inositol has been researched along with Diabetes Mellitus, Type 1 in 30 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To improve insulin sensitivity, insulin-sensitizing drugs such as metformin are commonly used in overweight and obese T1D patients." | 9.24 | A pilot study of D-chiro-inositol plus folic acid in overweight patients with type 1 diabetes. ( Defeudis, G; Del Toro, R; Fioriti, E; Guglielmi, C; Kyanvash, S; Maggi, D; Manfrini, S; Maurizi, AR; Menduni, M; Pantano, AL; Pozzilli, P, 2017) |
| "Authors would like to demonstrate the beneficial effect of myo-inositol supplementation in a pregnant woman with insulin-dependent type 2 diabetes mellitus and polycystic ovary syndrome." | 7.85 | [The myo-inositol is beneficial in the therapy of pregnancy with insulin-dependent type 2 diabetes and polycystic ovary syndrome]. ( Kun, A; Tornóczky, J, 2017) |
| "To improve insulin sensitivity, insulin-sensitizing drugs such as metformin are commonly used in overweight and obese T1D patients." | 5.24 | A pilot study of D-chiro-inositol plus folic acid in overweight patients with type 1 diabetes. ( Defeudis, G; Del Toro, R; Fioriti, E; Guglielmi, C; Kyanvash, S; Maggi, D; Manfrini, S; Maurizi, AR; Menduni, M; Pantano, AL; Pozzilli, P, 2017) |
| "Authors would like to demonstrate the beneficial effect of myo-inositol supplementation in a pregnant woman with insulin-dependent type 2 diabetes mellitus and polycystic ovary syndrome." | 3.85 | [The myo-inositol is beneficial in the therapy of pregnancy with insulin-dependent type 2 diabetes and polycystic ovary syndrome]. ( Kun, A; Tornóczky, J, 2017) |
| "Nocturnal hypoglycemia is one of the serious complications of intensive insulin therapy in patients with insulin-dependent diabetes mellitus (IDDM; type 1 DM)." | 2.69 | Voglibose administration before the evening meal improves nocturnal hypoglycemia in insulin-dependent diabetic patients with intensive insulin therapy. ( Komiya, I; Taira, M; Taira, T; Takasu, N; Tanaka, H, 2000) |
| "Sorbinil treatment reduced the elevated sorbitol levels in the diabetic patients to normal or slightly below normal, but did not affect the erythrocyte myo-inositol concentration." | 2.65 | myo-Inositol and sorbitol in erythrocytes from diabetic patients before and after sorbinil treatment. ( Lomecky-Janousek, MZ; Popp-Snijders, C; Schouten, JA; van der Veen, EA, 1984) |
| "The brain metabolites of 17 men with type 1 diabetes and 12 age-matched non-diabetic men (22-43 years old) were studied after an overnight fast (plasma glucose 9." | 1.35 | Hyperglycaemia is associated with changes in the regional concentrations of glucose and myo-inositol within the brain. ( Groop, PH; Heikkilä, O; Heikkinen, S; Lundbom, N; Mäkimattila, S; Timonen, M, 2009) |
| "Myo-inositol was even more elevated in patients with polyneuropathy (p = 0." | 1.32 | Alterations of cerebral metabolism in patients with diabetes mellitus studied by proton magnetic resonance spectroscopy. ( Feuerbach, S; Fründ, R; Geissler, A; Schölmerich, J; Zietz, B, 2003) |
| "Several autoantibodies related to Type 1 diabetes mellitus and their corresponding autoantigens have been previously identified." | 1.30 | Sera from children with type 1 diabetes mellitus react against a new group of antigens composed of lysophospholipids. ( Bleich, D; Chen, S; Lévy-Marchal, C; Polak, M; Swiderek, KM, 1999) |
