inositol has been researched along with Diabetic Retinopathy in 25 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Diabetic Retinopathy: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Myo-inositol is a precursor of inositol phospholipids (IPLs), whose metabolism is responsible for a number of signal transduction processes." | 5.28 | [Abnormal inositol phospholipid metabolism as a main factor causing pericyte drop-out in diabetic retinopathy]. ( Li, WY, 1989) |
| "MRI measurement of the retinal oxygenation response to a carbogen challenge appears to be a powerful new and noninvasive approach that may be useful for assessing aspects of pathophysiology underlying the development of diabetic retinopathy in galactosemic rats." | 3.70 | Subnormal retinal oxygenation response precedes diabetic-like retinopathy. ( Berkowitz, BA; Frank, RN; Hohman, TC; Kern, TS; Kowluru, RA; Prakash, M, 1999) |
| "myo-Inositol uptake was reduced to 34% of control after 6 days of continuous exposure to galactose." | 1.28 | Uncoupling of attenuated myo-[3H]inositol uptake and dysfunction in Na(+)-K(+)-ATPase pumping activity in hypergalactosemic cultured bovine lens epithelial cells. ( Cammarata, PR; Tse, D; Yorio, T, 1991) |
| "myo-Inositol was taken up by two Na-dependent transport systems, at least one of which was competitively inhibited by glucose." | 1.28 | Sorbitol, myo-inositol, and rod outer segment phagocytosis in cultured hRPE cells exposed to glucose. In vitro model of myo-inositol depletion hypothesis of diabetic complications. ( Brennan, MC; Del Monte, MA; Diaz, TC; Greene, DA; Lattimer, SA; Nakamura, J; Rabbani, R, 1991) |
| "Myo-inositol is a precursor of inositol phospholipids (IPLs), whose metabolism is responsible for a number of signal transduction processes." | 1.28 | [Abnormal inositol phospholipid metabolism as a main factor causing pericyte drop-out in diabetic retinopathy]. ( Li, WY, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (48.00) | 18.7374 |
| 1990's | 11 (44.00) | 18.2507 |
| 2000's | 1 (4.00) | 29.6817 |
| 2010's | 1 (4.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tong, J | 1 |
| Geng, H | 1 |
| Zhang, Z | 1 |
| Zhu, X | 1 |
| Meng, Q | 1 |
| Sun, X | 1 |
| Zhang, M | 1 |
| Qian, R | 1 |
| Sun, L | 1 |
| Liang, Q | 1 |
| HILGARTNER, HL | 1 |
| Van den Enden, MK | 1 |
| Nyengaard, JR | 1 |
| Ostrow, E | 1 |
| Burgan, JH | 1 |
| Williamson, JR | 1 |
| Lowe, WL | 1 |
| Florkiewicz, RZ | 1 |
| Yorek, MA | 1 |
| Spanheimer, RG | 1 |
| Albrecht, BN | 1 |
| Hotta, N | 2 |
| Koh, N | 1 |
| Sakakibara, F | 1 |
| Nakamura, J | 2 |
| Hamada, Y | 1 |
| Hara, T | 1 |
| Fukasawa, H | 1 |
| Kakuta, H | 1 |
| Sakamoto, N | 1 |
| Berkowitz, BA | 1 |
| Kowluru, RA | 1 |
| Frank, RN | 1 |
| Kern, TS | 1 |
| Hohman, TC | 1 |
| Prakash, M | 1 |
| Wakisaka, M | 1 |
| Yoshinari, M | 1 |
| Nakamura, S | 1 |
| Asano, T | 1 |
| Sonoki, K | 1 |
| Shi, Ah | 1 |
| Iwase, M | 1 |
| Takata, Y | 1 |
| Fujishima, M | 1 |
| Yoshii, H | 1 |
| Uchino, H | 1 |
| Ohmura, C | 1 |
| Watanabe, K | 1 |
| Tanaka, Y | 1 |
| Kawamori, R | 1 |
| Daumerie-Goffinet, C | 1 |
| Lambert, AE | 1 |
| Clements, RS | 2 |
| Radhakrishnamurthy, B | 1 |
| Berenson, GS | 1 |
| Pargaonkar, PS | 1 |
| Voors, AW | 1 |
| Srinivasan, SR | 1 |
| Plavidal, F | 1 |
| Dolan, P | 1 |
| Dalferes, ER | 1 |
| Cammarata, PR | 1 |
| Tse, D | 1 |
| Yorio, T | 1 |
| Del Monte, MA | 1 |
| Rabbani, R | 1 |
| Diaz, TC | 1 |
| Lattimer, SA | 1 |
| Brennan, MC | 1 |
| Greene, DA | 1 |
| Sano, T | 1 |
| Li, WY | 3 |
| Zhou, Q | 2 |
| Qin, M | 2 |
| Tao, L | 1 |
| Lou, M | 1 |
| Hu, TS | 2 |
| Hasegawa, M | 1 |
| Inoue, M | 1 |
| Doi, K | 1 |
| Mio, R | 1 |
| Sumino, K | 1 |
| Tang, L | 1 |
| Sinclair, SH | 1 |
| Nesler, CL | 1 |
| Schwartz, SS | 1 |
| MacGregor, LC | 1 |
| Matschinsky, FM | 1 |
| Winegrad, AI | 1 |
| Kador, PF | 1 |
| Kinoshita, JH | 1 |
| Niedermeier, S | 1 |
| Taniguchi, Y | 1 |
3 reviews available for inositol and Diabetic Retinopathy
| Article | Year |
|---|---|
[Diabetic microangiopathies].
