inositol has been researched along with Compensatory Hyperinsulinemia in 14 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Compensatory Hyperinsulinemia: A GLUCOSE-induced HYPERINSULINEMIA, a marker of insulin-resistant state. It is a mechanism to compensate for reduced sensitivity to insulin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "During the last decades, a substantial body of research has focused on the role of the two major inositol (Ins) stereoisomers, myoinositol (myoIns) and D-chiroinositol (D-chiroIns), both second messengers of insulin, in insulin-dependent processes, including polycystic ovary syndrome (PCOS)." | 8.93 | Physiological role and clinical utility of inositols in polycystic ovary syndrome. ( Bevilacqua, A; Bizzarri, M, 2016) |
| " Increased clearance of inositols might reduce tissue availability of DCI and decrease the release of DCI-IPG mediator, which could contribute to insulin resistance and compensatory hyperinsulinemia in Greek women, as previously described in American women." | 7.74 | Greek hyperinsulinemic women, with or without polycystic ovary syndrome, display altered inositols metabolism. ( Apridonidze, T; Baillargeon, JP; Diamanti-Kandarakis, E; Nestler, JE; Ostlund, RE, 2008) |
| " On such basis, we investigated the efficacy on insulin sensitivity and hormonal parameters of 8 weeks treatment with myo-inositol (MYO) (Inofert, ItalPharmaco, Milano, Italy) at the dosage of 2 g day in a group (n = 42) of obese PCOS patients,." | 6.77 | Differential insulin response to myo-inositol administration in obese polycystic ovary syndrome patients. ( Artini, PG; Campedelli, A; Chierchia, E; Genazzani, AD; Prati, A; Rattighieri, E; Ricchieri, F; Santagni, S; Simoncini, T, 2012) |
| "Thus, compensatory hyperinsulinemia might suppress renal clearance of DCI to increase plasma DCI levels and partially compensate for insulin resistance by improving DCI availability in men." | 5.35 | Hyperinsulinemia is closely related to low urinary clearance of D-chiro-inositol in men with a wide range of insulin sensitivity. ( Baillargeon, JP; Ostlund, RE; Villeneuve, MC, 2009) |
| "As in humans, monkeys with NIDDM have a lower urinary excretion rate of chiroinositol (CI), a component of a putative mediator of insulin action, compared to normal monkeys." | 5.29 | Chiroinositol deficiency and insulin resistance. I. Urinary excretion rate of chiroinositol is directly associated with insulin resistance in spontaneously diabetic rhesus monkeys. ( Bodkin, NL; Hansen, BC; Larner, J; Lilley, K; Ortmeyer, HK, 1993) |
| " Since it has been demonstrated a high incidence of insulin resistance in PCOS patients, our study aimed to evaluate the efficacy of the integrative treatment with D-chiro-inositol (DCI) (500 mg die, per os, for 12 weeks) on hormonal parameters and insulin sensitivity in a group of overweight/obese PCOS patients (body mass index; BMI > 26)." | 5.19 | Modulatory role of D-chiro-inositol (DCI) on LH and insulin secretion in obese PCOS patients. ( Chierchia, E; Despini, G; Genazzani, AD; Marini, G; Prati, A; Rattighieri, E; Santagni, S; Simoncini, T, 2014) |
| " We conclude that plasma levels of both pinitol and D-chiro-inositol are very responsive to pinitol ingestion, but insulin sensitivity does not increase after pinitol treatment in individuals with obesity and mild type 2 diabetes." | 5.09 | Effect of pinitol treatment on insulin action in subjects with insulin resistance. ( Christiansen, M; Davis, A; Hellerstein, MK; Horowitz, JF; Klein, S; Ostlund, RE, 2000) |
