inositol has been researched along with Diabetic Neuropathies in 112 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mononeuritis (or mononeuritis multiplex) seems to be the result of ischaemia due to intrinsic or extrinsic (altered coagulability) vascular disease." | 2.37 | [Pathogenesis of diabetic neuropathies]. ( Arlot, S; Lalau, JD; Quichaud, J, 1985) |
| "At 8 months galactosemia reduced NCV to 58% of control values, while ARI-treatment for 8 months improved NCV to 71% of control values." | 1.29 | Galactosemia produces ARI-preventable nodal changes similar to those of diabetic neuropathy. ( Basso, M; Cherian, PV; Hohman, TC; Kamijo, M; Sima, AA, 1994) |
| "Myoinositol influx was significantly but negatively correlated with the serum very low density lipoprotein (VLDL) cholesterol concentration in patients with and without neuropathy but not in the controls." | 1.29 | Relationship between myoinositol influx and lipids in diabetic neuropathy. ( Bomford, J; Ng, LL; Simmons, D, 1993) |
| "Iloprost was administered intraperitoneally to streptozotocin-induced diabetic rats at a dose of 10 micrograms/kg/day for a month." | 1.28 | Effect of a prostaglandin I2 derivative (iloprost) on peripheral neuropathy of diabetic rats. ( Ito, H; Kanazawa, A; Miwa, T; Ohno, A; Tanaka, A, 1992) |
| "The effect of streptozotocin diabetes of 4-week duration on the adrenergic motor transmission and on the nonadrenergic, noncholinergic, inhibitory transmission in the rat anococcygeus was investigated by recording contractile and relaxant activity of isolated muscle preparations taken from diabetic and age-matched control animals." | 1.28 | Effect of streptozotocin diabetes on motor and inhibitory transmission in rat anococcygeus. ( Luheshi, GN; Zar, MA, 1992) |
| "Myo-inositol was reduced approximately 50%." | 1.28 | [Alterations in the sorbitol pathway and Na(+)-K(+)-ATPase activity of peripheral nerve of alloxan-induced diabetic rats]. ( Lu, KM; Zhong, XL; Zhu, QY; Zhu, XX, 1990) |
| "Myo-inositol treatment did not affect nerve levels." | 1.28 | The effect of aldose reductase inhibition on the pattern of nerve conduction deficits in diabetic rats. ( Cameron, NE; Cotter, MA; Robertson, S, 1989) |
| "Treatment with Sorbinil (25 mg/kg/day, p." | 1.27 | Prevention and reversal of defective axonal transport and motor nerve conduction velocity in rats with experimental diabetes by treatment with the aldose reductase inhibitor Sorbinil. ( Mayer, JH; Moriarty, RJ; Tomlinson, DR, 1984) |
| "Erythromelalgia is a syndrome characterized by erythema, burning pain and increased skin temperature of the affected extremities." | 1.27 | Erythromelalgia associated with acute diabetic neuropathy: an unusual condition. ( Bosch, X; Esmatjes, E; Goday, A; Gomis, R; Nubiola, A; Vendrell, J; Vilardell, E, 1988) |
| "Myoinositol concentration was significantly decreased in patients with polyneuropathy compared with the controls." | 1.26 | Cerebrospinal fluid sorbitol and myoinositol in diabetic polyneuropathy. ( Bergström, L; Fogelholm, R; Servo, C, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 65 (58.04) | 18.7374 |
