inositol has been researched along with Depressive Disorder in 28 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study is a meta-analysis of inositol as a treatment for depression and anxiety disorders." | 8.90 | A meta-analysis of inositol for depression and anxiety disorders. ( Iwata, N; Kishi, T; Matsuda, Y; Mukai, T, 2014) |
| "All randomised controlled trials that compare treatment with inositol, whether as monotherapy or adjunctive therapy, to an alternative treatment, whether another antidepressant medication or placebo, for patients with a diagnosis of depressive disorder (diagnosed according to explicit criteria)." | 8.82 | Inositol for depressive disorders. ( Bhagwagar, Z; Geddes, J; Taylor, MJ; Wilder, H, 2004) |
| "This study is a meta-analysis of inositol as a treatment for depression and anxiety disorders." | 4.90 | A meta-analysis of inositol for depression and anxiety disorders. ( Iwata, N; Kishi, T; Matsuda, Y; Mukai, T, 2014) |
| "All randomised controlled trials that compare treatment with inositol, whether as monotherapy or adjunctive therapy, to an alternative treatment, whether another antidepressant medication or placebo, for patients with a diagnosis of depressive disorder (diagnosed according to explicit criteria)." | 4.82 | Inositol for depressive disorders. ( Bhagwagar, Z; Geddes, J; Taylor, MJ; Wilder, H, 2004) |
| "Clinical trials indicate that inositol may be effective in the treatment of patients with depression, panic disorder and obsessive compulsive disorder (OCD), but not in the treatment of patients with schizophrenia, Alzheimer's disease, ADHD or autism." | 4.81 | The effects of inositol treatment in animal models of psychiatric disorders. ( Belmaker, RH; Einat, H, 2001) |
| "Inositol has been reported to be an effective treatment in depression, and we hypothesized that inositol addition might enhance or speed up response to serotonin selective reuptake inhibitors (SSRI)." | 2.69 | Combination of inositol and serotonin reuptake inhibitors in the treatment of depression. ( Belmaker, RH; Levine, J; Martin, M; Mishori, A; Susnosky, M, 1999) |
| "Inositol is a simple polyol precursor in a second messenger system important in the brain." | 2.68 | Controlled trials of inositol in psychiatry. ( Levine, J, 1997) |
| "Chromium has a beneficial effect on eating-related atypical symptoms of depression, and may be a valuable agent in treating atypical depression and seasonal affective disorder." | 2.47 | Second-tier natural antidepressants: review and critique. ( Dalton, ED; Fava, M; Iovieno, N; Mischoulon, D, 2011) |
| "CSF inositol was reported to be reduced in depression and inositol has been reported to be effective in treatment of depression." | 1.29 | CSF inositol does not predict antidepressant response to inositol. Short communication. ( Agam, G; Belmaker, RH; Bersudsky, Y; Kurtzman, L; Levine, J; Rapoport, A; Shapiro, J; Zimmerman, J, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.57) | 18.7374 |
| 1990's | 10 (35.71) | 18.2507 |
| 2000's | 10 (35.71) | 29.6817 |
| 2010's | 7 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, W | 1 |
| Yu, H | 1 |
| Jiang, B | 1 |
| Zheng, L | 1 |
| Yu, S | 1 |
| Pan, B | 1 |
| Yu, R | 1 |
| Mukai, T | 1 |
| Kishi, T | 1 |
| Matsuda, Y | 1 |
| Iwata, N | 1 |
| Bogdanova, OV | 1 |
| Abdullah, O | 1 |
| Kanekar, S | 1 |
| Bogdanov, VB | 1 |
| Prescot, AP | 1 |
| Renshaw, PF | 1 |
| Guo, Z | 1 |
| Zhang, J | 3 |
| Liu, X | 1 |
| Hou, H | 1 |
| Cao, Y | 1 |
| Wei, F | 1 |
| Li, J | 1 |
| Chen, X | 1 |
| Shen, Y | 1 |
| Chen, W | 1 |
| Li, H | 1 |
| Xu, H | 1 |
| Zhang, Y | 1 |
| Guan, J | 1 |
| Xu, C | 1 |
| Shen, Z | 1 |
| Xiao, B | 1 |
| Liang, C | 1 |
| Chen, K | 1 |
| Wu, R | 1 |
| Taylor, MJ | 2 |
| Selvaraj, S | 1 |
| Norbury, R | 1 |
| Jezzard, P | 1 |
| Cowen, PJ | 1 |
| Iovieno, N | 1 |
| Dalton, ED | 1 |
| Fava, M | 1 |
| Mischoulon, D | 1 |
| Howland, RH | 1 |
| Nemets, B | 1 |
| Talesnick, B | 1 |
| Belmaker, RH | 10 |
| Levine, J | 10 |
| Panchalingam, K | 2 |
| McClure, RJ | 1 |
| Gershon, S | 2 |
| Pettegrew, JW | 2 |
| VIDAL-TEIXIDOR, R | 1 |
| Wilder, H | 1 |
| Bhagwagar, Z | 1 |
| Geddes, J | 1 |
| Elderkin-Thompson, V | 1 |