| "Myoinositol influx was significantly but negatively correlated with the serum very low density lipoprotein (VLDL) cholesterol concentration in patients with and without neuropathy but not in the controls." | 1.29 | Relationship between myoinositol influx and lipids in diabetic neuropathy. ( Bomford, J; Ng, LL; Simmons, D, 1993) |
| "Erythromelalgia is a syndrome characterized by erythema, burning pain and increased skin temperature of the affected extremities." | 1.27 | Erythromelalgia associated with acute diabetic neuropathy: an unusual condition. ( Bosch, X; Esmatjes, E; Goday, A; Gomis, R; Nubiola, A; Vendrell, J; Vilardell, E, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (23.33) | 18.7374 |
| 1990's | 11 (36.67) | 18.2507 |
| 2000's | 9 (30.00) | 29.6817 |
| 2010's | 3 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kun, A | 1 |
| Tornóczky, J | 1 |
| Zhang, H | 1 |
| Huang, M | 1 |
| Gao, L | 1 |
| Lei, H | 1 |
| Maurizi, AR | 1 |
| Menduni, M | 1 |
| Del Toro, R | 1 |
| Kyanvash, S | 1 |
| Maggi, D | 1 |
| Guglielmi, C | 1 |
| Pantano, AL | 1 |
| Defeudis, G | 1 |
| Fioriti, E | 1 |
| Manfrini, S | 1 |
| Pozzilli, P | 1 |
| Heikkilä, O | 1 |
| Lundbom, N | 1 |
| Timonen, M | 1 |
| Groop, PH | 1 |
| Heikkinen, S | 1 |
| Mäkimattila, S | 1 |
| Watanabe, K | 1 |
| Kawamori, R | 1 |
| Geissler, A | 1 |
| Fründ, R | 1 |
| Schölmerich, J | 1 |
| Feuerbach, S | 1 |
| Zietz, B | 1 |
| Jung, TS | 1 |
| Hahm, JR | 1 |
| Kim, JJ | 1 |
| Jung, JH | 1 |
| Kang, MY | 1 |
| Moon, SW | 1 |
| Lee, KW | 1 |
| Kim, HC | 1 |
| Lee, JD | 1 |
| Kim, JH | 1 |
| Kim, DR | 1 |
| Chung, SI | 1 |
| Rankins, D | 1 |
| Wellard, RM | 1 |
| Cameron, F | 1 |
| McDonnell, C | 1 |
| Northam, E | 1 |
| Kawashima, S | 1 |
| Kaneto, H | 1 |
| Sakamoto, K | 1 |
| Yasuda, T | 1 |
| Kuroda, A | 1 |
| Shiraiwa, T | 1 |
| Yamamoto, K | 1 |
| Kasami, R | 1 |
| Matsuoka, TA | 1 |
| Yamasaki, Y | 1 |
| Matsuhisa, M | 1 |
| Merimee, TJ | 1 |
| Misbin, RI | 1 |
| Gold, L | 1 |
| Greene, DA | 2 |
| Varma, SD | 1 |
| Richards, RD | 1 |
| Popp-Snijders, C | 1 |
| Lomecky-Janousek, MZ | 1 |
| Schouten, JA | 1 |
| van der Veen, EA | 1 |
| Dyck, PJ | 1 |
| Sherman, WR | 2 |
| Hallcher, LM | 1 |
| Service, FJ | 1 |
| O'Brien, PC | 1 |
| Grina, LA | 1 |
| Palumbo, PJ | 1 |
| Swanson, CJ | 1 |
| Dayhaw-Barker, P | 1 |
| Hacibekiroğlu, M | 1 |
| Akçay, T | 1 |
| Simmons, D | 2 |
| Ng, LL | 2 |
| Bomford, J | 2 |
| Ostlund, RE | 1 |
| McGill, JB | 1 |
| Herskowitz, I | 1 |
| Kipnis, DM | 1 |
| Santiago, JV | 1 |
| Larner, J | 2 |
| Craig, JW | 1 |
| Bleich, D | 1 |
| Polak, M | 1 |
| Chen, S | 1 |
| Swiderek, KM | 1 |
| Lévy-Marchal, C | 1 |
| Taira, M | 1 |
| Takasu, N | 1 |
| Komiya, I | 1 |
| Taira, T | 1 |
| Tanaka, H | 1 |
| Sundkvist, G | 1 |
| Dahlin, LB | 1 |
| Nilsson, H | 1 |
| Eriksson, KF | 1 |
| Lindgärde, F | 1 |
| Rosén, I | 1 |
| Lattimer, SA | 1 |
| Sima, AA | 2 |
| Sullivan, K | 1 |
| Chakrabarti, S | 1 |
| Hotta, N | 1 |
| Sano, T | 1 |
| Moller, DE | 1 |
| Moses, AC | 1 |
| Loy, A | 1 |
| Lurie, KG | 1 |
| Ghosh, A | 1 |
| Wilson, JM | 1 |
| MacGregor, LC | 1 |
| Matschinsky, FM | 1 |
| Airey, CM | 1 |
| Price, DE | 1 |
| Kemp, JV | 1 |
| Perkins, CM | 1 |
| Wales, JK | 1 |
| Vendrell, J | 1 |
| Nubiola, A | 1 |
