inositol has been researched along with Cognitive Dysfunction in 20 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Cognitive Dysfunction: Diminished or impaired mental and/or intellectual function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amnestic mild cognitive impairment (aMCI) is often the prodromal stage to AD." | 1.43 | (1)H-MRS asymmetry changes in the anterior and posterior cingulate gyrus in patients with mild cognitive impairment and mild Alzheimer's disease. ( Chen, W; Chen, X; Guo, Z; Hou, H; Liu, X; Shen, Y; Wei, F, 2016) |
| "The genetic etiology of late-onset Alzheimer's disease (LOAD) has proven complex, involving clinical and genetic heterogeneity and gene-gene interactions." | 1.40 | Genetic interactions within inositol-related pathways are associated with longitudinal changes in ventricle size. ( Hohman, TJ; Koran, ME; Meda, SA; Thornton-Wells, TA, 2014) |
| "The diagnosis of mild or questionable Alzheimer's disease (AD) depends on clinical criteria that often leave a margin for doubt." | 1.37 | Contribution of 1H spectroscopy to a brief cognitive-functional test battery for the diagnosis of mild Alzheimer's disease. ( Andreiuolo, PA; Bottino, CM; de Oliveira-Souza, R; Moll, J; Silveira de Souza, A; Tovar-Moll, F, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 14 (70.00) | 24.3611 |
| 2020's | 6 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shad, KF | 1 |
| Soubra, W | 1 |
| Cordato, DJ | 1 |
| Cengiz, S | 1 |
| Arslan, DB | 1 |
| Kicik, A | 1 |
| Erdogdu, E | 1 |
| Yildirim, M | 1 |
| Hatay, GH | 1 |
| Tufekcioglu, Z | 1 |
| Uluğ, AM | 1 |
| Bilgic, B | 1 |
| Hanagasi, H | 1 |
| Demiralp, T | 1 |
| Gurvit, H | 1 |
| Ozturk-Isik, E | 1 |
| Gozdas, E | 1 |
| Hinkley, L | 1 |
| Fingerhut, H | 1 |
| Dacorro, L | 1 |
| Gu, M | 1 |
| Sacchet, MD | 1 |
| Hurd, R | 1 |
| Hosseini, SMH | 1 |
| Levin, O | 1 |
| Vints, WAJ | 1 |
| Ziv, G | 1 |
| Katkutė, G | 1 |
| Kušleikienė, S | 1 |
| Valatkevičienė, K | 1 |
| Sheoran, S | 1 |
| Drozdova-Statkevičienė, M | 1 |
| Gleiznienė, R | 1 |
| Pääsuke, M | 1 |
| Dudonienė, V | 1 |
| Himmelreich, U | 1 |
| Česnaitienė, VJ | 1 |
| Masiulis, N | 1 |
| Peña-Bautista, C | 1 |
| Torres-Cuevas, I | 1 |
| Baquero, M | 1 |
| Ferrer, I | 1 |
| García, L | 1 |
| Vento, M | 1 |
| Cháfer-Pericás, C | 1 |
| Lepping, RJ | 1 |
| Montgomery, RN | 1 |
| Sharma, P | 1 |
| Mahnken, JD | 1 |
| Vidoni, ED | 1 |
| Choi, IY | 1 |
| Sarnak, MJ | 1 |
| Brooks, WM | 1 |
| Burns, JM | 1 |
| Gupta, A | 1 |
| Waragai, M | 1 |
| Moriya, M | 1 |
| Nojo, T | 1 |
| Liu, Y | 1 |
| Cai, ZL | 1 |
| Xue, S | 1 |
| Zhou, X | 1 |
| Wu, F | 1 |
| Kantarci, K | 1 |
| Menezes, TL | 1 |
| Andrade-Valença, LP | 1 |
| Valença, MM | 1 |
| Tumati, S | 1 |
| Martens, S | 1 |
| Aleman, A | 1 |
| Targosz-Gajniak, MG | 1 |
| Siuda, JS | 1 |
| Wicher, MM | 1 |
| Banasik, TJ | 1 |
| Bujak, MA | 1 |
| Augusciak-Duma, AM | 1 |
| Opala, G | 1 |
| Koran, ME | 1 |
| Hohman, TJ | 1 |
| Meda, SA | 1 |
| Thornton-Wells, TA | 1 |
| Suriyajakryuththana, W | 1 |
| Tuntiyatorn, L | 1 |
| Teepprasarn, N | 1 |
| Sukying, C | 1 |
| Almuqbel, M | 1 |
| Melzer, TR | 1 |
| Myall, DJ | 1 |
| MacAskill, MR | 1 |
| Pitcher, TL | 1 |
| Livingston, L | 1 |
| Wood, KL | 1 |
| Keenan, RJ | 1 |
| Dalrymple-Alford, JC | 1 |
| Anderson, TJ | 1 |
| Guo, Z | 1 |
| Liu, X | 1 |
| Hou, H | 1 |
| Wei, F | 1 |
| Chen, X | 1 |
| Shen, Y | 1 |
| Chen, W | 1 |
| Foy, CM | 1 |
| Daly, EM | 1 |
| Glover, A | 1 |
| O'Gorman, R | 1 |
| Simmons, A | 1 |
| Murphy, DG | 1 |
| Lovestone, S | 1 |
| Wang, T | 1 |
| Xiao, S | 1 |
| Li, X | 1 |
| Ding, B | 1 |
| Ling, H | 1 |
| Chen, K | 1 |
| Fang, Y | 1 |
| Walecki, J | 1 |
| Barcikowska, M | 1 |
| Ćwikła, JB | 1 |
| Gabryelewicz, T | 1 |
| Silveira de Souza, A | 1 |
| de Oliveira-Souza, R | 1 |
| Moll, J | 1 |
| Tovar-Moll, F | 1 |
| Andreiuolo, PA | 1 |
| Bottino, CM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cognitive Impairment and Imaging Correlates in End Stage Renal Disease[NCT01883349] | 140 participants (Anticipated) | Observational | 2013-03-31 | Recruiting | |||
| Open Label Study for the Use of Tyrosine Kinase Inhibitors for Treatment of Cognitive Decline Due to Degenerative Dementias[NCT02921477] | Phase 1 | 150 participants (Anticipated) | Interventional | 2016-09-30 | Enrolling by invitation | ||