| "During the last decades, a substantial body of research has focused on the role of the two major inositol (Ins) stereoisomers, myoinositol (myoIns) and D-chiroinositol (D-chiroIns), both second messengers of insulin, in insulin-dependent processes, including polycystic ovary syndrome (PCOS)." | 4.93 | Physiological role and clinical utility of inositols in polycystic ovary syndrome. ( Bevilacqua, A; Bizzarri, M, 2016) |
| "This study was designed to investigate the protective effects of d-Chiro-Inositol (DCI) enriched tartary buckwheat extract (DTBE) against high fructose (HF) diet-induced hyperglycemia and liver injury in mice." | 3.81 | Hypoglycemic and hepatoprotective effects of D-chiro-inositol-enriched tartary buckwheat extract in high fructose-fed mice. ( Guo, J; Hu, Y; Luo, Y; Ren, D; Yang, X; Zhao, Y, 2015) |
| " Increased clearance of inositols might reduce tissue availability of DCI and decrease the release of DCI-IPG mediator, which could contribute to insulin resistance and compensatory hyperinsulinemia in Greek women, as previously described in American women." | 3.74 | Greek hyperinsulinemic women, with or without polycystic ovary syndrome, display altered inositols metabolism. ( Apridonidze, T; Baillargeon, JP; Diamanti-Kandarakis, E; Nestler, JE; Ostlund, RE, 2008) |
| "Sitagliptin or voglibose combined with SAP can improve glucose control and protect islet function for patients with newly diagnosed T2DM." | 2.82 | [Comparison of therapeutic effects between sitagliptin and voglibose both combined with sensor-augmented insulin pump in newly diagnosed type 2 diabetes]. ( Bai, R; Du, JL; Liu, D; Shi, CH; Wang, H; Wang, L; Wang, YB; Yang, Y; Zhang, XY, 2016) |
| " On such basis, we investigated the efficacy on insulin sensitivity and hormonal parameters of 8 weeks treatment with myo-inositol (MYO) (Inofert, ItalPharmaco, Milano, Italy) at the dosage of 2 g day in a group (n = 42) of obese PCOS patients,." | 2.77 | Differential insulin response to myo-inositol administration in obese polycystic ovary syndrome patients. ( Artini, PG; Campedelli, A; Chierchia, E; Genazzani, AD; Prati, A; Rattighieri, E; Ricchieri, F; Santagni, S; Simoncini, T, 2012) |
| "Thus, compensatory hyperinsulinemia might suppress renal clearance of DCI to increase plasma DCI levels and partially compensate for insulin resistance by improving DCI availability in men." | 1.35 | Hyperinsulinemia is closely related to low urinary clearance of D-chiro-inositol in men with a wide range of insulin sensitivity. ( Baillargeon, JP; Ostlund, RE; Villeneuve, MC, 2009) |
| "As in humans, monkeys with NIDDM have a lower urinary excretion rate of chiroinositol (CI), a component of a putative mediator of insulin action, compared to normal monkeys." | 1.29 | Chiroinositol deficiency and insulin resistance. I. Urinary excretion rate of chiroinositol is directly associated with insulin resistance in spontaneously diabetic rhesus monkeys. ( Bodkin, NL; Hansen, BC; Larner, J; Lilley, K; Ortmeyer, HK, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 7 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Genazzani, AD | 4 |
| Santagni, S | 2 |
| Rattighieri, E | 2 |
| Chierchia, E | 2 |
| Despini, G | 1 |
| Marini, G | 1 |
| Prati, A | 2 |
| Simoncini, T | 2 |
| Hu, Y | 1 |
| Zhao, Y | 1 |
| Ren, D | 1 |
| Guo, J | 1 |
| Luo, Y | 1 |
| Yang, X | 1 |
| Bevilacqua, A | 1 |
| Bizzarri, M | 1 |
| Shi, CH | 1 |
| Wang, L | 1 |
| Bai, R | 1 |
| Wang, YB | 1 |
| Liu, D | 1 |
| Zhang, XY | 1 |
| Wang, H | 1 |
| Yang, Y | 1 |
| Du, JL | 1 |
| Villeneuve, MC | 1 |
| Ostlund, RE | 3 |
| Baillargeon, JP | 2 |
| Kobayashi, T | 1 |