| 1990's | 37 (33.04) | 18.2507 |
| 2000's | 7 (6.25) | 29.6817 |
| 2010's | 2 (1.79) | 24.3611 |
| 2020's | 1 (0.89) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, J | 1 |
| Guo, P | 1 |
| Liu, X | 1 |
| Liao, H | 1 |
| Chen, K | 1 |
| Wang, Y | 1 |
| Qin, J | 1 |
| Yang, F | 1 |
| Freeman, OJ | 1 |
| Unwin, RD | 1 |
| Dowsey, AW | 1 |
| Begley, P | 1 |
| Ali, S | 1 |
| Hollywood, KA | 1 |
| Rustogi, N | 1 |
| Petersen, RS | 1 |
| Dunn, WB | 1 |
| Cooper, GJ | 1 |
| Gardiner, NJ | 1 |
| Farias, VX | 1 |
| Macêdo, FH | 1 |
| Oquendo, MB | 1 |
| Tomé, AR | 1 |
| Báo, SN | 1 |
| Cintra, DO | 1 |
| Santos, CF | 1 |
| Albuquerque, AA | 1 |
| Heimark, DB | 1 |
| Larner, J | 1 |
| Fonteles, MC | 1 |
| Leal-Cardoso, JH | 1 |
| Nascimento, NR | 1 |
| Nakashima, E | 1 |
| Nakamura, J | 3 |
| GARCIA-BUNUEL, L | 1 |
| GARCIA-BUNUEL, M | 1 |
| Nakashima, S | 1 |
| Ziegler, D | 1 |
| Greene, DA | 22 |
| Lattimer, SA | 13 |
| Mayer, JH | 4 |
| Tomlinson, DR | 10 |
| Moriarty, RJ | 1 |
| Finegold, D | 1 |
| Nolle, S | 1 |
| Bernstein, M | 1 |
| Sidenius, P | 1 |
| Clements, RS | 7 |
| Bell, DS | 1 |
| Brown, MJ | 1 |
| Braunstein, SN | 1 |
| Schwartz, SS | 1 |
| Asbury, AK | 1 |
| Winegrad, AI | 4 |
| Dyck, PJ | 2 |
| Sherman, WR | 2 |
| Hallcher, LM | 1 |
| Service, FJ | 1 |
| O'Brien, PC | 1 |
| Grina, LA | 1 |
| Palumbo, PJ | 1 |
| Swanson, CJ | 1 |
| Hotta, N | 2 |
| Kakuta, H | 1 |
| Fukasawa, H | 1 |
| Koh, N | 1 |
| Sakakibara, F | 1 |
| Hamada, Y | 1 |
| Wakao, T | 1 |
| Hara, T | 1 |
| Mori, K | 1 |
| Wright, RA | 1 |
| Nukada, H | 1 |
| Kamijo, M | 5 |
| Basso, M | 1 |
| Cherian, PV | 1 |
| Hohman, TC | 2 |
| Sima, AA | 10 |
| Ido, Y | 2 |
| McHowat, J | 1 |
| Chang, KC | 1 |
| Arrigoni-Martelli, E | 1 |
| Orfalian, Z | 1 |
| Kilo, C | 1 |
| Corr, PB | 1 |
| Williamson, JR | 3 |
| Simmons, D | 2 |
| Ng, LL | 2 |
| Bomford, J | 2 |
| Stevens, MJ | 4 |
| Feldman, EL | 1 |
| Killen, PD | 1 |
| Henry, DN | 1 |
| Thomas, T | 1 |
| Dananberg, J | 1 |
| Van Huysen, C | 1 |
| Carrington, AL | 1 |
| Calcutt, NA | 1 |
| Ettlinger, CB | 1 |
| Gustafsson, T | 1 |
| Eichberg, J | 2 |
| Abe, S | 1 |
| Berti-Mattera, LN | 1 |
| Day, NS | 1 |
| Lowery, JM | 1 |
| Zhu, X | 1 |
| Peterson, RG | 1 |
| Yorek, MA | 3 |
| Wiese, TJ | 2 |
| Davidson, EP | 3 |
| Dunlap, JA | 3 |
| Stefani, MR | 1 |
| Conner, CE | 1 |
| Cameron, NE | 3 |
| Cotter, MA | 3 |
| Maxfield, EK | 1 |
| Hirano, F | 1 |
| Tanaka, H | 1 |
| Okamoto, K | 1 |
| Makino, Y | 1 |
| Inaba, M | 1 |
| Nomura, Y | 1 |
| Fukawa, E | 1 |
| Miura, T | 1 |
| Tani, T | 1 |
| Makino, I | 1 |
| Shindo, H | 2 |
| Thomas, TP | 1 |
| Larkin, DD | 1 |
| Karihaloo, AK | 1 |
| Inada, H | 1 |
| Onaya, T | 2 |
| Ristic, H | 1 |
| Merry, A | 1 |
| Lightle, RL | 1 |
| Pierzchala, K | 1 |
| Kishi, Y | 1 |
| Schmelzer, JD | 2 |
| Yao, JK | 3 |
| Zollman, PJ | 1 |
| Nickander, KK | 1 |
| Tritschler, HJ | 1 |
| Low, PA | 3 |
| Sundkvist, G | 1 |
| Dahlin, LB | 2 |
| Nilsson, H | 1 |
| Eriksson, KF | 1 |
