inositol has been researched along with Chronic Disease in 36 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "It was recently demonstrated that renal failure and exogenous urea prevent myelinolysis induced by rapid correction of experimental hyponatremia." | 7.71 | Rapid (24-hour) reaccumulation of brain organic osmolytes (particularly myo-inositol) in azotemic rats after correction of chronic hyponatremia. ( Decaux, G; Schroöeder, B; Silver, S; Soupart, A; Sterns, R, 2002) |
| "We tested the ability of lithium (Li(+)) to block heat hyperalgesia, cold allodynia, mechanical allodynia and mechanical hyperalgesia in rats experimentally subjected to painful peripheral neuropathy." | 7.70 | Intrathecal lithium reduces neuropathic pain responses in a rat model of peripheral neuropathy. ( Inoue, T; Mashimo, T; Shibata, M; Shimizu, T; Wakisaka, S; Yoshiya, I, 2000) |
| "Serum and urinary myo-inositol and urinary glucose were estimated by means of gas-liquid chromatography in 54 patients with glomerulonephritis with and without renal failure." | 7.65 | Changes in serum and urinary myo-inositol levels in chronic glomerulonephritis. ( Pitkänen, E, 1976) |
| "The inositol compounds were administered via the drinking fluid." | 5.34 | Inhibition of chronic ulcerative colitis associated adenocarcinoma development in mice by inositol compounds. ( Liao, J; Lu, GG; Seril, DN; Yang, AL; Yang, GY, 2007) |
| "The purpose of this study is to explore depression metabolic markers in rat hippocampus and to investigate the anti-depressant effect of genipin and its mechanisms using nuclear magnetic resonance (NMR) metabonomics." | 3.80 | [1H NMR based metabonomics study on the antidepressant effect of genipin in rat hippocampus]. ( Gao, S; Peng, GJ; Qin, XM; Shi, BY; Tian, JS, 2014) |
| "In this study, cognitively intact chronic hypertensive older patients had a higher white matter myoinositol/creatine ratio compared with healthy older subjects, suggesting that myoinositol may be a sensitive marker of the effects of chronic hypertension on the brain." | 3.71 | Proton magnetic resonance spectroscopy reveals similar white matter biochemical changes in patients with chronic hypertension and early Alzheimer's disease. ( Benedetti, C; Catani, M; Cherubini, A; Howard, R; Mariani, E; Mecocci, P; Metastasio, A; Pelliccioli, GP; Senin, U; Tarducci, R, 2002) |
| "It was recently demonstrated that renal failure and exogenous urea prevent myelinolysis induced by rapid correction of experimental hyponatremia." | 3.71 | Rapid (24-hour) reaccumulation of brain organic osmolytes (particularly myo-inositol) in azotemic rats after correction of chronic hyponatremia. ( Decaux, G; Schroöeder, B; Silver, S; Soupart, A; Sterns, R, 2002) |
| "We tested the ability of lithium (Li(+)) to block heat hyperalgesia, cold allodynia, mechanical allodynia and mechanical hyperalgesia in rats experimentally subjected to painful peripheral neuropathy." | 3.70 | Intrathecal lithium reduces neuropathic pain responses in a rat model of peripheral neuropathy. ( Inoue, T; Mashimo, T; Shibata, M; Shimizu, T; Wakisaka, S; Yoshiya, I, 2000) |
| " First, in patients with cerebral infarctions, increased concentrations of lactate were found in the majority of patients, and N-acetyl aspartate (NAA) was reduced to a significantly greater extent than choline (Cho) or creatine (Cre)." | 3.68 | Proton magnetic resonance spectroscopy of human brain: applications to normal white matter, chronic infarction, and MRI white matter signal hyperintensities. ( Calabrese, G; Deicken, R; Fein, G; Fisher, SN; Hetherington, HP; Sappey-Marinier, D; Van Dyke, C; Weiner, MW, 1992) |
| "Serum and urinary myo-inositol and urinary glucose were estimated by means of gas-liquid chromatography in 54 patients with glomerulonephritis with and without renal failure." | 3.65 | Changes in serum and urinary myo-inositol levels in chronic glomerulonephritis. ( Pitkänen, E, 1976) |
| "Oral inositol treatment of 8 patients is shown to significantly increase CSF inositol by almost 70%, suggesting possible CNS therapeutic applications of this compound and possible CNS side-effects of systemic therapy." | 2.67 | Inositol treatment raises CSF inositol levels. ( Agam, G; Belmaker, RH; Bersudsky, Y; Kofman, O; Lev, L; Levine, J; Rapaport, A; Shapiro, J, 1993) |
