inositol has been researched along with Diabetic Nephropathies in 28 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Diabetic Nephropathies: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A series of in vivo and in vitro investigations was performed to examine the localisation of sorbitol pathway activity in the rat renal cortex and to investigate the possible relation that the acculumation of sorbitol pathway intermediates in renal cortical tissue may have to the pathogenesis of renal complications in diabetes mellitus." | 7.65 | The localisation of sorbitol pathway activity in the rat renal cortex and its relationship to the pathogenesis of the renal complications of diabetes mellitus. ( Hollows, FC; Hutton, JC; Schofield, PJ; Williams, JF, 1975) |
| "A series of in vivo and in vitro investigations was performed to examine the localisation of sorbitol pathway activity in the rat renal cortex and to investigate the possible relation that the acculumation of sorbitol pathway intermediates in renal cortical tissue may have to the pathogenesis of renal complications in diabetes mellitus." | 3.65 | The localisation of sorbitol pathway activity in the rat renal cortex and its relationship to the pathogenesis of the renal complications of diabetes mellitus. ( Hollows, FC; Hutton, JC; Schofield, PJ; Williams, JF, 1975) |
| "Myo-inositol treatment resulted in positive modulation of PINK1/Parkin pathway as well as PHB2 and NIX." | 1.72 | Renoprotective potential of myo-inositol on diabetic kidney disease: Focus on the role of the PINK1/Parkin pathway and mitophagy receptors. ( Arruri, VK; Kalvala, AK; Khatri, DK; Sherkhane, B; Singh, SB, 2022) |
| "Epalrestat is an inhibitor of aldose reductase in the polyol pathway and is used for the management of diabetic neuropathy clinically." | 1.51 | The aldose reductase inhibitor epalrestat exerts nephritic protection on diabetic nephropathy in db/db mice through metabolic modulation. ( Aa, JY; Ding, F; Gao, HX; He, J; Sun, RB; Wang, GJ; Wang, JK; Xie, Y; Yang, N; Zeng, CH; Zhang, JW; Zhu, XD, 2019) |
| "Diabetic nephropathy is a serious complication of diabetes mellitus with a pressing need for effective metabolic markers to detect renal impairment." | 1.42 | The diabetic rat kidney mediates inosituria and selective urinary partitioning of D-chiro-inositol. ( Chang, HH; Choong, B; Loomes, KM; Phillips, AR, 2015) |
| "The implication of MIOX expression in diabetic nephropathy, however, has not been revealed." | 1.35 | Increased expression of myo-inositol oxygenase is involved in the tubulointerstitial injury of diabetic nephropathy. ( Liu, C; Lu, Y; Miao, X; Wu, X; Xu, K, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (39.29) | 18.7374 |
| 1990's | 8 (28.57) | 18.2507 |
| 2000's | 2 (7.14) | 29.6817 |
| 2010's | 5 (17.86) | 24.3611 |
| 2020's | 2 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Sherkhane, B | 1 |
| Kalvala, AK | 1 |
| Arruri, VK | 1 |
| Khatri, DK | 1 |
| Singh, SB | 1 |
| Fan, C | 1 |
| Zhang, D | 1 |
| Zhang, J | 1 |
| Li, J | 1 |
| Wang, Y | 1 |
| Gao, L | 1 |
| Han, S | 1 |
| He, J | 1 |
| Gao, HX | 1 |
| Yang, N | 1 |
| Zhu, XD | 1 |
| Sun, RB | 1 |
| Xie, Y | 1 |
| Zeng, CH | 1 |
| Zhang, JW | 1 |
| Wang, JK | 1 |
| Ding, F | 1 |
| Aa, JY | 1 |
| Wang, GJ | 1 |
| Croze, ML | 1 |
| Soulage, CO | 1 |
| Li, XW | 1 |
| Liu, Y | 1 |
| Hao, W | 1 |
| Yang, JR | 1 |
| Chang, HH | 2 |
| Choong, B | 1 |
| Phillips, AR | 1 |
| Loomes, KM | 2 |
| Chao, HN | 1 |
| Walker, CS | 1 |