| Lindgärde, F | 1 |
| Rosén, I | 1 |
| Sullivan, K | 1 |
| Kato, N | 2 |
| Mizuno, K | 2 |
| Makino, M | 1 |
| Suzuki, T | 1 |
| Yagihashi, S | 3 |
| Yoshii, H | 1 |
| Uchino, H | 1 |
| Ohmura, C | 1 |
| Watanabe, K | 1 |
| Tanaka, Y | 1 |
| Kawamori, R | 1 |
| Coppey, LJ | 1 |
| Lund, DD | 1 |
| Salway, JG | 1 |
| Whitehead, L | 1 |
| Finnegan, JA | 1 |
| Karunanayaka, A | 1 |
| Barnett, D | 1 |
| Payne, RB | 1 |
| De Jesus, PV | 1 |
| Anderson, JW | 1 |
| Vourganti, B | 1 |
| Kuba, T | 1 |
| Oh, SJ | 1 |
| Darnell, B | 1 |
| Gregersen, G | 3 |
| Børsting, H | 1 |
| Theil, P | 1 |
| Servo, C | 2 |
| Daumerie-Goffinet, C | 1 |
| Lambert, AE | 1 |
| Amabile, G | 1 |
| Parisi, L | 1 |
| Bianco, F | 1 |
| Bergström, L | 1 |
| Fogelholm, R | 1 |
| Ohno, A | 1 |
| Kanazawa, A | 1 |
| Tanaka, A | 1 |
| Miwa, T | 1 |
| Ito, H | 1 |
| Yasuda, H | 3 |
| Sonobe, M | 3 |
| Hisanaga, T | 1 |
| Kawabata, T | 1 |
| Maeda, K | 1 |
| Kikkawa, R | 2 |
| Shigeta, Y | 3 |
| Matsubara, A | 1 |
| Nakano, K | 1 |
| Kurono, M | 1 |
| Luheshi, GN | 1 |
| Zar, MA | 1 |
| Karjalainen, T | 1 |
| Tawata, M | 1 |
| Aida, K | 1 |
| Smith, WJ | 1 |
| Diemel, LT | 1 |
| Leach, RM | 1 |
| Das, AK | 1 |
| Vijayaraghavan, MV | 1 |
| Kato, K | 2 |
| Nakayama, K | 1 |
| Ohta, M | 1 |
| Murakami, N | 1 |
| Murakami, K | 1 |
| Mizota, M | 1 |
| Miwa, I | 1 |
| Okuda, J | 1 |
| Kito, S | 1 |
| Yamamura, Y | 1 |
| Wasada, T | 1 |
| Schmidt, RE | 2 |
| Plurad, SB | 2 |
| Coleman, BD | 1 |
| Tilton, RG | 2 |
| Iwamoto, Y | 1 |
| Hasegawa, M | 1 |
| Inoue, M | 1 |
| Doi, K | 1 |
| Mio, R | 1 |
| Sumino, K | 1 |
| Mirrlees, DJ | 1 |
| Lu, KM | 1 |
| Zhong, XL | 1 |
| Zhu, XX | 1 |
| Zhu, QY | 1 |
| Willars, GB | 2 |
| Robinson, JP | 3 |
| Archer, DR | 1 |
| McLean, WG | 1 |
| Alberghina, M | 1 |
| Compton, AM | 1 |
| Keen, P | 1 |
| Robertson, S | 1 |
| Yamashita, M | 2 |
| Terada, M | 2 |
| Hatanaka, I | 2 |
| Huitian, Z | 1 |
| Lattimer-Greene, S | 1 |
| Umehara, F | 1 |
| Balabolkin, MI | 1 |
| Islambekov, RR | 1 |
| Arendrup, K | 1 |
| Hawley, J | 1 |
| Hawthorne, JN | 1 |
| Ward, KK | 1 |
| Monckton, G | 1 |
| Marusyk, H | 1 |
| Bell, ME | 1 |
| Carroll, PB | 1 |
| Thornton, BM | 1 |
| Wuarin-Bierman, L | 1 |
| Zahnd, GR | 1 |
| Gillon, KR | 1 |
| King, RH | 1 |
| Thomas, PK | 1 |
| Zimmerman, BR | 1 |
| Vilen, TH | 1 |
| Minnerath, SR | 1 |
| Karnes, JL | 1 |
| Poduslo, JF | 1 |
| Miyamoto, Y | 1 |
| Amenomori, M | 1 |
| Motoyama, Y | 1 |
| Kofo-Abayomi, A | 1 |
| Lucas, PD | 1 |
| Vendrell, J | 1 |
| Nubiola, A | 1 |
| Goday, A | 1 |
| Bosch, X | 1 |
| Esmatjes, E | 1 |
| Gomis, R | 1 |
| Vilardell, E | 1 |
| Inaba, H | 1 |
| Yano, T | 1 |
| Lalau, JD | 1 |
| Arlot, S | 1 |
| Quichaud, J | 1 |
| Kador, PF | 1 |
| Kinoshita, JH | 1 |
| Macfarlane, CM | 1 |
| Gabbay, KH | 1 |
| Merola, LO | 1 |
| Field, RA | 1 |
28 reviews available for inositol and Diabetic Neuropathies
| Article | Year |
|---|---|
[Myo-inositol].
Topics: Biomarkers; Diabetic Nephropathies; Diabetic Neuropathies; Heat-Shock Proteins; Humans; Inositol; Me | 2002 |
[Inositol].