Topics: Basement Membrane; Blood Viscosity; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies | 1978 |
Biochemical derangements in diabetes mellitus.
Topics: Aorta; Basement Membrane; Blood Platelets; Blood Proteins; Carbohydrate Metabolism; Diabetes Mellitu | 1979 |
New therapies for the chronic complications of older diabetic patients.
Topics: Aged; Aldehyde Reductase; Blood Glucose; Cell Membrane Permeability; Coronary Disease; Diabetes Comp | 1986 |
1 trial available for inositol and Diabetic Retinopathy
| Article | Year |
|---|---|
[Experiences in the treatment of diabetic retinopathies].
Topics: Clinical Trials as Topic; Diabetes Mellitus; Diabetic Retinopathy; Humans; Inositol; Rutin; Vitamin | 1966 |
21 other studies available for inositol and Diabetic Retinopathy
| Article | Year |
|---|---|
Brain metabolite alterations demonstrated by proton magnetic resonance spectroscopy in diabetic patients with retinopathy.
Topics: Adult; Aspartic Acid; Brain; Case-Control Studies; Choline; Corpus Striatum; Diabetes Mellitus, Type | 2014 |
Diabetic retinopathies, effect of lipotropic substances (lipotriad) in treatment.
Topics: Choline; Diabetes Complications; Diabetic Retinopathy; Disease; Fats; Humans; Inositol; Lipid Metabo | 1955 |
Elevated glucose levels increase retinal glycolysis and sorbitol pathway metabolism. Implications for diabetic retinopathy.
Topics: Aldehyde Reductase; Animals; Diabetic Retinopathy; Fluorenes; Fructose; Glucose; Glycolysis; Hydanto | 1995 |
Regulation of growth factor mRNA levels in the eyes of diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Retino | 1995 |
Effect of propionyl-L-carnitine on oscillatory potentials in electroretinogram in streptozotocin-diabetic rats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Body Weight; | 1996 |
Subnormal retinal oxygenation response precedes diabetic-like retinopathy.
Topics: Animals; Blood Glucose; Carbon Dioxide; Diabetic Retinopathy; Fructose; Galactitol; Galactose; Galac | 1999 |
Suppression of sodium-dependent glucose uptake by captopril improves high-glucose-induced morphological and functional changes of cultured bovine retinal pericytes.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Biological Transport, Active; Captopril; Cattle; | 1999 |
Clinical usefulness of measuring urinary polyol excretion by gas-chromatography/mass-spectrometry in type 2 diabetes to assess polyol pathway activity.
Topics: Adult; Albuminuria; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Diabetic Retino | 2001 |
Serum-free and protein-bound sugars and cardiovascular complications in diabetes mellitus.
Topics: Adult; Age Factors; Aged; Analysis of Variance; Blood Glucose; Blood Pressure; Cardiovascular Diseas | 1976 |
Uncoupling of attenuated myo-[3H]inositol uptake and dysfunction in Na(+)-K(+)-ATPase pumping activity in hypergalactosemic cultured bovine lens epithelial cells.
Topics: Aldehyde Reductase; Animals; Biological Transport, Active; Cattle; Diabetic Retinopathy; Epithelium; | 1991 |
Sorbitol, myo-inositol, and rod outer segment phagocytosis in cultured hRPE cells exposed to glucose. In vitro model of myo-inositol depletion hypothesis of diabetic complications.
Topics: Adult; Aldehyde Reductase; Cells, Cultured; Diabetic Retinopathy; Glucose; Humans; Imidazoles; Imida | 1991 |
[Risk factors of developing diabetic complications].
Topics: Animals; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetic Retinopathy; Female; Glycoprotei | 1991 |
Reduced absolute rate of myo-inositol biosynthesis of cultured bovine retinal capillary pericytes in high glucose.
Topics: Animals; Capillaries; Cats; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Diabetic | 1991 |
[Clinical significance of serum myo-inositol analysis in the diabetic complications].
Topics: Animals; Diabetic Angiopathies; Diabetic Neuropathies; Diabetic Retinopathy; Gas Chromatography-Mass | 1990 |
Intramural pericyte degeneration in early diabetic retinopathy study in vitro.
Topics: Animals; Arterioles; Capillaries; Cattle; Cells, Cultured; Diabetic Retinopathy; DNA; Glucose; Inosi | 1990 |
Retinopathy in the pregnant diabetic.
Topics: Adult; Blood Flow Velocity; Diabetic Angiopathies; Diabetic Retinopathy; Enzymes; Female; Fluorescei | 1985 |
[Abnormal inositol phospholipid metabolism as a main factor causing pericyte drop-out in diabetic retinopathy].
Topics: Aldehyde Reductase; Animals; Cattle; Cell Line; Diabetic Retinopathy; Glucose; Imidazoles; Imidazoli | 1989 |
Experimental diabetes mellitus impairs the function of the retinal pigmented epithelium.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Electroretinography; Glucose; Imidaz | 1986 |
Banting lecture 1986. Does a common mechanism induce the diverse complications of diabetes?
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Ne | 1987 |
Role of aldose reductase in the development of diabetes-associated complications.
Topics: Aldehyde Reductase; Animals; Corneal Diseases; Diabetic Neuropathies; Diabetic Retinopathy; Humans; | 1985 |
[Experiences with miscellaneous medical treatments of diabetic retinopathy].
Topics: Anticholesteremic Agents; Dextrans; Diabetic Retinopathy; Humans; Inositol; Nicotinic Acids; Sulfate | 1969 |