inositol has been researched along with Classic Galactosemia in 21 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cellular accumulation of galactitol has been suggested to cause the apparent dietary-independent, long-term complications in classic galactosemia." | 4.79 | The role of polyols in the pathophysiology of hypergalactosemia. ( Berry, GT, 1995) |
| "Classic Galactosemia (CG) is a devastating inborn error of the metabolism caused by mutations in the GALT gene encoding the enzyme galactose-1 phosphate uridylyltransferase in galactose metabolism." | 4.12 | Harnessing the Power of Purple Sweet Potato Color and ( Hagen-Lillevik, S; Hale, G; Johnson, J; Lai, K; Persinger, J; Siddiqi, A, 2022) |
| "MRI measurement of the retinal oxygenation response to a carbogen challenge appears to be a powerful new and noninvasive approach that may be useful for assessing aspects of pathophysiology underlying the development of diabetic retinopathy in galactosemic rats." | 3.70 | Subnormal retinal oxygenation response precedes diabetic-like retinopathy. ( Berkowitz, BA; Frank, RN; Hohman, TC; Kern, TS; Kowluru, RA; Prakash, M, 1999) |
| " Yet, if this metabolic pathway is perturbed due to congenital deficiencies of the three associated enzymes, or an overwhelming presence of galactose, this monosaccharide which is abundantly present in milk and many non-dairy foodstuffs, will become highly toxic to humans and animals." | 2.45 | Galactose toxicity in animals. ( Elsas, LJ; Lai, K; Wierenga, KJ, 2009) |
| "Lens galactitol levels were reduced approximately 57% in 10-day galactose-fed rats treated with the ARI (tolrestat, 100 mg/kg bwt/day, 6-day pretreatment); the changes in the lower segment of glycolysis, alpha-glycerophosphate levels, redox state of NAD-couples, and energy metabolism were partially prevented while NADP+/ NADPH ratios were unchanged and galactose 1-phosphate levels were further increased." | 1.30 | Glycolytic pathway, redox state of NAD(P)-couples and energy metabolism in lens in galactose-fed rats: effect of an aldose reductase inhibitor. ( Burgan, J; Faller, A; Obrosova, I; Ostrow, E; Williamson, JR, 1997) |
| "At 8 months galactosemia reduced NCV to 58% of control values, while ARI-treatment for 8 months improved NCV to 71% of control values." | 1.29 | Galactosemia produces ARI-preventable nodal changes similar to those of diabetic neuropathy. ( Basso, M; Cherian, PV; Hohman, TC; Kamijo, M; Sima, AA, 1994) |
| " One group of dogs was untreated while three other groups were orally dosed with 0." | 1.28 | The prevention of biochemical changes in lens, retina, and nerve of galactosemic dogs by the aldose reductase inhibitor AL01576. ( Brazzell, RK; Chandler, ML; Dickerson, JE; Lou, MF; York, BM, 1989) |
| "Galactitol is a component of normal amniotic fluid with a mean concentration of 0." | 1.27 | Stable isotope dilution analysis of galactitol in amniotic fluid: an accurate approach to the prenatal diagnosis of galactosemia. ( Jakobs, C; Nyhan, WL; Sweetman, L; Warner, TG, 1984) |