Topics: Animals; Atrophy; Biomarkers; Brain; Chromatography, Gas; Diabetic Neuropathies; Gas Chromatography- | 2004 |
Defects of axonal transport in diabetes mellitus--a possible contribution to the aetiology of diabetic neuropathy.
Topics: Animals; Axonal Transport; Body Temperature; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dia | 1984 |
The axonopathy of diabetic neuropathy.
Topics: Animals; Axons; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Edem | 1982 |
Diabetic neuropathy: peripheral and autonomic syndromes.
Topics: Cachexia; Cranial Nerve Diseases; Diabetic Neuropathies; Diarrhea; Digestive System; Erectile Dysfun | 1982 |
Aldose reductase inhibitors: an approach to the treatment of diabetic nerve damage.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Neuropathi | 1993 |
Inositol and phospholipid metabolism in diabetic nerve.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Humans; Inositol; Inositol Phosphat | 1993 |
[Myo-inositol].
Topics: Diabetes Mellitus; Diabetic Neuropathies; Gas Chromatography-Mass Spectrometry; Humans; Inositol | 1998 |
[Contemporary views on the pathogenesis of diabetic neuropathy].
Topics: Adenosine Triphosphatases; Basement Membrane; Diabetic Neuropathies; Endothelium, Vascular; Free Rad | 1998 |
Metabolic abnormalities contributing to diabetic complications. II. Peripheral nerves.
Topics: Animals; Axons; Cricetinae; Diabetes Mellitus; Diabetic Neuropathies; Disease Models, Animal; Glucos | 1976 |
[Diabetic microangiopathies].
Topics: Basement Membrane; Blood Viscosity; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies | 1978 |
Biochemical derangements in diabetes mellitus.
Topics: Aorta; Basement Membrane; Blood Platelets; Blood Proteins; Carbohydrate Metabolism; Diabetes Mellitu | 1979 |
[Neuron damage in diabetes mellitus: study of the possible factors involved and the therapeutic problem].
Topics: Animals; Diabetic Neuropathies; Glucose; Humans; Hypoglycemic Agents; Inositol; Insulin; Lipid Metab | 1979 |
[The pathogenesis of polyneuropathies].
Topics: Diabetic Neuropathies; Female; Glucose; Humans; Inositol; Male; Peripheral Nervous System Diseases; | 1991 |
Diabetic peripheral neuropathy.
Topics: Diabetic Neuropathies; Humans; Inositol; Sorbitol | 1991 |
[Diabetic neuropathy--a review of pathological studies].
Topics: Adolescent; Adult; Aged; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Mo | 1991 |
Peripheral nerve biochemistry in diabetes.
Topics: Animals; Axonal Transport; Carbohydrate Metabolism; CDP-Diacylglycerol-Inositol 3-Phosphatidyltransf | 1985 |
Metabolic correlates and axonal transport in nerves during experimental diabetes.
Topics: Animals; Axonal Transport; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Inositol; Periphe | 1986 |
Pathogenesis of diabetic neuropathy: role of altered phosphoinositide metabolism.
Topics: Animals; Diabetic Neuropathies; Disease Models, Animal; Humans; Inositol; Neural Conduction; Periphe | 1989 |
Are disturbances of sorbitol, phosphoinositide, and Na+-K+-ATPase regulation involved in pathogenesis of diabetic neuropathy?
Topics: Animals; Diabetic Neuropathies; Glucose; Humans; Inositol; Neural Conduction; Peripheral Nerves; Pho | 1988 |
Sorbitol, myo-inositol and sodium-potassium ATPase in diabetic peripheral nerve.
Topics: Animals; Blood Glucose; Diabetic Neuropathies; Energy Metabolism; Humans; Inositol; Sodium-Potassium | 1986 |
Current aspects of research on the pathogenesis of diabetic neuropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Humans; Inositol; Microcirculation; | 1986 |
Altered sorbitol and myo-inositol metabolism as the basis for defective protein kinase C and (Na,K)-ATPase regulation in diabetic neuropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Humans; Inositol; Peripheral Nerves | 1986 |
New therapies for the chronic complications of older diabetic patients.
Topics: Aged; Aldehyde Reductase; Blood Glucose; Cell Membrane Permeability; Coronary Disease; Diabetes Comp | 1986 |
The pathology of diabetic neuropathy and the effects of aldose reductase inhibitors.
Topics: Aldehyde Reductase; Autonomic Nervous System; Axons; Blood Glucose; Connective Tissue; Diabetic Neur | 1986 |
[Pathogenesis of diabetic neuropathies].
