inositol has been researched along with Depression, Involutional in 30 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Depression, Involutional: Form of depression in those MIDDLE AGE with feelings of ANXIETY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "83 weeks) in patients with unipolar depression (studies=4, n=187; monotherapy vs lithium=1, augmentation of antidepressants vs placebo=3) or bipolar depression (studies=14, n=1965; monotherapy vs placebo=5, monotherapy vs lithium or olanzapine+fluoxetine=2, augmentation of antidepressants vs placebo=1, augmentation of mood stabilizers vs placebo=3, augmentation of mood stabilizers vs trancylpromine, citalopram, or inositol=3) were meta-analyzed." | 8.93 | Lamotrigine compared to placebo and other agents with antidepressant activity in patients with unipolar and bipolar depression: a comprehensive meta-analysis of efficacy and safety outcomes in short-term trials. ( Anghelescu, IG; Correll, CU; Gao, K; Normann, C; Reis, C; Schaffer, A; Solmi, M; van der Loos, ML; Veronese, N; Zaninotto, L, 2016) |
| "83 weeks) in patients with unipolar depression (studies=4, n=187; monotherapy vs lithium=1, augmentation of antidepressants vs placebo=3) or bipolar depression (studies=14, n=1965; monotherapy vs placebo=5, monotherapy vs lithium or olanzapine+fluoxetine=2, augmentation of antidepressants vs placebo=1, augmentation of mood stabilizers vs placebo=3, augmentation of mood stabilizers vs trancylpromine, citalopram, or inositol=3) were meta-analyzed." | 4.93 | Lamotrigine compared to placebo and other agents with antidepressant activity in patients with unipolar and bipolar depression: a comprehensive meta-analysis of efficacy and safety outcomes in short-term trials. ( Anghelescu, IG; Correll, CU; Gao, K; Normann, C; Reis, C; Schaffer, A; Solmi, M; van der Loos, ML; Veronese, N; Zaninotto, L, 2016) |
| "Inositol has demonstrated antidepressant effects but in a controlled double blind augmentation trial did not improve depression in SSRI treatment failures." | 2.69 | Inositol addition does not improve depression in SSRI treatment failures. ( Belmaker, RH; Levine, J; Mishory, A; Nemets, B, 1999) |
| "Mood disorders and Major Depressive Disorder, in particular, appear to be some of the most common psychiatric disorders with a high rate of comorbidity most frequently of anxiety or substance abuse disorders (alcohol use disorder)." | 2.66 | Immunological Disturbances and Neuroimaging Findings in Major Depressive Disorder (MDD) and Alcohol Use Disorder (AUD) Comorbid Patients. ( Kakanakova, A; Maes, M; Popov, S, 2020) |
| "Discovering biomarkers of major depressive disorder (MDD) can give a deeper understanding of this mood disorder and improve the ability to screen for, diagnose, and treat MDD." | 1.72 | Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats. ( Beškoski, V; Filipović, D; Lješević, M; Nikolić, M; Perić, I, 2022) |
| "Previous studies have shown major depressive disorder (MDD) is associated with altered neuro-metabolites in the anterior cingulate cortex (ACC)." | 1.72 | Regional metabolic heterogeneity in anterior cingulate cortex in major depressive disorder: A multi-voxel ( Ban, M; He, J; Kong, L; Wang, D; Xiao, Q; Yuan, F; Zhu, X, 2022) |
