inositol has been researched along with Demyelinating Diseases in 16 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Demyelinating Diseases: Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Myoinositol-treated animals had significantly fewer demyelinating lesions than mannitol (2." | 5.33 | Myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats. ( Rojiani, AM; Schroeder, BM; Silver, SM; Sterns, RH, 2006) |
| "Citrulline was more frequently identified in the brains of patients with early-onset MS than in healthy subjects by (1)H-MR spectroscopy, suggesting an association of increased citrullination of myelin proteins with demyelinating diseases." | 5.14 | Assessment of citrullinated myelin by 1H-MR spectroscopy in early-onset multiple sclerosis. ( Aksu, AO; Anlar, B; Haspolat, S; Karabulut, E; Kurne, A; Kurul, S; Oguz, KK; Senbil, N; Serdaroglu, A; Teber, S, 2009) |
| " Strongly elevated concentrations of myo-inositol in conjunction with normal or increased choline-containing compounds in all regions investigated point to astrocytosis and demyelination." | 3.72 | Cerebral proton magnetic resonance spectroscopy in infantile Alexander disease. ( Brockmann, K; Dechent, P; Frahm, J; Hanefeld, F; Haupt, M; Meins, M; Sperner, J; Stephani, U, 2003) |
| "Active demyelination or increased myelin turnover might contribute to the hitherto unexplained WMD of this rare disorder." | 1.33 | White-matter disease in 18q deletion (18q-) syndrome: magnetic resonance spectroscopy indicates demyelination or increased myelin turnover rather than dysmyelination. ( Anhuf, D; Häusler, M; Möller-Hartmann, W; Ramaekers, VT; Schüler, H; Thron, A; Zerres, K, 2005) |
| "Myoinositol-treated animals had significantly fewer demyelinating lesions than mannitol (2." | 1.33 | Myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats. ( Rojiani, AM; Schroeder, BM; Silver, SM; Sterns, RH, 2006) |
| "The mechanisms behind the demyelination that is characteristic of multiple sclerosis (MS) are still poorly understood." | 1.30 | Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy. ( Bitsch, A; Brück, W; Bruhn, H; Frahm, J; Lassmann, H; Stringaris, A; Vougioukas, V, 1999) |
| "Despite regional variability of demyelination, proton magnetic resonance spectroscopy revealed a specific metabolic pattern in all patients, with only moderate reduction of N-acetylaspartate, normal or reduced choline-containing compounds, normal or enhanced myo-inositol and no detectable lactate, which differs from findings in progressive cerebral adrenoleukodystrophy which usually exhibits a severe reduction of N-acetylaspartate and marked increases of choline-containing compounds, myo-inositol, and lactate." | 1.29 | Arrested cerebral adrenoleukodystrophy: a clinical and proton magnetic resonance spectroscopy study in three patients. ( Frahm, J; Hanefeld, F; Hunneman, DH; Jost, W; Korenke, GC; Krasemann, E; Pouwels, PJ; Stoeckler, S, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (25.00) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 8 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oguz, KK | 1 |
| Kurne, A | 1 |
| Aksu, AO | 1 |
| Karabulut, E | 1 |
| Serdaroglu, A | 1 |
| Teber, S | 1 |
| Haspolat, S | 1 |
| Senbil, N | 1 |
| Kurul, S | 1 |
| Anlar, B | 1 |
| Brockmann, K | 1 |
| Dechent, P | 1 |
| Meins, M | 1 |
| Haupt, M | 1 |
| Sperner, J | 1 |
| Stephani, U | 1 |
| Frahm, J | 3 |
| Hanefeld, F | 2 |
| Tarasów, E | 1 |
| Wiercińska-Drapało, A | 1 |
| Walecki, J | 1 |
| Prokopowicz, D | 1 |
| Häusler, M | 1 |
| Anhuf, D | 1 |
| Schüler, H | 1 |
| Ramaekers, VT | 1 |
| Thron, A | 1 |
| Zerres, K | 1 |
| Möller-Hartmann, W | 1 |
| Silver, SM | 2 |
| Schroeder, BM | 1 |
| Sterns, RH | 2 |
| Rojiani, AM | 1 |
| De Stefano, N | 1 |
| Matthews, PM | 1 |
| Antel, JP | 1 |
| Preul, M | 1 |
| Francis, G | 1 |
| Arnold, DL | 1 |
| Korenke, GC | 1 |
| Pouwels, PJ | 2 |
| Hunneman, DH | 1 |
| Stoeckler, S | 1 |
| Krasemann, E | 1 |
| Jost, W | 1 |
| Bitsch, A | 1 |
| Bruhn, H | 1 |
| Vougioukas, V | 1 |
| Stringaris, A | 1 |
| Lassmann, H | 1 |
| Brück, W | 1 |
| van der Knaap, MS | 1 |
| Wevers, RA | 1 |
| Struys, EA | 1 |
| Verhoeven, NM | 1 |
| Engelke, UF | 1 |
| Feikema, W | 1 |
| Valk, J | 1 |
| Jakobs, C | 1 |
| Blüml, S | 1 |
| Hwang, JH | 1 |
| Moreno, A | 1 |
| Ross, BD | 1 |
| Pozdniakov, AV | 1 |
| Tiutin, LA | 1 |
| Bisaga, GN | 1 |
| Odinak, MM | 1 |
| Liveson, JA | 1 |
| Gardner, J | 1 |
| Bornstein, MB | 1 |
| Winegrad, AI | 1 |
| Greene, DA | 1 |
| Kayden, HJ | 1 |
| Reagan, TJ | 1 |
| Mize, CE | 1 |
| Herndon, JH | 1 |
| Steinberg, D | 1 |
| Wolf, LM | 1 |
| Laudat, P | 1 |
| Chaumont, P | 1 |
| Bonduelle, M | 1 |
1 review available for inositol and Demyelinating Diseases
| Article | Year |
|---|---|
Brain volume regulation in response to hypo-osmolality and its correction.