Topics: Animals; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Neuropathies; Energy Metabolism; Humans; | 1985 |
Somatic neurophysiology in diabetes. Basic observations and the effect of treatment.
Topics: Adolescent; Adult; Aged; Animals; Calcium; Diabetic Neuropathies; Humans; Imidazoles; Imidazolidines | 1985 |
Review of myo-inositol and sorbinil studies.
Topics: Adolescent; Adult; Aldehyde Reductase; Clinical Trials as Topic; Diabetic Neuropathies; Diet; Double | 1985 |
4 trials available for inositol and Diabetic Neuropathies
| Article | Year |
|---|---|
Comparison of clinical couse and sequential electrophysiological tests in diabetics with symptomatic polyneuropathy and its implications for clinical trials.
Topics: Achilles Tendon; Adult; Blood Glucose; Clinical Trials as Topic; Diabetic Neuropathies; Electrophysi | 1981 |
Effect of myo-inositol on peripheral-nerve function in diabetes.
Topics: Aged; Clinical Trials as Topic; Diabetes Mellitus; Diabetic Neuropathies; Dose-Response Relationship | 1978 |
Myoinositol and function of peripheral nerves in human diabetics. A controlled clinical trial.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Diabetic Neuropathies; Double-Blind Method; Drug | 1978 |
Review of myo-inositol and sorbinil studies.
Topics: Adolescent; Adult; Aldehyde Reductase; Clinical Trials as Topic; Diabetic Neuropathies; Diet; Double | 1985 |
81 other studies available for inositol and Diabetic Neuropathies
| Article | Year |
|---|---|
Sinomenine alleviates diabetic peripheral neuropathic pain through inhibition of the inositol-requiring enzyme 1 alpha-X-box binding protein 1 pathway by downregulating prostaglandin-endoperoxide synthase 2.
Topics: Animals; Cyclooxygenase 2; Diabetes Mellitus; Diabetic Neuropathies; Inositol; Microglia; Neuralgia; | 2023 |
Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy.
Topics: Animals; Carnitine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; | 2016 |
Chronic treatment with D-chiro-inositol prevents autonomic and somatic neuropathy in STZ-induced diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Electric Stimulation; Inositol; Mal | 2011 |
CEREBROSPINAL FLUID LEVELS OF FREE MYOINOSITOL IN SOME NEUROLOGICAL DISORDERS.
Topics: Biochemical Phenomena; Biochemistry; Cerebrospinal Fluid; Child; Dementia; Diabetic Neuropathies; Ge | 1965 |
Treatment of diabetic neuropathy and neuropathic pain: how far have we come?
Topics: Aldehyde Reductase; Analgesics, Opioid; Clinical Trials as Topic; Diabetic Neuropathies; Enzyme Inhi | 2008 |
Action of sorbinil in diabetic peripheral nerve. Relationship of polyol (sorbitol) pathway inhibition to a myo-inositol-mediated defect in sodium-potassium ATPase activity.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Imidazoles; Imidazol | 1984 |
Prevention of defects of axonal transport and nerve conduction velocity by oral administration of myo-inositol or an aldose reductase inhibitor in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Blood Glucose; Diabetes Mellitus, Experimental; Diabe | 1983 |
Prevention and reversal of defective axonal transport and motor nerve conduction velocity in rats with experimental diabetes by treatment with the aldose reductase inhibitor Sorbinil.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Choline O-Acetyltransferase; Diabetes Mellitus, Exper | 1984 |
Polyol pathway activity and myo-inositol metabolism. A suggested relationship in the pathogenesis of diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fructose; Gluco | 1983 |
Human diabetic endoneurial sorbitol, fructose, and myo-inositol related to sural nerve morphometry.
Topics: Diabetes Mellitus, Type 1; Diabetic Neuropathies; Fructose; Humans; Inositol; Middle Aged; Periphera | 1980 |
Effect of a potent new aldose reductase inhibitor, (5-(3-thienyltetrazol-1-yl)acetic acid (TAT), on diabetic neuropathy in rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic N | 1995 |
Vascular and metabolic factors in the pathogenesis of experimental diabetic neuropathy in mature rats.
Topics: Animals; Diabetic Neuropathies; Fructose; Glucose; Inositol; Male; Neural Conduction; Peripheral Ner | 1994 |
Galactosemia produces ARI-preventable nodal changes similar to those of diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Axons; Body Weight; Diabetic Neuropathies; Fructose; Galactitol; Galact | 1994 |
Neural dysfunction and metabolic imbalances in diabetic rats. Prevention by acetyl-L-carnitine.
Topics: Acetylcarnitine; Animals; Ca(2+) Mg(2+)-ATPase; Carnitine; Diabetes Mellitus, Experimental; Diabetic | 1994 |
Relationship between myoinositol influx and lipids in diabetic neuropathy.