| "Although the comorbidity between migraine and major depressive disorder (MDD) has been recognized, the pathophysiology remains unclear." | 1.42 | Increased myo-inositol level in dorsolateral prefrontal cortex in migraine patients with major depression. ( Chen, HC; Fuh, JL; Liang, JF; Lirng, JF; Tsai, CF; Wang, SJ, 2015) |
| "Seventy-five elderly patients with major depressive disorder in remission underwent assessment of insight using the Mood Disorders Insight Scale (MDIS), including awareness, attribution, and need for treatment." | 1.36 | Brain proton magnetic resonance spectroscopic study of insight among elders with late-life depression in remission. ( Chang, HC; Chen, CS; Ko, CH; Kuo, YT; Li, CW; Lin, HF; Liu, GC; Yeh, YC; Yen, CF, 2010) |
| "Patients with late-life major depressive disorder had a significantly lower NAA/creatine ratio in the left frontal white matter, and higher Cho/creatine and myo-inositol/creatine ratios in the left basal ganglia when compared with the control subjects." | 1.35 | Proton magnetic resonance spectroscopy of late-life major depressive disorder. ( Chen, CS; Chiang, IC; Hsieh, TJ; Kuo, YT; Li, CW; Lin, HF; Lin, WC; Liu, GC; Lu, CY, 2009) |
| "The neural underpinnings of major depressive disorder (MDD) are unknown but there is evidence for structural alteration in the hippocampus that may become more pronounced over the course of illness." | 1.35 | Hippocampal metabolic abnormalities at first onset and with recurrent episodes of a major depressive disorder: a proton magnetic resonance spectroscopy study. ( Hall, GB; MacQueen, GM; Milne, A; Soreni, N; Yucel, K, 2009) |
| "Patients with type 2 diabetes and major depression (n=20) were scanned along with patients with diabetes alone (n=24) and healthy controls (n=21) on a 1." | 1.34 | Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy. ( Ajilore, O; Binesh, N; Darwin, C; Haroon, E; Kumar, A; Kumaran, S; Miller, J; Mintz, J; Thomas, MA, 2007) |
| "Tolcapone is a catechol-O-methyltransferase (COMT) inhibitor that has shown efficacy in the treatment of Parkinson's disease." | 1.30 | Open study of the catechol-O-methyltransferase inhibitor tolcapone in major depressive disorder. ( Alpert, JE; Bottiglieri, T; Fava, M; Kolsky, AR; Magni, G; Moore, C; Moroz, G; Nierenberg, AA; Renshaw, P; Rosenbaum, JF; Spillmann, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.67) | 18.2507 |
| 2000's | 14 (46.67) | 29.6817 |
| 2010's | 11 (36.67) | 24.3611 |
| 2020's | 3 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Perić, I | 1 |
| Lješević, M | 1 |
| Beškoski, V | 1 |
| Nikolić, M | 1 |
| Filipović, D | 1 |
| He, J | 1 |
| Wang, D | 1 |
| Ban, M | 1 |
| Kong, L | 1 |
| Xiao, Q | 1 |
| Yuan, F | 1 |
| Zhu, X | 1 |
| Kakanakova, A | 1 |
| Popov, S | 1 |
| Maes, M | 1 |
| Shan, Y | 1 |
| Jia, Y | 1 |
| Zhong, S | 1 |
| Li, X | 1 |
| Zhao, H | 1 |
| Chen, J | 1 |
| Lu, Q | 1 |
| Zhang, L | 1 |
| Li, Z | 1 |
| Lai, S | 1 |
| Wang, Y | 1 |
| Shirayama, Y | 1 |
| Takahashi, M | 1 |
| Osone, F | 1 |
| Hara, A | 1 |
| Okubo, T | 1 |
| Chen, LP | 1 |
| Dai, HY | 1 |
| Dai, ZZ | 1 |
| Xu, CT | 2 |
| Wu, RH | 2 |
| Lirng, JF | 1 |
| Chen, HC | 1 |
| Fuh, JL | 1 |
| Tsai, CF | 1 |
| Liang, JF | 1 |