| Choong, SY | 1 |
| Phillips, A | 1 |
| Lu, Y | 1 |
| Liu, C | 2 |
| Miao, X | 1 |
| Xu, K | 1 |
| Wu, X | 1 |
| Nakashima, E | 1 |
| Nakamura, J | 1 |
| Cohen, AM | 1 |
| Wald, H | 1 |
| Popovtzer, M | 1 |
| Rosenmann, E | 1 |
| Inman, SR | 1 |
| Porter, JP | 1 |
| Fleming, JT | 1 |
| Hutton, JC | 1 |
| Schofield, PJ | 1 |
| Williams, JF | 1 |
| Hollows, FC | 1 |
| Daumerie-Goffinet, C | 1 |
| Lambert, AE | 1 |
| Clements, RS | 2 |
| Servo, C | 1 |
| Pitkänen, E | 1 |
| Radhakrishnamurthy, B | 1 |
| Berenson, GS | 1 |
| Pargaonkar, PS | 1 |
| Voors, AW | 1 |
| Srinivasan, SR | 1 |
| Plavidal, F | 1 |
| Dolan, P | 1 |
| Dalferes, ER | 1 |
| Lohr, JW | 1 |
| Bennett, MI | 1 |
| Pochal, MA | 1 |
| McReynolds, J | 1 |
| Acara, M | 1 |
| Willsky, GR | 1 |
| Ziyadeh, FN | 1 |
| Simmons, DA | 2 |
| Snipes, ER | 1 |
| Goldfarb, S | 2 |
| Iwamoto, Y | 1 |
| Fujita, T | 1 |
| Ohi, H | 1 |
| Hatano, M | 1 |
| Moller, DE | 1 |
| Moses, AC | 1 |
| Cai, F | 1 |
| Liang, J | 1 |
| Liao, X | 1 |
| Greene, DA | 1 |
| Winegrad, AI | 1 |
| Cohen, M | 1 |
| Kern, EF | 1 |
| Macfarlane, CM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Myo-inositol for the Management of Poor Ovarian Responders: A Prospective Randomized Controlled Trial[NCT04273256] | Phase 2/Phase 3 | 226 participants (Anticipated) | Interventional | 2020-02-11 | Recruiting | ||
| Effect of Myoinositol on Serum Asprosin Levels in Pregnant Women[NCT05943158] | 40 participants (Actual) | Interventional | 2021-06-01 | Completed | |||
| Different Effects of Inositol Stereoisomers on Insulin Sensitivity in Women With Gestational Diabetes[NCT02097069] | 80 participants (Anticipated) | Interventional | 2014-04-30 | Not yet recruiting | |||
| Effects of a Supplementation With Zinc and Myo-inositol in Paediatric Obesity[NCT03283813] | Phase 4 | 60 participants (Anticipated) | Interventional | 2018-02-05 | Recruiting | ||
| Reduction of Insulin Therapy Under Myo-inositol for the Treatment of Gestational Diabetes Mellitus: a Randomized Multicenter and Prospective Trial. MYO-GDM Study[NCT03875755] | 1,080 participants (Anticipated) | Interventional | 2020-03-04 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for inositol and Diabetic Nephropathies
| Article | Year |
|---|---|
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
Potential role and therapeutic interests of myo-inositol in metabolic diseases.
Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human | 2013 |
[Myo-inositol].
Topics: Biomarkers; Diabetic Nephropathies; Diabetic Neuropathies; Heat-Shock Proteins; Humans; Inositol; Me | 2002 |
[Diabetic microangiopathies].
Topics: Basement Membrane; Blood Viscosity; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies | 1978 |
Biochemical derangements in diabetes mellitus.
Topics: Aorta; Basement Membrane; Blood Platelets; Blood Proteins; Carbohydrate Metabolism; Diabetes Mellitu | 1979 |
Acute and chronic complications of diabetes mellitus in older patients.
Topics: Adult; Aged; Aging; Blood Pressure; Diabetes Complications; Diabetes Mellitus; Diabetic Coma; Diabet | 1986 |
New therapies for the chronic complications of older diabetic patients.
Topics: Aged; Aldehyde Reductase; Blood Glucose; Cell Membrane Permeability; Coronary Disease; Diabetes Comp | 1986 |
22 other studies available for inositol and Diabetic Nephropathies
| Article | Year |
|---|---|
Renoprotective potential of myo-inositol on diabetic kidney disease: Focus on the role of the PINK1/Parkin pathway and mitophagy receptors.