Topics: Blood Glucose; Blood Pressure; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; D | 1993 |
Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic N | 1993 |
Effects of treatment with myo-inositol or its 1,2,6-trisphosphate (PP56) on nerve conduction in streptozotocin-diabetes.
Topics: Action Potentials; Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropat | 1993 |
Reduced motor nerve conduction velocity and Na(+)-K(+)-ATPase activity in rats maintained on L-fucose diet. Reversal by myo-inositol supplementation.
Topics: Animals; Biological Transport; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Neuropathi | 1993 |
Anti-oxidant treatment prevents the development of peripheral nerve dysfunction in streptozotocin-diabetic rats.
Topics: Action Potentials; Animals; Butylated Hydroxytoluene; Capillaries; Diabetes Mellitus, Experimental; | 1993 |
Natural course of diabetic peripheral neuropathy in spontaneous-onset diabetic Chinese hamsters.
Topics: Aging; Animals; Cricetinae; Cricetulus; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Electrophy | 1995 |
Modulation of basal nitric oxide-dependent cyclic-GMP production by ambient glucose, myo-inositol, and protein kinase C in SH-SY5Y human neuroblastoma cells.
Topics: Base Sequence; Cholinergic Fibers; Cyclic GMP; Diabetic Neuropathies; Glucose; Humans; Inositol; Mod | 1996 |
Primary preventive and secondary interventionary effects of acetyl-L-carnitine on diabetic neuropathy in the bio-breeding Worcester rat.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcarnitine; Alprostadil; Animals; Diabetic Neuropathies; Dinopros | 1996 |
Interactions between essential fatty acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats.
Topics: Acetanilides; Aldehyde Reductase; Analysis of Variance; Animals; Arginine; Blood Glucose; Body Weigh | 1996 |
Supplemental myo-inositol prevents L-fucose-induced diabetic neuropathy.
Topics: Animals; Diabetic Neuropathies; Fucose; Inositol; Male; Neural Conduction; Rats; Rats, Sprague-Dawle | 1997 |
Alpha-lipoic acid: effect on glucose uptake, sorbitol pathway, and energy metabolism in experimental diabetic neuropathy.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relati | 1999 |
Sorbitol and myo-inositol levels and morphology of sural nerve in relation to peripheral nerve function and clinical neuropathy in men with diabetic, impaired, and normal glucose tolerance.
Topics: Diabetes Mellitus, Type 1; Diabetic Neuropathies; Glucose Intolerance; Glucose Tolerance Test; Human | 2000 |
Effects of 15-month aldose reductase inhibition with fidarestat on the experimental diabetic neuropathy in rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic N | 2000 |
Clinical usefulness of measuring urinary polyol excretion by gas-chromatography/mass-spectrometry in type 2 diabetes to assess polyol pathway activity.
Topics: Adult; Albuminuria; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Diabetic Retino | 2001 |
Slowing of motor nerve conduction velocity in streptozotocin-induced diabetic rats is preceded by impaired vasodilation in arterioles that overlie the sciatic nerve.
Topics: Acetylcholine; Animals; Arterioles; Biomarkers; Diabetes Mellitus, Experimental; Diabetic Neuropathi | 2000 |
Effects of insulin and dietary myoinositol on impaired peripheral motor nerve conduction velocity in acute streptozotocin diabetes.
Topics: Animals; Diabetes Mellitus; Diabetic Neuropathies; Inositol; Insulin; Male; Neural Conduction; Perip | 1975 |
Dietary myo-inositol intake and peripheral nerve function in diabetic neuropathy.
Topics: Adult; Blood Glucose; Diabetic Neuropathies; Diet; Female; Humans; Inositol; Kinetics; Male; Median | 1979 |
Dietary myo-inositol and diabetic neuropathy.
Topics: Blood Glucose; Diabetic Neuropathies; Humans; Inositol; Neural Conduction | 1979 |
Cerebrospinal fluid sorbitol and myoinositol in diabetic polyneuropathy.
Topics: Adult; Aged; Blood Glucose; Diabetic Neuropathies; Dietary Carbohydrates; Humans; Hypoglycemic Agent | 1977 |
Diabetic polyneuropathy: the importance of insulin deficiency, hyperglycemia and alterations in myoinositol metabolism in its pathogenesis.
Topics: Acute Disease; Animals; Demyelinating Diseases; Diabetes Mellitus, Experimental; Diabetic Neuropathi | 1976 |
Effect of a prostaglandin I2 derivative (iloprost) on peripheral neuropathy of diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Cyclic AMP; Diabetes Mellitus, Experimental; Diabetic Neuropath | 1992 |
A combination of the aldose reductase inhibitor, statil, and the prostaglandin E1 analogue, OP1206.alpha CD, completely improves sciatic motor nerve conduction velocity in streptozocin-induced chronically diabetic rats.