| Thomas, MA | 1 |
| Binesh, N | 1 |
| Mintz, J | 1 |
| Haroon, E | 1 |
| Dunkin, JJ | 1 |
| Kumar, A | 1 |
| Glodzik-Sobanska, L | 1 |
| Slowik, A | 1 |
| McHugh, P | 1 |
| Sobiecka, B | 1 |
| Kozub, J | 1 |
| Rich, KE | 1 |
| Urbanik, A | 1 |
| Szczudlik, A | 1 |
| Barak, Y | 3 |
| Kofman, O | 5 |
| Gonzalves, M | 1 |
| Szor, H | 1 |
| Elizur, A | 1 |
| Witztum, E | 1 |
| Greenberg, BD | 1 |
| Bersudsky, Y | 2 |
| Agam, G | 3 |
| Kurtzman, L | 1 |
| Rapoport, A | 1 |
| Zimmerman, J | 1 |
| Shapiro, J | 2 |
| Mishori, A | 1 |
| Susnosky, M | 1 |
| Martin, M | 1 |
| Biegon, A | 1 |
| Seker, A | 1 |
| Pies, R | 1 |
| Einat, H | 1 |
| Sharma, R | 1 |
| Venkatasubramanian, PN | 1 |
| Bárány, M | 1 |
| Davis, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Rhodiola Rosea in Adults With Attention Deficit/Hyperactivity Disorder[NCT02737020] | Phase 4 | 60 participants (Anticipated) | Interventional | 2016-04-30 | Recruiting | ||
| Effects of 800mg of Rhodiola Rosea in Attention in Adults With Attention-Deficit/Hyperactivity Disorder[NCT02737033] | Phase 4 | 60 participants (Anticipated) | Interventional | 2016-04-30 | Recruiting | ||
| Inositol for Comorbid Anxiety in Children and Adolescents With Bipolar Disorder[NCT02811133] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2023-08-31 | Withdrawn (stopped due to Funding terminated) | ||
| Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in PCOS Patients.[NCT01246310] | 24 participants (Actual) | Interventional | 2010-11-30 | Terminated (stopped due to The number of patients enrolled was insufficient to match the calculated sample size and to carry out statistical analyses) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for inositol and Depressive Disorder
| Article | Year |
|---|---|
A meta-analysis of inositol for depression and anxiety disorders.
Topics: Anxiety Disorders; Depressive Disorder; Humans; Inositol; Randomized Controlled Trials as Topic; Tre | 2014 |
Second-tier natural antidepressants: review and critique.
Topics: 5-Hydroxytryptophan; Antidepressive Agents; Chromium; Complementary Therapies; Depressive Disorder; | 2011 |
Second-tier natural antidepressants: review and critique.
Topics: 5-Hydroxytryptophan; Antidepressive Agents; Chromium; Complementary Therapies; Depressive Disorder; | 2011 |
Second-tier natural antidepressants: review and critique.
Topics: 5-Hydroxytryptophan; Antidepressive Agents; Chromium; Complementary Therapies; Depressive Disorder; | 2011 |
Second-tier natural antidepressants: review and critique.
Topics: 5-Hydroxytryptophan; Antidepressive Agents; Chromium; Complementary Therapies; Depressive Disorder; | 2011 |
Inositol for depressive disorders.
Topics: Antidepressive Agents; Depressive Disorder; Humans; Inositol; Randomized Controlled Trials as Topic | 2004 |
Ziskind-Somerfeld Research Award 1993. Biochemical, behavioral, and clinical studies of the role of inositol in lithium treatment and depression.
Topics: Adult; Aged; Animals; Behavior, Animal; Bipolar Disorder; Brain; Clinical Trials as Topic; Depressiv | 1993 |
How does lithium work on manic depression? Clinical and psychological correlates of the inositol theory.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Blood-Brain Barrier; Brain; Depressive Disorder; Diures | 1996 |
Adverse neuropsychiatric reactions to herbal and over-the-counter "antidepressants".
Topics: Adverse Drug Reaction Reporting Systems; Antidepressive Agents; Dehydroepiandrosterone; Depressive D | 2000 |
The effects of inositol treatment in animal models of psychiatric disorders.
Topics: Affect; Animals; Arousal; Depressive Disorder; Disease Models, Animal; Humans; Inositol; Mental Diso | 2001 |
5 trials available for inositol and Depressive Disorder
| Article | Year |
|---|---|
Myo-inositol has no beneficial effect on premenstrual dysphoric disorder.
Topics: Adult; Cross-Over Studies; Depressive Disorder; Double-Blind Method; Female; Humans; Inositol; Preme | 2002 |
Follow-up and relapse analysis of an inositol study of depression.
Topics: Adult; Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Double-Blind Method; Female; Fo | 1995 |
Double-blind, controlled trial of inositol treatment of depression.