| Taguchi, K | 1 |
| Nemoto, S | 1 |
| Nogami, T | 1 |
| Matsumoto, T | 1 |
| Kamata, K | 1 |
| Unfer, V | 1 |
| Carlomagno, G | 1 |
| Dante, G | 1 |
| Facchinetti, F | 1 |
| Ricchieri, F | 2 |
| Campedelli, A | 1 |
| Artini, PG | 1 |
| Odaka, H | 1 |
| Lanzoni, C | 1 |
| Jasonni, VM | 1 |
| Nestler, JE | 1 |
| Apridonidze, T | 1 |
| Diamanti-Kandarakis, E | 1 |
| Ortmeyer, HK | 1 |
| Bodkin, NL | 1 |
| Lilley, K | 1 |
| Larner, J | 1 |
| Hansen, BC | 1 |
| Davis, A | 1 |
| Christiansen, M | 1 |
| Horowitz, JF | 1 |
| Klein, S | 1 |
| Hellerstein, MK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Myo-inositol for the Management of Poor Ovarian Responders: A Prospective Randomized Controlled Trial[NCT04273256] | Phase 2/Phase 3 | 226 participants (Anticipated) | Interventional | 2020-02-11 | Recruiting | ||
| Effect of Myoinositol on Serum Asprosin Levels in Pregnant Women[NCT05943158] | 40 participants (Actual) | Interventional | 2021-06-01 | Completed | |||
| Graceful Lifestyle Changes Intervention Study for Women With PCOS and Infertility[NCT02630485] | 240 participants (Anticipated) | Interventional | 2015-12-31 | Not yet recruiting | |||
| Reduction of Insulin Therapy Under Myo-inositol for the Treatment of Gestational Diabetes Mellitus: a Randomized Multicenter and Prospective Trial. MYO-GDM Study[NCT03875755] | 1,080 participants (Anticipated) | Interventional | 2020-03-04 | Recruiting | |||
| Effects of a Supplementation With Zinc and Myo-inositol in Paediatric Obesity[NCT03283813] | Phase 4 | 60 participants (Anticipated) | Interventional | 2018-02-05 | Recruiting | ||
| [NCT01626443] | Phase 4 | 46 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for inositol and Compensatory Hyperinsulinemia
| Article | Year |
|---|---|
Physiological role and clinical utility of inositols in polycystic ovary syndrome.
Topics: Female; Humans; Hyperinsulinism; Inositol; Insulin Resistance; Polycystic Ovary Syndrome; Stereoisom | 2016 |
Inositol as putative integrative treatment for PCOS.
Topics: Female; Humans; Hyperandrogenism; Hyperinsulinism; Inositol; Inositol Phosphates; Insulin; Insulin R | 2016 |
Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials.
Topics: Adult; Dietary Supplements; Female; Fertility Agents, Female; Folic Acid; Gonadotropins, Pituitary; | 2012 |
Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials.
Topics: Adult; Dietary Supplements; Female; Fertility Agents, Female; Folic Acid; Gonadotropins, Pituitary; | 2012 |
Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials.
Topics: Adult; Dietary Supplements; Female; Fertility Agents, Female; Folic Acid; Gonadotropins, Pituitary; | 2012 |
Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials.
Topics: Adult; Dietary Supplements; Female; Fertility Agents, Female; Folic Acid; Gonadotropins, Pituitary; | 2012 |
Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials.
Topics: Adult; Dietary Supplements; Female; Fertility Agents, Female; Folic Acid; Gonadotropins, Pituitary; | 2012 |
Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials.
Topics: Adult; Dietary Supplements; Female; Fertility Agents, Female; Folic Acid; Gonadotropins, Pituitary; | 2012 |
Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials.
Topics: Adult; Dietary Supplements; Female; Fertility Agents, Female; Folic Acid; Gonadotropins, Pituitary; | 2012 |
Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials.
Topics: Adult; Dietary Supplements; Female; Fertility Agents, Female; Folic Acid; Gonadotropins, Pituitary; | 2012 |
Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials.