Topics: Acute Disease; Animals; Brain; Brain Edema; Chronic Disease; Demyelinating Diseases; Humans; Hyponat | 2006 |
1 trial available for inositol and Demyelinating Diseases
| Article | Year |
|---|---|
Assessment of citrullinated myelin by 1H-MR spectroscopy in early-onset multiple sclerosis.
Topics: Adolescent; Age of Onset; Aspartic Acid; Child; Child, Preschool; Choline; Citrulline; Creatine; Dem | 2009 |
14 other studies available for inositol and Demyelinating Diseases
| Article | Year |
|---|---|
Cerebral proton magnetic resonance spectroscopy in infantile Alexander disease.
Topics: Alexander Disease; Aspartic Acid; Brain; Child; Child, Preschool; Demyelinating Diseases; Disease Pr | 2003 |
[CNS changes in HIV-infected patients: magnetic resonance spectroscopy].
Topics: AIDS Dementia Complex; Brain; Choline; Demyelinating Diseases; HIV Seropositivity; Humans; Inositol; | 2003 |
White-matter disease in 18q deletion (18q-) syndrome: magnetic resonance spectroscopy indicates demyelination or increased myelin turnover rather than dysmyelination.
Topics: Aspartic Acid; Brain Diseases; Choline; Chromosome Deletion; Chromosomes, Human, Pair 18; Demyelinat | 2005 |
Myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats.
Topics: Animals; Arginine Vasopressin; Behavior, Animal; Blood Glucose; Brain; Demyelinating Diseases; Disea | 2006 |
Chemical pathology of acute demyelinating lesions and its correlation with disability.
Topics: Adult; Aspartic Acid; Brain Chemistry; Choline; Demyelinating Diseases; Disability Evaluation; Femal | 1995 |
Arrested cerebral adrenoleukodystrophy: a clinical and proton magnetic resonance spectroscopy study in three patients.
Topics: Aspartic Acid; Brain; Brain Diseases, Metabolic; Child; Choline; Demyelinating Diseases; Female; Hum | 1996 |
Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy.
Topics: Adult; Aspartic Acid; Axons; Biopsy, Needle; Blood-Brain Barrier; Brain; Cell Division; Choline; Dem | 1999 |
Leukoencephalopathy associated with a disturbance in the metabolism of polyols.
Topics: Adolescent; Aspartic Acid; Carbohydrate Metabolism, Inborn Errors; Choline; Creatine; Demyelinating | 1999 |
Novel peak assignments of in vivo (13)C MRS in human brain at 1.5 T.
Topics: Adult; Aspartic Acid; Bicarbonates; Brain; Carbon Isotopes; Child, Preschool; Creatine; Demyelinatin | 2000 |
[Proton magnetic-resonance spectroscopy in remitting and secondary-progressive multiple sclerosis].
Topics: Adolescent; Adult; Aspartic Acid; Brain; Choline; Creatine; Demyelinating Diseases; Female; gamma-Am | 2001 |
Tissue culture studies of possible uremic neurotoxins: myoinositol.
Topics: Animals; Culture Techniques; Cytoplasmic Granules; Cytoskeleton; Demyelinating Diseases; Ganglia, Sp | 1977 |
Diabetic polyneuropathy: the importance of insulin deficiency, hyperglycemia and alterations in myoinositol metabolism in its pathogenesis.
Topics: Acute Disease; Animals; Demyelinating Diseases; Diabetes Mellitus, Experimental; Diabetic Neuropathi | 1976 |
Diffuse cerebral sclerosis erroneously reported as Refsum's syndrome.
Topics: Adult; Brain; Carbon Isotopes; Cerebral Cortex; Demyelinating Diseases; Diagnosis, Differential; Dif | 1973 |
[Refsum's disease. Clinical and biochemical evolution under a phytol-free diet. Complementary biochemical studies. Supplement of the 1966 report].
Topics: Adult; Biopsy; Child; Demyelinating Diseases; Denervation; Diet; Female; Follow-Up Studies; Humans; | 1969 |