Topics: Aldehyde Reductase; Alprostadil; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hy | 1992 |
Effects of a new aldose reductase inhibitor, (2S, 4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-ca rboxamid e (SNK-860), on the slowing of motor nerve conduction velocity and metabolic abnormalities in the peripheral nerve in acute streptozo
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic N | 1992 |
Effect of streptozotocin diabetes on motor and inhibitory transmission in rat anococcygeus.
Topics: Aldehyde Reductase; Animals; Autonomic Nervous System Diseases; Diabetes Mellitus, Experimental; Dia | 1992 |
The role of cyclic adenosine 3',5'-monophosphate and polyol metabolism in diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Chalcone; Chalcones; Cyclic AMP; Cyclic GMP; Diabetes Me | 1992 |
Abnormal myoinositol influx in human leucocytes in diabetes but not specifically in diabetic neuropathy.
Topics: Biological Transport; Blood Glucose; Blood Pressure; Carbon Radioisotopes; Diabetes Mellitus, Type 1 | 1992 |
Understanding diabetic neuropathy.
Topics: Diabetic Neuropathies; Humans; Hyperglycemia; Inositol; Nerve Growth Factors; Peripheral Nerves; Tim | 1991 |
Central hypoxaemia in rats provokes neurological defects similar to those seen in experimental diabetes mellitus: evidence for a partial role of endoneurial hypoxia in diabetic neuropathy.
Topics: Animals; Diabetic Neuropathies; Glucose; Hypoxia; Inositol; Male; Nerve Tissue Proteins; Neural Cond | 1991 |
Effects of novel aldose reductase inhibitors, M16209 and M16287, on streptozotocin-induced diabetic neuropathy in rats.
Topics: Aldehyde Reductase; Animals; Benzofurans; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Do | 1991 |
[Diabetic neuropathy--pathogenesis and precipitating factors].
Topics: Alcohol Drinking; Animals; Diabetic Neuropathies; Energy Metabolism; Fructose; Glucose; Humans; Imid | 1991 |
Effects of sorbinil, dietary myo-inositol supplementation, and insulin on resolution of neuroaxonal dystrophy in mesenteric nerves of streptozocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Autonomic Nervous System; Axons; Blood Glucose; Diabetes Mellitus, Expe | 1991 |
[Diabetic complication].
Topics: Aldehyde Reductase; Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetic Nephropathies; Diabe | 1991 |
[Clinical significance of serum myo-inositol analysis in the diabetic complications].
Topics: Animals; Diabetic Angiopathies; Diabetic Neuropathies; Diabetic Retinopathy; Gas Chromatography-Mass | 1990 |
Effects of long-term aldose reductase inhibition on development of experimental diabetic neuropathy. Ultrastructural and morphometric studies of sural nerve in streptozocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Inositol; Male; | 1990 |
[Alterations in the sorbitol pathway and Na(+)-K(+)-ATPase activity of peripheral nerve of alloxan-induced diabetic rats].
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Glucose; Inositol; Male; Ouabain; R | 1990 |
A sodium-pump defect in diabetic peripheral nerve corrected by sorbinil administration: relationship to myo-inositol metabolism and nerve conduction slowing.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Energy Metabolism; Humans; Imidazol | 1986 |
Studies of sorbinil on axonal transport in streptozotocin-diabetic rats.
Topics: Animals; Axonal Transport; Blood Glucose; Choline O-Acetyltransferase; Diabetes Mellitus, Experiment | 1986 |
Prevention of defects of axonal transport in experimental diabetes by aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Choline O-Acetyltransferase; Diabetic Neuropathies; I | 1986 |
Treatment with an aldose reductase inhibitor can reduce the susceptibility of fast axonal transport following nerve compression in the streptozotocin-diabetic rat.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Diabetes Mellitus, Experimental; Diabetic Neuropathie | 1987 |
Essential fatty acid treatment--effects on nerve conduction, polyol pathway and axonal transport in streptozotocin diabetic rats.
Topics: Animals; Axonal Transport; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fatty Acids, Esse | 1989 |
Effects of aldose reductase inhibitor sorbinil on neuroaxonal dystrophy and levels of myo-inositol and sorbitol in sympathetic autonomic ganglia of streptozocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Axons; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Galactos | 1989 |
The effect of aldose reductase inhibition on the pattern of nerve conduction deficits in diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Inositol; Kinet | 1989 |
Effect of prostaglandin E1 analogue TFC 612 on diabetic neuropathy in streptozocin-induced diabetic rats. Comparison with aldose reductase inhibitor ONO 2235.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Alprostadil; Animals; Diabetes Mellitus, Experimental; D | 1989 |
[Recent advances in the pathogenesis of diabetic neuropathy].