| Focused Ultrasound Delivery of Exosomes for Treatment of Refractory Depression, Anxiety, and Neurodegenerative Dementias[NCT04202770] | 300 participants (Anticipated) | Interventional | 2019-12-01 | Suspended (stopped due to Pending COVID-19 pandemic; pending status of product development) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for inositol and Cognitive Dysfunction
| Article | Year |
|---|---|
Proton MRS in mild cognitive impairment.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Biomarkers; Brain; Choline; Cognitive Dysfunction; Creati | 2013 |
Magnetic resonance spectroscopy in mild cognitive impairment: systematic review and meta-analysis.
Topics: Aspartic Acid; Choline; Cognitive Dysfunction; Creatine; Humans; Inositol; Magnetic Resonance Spectr | 2013 |
18 other studies available for inositol and Cognitive Dysfunction
| Article | Year |
|---|---|
The Auditory Afferent Pathway as a Clinical Marker of Alzheimer's Disease.
Topics: Acoustic Stimulation; Afferent Pathways; Aged; Alzheimer Disease; Aspartic Acid; Biomarkers; Cerebra | 2022 |
Identification of metabolic correlates of mild cognitive impairment in Parkinson's disease using magnetic resonance spectroscopic imaging and machine learning.
Topics: Cognitive Dysfunction; Creatine; Humans; Inositol; Machine Learning; Magnetic Resonance Imaging; Mag | 2022 |
Topics: Aged; Alzheimer Disease; Aspartic Acid; Cognition; Cognitive Dysfunction; Creatine; Glutamic Acid; H | 2022 |
Neurometabolic correlates of posturography in normal aging and older adults with mild cognitive impairment: Evidence from a
Topics: Aged; Aging; Aspartic Acid; Choline; Cognitive Dysfunction; Creatine; Glutamine; Humans; Inositol; P | 2023 |
Early neurotransmission impairment in non-invasive Alzheimer Disease detection.
Topics: Acetylcholine; Aged; Alzheimer Disease; Amino Acids; Biomarkers; Cognitive Dysfunction; Creatine; Fe | 2020 |
Normalization of Cerebral Blood Flow, Neurochemicals, and White Matter Integrity after Kidney Transplantation.
Topics: Adult; Aged; Case-Control Studies; Cerebrovascular Circulation; Choline; Cognition; Cognitive Dysfun | 2021 |
Decreased N-Acetyl Aspartate/Myo-Inositol Ratio in the Posterior Cingulate Cortex Shown by Magnetic Resonance Spectroscopy May Be One of the Risk Markers of Preclinical Alzheimer's Disease: A 7-Year Follow-Up Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Biomarkers; Cognitive Dysfunction; Diseas | 2017 |
Proxies of cognitive reserve and their effects on neuropsychological performance in patients with mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Choline; Cognitive Dysfunction; Cognitive Reserv | 2013 |
Magnetic resonance imaging study cannot individually distinguish individuals with mild cognitive impairment, mild Alzheimer's disease, and normal aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Di | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Genetic interactions within inositol-related pathways are associated with longitudinal changes in ventricle size.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognitive Dysfunction; Down-Regulation; Enzymes; Female; | 2014 |
Proton magnetic resonance spectroscopy in mild cognitive impairment and Alzheimer's disease: a preliminary study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Case-Control Studies; Choline; Cognitive | 2014 |
Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson's disease in a clinical setting.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Bayes Theorem; Case-Control Studies; Choline; Cognitive Dysf | 2016 |
(1)H-MRS asymmetry changes in the anterior and posterior cingulate gyrus in patients with mild cognitive impairment and mild Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Creatine; Dominance, Cerebra | 2016 |
Hippocampal proton MR spectroscopy in early Alzheimer's disease and mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Case-Control Studies; Choline; Cognitive | 2011 |
Using proton magnetic resonance spectroscopy to identify mild cognitive impairment.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Case-Control Studies; Choline; Cognitive Dysfunction; | 2012 |
N-acetylaspartate, choline, myoinositol, glutamine and glutamate (glx) concentration changes in proton MR spectroscopy (1H MRS) in patients with mild cognitive impairment (MCI).
Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Disease Progression; Female; | 2011 |
Contribution of 1H spectroscopy to a brief cognitive-functional test battery for the diagnosis of mild Alzheimer's disease.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cognitive Dys | 2011 |