| Wang, SJ | 1 |
| Njau, S | 1 |
| Joshi, SH | 1 |
| Leaver, AM | 1 |
| Vasavada, M | 1 |
| Van Fleet, J | 1 |
| Espinoza, R | 1 |
| Narr, KL | 1 |
| Jollant, F | 1 |
| Richard-Devantoy, S | 1 |
| Ding, Y | 1 |
| Turecki, G | 1 |
| Bechara, A | 1 |
| Near, J | 1 |
| Solmi, M | 1 |
| Veronese, N | 1 |
| Zaninotto, L | 1 |
| van der Loos, ML | 1 |
| Gao, K | 1 |
| Schaffer, A | 1 |
| Reis, C | 1 |
| Normann, C | 1 |
| Anghelescu, IG | 1 |
| Correll, CU | 1 |
| Tan, HZ | 1 |
| Li, H | 1 |
| Liu, CF | 1 |
| Guan, JT | 1 |
| Guo, XB | 1 |
| Wen, CH | 1 |
| Ou, SM | 1 |
| Zhang, YN | 1 |
| Zhang, J | 1 |
| Shen, ZW | 1 |
| Wang, XQ | 1 |
| Haroon, E | 2 |
| Watari, K | 1 |
| Thomas, A | 2 |
| Ajilore, O | 2 |
| Mintz, J | 3 |
| Elderkin-Thompson, V | 1 |
| Darwin, C | 2 |
| Kumaran, S | 2 |
| Kumar, A | 3 |
| Venkatraman, TN | 1 |
| Krishnan, RR | 1 |
| Steffens, DC | 1 |
| Song, AW | 1 |
| Taylor, WD | 1 |
| Chen, CS | 2 |
| Chiang, IC | 1 |
| Li, CW | 2 |
| Lin, WC | 1 |
| Lu, CY | 1 |
| Hsieh, TJ | 1 |
| Liu, GC | 2 |
| Lin, HF | 2 |
| Kuo, YT | 2 |
| Milne, A | 1 |
| MacQueen, GM | 1 |
| Yucel, K | 1 |
| Soreni, N | 1 |
| Hall, GB | 1 |
| Kaymak, SU | 1 |
| Demir, B | 1 |
| Oğuz, KK | 1 |
| Sentürk, S | 1 |
| Uluğ, B | 1 |
| Ko, CH | 1 |
| Yeh, YC | 1 |
| Chang, HC | 1 |
| Yen, CF | 1 |
| Zheng, P | 1 |
| Gao, HC | 1 |
| Li, Q | 1 |
| Shao, WH | 1 |
| Zhang, ML | 1 |
| Cheng, K | 1 |
| Yang, DY | 1 |
| Fan, SH | 1 |
| Chen, L | 1 |
| Fang, L | 1 |
| Xie, P | 1 |
| Das, P | 1 |
| Tanious, M | 1 |
| Fritz, K | 1 |
| Dodd, S | 1 |
| Dean, OM | 1 |
| Berk, M | 1 |
| Malhi, GS | 1 |
| Levine, J | 2 |
| Leventhal, U | 1 |
| Lerner, V | 1 |
| Belmaker, RH | 2 |
| Vythilingam, M | 1 |
| Charles, HC | 1 |
| Tupler, LA | 1 |
| Blitchington, T | 1 |
| Kelly, L | 1 |
| Krishnan, KR | 1 |
| Rosenberg, DR | 1 |
| Mirza, Y | 1 |
| Russell, A | 1 |
| Tang, J | 1 |
| Smith, JM | 1 |
| Banerjee, SP | 1 |
| Bhandari, R | 1 |
| Rose, M | 1 |
| Ivey, J | 1 |
| Boyd, C | 1 |
| Moore, GJ | 1 |
| Caetano, SC | 1 |
| Fonseca, M | 1 |
| Olvera, RL | 1 |
| Nicoletti, M | 1 |
| Hatch, JP | 1 |
| Stanley, JA | 1 |
| Hunter, K | 1 |
| Lafer, B | 1 |
| Pliszka, SR | 1 |
| Soares, JC | 1 |
| Coupland, NJ | 1 |
| Ogilvie, CJ | 1 |
| Hegadoren, KM | 1 |
| Seres, P | 1 |
| Hanstock, CC | 1 |
| Allen, PS | 1 |
| Nierenberg, AA | 2 |
| Ostacher, MJ | 1 |
| Calabrese, JR | 1 |
| Ketter, TA | 1 |
| Marangell, LB | 1 |
| Miklowitz, DJ | 1 |
| Miyahara, S | 1 |
| Bauer, MS | 1 |
| Thase, ME | 1 |
| Wisniewski, SR | 1 |
| Sachs, GS | 1 |
| Yildiz-Yesiloglu, A | 1 |
| Ankerst, DP | 1 |
| Binesh, N | 1 |
| Miller, J | 1 |
| Thomas, MA | 1 |
| Fava, M | 1 |
| Rosenbaum, JF | 1 |
| Kolsky, AR | 1 |
| Alpert, JE | 1 |
| Spillmann, M | 1 |
| Moore, C | 1 |
| Renshaw, P | 1 |
| Bottiglieri, T | 1 |
| Moroz, G | 1 |
| Magni, G | 1 |
| Nemets, B | 1 |
| Mishory, A | 1 |
| Lavretsky, H | 1 |
| Yue, K | 1 |
| Huda, A | 1 |
| Curran, J | 1 |
| Venkatraman, T | 1 |
| Estanol, L | 1 |
| Mega, M | 1 |
| Toga, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| Pharmacogenetics and Neuroimaging in Major Depressive Disorder (PAN-D)[NCT01568684] | Phase 1 | 0 participants (Actual) | Interventional | 2012-03-12 | Withdrawn | ||
| Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)[NCT00012558] | 5,000 participants | Interventional | 1998-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for inositol and Depression, Involutional
| Article | Year |
|---|---|
Immunological Disturbances and Neuroimaging Findings in Major Depressive Disorder (MDD) and Alcohol Use Disorder (AUD) Comorbid Patients.
Topics: Alcoholism; Anxiety Disorders; Brain; Comorbidity; Cytokines; Depressive Disorder, Major; gamma-Amin | 2020 |
Lamotrigine compared to placebo and other agents with antidepressant activity in patients with unipolar and bipolar depression: a comprehensive meta-analysis of efficacy and safety outcomes in short-term trials.
Topics: Anticonvulsants; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bip | 2016 |
Review of 1H magnetic resonance spectroscopy findings in major depressive disorder: a meta-analysis.
Topics: Aspartic Acid; Brain; Choline; Creatine; Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutam | 2006 |
5 trials available for inositol and Depression, Involutional
| Article | Year |
|---|---|
Anterior cingulate cortex and cerebellar hemisphere neurometabolite changes in depression treatment: A 1H magnetic resonance spectroscopy study.
Topics: Adolescent; Adult; Antidepressive Agents; Aspartic Acid; Cerebellum; Choline; Depressive Disorder, M | 2014 |
Metabolite profiles in the anterior cingulate cortex of depressed patients differentiate those taking N-acetyl-cysteine versus placebo.
Topics: Acetylcysteine; Aspartic Acid; Depressive Disorder, Major; Double-Blind Method; Female; Free Radical | 2013 |
Proton spectroscopy study of the left dorsolateral prefrontal cortex in pediatric depressed patients.
Topics: Adolescent; Child; Choline; Depressive Disorder, Major; Female; Glutamine; Humans; Inositol; Magneti | 2005 |
Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone.
Topics: Adult; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Depressive Di | 2006 |
Inositol addition does not improve depression in SSRI treatment failures.
Topics: Adult; Aged; Depressive Disorder, Major; Double-Blind Method; Drug Therapy, Combination; Female; Hum | 1999 |
22 other studies available for inositol and Depression, Involutional
| Article | Year |
|---|---|
Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats.
Topics: Animals; Cholesterol; Depressive Disorder, Major; Fatty Acids; gamma-Aminobutyric Acid; Hippocampus; | 2022 |
Regional metabolic heterogeneity in anterior cingulate cortex in major depressive disorder: A multi-voxel
Topics: Aspartic Acid; Depressive Disorder, Major; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol | 2022 |
Correlations between working memory impairment and neurometabolites of prefrontal cortex and lenticular nucleus in patients with major depressive disorder.
Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Corpus Striatum; Creatine; Depressive Disorder, | 2018 |
Myo-inositol, Glutamate, and Glutamine in the Prefrontal Cortex, Hippocampus, and Amygdala in Major Depression.
Topics: Adult; Amygdala; Depressive Disorder, Major; Female; Glutamic Acid; Glutamine; Hippocampus; Humans; | 2017 |
Increased myo-inositol level in dorsolateral prefrontal cortex in migraine patients with major depression.