| Goday, A | 1 |
| Bosch, X | 1 |
| Esmatjes, E | 1 |
| Gomis, R | 1 |
| Vilardell, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study of D-Chiro-Inositol Plus Folic Acid in Overweight Patients With Type 1 Diabetes[NCT02730949] | Phase 3 | 26 participants (Actual) | Interventional | 2014-03-31 | Completed | ||
| Effects of a Supplementation With Zinc and Myo-inositol in Paediatric Obesity[NCT03283813] | Phase 4 | 60 participants (Anticipated) | Interventional | 2018-02-05 | Recruiting | ||
| [NCT01514942] | Phase 4 | 0 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for inositol and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
[Combination therapy with insulin and alpha-glucosidase inhibitor].
Topics: Acarbose; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Drug Thera | 2002 |
Mechanisms of pathogenesis in diabetes mellitus.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Histocompatibilit | 1995 |
4 trials available for inositol and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
A pilot study of D-chiro-inositol plus folic acid in overweight patients with type 1 diabetes.
Topics: Adolescent; Adult; Blood Glucose; Diabetes Mellitus, Type 1; Female; Folic Acid; Humans; Inositol; I | 2017 |
myo-Inositol and sorbitol in erythrocytes from diabetic patients before and after sorbinil treatment.
Topics: Adult; Aldehyde Reductase; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabetes Mellitus, T | 1984 |
Voglibose administration before the evening meal improves nocturnal hypoglycemia in insulin-dependent diabetic patients with intensive insulin therapy.
Topics: Adolescent; Adult; Aged; Blood Glucose; Circadian Rhythm; Diabetes Mellitus, Type 1; Drug Administra | 2000 |
The effect of aldose reductase inhibition on erythrocyte polyols and galactitol accumulation in diabetic patients.
Topics: Aldehyde Reductase; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, | 1989 |
24 other studies available for inositol and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
[The myo-inositol is beneficial in the therapy of pregnancy with insulin-dependent type 2 diabetes and polycystic ovary syndrome].
Topics: Adult; Diabetes Mellitus, Type 1; Female; Humans; Infant, Newborn; Inositol; Polycystic Ovary Syndro | 2017 |
Region-specific cerebral metabolic alterations in streptozotocin-induced type 1 diabetic rats: an in vivo proton magnetic resonance spectroscopy study.
Topics: Animals; Aspartic Acid; Blood Glucose; Brain Chemistry; Corpus Striatum; Diabetes Mellitus, Experime | 2015 |
Hyperglycaemia is associated with changes in the regional concentrations of glucose and myo-inositol within the brain.
Topics: Adult; Blood Glucose; Blood Pressure; Body Mass Index; Brain; C-Reactive Protein; Cholesterol, HDL; | 2009 |
Alterations of cerebral metabolism in patients with diabetes mellitus studied by proton magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Blood Glucose; Brain; Chlorides; Choline; Creatinine; Diabetes Mellitus, Type | 2003 |
Determination of urinary Myo-/chiro-inositol ratios from Korean diabetes patients.
Topics: Adult; Aged; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Inositol; Insulin | 2005 |
The impact of acute hypoglycemia on neuropsychological and neurometabolite profiles in children with type 1 diabetes.