Topics: Adult; Dietary Supplements; Female; Fertility Agents, Female; Folic Acid; Gonadotropins, Pituitary; | 2012 |
Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials.
Topics: Adult; Dietary Supplements; Female; Fertility Agents, Female; Folic Acid; Gonadotropins, Pituitary; | 2012 |
Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials.
Topics: Adult; Dietary Supplements; Female; Fertility Agents, Female; Folic Acid; Gonadotropins, Pituitary; | 2012 |
Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials.
Topics: Adult; Dietary Supplements; Female; Fertility Agents, Female; Folic Acid; Gonadotropins, Pituitary; | 2012 |
Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials.
Topics: Adult; Dietary Supplements; Female; Fertility Agents, Female; Folic Acid; Gonadotropins, Pituitary; | 2012 |
Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials.
Topics: Adult; Dietary Supplements; Female; Fertility Agents, Female; Folic Acid; Gonadotropins, Pituitary; | 2012 |
Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials.
Topics: Adult; Dietary Supplements; Female; Fertility Agents, Female; Folic Acid; Gonadotropins, Pituitary; | 2012 |
Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials.
Topics: Adult; Dietary Supplements; Female; Fertility Agents, Female; Folic Acid; Gonadotropins, Pituitary; | 2012 |
[alpha-Glucosidase inhibitor, its structure and mechanism of antidiabetic action].
Topics: Acarbose; Animals; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glycoside Hydrolase Inhibitors; Hum | 2002 |
5 trials available for inositol and Compensatory Hyperinsulinemia
| Article | Year |
|---|---|
Modulatory role of D-chiro-inositol (DCI) on LH and insulin secretion in obese PCOS patients.
Topics: Adult; Body Mass Index; Dietary Supplements; Family Health; Female; Gonadotropin-Releasing Hormone; | 2014 |
[Comparison of therapeutic effects between sitagliptin and voglibose both combined with sensor-augmented insulin pump in newly diagnosed type 2 diabetes].
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Glucose; Glucose Tolerance Test; Glycated Hemoglobin; Huma | 2016 |
Differential insulin response to myo-inositol administration in obese polycystic ovary syndrome patients.
Topics: Adult; Body Mass Index; Dietary Supplements; Female; Folic Acid; Follicle Stimulating Hormone; Gluco | 2012 |
Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome.
Topics: Blood Glucose; Body Mass Index; Body Weight; Estradiol; Female; Folic Acid; Follicle Stimulating Hor | 2008 |
Effect of pinitol treatment on insulin action in subjects with insulin resistance.
Topics: Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucose Cl | 2000 |
5 other studies available for inositol and Compensatory Hyperinsulinemia
| Article | Year |
|---|---|
Hypoglycemic and hepatoprotective effects of D-chiro-inositol-enriched tartary buckwheat extract in high fructose-fed mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Glucose; C-Reactive Protein; Chemi | 2015 |
Hyperinsulinemia is closely related to low urinary clearance of D-chiro-inositol in men with a wide range of insulin sensitivity.
Topics: 17-alpha-Hydroxypregnenolone; Adolescent; Adult; Androstenedione; Blood Glucose; Cross-Sectional Stu | 2009 |
Activation of the PDK-1/Akt/eNOS pathway involved in aortic endothelial function differs between hyperinsulinemic and insulin-deficient diabetic rats.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Acetylcholine; Animals; Aorta; Blood Glucose; Blood Pr | 2009 |
Greek hyperinsulinemic women, with or without polycystic ovary syndrome, display altered inositols metabolism.
Topics: Adolescent; Adult; Body Mass Index; Case-Control Studies; Female; Glucose Tolerance Test; Greece; Hu | 2008 |
Chiroinositol deficiency and insulin resistance. I. Urinary excretion rate of chiroinositol is directly associated with insulin resistance in spontaneously diabetic rhesus monkeys.
Topics: Analysis of Variance; Animals; Diabetes Mellitus, Type 2; Female; Glucose Tolerance Test; Hyperinsul | 1993 |