellens, NPK	1
O'Reilly, MA	1
Hynynen, K	1
Aubert, I	1
Unver, N	1
Delgado, O	1
Zeleke, K	1
Cumpian, A	1
Tang, X	1
Caetano, MS	1
Wang, H	2
Katayama, H	1
Yu, H	1
Szabo, E	1
Wistuba, II	1
Moghaddam, SJ	1
Hanash, SM	1
Ostrin, EJ	1
Zhang, B	1
Gao, C	1
Li, Y	2
Negri, A	1
Javidnia, P	1
Mu, R	1
Zhang, X	2
Vendome, J	1
Gold, B	1
Roberts, J	1
Barman, D	1
Ioerger, T	1
Sacchettini, JC	1
Jiang, X	1
Burns-Huang, K	1
Warrier, T	1
Ling, Y	1
Warren, JD	1
Oren, DA	1
Beuming, T	1
Wu, J	1
Li, H	2
Rhee, KY	1
Nathan, CF	1
Liu, G	1
Somersan-Karakaya, S	1
Lambert, C	1
Cubedo, J	1
Padró, T	1
Vilahur, G	1
López-Bernal, S	1
Rocha, M	1
Hernández-Mijares, A	1
Badimon, L	1
Papadopoulos, VE	1
Nikolopoulou, G	1
Antoniadou, I	1
Karachaliou, A	1
Arianoglou, G	1
Emmanouilidou, E	1
Sardi, SP	1
Stefanis, L	1
Vekrellis, K	1
Ferrer, MD	1
Ketteler, M	1
Tur, F	1
Tur, E	1
Isern, B	1
Salcedo, C	1
Joubert, PH	1
Behets, GJ	1
Neven, E	1
D'Haese, PC	1
Perelló, J	1
Hong, J	1
Nachkebia, S	1
Tun, SM	1
Petzer, A	1
Windsor, JA	1
Hickey, AJ	1
Phillips, AR	1
Giuliani, A	1
Bizzarri, M	1
Sekar, S	1
Grandjean, J	2
Garnell, JF	1
Willems, R	1
Duytschaever, H	1
Seramani, S	1
Su, H	1
Ver Donck, L	1
Bhakoo, KK	1
Mus, L	1
Siani, F	1
Giuliano, C	1
Ghezzi, C	1
Cerri, S	1
Blandini, F	1
Kuo, CL	1
Kallemeijn, WW	1
Lelieveld, LT	1
Mirzaian, M	1
Zoutendijk, I	1
Vardi, A	2
Futerman, AH	3
Meijer, AH	1
Spaink, HP	1
Overkleeft, HS	1
Aerts, JMFG	1
Artola, M	1
Yanez Lopez, M	1
Pardon, MC	1
Baiker, K	1
Prior, M	1
Yuchun, D	1
Agostini, A	1
Bai, L	1
Auer, DP	1
Faas, HM	1
Yuan, C	1
Yang, P	1
Jiang, L	1
de Castro, NM	1
Yaqoob, P	1
de la Fuente, M	1
Baeza, I	1
Claus, SP	1
Kantarci, K	1
Thomason, LA	1
Aytan, N	1
Choi, JK	2
Carreras, I	1
Kowall, NW	1
Jenkins, BG	2
Dedeoglu, A	2
Marjańska, M	1
Weigand, SD	1
Preboske, G	1
Wengenack, TM	1
Chamberlain, R	1
Curran, GL	1
Poduslo, JF	1
Garwood, M	1
Kobayashi, D	1
Lin, JC	1
Jack, CR	1
Ginns, EI	1
Mak, SK	1
Ko, N	1
Karlgren, J	1
Akbarian, S	1
Chou, VP	1
Guo, Y	1
Lim, A	1
Samuelsson, S	1
LaMarca, ML	1
Vazquez-DeRose, J	1
Manning-Boğ, AB	2
Ohnishi, T	1
Murata, T	1
Watanabe, A	1
Hida, A	1
Ohba, H	1
Iwayama, Y	1
Mishima, K	1
Gondo, Y	1
Yoshikawa, T	1
Xu, YH	3
Xu, K	1
Sun, Y	3
Liou, B	1
Quinn, B	3
Li, RH	1
Xue, L	1
Setchell, KD	1
Witte, D	3
Grabowski, GA	4
Bolognin, S	1
Buffelli, M	1
Puoliväli, J	1
Iqbal, K	1
Forkel, S	1
Schön, M	1
Hildmann, A	1
Claßen, A	1
John, SM	1
Danker, K	1
Schön, MP	1
Hashiguchi, C	1
Kawamoto, S	1
Kasai, T	1
Nishi, Y	1
Nagaoka, E	1
Suzuki, S	1
Suzuki, C	1
Hinokio, Y	1
Ishigaki, Y	1
Katagiri, H	1
Kanzaki, M	1
Azev, VN	1
Chakraborty, N	1
d'Alarcao, M	1
Zheng, L	1
Wu, T	1
Li, J	1
Zhang, Q	1
Li, X	1
Yuan, F	1
Wang, L	2
Li, CX	1
Komery, A	1
Mao, H	1
Herndon, JG	1
Novembre, FJ	1
Schiebler, M	1
Brown, K	1
Hegyi, K	1
Newton, SM	1
Renna, M	1
Hepburn, L	1
Klapholz, C	1
Coulter, S	1
Obregón-Henao, A	1
Henao Tamayo, M	1
Basaraba, R	1
Kampmann, B	1
Henry, KM	1
Burgon, J	1
Renshaw, SA	1
Fleming, A	1
Kay, RR	1
Anderson, KE	1
Hawkins, PT	1
Ordway, DJ	1
Rubinsztein, DC	2
Floto, RA	1
Rammes, G	1
Gravius, A	1
Ruitenberg, M	1
Wegener, N	1
Chambon, C	1
Sroka-Saidi, K	1
Jeggo, R	1
Staniaszek, L	1
Spanswick, D	1
O'Hare, E	2
Palmer, P	1
Kim, EM	1
Bywalez, W	1
Egger, V	1
Parsons, CG	1
Tušková, R	1
Lipták, B	1
Szomolányi, P	1
Vančová, O	1
Uličná, O	1
Sumbalová, Z	1
Kucharská, J	1
Dubovický, M	1
Trattnig, S	1
Liptaj, T	1
Kašparová, S	1
Doert, A	1
Pilatus, U	1
Zanella, F	1
Müller, WE	1
Eckert, GP	1
Turan, GA	1
Eskicioglu, F	1
Sivrikoz, ON	1
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