Topics: Acute Disease; Aspartic Acid; Attention; Blood Glucose; Child; Diabetes Mellitus, Type 1; Female; Fo | 2005 |
Acute progression of severe insulin edema accompanied by pericardial and pleural effusion in a patient with type 2 diabetes.
Topics: Administration, Oral; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Disease Progression; Ede | 2008 |
Elevated L-xylulose concentrations in serum: a difference between type I and type II diabetes.
Topics: Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glucuronates; Glucuronic Acid; | 1984 |
Metabolic abnormalities in diabetic peripheral nerve: relation to impaired function.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Energy Metabolism; Female; Gluc | 1983 |
Etiology of cataracts in diabetics.
Topics: Adolescent; Adult; Aldehyde Reductase; Animals; Blood Glucose; Cataract; Child; Child, Preschool; Di | 1984 |
Human diabetic endoneurial sorbitol, fructose, and myo-inositol related to sural nerve morphometry.
Topics: Diabetes Mellitus, Type 1; Diabetic Neuropathies; Fructose; Humans; Inositol; Middle Aged; Periphera | 1980 |
The role of plasma, erythrocyte and platelet myo-inositol levels in the development of diabetic microangiopathy.
Topics: Adult; Blood Platelets; Creatinine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic A | 1994 |
Relationship between myoinositol influx and lipids in diabetic neuropathy.
Topics: Blood Glucose; Blood Pressure; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; D | 1993 |
D-chiro-inositol metabolism in diabetes mellitus.
Topics: Adult; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gas Chromatography-M | 1993 |
Urinary myo-inositol-to-chiro-inositol ratios and insulin resistance.
Topics: Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gas Chromatography-Mass Spectrometry; Humans; | 1996 |
Sera from children with type 1 diabetes mellitus react against a new group of antigens composed of lysophospholipids.
Topics: Autoantibodies; Child; Diabetes Mellitus, Type 1; Female; Gas Chromatography-Mass Spectrometry; Huma | 1999 |
Sorbitol and myo-inositol levels and morphology of sural nerve in relation to peripheral nerve function and clinical neuropathy in men with diabetic, impaired, and normal glucose tolerance.
Topics: Diabetes Mellitus, Type 1; Diabetic Neuropathies; Glucose Intolerance; Glucose Tolerance Test; Human | 2000 |
D-chiro-inositol--its functional role in insulin action and its deficit in insulin resistance.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 1; Glycogen Synthase; Inositol; Insulin; Insulin Res | 2002 |
D-chiro-inositol--its functional role in insulin action and its deficit in insulin resistance.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 1; Glycogen Synthase; Inositol; Insulin; Insulin Res | 2002 |
D-chiro-inositol--its functional role in insulin action and its deficit in insulin resistance.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 1; Glycogen Synthase; Inositol; Insulin; Insulin Res | 2002 |
D-chiro-inositol--its functional role in insulin action and its deficit in insulin resistance.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 1; Glycogen Synthase; Inositol; Insulin; Insulin Res | 2002 |
The effect of myo-inositol treatment on basement membrane thickening in the BB/W-rat retina.
Topics: Animals; Basement Membrane; Blood Glucose; Capillaries; Diabetes Mellitus, Type 1; Diabetic Angiopat | 1992 |
Abnormal myoinositol influx in human leucocytes in diabetes but not specifically in diabetic neuropathy.
Topics: Biological Transport; Blood Glucose; Blood Pressure; Carbon Radioisotopes; Diabetes Mellitus, Type 1 | 1992 |
[Risk factors of developing diabetic complications].
Topics: Animals; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetic Retinopathy; Female; Glycoprotei | 1991 |
Advances in the diagnosis and pathogenesis of diabetes mellitus and its complications.
Topics: Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Dia | 1990 |
Diabetes and the myo-inositol paradox.
Topics: Animals; Aqueous Humor; Blood Glucose; Cornea; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 1990 |
Erythromelalgia associated with acute diabetic neuropathy: an unusual condition.
Topics: Acute Disease; Adult; Carbamazepine; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Erythromelalg | 1988 |