| "Both diabetic hyperglycemia and galactosemia caused the prolongation of peak latencies and in some cases a reduction in the amplitudes of oscillatory potentials on the b-wave." | 1.27 | The development of electroretinogram abnormalities and the possible role of polyol pathway activity in diabetic hyperglycemia and galactosemia. ( Fujimori, S; Hirata, Y; Okada, K; Segawa, M, 1988) |
| "A more mild degree of galactosemia, induced by 5 or 21 days of feeding a diet containing 10% galactose to nondiabetic rats, provoked an increase in nerve water content associated with polyol levels of a similar order to those seen in diabetes." | 1.27 | Does galactose feeding provide a valid model of consequences of exaggerated polyol-pathway flux in peripheral nerve in experimental diabetes? ( Lambourne, JE; Tomlinson, DR; Willars, GB, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (57.14) | 18.7374 |
| 1990's | 7 (33.33) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Hagen-Lillevik, S | 1 |
| Johnson, J | 1 |
| Siddiqi, A | 1 |
| Persinger, J | 1 |
| Hale, G | 1 |
| Lai, K | 2 |
| Elsas, LJ | 1 |
| Wierenga, KJ | 1 |
| WELLS, WW | 2 |
| PITTMAN, TA | 1 |
| WELLS, HJ | 1 |
| EGAN, TJ | 1 |
| Jakobs, C | 1 |
| Warner, TG | 1 |
| Sweetman, L | 1 |
| Nyhan, WL | 1 |
| Yue, DK | 1 |
| Hanwell, MA | 1 |
| Satchell, PM | 1 |
| Handelsman, DJ | 1 |
| Turtle, JR | 1 |
| Berry, GT | 1 |
| Kamijo, M | 1 |
| Basso, M | 1 |
| Cherian, PV | 1 |
| Hohman, TC | 2 |
| Sima, AA | 1 |
| Obrosova, I | 1 |
| Faller, A | 1 |
| Burgan, J | 1 |
| Ostrow, E | 1 |
| Williamson, JR | 1 |
| Takemoto, DJ | 1 |
| Berkowitz, BA | 1 |
| Kowluru, RA | 1 |
| Frank, RN | 1 |
| Kern, TS | 2 |
| Prakash, M | 1 |
| Radhakrishnamurthy, B | 1 |
| Berenson, GS | 1 |
| Pargaonkar, PS | 1 |
| Voors, AW | 1 |
| Srinivasan, SR | 1 |
| Plavidal, F | 1 |
| Dolan, P | 1 |
| Dalferes, ER | 1 |
| Tomlinson, DR | 2 |
| Filliatreau, G | 1 |
| Figliomeni, B | 1 |
| Hassig, R | 1 |
| Di Giamberardino, L | 1 |
| Willars, GB | 2 |
| Engerman, RL | 1 |
| Brivet, M | 1 |
| Migayron, F | 1 |
| Roger, J | 1 |
| Cheron, G | 1 |
| Lemonnier, A | 1 |
| Lou, MF | 1 |
| Dickerson, JE | 1 |
| Chandler, ML | 1 |
| Brazzell, RK | 1 |
| York, BM | 1 |
| Miwa, I | 1 |
| Kanbara, M | 1 |
| Wakazono, H | 1 |
| Okuda, J | 1 |
| Segawa, M | 1 |
| Hirata, Y | 1 |
| Fujimori, S | 1 |
| Okada, K | 1 |
| Lambourne, JE | 1 |
| McIntyre, JP | 1 |
| Schlichter, DJ | 1 |
| Wacholtz, MC | 1 |
| Spieker, SE | 1 |
| Van Heyningen, R | 1 |
| Broekhuyse, RM | 1 |
3 reviews available for inositol and Classic Galactosemia
| Article | Year |
|---|---|
Galactose toxicity in animals.
Topics: Animals; Galactitol; Galactokinase; Galactose; Galactosemias; Galactosephosphates; Humans; Infant, N | 2009 |
The role of polyols in the pathophysiology of hypergalactosemia.
Topics: Animals; Galactitol; Galactosemias; Humans; Inositol | 1995 |
Galactose cataract: a review.
Topics: Age Factors; Alcohol Oxidoreductases; Aminoisobutyric Acids; Animals; Cataract; Dairy Products; Gala | 1971 |
18 other studies available for inositol and Classic Galactosemia
| Article | Year |
|---|---|
Harnessing the Power of Purple Sweet Potato Color and
Topics: Animals; Color; Female; Galactose; Galactosemias; Inositol; Ipomoea batatas; Mice; UTP-Hexose-1-Phos | 2022 |
THE ISOLATION AND IDENTIFICATION OF GALACTITOL FROM THE BRAINS OF GALACTOSEMIA PATIENTS.