Topics: Animals; Axons; Diabetic Neuropathies; Humans; Inositol; Phosphocreatine; Sorbitol | 1989 |
[Diabetic polyneuropathy].
Topics: Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Humans; Hyperglycemia; Inositol; P | 1989 |
Polyols and myo-inositol in diabetic neuropathy--of mice and men.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Galactitol; Inositol; Mice; Periphe | 1989 |
High-dose dietary myo-inositol supplementation does not alter the ischaemia phenomenon in human diabetics.
Topics: Adolescent; Adult; Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Dose-Response R | 1989 |
Pathogenesis of diabetic neuropathy.
Topics: Diabetic Neuropathies; Humans; Inositol; Peripheral Nerves; Sorbitol | 1989 |
Experimental chronic hypoxic neuropathy: relevance to diabetic neuropathy.
Topics: Animals; Diabetic Neuropathies; Disease Models, Animal; Electrophysiology; Glycated Hemoglobin; Hexo | 1986 |
Axonal transport and nerve conduction velocity in animal models of diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Axons; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Imidazol | 1985 |
The effects of myoinositol on the autonomic neuropathy in the streptozotocin diabetic rat--a freeze fracture study.
Topics: Adrenergic Fibers; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Freeze Fracturin | 1988 |
Decreased incorporation of [3H]inositol and [3H]glycerol into glycerolipids of sciatic nerve from the streptozotocin diabetic rat.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Female; Glycerol; Inositol; Lipid M | 1985 |
Recent advances in the therapy of diabetic peripheral neuropathy by means of an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Biological Transport; Diabetic Neuropathies; Humans; Imidazoles; Imidaz | 1985 |
Protein kinase C agonists acutely normalize decreased ouabain-inhibitable respiration in diabetic rabbit nerve. Implications for (Na,K)-ATPase regulation and diabetic complications.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diglycerides; Glycerides; Inositol; | 1986 |
Axo-glial dysjunction. A novel structural lesion that accounts for poorly reversible slowing of nerve conduction in the spontaneously diabetic bio-breeding rat.
Topics: Animals; Axons; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Electrophysiology; Inositol; | 1986 |
Glutathione redox state is not the link between polyol pathway activity and myo-inositol-related Na+-K+-ATPase defect in experimental diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Glutathione; Im | 1986 |
Banting lecture 1986. Does a common mechanism induce the diverse complications of diabetes?
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Ne | 1987 |
The polyol pathway in dysfunction of diabetic peripheral nerve.
Topics: Aldehyde Reductase; Animals; Diabetic Neuropathies; Humans; Inositol; Neural Conduction; Peripheral | 1985 |
Nerve glucose, fructose, sorbitol, myo-inositol, and fiber degeneration and regeneration in diabetic neuropathy.
Topics: Adolescent; Adult; Aged; Aldehyde Reductase; Diabetes Mellitus; Diabetic Neuropathies; Erythrocytes; | 1988 |
A new prostaglandin E1 analogue (TFC-612) prevents a decrease in motor nerve conduction velocity in streptozocin-diabetic rats.
Topics: Alprostadil; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Inositol; Insulin; Mal | 1988 |
A comparison between atria from control and streptozotocin-diabetic rats: the effects of dietary myoinositol.
Topics: Acetylcholine; Animals; Autonomic Nervous System; Blood Glucose; Diabetes Mellitus, Experimental; Di | 1988 |
Erythromelalgia associated with acute diabetic neuropathy: an unusual condition.
Topics: Acute Disease; Adult; Carbamazepine; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Erythromelalg | 1988 |
[Effect of trapidil on neuropathy in diabetic mice].
Topics: Animals; Blood Glucose; Cholesterol, HDL; Diabetes Mellitus, Experimental; Diabetic Neuropathies; In | 1986 |
Recent advances in the pathogenesis of diabetic neuropathy.
Topics: Animals; Capillaries; Diabetic Neuropathies; Humans; Hypoxia; Inositol; Ischemia; Neural Conduction; | 1987 |
Role of aldose reductase in the development of diabetes-associated complications.
Topics: Aldehyde Reductase; Animals; Corneal Diseases; Diabetic Neuropathies; Diabetic Retinopathy; Humans; | 1985 |
Secondary changes in diabetes mellitus with particular reference to retinopathy and neuropathy.
Topics: Diabetes Mellitus; Diabetic Nephropathies; Diabetic Neuropathies; Glucose; Humans; Hypoxia; Inositol | 1985 |
Sorbitol pathway: presence in nerve and cord with substrate accumulation in diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fructose; Glucose; In Vitro Techniq | 1966 |