Topics: Adolescent; Adult; Depressive Disorder, Major; Female; Humans; Inositol; Magnetic Resonance Spectros | 2015 |
Variations in myo-inositol in fronto-limbic regions and clinical response to electroconvulsive therapy in major depression.
Topics: Adult; Cross-Sectional Studies; Depressive Disorder, Major; Electroconvulsive Therapy; Female; Front | 2016 |
Prefrontal inositol levels and implicit decision-making in healthy individuals and depressed patients.
Topics: Adult; Aspartic Acid; Decision Making; Delay Discounting; Depressive Disorder, Major; Diagnostic and | 2016 |
Main Effects of Diagnoses, Brain Regions, and their Interaction Effects for Cerebral Metabolites in Bipolar and Unipolar Depressive Disorders.
Topics: Adult; Aspartic Acid; Biomarkers; Bipolar Disorder; Case-Control Studies; Choline; Creatine; Depress | 2016 |
Prefrontal myo-inositol concentration and visuospatial functioning among diabetic depressed patients.
Topics: Aged; Cognition Disorders; Depressive Disorder, Major; Diabetes Mellitus, Type 2; Female; Humans; In | 2009 |
Biochemical abnormalities of the medial temporal lobe and medial prefrontal cortex in late-life depression.
Topics: Aspartic Acid; Choline; Creatine; Depressive Disorder, Major; Energy Metabolism; Functional Laterali | 2009 |
Proton magnetic resonance spectroscopy of late-life major depressive disorder.
Topics: Aged; Aging; Aspartic Acid; Basal Ganglia; Biomarkers; Brain; Choline; Cognition; Creatine; Depressi | 2009 |
Hippocampal metabolic abnormalities at first onset and with recurrent episodes of a major depressive disorder: a proton magnetic resonance spectroscopy study.
Topics: Adult; Analysis of Variance; Aspartic Acid; Choline; Depressive Disorder, Major; Female; Glutamic Ac | 2009 |
Antidepressant effect detected on proton magnetic resonance spectroscopy in drug-naïve female patients with first-episode major depression.
Topics: Adult; Antidepressive Agents; Aspartic Acid; Case-Control Studies; Choline; Creatine; Depressive Dis | 2009 |
Brain proton magnetic resonance spectroscopic study of insight among elders with late-life depression in remission.
Topics: Aged; Aspartic Acid; Awareness; Choline; Creatine; Depressive Disorder, Major; Dominance, Cerebral; | 2010 |
Plasma metabonomics as a novel diagnostic approach for major depressive disorder.
Topics: Acetates; Adult; Amino Acids; Biomarkers; Case-Control Studies; Creatine; Creatinine; Depressive Dis | 2012 |
Inositol treatment has no effect on the dexamethasone suppression test.
Topics: Adult; Brain; Depressive Disorder, Major; Dexamethasone; Diagnostic and Statistical Manual of Mental | 2001 |
Focal and lateralized subcortical abnormalities in unipolar major depressive disorder: an automated multivoxel proton magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Brain Mapping; Choline; Creatine; Depressive Disorder, | 2003 |
Reduced anterior cingulate glutamatergic concentrations in childhood OCD and major depression versus healthy controls.
Topics: Adolescent; Aspartic Acid; Child; Choline; Creatine; Depressive Disorder, Major; Female; Glutamic Ac | 2004 |
Decreased prefrontal Myo-inositol in major depressive disorder.
Topics: Adult; Aspartic Acid; Brain Chemistry; Brain Mapping; Case-Control Studies; Choline; Creatine; Depre | 2005 |
Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Chemistry; Choline; Creatine; Depressive Disord | 2007 |
Open study of the catechol-O-methyltransferase inhibitor tolcapone in major depressive disorder.
Topics: Adult; Benzophenones; Catechol O-Methyltransferase Inhibitors; Caudate Nucleus; Choline; Depressive | 1999 |
Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy.
Topics: Aged; Aspartic Acid; Choline; Creatine; Depressive Disorder, Major; Dominance, Cerebral; Energy Meta | 2002 |