Topics: Adult; Aged; Bipolar Disorder; Depressive Disorder; Double-Blind Method; Female; Humans; Inositol; M | 1995 |
Double-blind, controlled trial of inositol treatment of depression.
Topics: Adult; Aged; Bipolar Disorder; Depressive Disorder; Double-Blind Method; Female; Humans; Inositol; M | 1995 |
Double-blind, controlled trial of inositol treatment of depression.
Topics: Adult; Aged; Bipolar Disorder; Depressive Disorder; Double-Blind Method; Female; Humans; Inositol; M | 1995 |
Double-blind, controlled trial of inositol treatment of depression.
Topics: Adult; Aged; Bipolar Disorder; Depressive Disorder; Double-Blind Method; Female; Humans; Inositol; M | 1995 |
Controlled trials of inositol in psychiatry.
Topics: Adult; Alzheimer Disease; Depressive Disorder; Double-Blind Method; Female; Humans; Inositol; Male; | 1997 |
Combination of inositol and serotonin reuptake inhibitors in the treatment of depression.
Topics: Adult; Aged; Analysis of Variance; Depressive Disorder; Double-Blind Method; Drug Therapy, Combinati | 1999 |
16 other studies available for inositol and Depressive Disorder
| Article | Year |
|---|---|
[Correlation of neurochemical metabolism with memory function in young adult patients with first-episode depression studied with proton magnetic resonance spectroscopy].
Topics: Adolescent; Adult; Aspartic Acid; Case-Control Studies; Creatine; Depressive Disorder; Female; Hippo | 2013 |
Neurochemical alterations in frontal cortex of the rat after one week of hypobaric hypoxia.
Topics: Alanine; Altitude; Animals; Corpus Striatum; Creatine; Depressive Disorder; Female; Frontal Lobe; Gl | 2014 |
Neurometabolic characteristics in the anterior cingulate gyrus of Alzheimer's disease patients with depression: a (1)H magnetic resonance spectroscopy study.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Cognition Disorders; Creatine; Depressive Disorder; Female; | 2015 |
Differential neurometabolite alterations in brains of medication-free individuals with bipolar disorder and those with unipolar depression: a two-dimensional proton magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Depressive Disorder; Female; Gyrus Cingul | 2016 |
Normal glutamate but elevated myo-inositol in anterior cingulate cortex in recovered depressed patients.
Topics: Adolescent; Adult; Depressive Disorder; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Ino | 2009 |
Dietary supplement drug therapies for depression.
Topics: Antidepressive Agents; Antidepressive Agents, Second-Generation; Depressive Disorder; Dietary Supple | 2012 |
Effects of acetyl-L-carnitine and myo-inositol on high-energy phosphate and membrane phospholipid metabolism in zebra fish: a 31P-NMR-spectroscopy study.
Topics: Acetylcarnitine; Animals; Depressive Disorder; Humans; Inositol; Magnetic Resonance Spectroscopy; Me | 2003 |
[On the treatment of depressive states in aged persons].
Topics: Dementia; Depression; Depressive Disorder; Humans; Inositol; Pentylenetetrazole; Psychotic Disorders | 1963 |
Brain metabolites and cognitive function among older depressed and healthy individuals using 2D MR spectroscopy.
Topics: Age Factors; Aged; Aged, 80 and over; Brain; Case-Control Studies; Choline; Cognition; Creatine; Dep | 2004 |
Single voxel proton magnetic resonance spectroscopy in post-stroke depression.
Topics: Aged; Aspartic Acid; Cerebral Infarction; Choline; Creatine; Depressive Disorder; Dominance, Cerebra | 2006 |
Inositol-induced mania?
Topics: Adult; Bipolar Disorder; Depressive Disorder; Dose-Response Relationship, Drug; Humans; Inositol; Ma | 1996 |
CSF inositol does not predict antidepressant response to inositol. Short communication.
Topics: Adult; Aged; Antidepressive Agents; Bipolar Disorder; Case-Control Studies; Depressive Disorder; Fem | 1996 |
Stability of CSF metabolites measured by proton NMR.
Topics: Amino Acids; Depressive Disorder; Glucose; Humans; Inositol; Lactic Acid; Magnetic Resonance Spectro | 2000 |
Scyllo-inositol in post-mortem brain of bipolar, unipolar and schizophrenic patients.
Topics: Adolescent; Adult; Aged; Animals; Antipsychotic Agents; Bipolar Disorder; Brain; Depressive Disorder | 2000 |
Proton magnetic resonance spectroscopy of the brain in schizophrenic and affective patients.
Topics: Adult; Aspartic Acid; Basal Ganglia; Bipolar Disorder; Choline; Creatine; Depressive Disorder; Energ | 1992 |
Lithium research: state of the art.
Topics: Animals; Bipolar Disorder; Brain; Depressive Disorder; Humans; Inositol; Inositol Phosphates; Lithiu | 1990 |