Topics: Alcohols; Brain; Brain Chemistry; Carbohydrate Metabolism; Chromatography; Electrophoresis; Galactit | 1965 |
Stable isotope dilution analysis of galactitol in amniotic fluid: an accurate approach to the prenatal diagnosis of galactosemia.
Topics: Amniotic Fluid; Female; Galactitol; Galactosemias; Gas Chromatography-Mass Spectrometry; Humans; Ino | 1984 |
The effects of aldose reductase inhibition on nerve sorbitol and myoinositol concentrations in diabetic and galactosemic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Erythrocytes; Female; Galactosemias; I | 1984 |
Galactosemia produces ARI-preventable nodal changes similar to those of diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Axons; Body Weight; Diabetic Neuropathies; Fructose; Galactitol; Galact | 1994 |
Glycolytic pathway, redox state of NAD(P)-couples and energy metabolism in lens in galactose-fed rats: effect of an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Energy Metabolism; Enzyme Inhibitors; Galactitol; Galactose; Galactosem | 1997 |
Decreases in Raf-1 levels in galactosaemic lens epithelial cells are partially reversed by myo-inositol.
Topics: Animals; Cattle; Cell Division; Cells, Cultured; DNA; Epithelial Cells; Galactose; Galactosemias; In | 1998 |
Subnormal retinal oxygenation response precedes diabetic-like retinopathy.
Topics: Animals; Blood Glucose; Carbon Dioxide; Diabetic Retinopathy; Fructose; Galactitol; Galactose; Galac | 1999 |
Serum-free and protein-bound sugars and cardiovascular complications in diabetes mellitus.
Topics: Adult; Age Factors; Aged; Analysis of Variance; Blood Glucose; Blood Pressure; Cardiovascular Diseas | 1976 |
Proteins of slow axonal transport in sciatic motoneurones of rats with streptozotocin-induced diabetes or galactosaemia.
Topics: Animals; Autoradiography; Axonal Transport; Carbohydrates; Diabetes Mellitus, Experimental; Electrop | 1990 |
Retinal polyol and myo-inositol in galactosemic dogs given an aldose-reductase inhibitor.
Topics: Aldehyde Reductase; Alloxan; Animals; Chromatography, Gas; Diabetes Mellitus, Experimental; Disease | 1991 |
Lens hexitols and cataract formation during lactation in a woman heterozygote for galactosaemia.
Topics: Adult; Cataract; Female; Galactitol; Galactokinase; Galactosemias; Genetic Carrier Screening; Humans | 1989 |
The prevention of biochemical changes in lens, retina, and nerve of galactosemic dogs by the aldose reductase inhibitor AL01576.
Topics: Administration, Oral; Aldehyde Reductase; Analysis of Variance; Animals; Dogs; Fluorenes; Galactitol | 1989 |
Analysis of sorbitol, galactitol, and myo-inositol in lens and sciatic nerve by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Galactitol; Galactos | 1988 |
The development of electroretinogram abnormalities and the possible role of polyol pathway activity in diabetic hyperglycemia and galactosemia.
Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Electroretinography; Galactitol; Galactosemias; | 1988 |
Does galactose feeding provide a valid model of consequences of exaggerated polyol-pathway flux in peripheral nerve in experimental diabetes?
Topics: Animals; Blood Glucose; Body Water; Body Weight; Diabetes Mellitus, Experimental; Galactosemias; Ino | 1987 |
Studies on myo-inositol metabolism in galactosemia.
Topics: Adenosine Triphosphate; Aging; Alcohols; Alkaline Phosphatase; Animals; Brain; Carbon Isotopes; Diet | 1969 |
Changes in myo-inositol permeability in the lens due to cataractous conditions.
Topics: Alcohols; Animals; Cataract; Diabetes Complications; Female; Galactosemias; Inositol; Lens, Crystall | 1968 |