Topics: Animals; Diabetes Mellitus; Diabetic Nephropathies; Glucose; Inositol; Mitophagy; Protein Kinases; R | 2022 |
The effect of D-chiro-inositol on renal protection in diabetic mice.
Topics: Animals; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Female; Humans; Inosit | 2022 |
The aldose reductase inhibitor epalrestat exerts nephritic protection on diabetic nephropathy in db/db mice through metabolic modulation.
Topics: Albuminuria; Aldehyde Reductase; Animals; Diabetic Nephropathies; Enzyme Inhibitors; Fructose; Inosi | 2019 |
Sequoyitol ameliorates diabetic nephropathy in diabetic rats induced with a high-fat diet and a low dose of streptozotocin.
Topics: Animals; Cell Survival; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diet, High-Fat; Hyp | 2014 |
The diabetic rat kidney mediates inosituria and selective urinary partitioning of D-chiro-inositol.
Topics: Animals; Biomarkers; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glomerular Filtration | 2015 |
Renal depletion of myo-inositol is associated with its increased degradation in animal models of metabolic disease.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Hypertension; Inositol; Inositol O | 2015 |
Increased expression of myo-inositol oxygenase is involved in the tubulointerstitial injury of diabetic nephropathy.
Topics: Actins; Animals; Cadherins; Cell Line; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fibr | 2009 |
Effect of myo-inositol supplementation on the development of renal pathological changes in the Cohen diabetic (type 2) rat.
Topics: Animals; Blood Glucose; Body Weight; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; | 1995 |
Dietary myo-inositol restores diabetic renal arteriolar reactivity to angiotensin II but not to norepinephrine.
Topics: Acetylcholine; Angiotensin II; Animals; Arterioles; Blood Glucose; Diabetes Mellitus, Experimental; | 1996 |
The localisation of sorbitol pathway activity in the rat renal cortex and its relationship to the pathogenesis of the renal complications of diabetes mellitus.
Topics: Animals; Chromatography, Gas; Diabetes Mellitus; Diabetic Nephropathies; Fructose; Glucose; Inositol | 1975 |
Variation in polyol levels in cerebrospinal fluid and serum in diabetic patients.
Topics: Aged; Blood Glucose; Creatinine; Deoxyglucose; Diabetes Mellitus; Diabetic Nephropathies; Ethers, Cy | 1975 |
Serum-free and protein-bound sugars and cardiovascular complications in diabetes mellitus.
Topics: Adult; Age Factors; Aged; Analysis of Variance; Blood Glucose; Blood Pressure; Cardiovascular Diseas | 1976 |
Effect of vanadate on renal hypertrophy and sorbitol accumulation in streptozotocin induced diabetes in rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Hypertrophy; Inosit | 1991 |
Effect of myo-inositol on cell proliferation and collagen transcription and secretion in proximal tubule cells cultured in elevated glucose.
Topics: Animals; Cell Division; Cell Line; Diabetic Nephropathies; Glucose; Inositol; Kidney Tubules, Proxim | 1991 |
[Diabetic complication].
Topics: Aldehyde Reductase; Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetic Nephropathies; Diabe | 1991 |
[Diabetic nephropathy--mechanism of incidence and risk factor].
Topics: Blood Glucose; Blood Pressure; Diabetic Nephropathies; Glomerular Filtration Rate; Glycoproteins; Gl | 1991 |
Advances in the diagnosis and pathogenesis of diabetes mellitus and its complications.
Topics: Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Dia | 1990 |
[Preliminary report of efficacy of diabetic polyneuropathy treated with large dose inositol].
Topics: Adult; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Inositol; Male; Middle Age | 1990 |
Banting lecture 1986. Does a common mechanism induce the diverse complications of diabetes?
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Ne | 1987 |
Aldose reductase inhibition, glomerular metabolism, and diabetic nephropathy.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Imidazoles; Im | 1985 |
Amelioration of glomerular hyperfiltration in acute experimental diabetes mellitus by dietary myo-inositol supplementation and aldose reductase inhibition.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diet; Glomerul | 1986 |
Secondary changes in diabetes mellitus with particular reference to retinopathy and neuropathy.
Topics: Diabetes Mellitus; Diabetic Nephropathies; Diabetic Neuropathies; Glucose; Humans; Hypoxia; Inositol | 1985 |