| "Sixteen patients with medication overuse headache were compared with 16 matched patients without medication overuse headache and 16 matched healthy controls." | 1.56 | Brain metabolites in chronic migraine patients with medication overuse headache. ( Chen, WT; Fuh, JL; Lai, KL; Lin, YR; Niddam, DM; Tsai, SY; Wang, SJ, 2020) |
| "Chronic migraine was associated with N-acetyl-aspartate reductions in the bilateral thalami and in the right anterior cingulate." | 1.48 | Neurochemical changes in the medial wall of the brain in chronic migraine. ( Chen, WT; Fuh, JL; Lai, KL; Lin, YR; Niddam, DM; Tsai, SY; Wang, SJ, 2018) |
| "Acute-on-chronic liver failure (ACLF), acute liver failure (ALF) and chronic liver disease (CLD) are common forms of liver failure and present with similar clinical profiles." | 1.35 | In vivo 1H magnetic resonance spectroscopy-derived metabolite variations between acute-on-chronic liver failure and acute liver failure. ( Gupta, RK; Nath, K; Radha Krishna, Y; Saraswat, VA; Thomas, MA; Verma, A, 2008) |
| "The inositol compounds were administered via the drinking fluid." | 1.34 | Inhibition of chronic ulcerative colitis associated adenocarcinoma development in mice by inositol compounds. ( Liao, J; Lu, GG; Seril, DN; Yang, AL; Yang, GY, 2007) |
| "Since 1) dilated cardiomyopathy (DCM) causes chronic heart failure (CHF), and 2) augmentation of neurohumoral factors such as angiotensin II impairs glucose metabolism, we examined the rate of abnormal glucose metabolism in patients having both DCM and CHF and whether correction of the impairment of glucose metabolism would improve the pathophysiology of CHF in DCM patients." | 1.33 | Abnormal glucose tolerance contributes to the progression of chronic heart failure in patients with dilated cardiomyopathy. ( Asakura, M; Asanuma, H; Hashimura, K; Kanzaki, H; Kim, J; Kitakaze, M; Kokubo, Y; Komamura, K; Nakatani, S; Tomoike, H, 2006) |
| "Myo-inositol concentration was decreased in liver, heart and kidney but not in brain, pancreas and skeletal muscle." | 1.28 | Effect of short- and long-term diabetes on carnitine and myo-inositol in rats. ( Baker, H; DeAngelis, B; Frank, O; Jyothirmayi, GN; Reddi, AS, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (25.00) | 18.7374 |
| 1990's | 8 (22.22) | 18.2507 |
| 2000's | 15 (41.67) | 29.6817 |
| 2010's | 3 (8.33) | 24.3611 |
| 2020's | 1 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Niddam, DM | 2 |
| Lai, KL | 2 |
| Tsai, SY | 2 |
| Lin, YR | 2 |
| Chen, WT | 2 |
| Fuh, JL | 2 |
| Wang, SJ | 2 |
| Peng, GJ | 1 |
| Shi, BY | 1 |
| Tian, JS | 1 |
| Gao, S | 1 |
| Qin, XM | 1 |
| Ding, D | 1 |
| Shi, Y | 1 |
| Shaltiel, G | 1 |
| Azab, AN | 1 |
| Pullumbi, E | 1 |
| Campbell, A | 1 |
| Mehta, DV | 1 |
| Agam, G | 2 |
| Greenberg, ML | 1 |
| Balreira, A | 1 |
| Cavallari, M | 1 |
| Sá Miranda, MC | 1 |
| Arosa, FA | 1 |
| Duarte, JM | 1 |
| Carvalho, RA | 1 |
| Cunha, RA | 1 |
| Gruetter, R | 1 |
| Catani, M | 1 |
| Mecocci, P | 1 |
| Tarducci, R | 1 |
| Howard, R | 1 |
| Pelliccioli, GP | 1 |
| Mariani, E | 1 |
| Metastasio, A | 1 |
| Benedetti, C | 1 |
| Senin, U | 1 |
| Cherubini, A | 1 |
| SCHIAVETTI, A | 1 |
| Yamasue, H | 1 |
| Fukui, T | 1 |
| Fukuda, R | 1 |
| Kasai, K | 1 |
| Iwanami, A | 1 |
| Kato, N | 1 |
| Kato, T | 1 |
| Fuller, RA | 1 |
| Westmoreland, SV | 1 |
| Ratai, E | 1 |
| Greco, JB | 1 |
| Kim, JP | 1 |
| Lentz, MR | 1 |
| He, J | 1 |
| Sehgal, PK | 1 |
| Masliah, E | 1 |
| Halpern, E | 1 |
| Lackner, AA | 1 |
| González, RG | 1 |
| Chang, L | 1 |
| Ernst, T | 1 |
| Speck, O | 1 |
| Grob, CS | 1 |
| Srinivasan, R | 1 |
| Sailasuta, N | 1 |
| Hurd, R | 1 |
| Nelson, S | 1 |
| Pelletier, D | 1 |
| Sterns, RH | 1 |
| Silver, SM | 1 |
| Liao, J | 1 |
| Seril, DN | 1 |
| Yang, AL | 1 |
| Lu, GG | 1 |
| Yang, GY | 1 |
| Kim, J | 1 |
| Nakatani, S | 1 |
| Hashimura, K | 1 |
| Komamura, K | 1 |
| Kanzaki, H | 1 |
| Asakura, M | 1 |
| Asanuma, H | 1 |
| Kokubo, Y | 1 |
| Tomoike, H | 1 |
| Kitakaze, M | 1 |
| Verma, A | 1 |
| Saraswat, VA | 1 |
| Radha Krishna, Y | 1 |
| Nath, K | 1 |
| Thomas, MA | 1 |
| Gupta, RK | 1 |
| Dickstein, DP | 1 |
| van der Veen, JW | 1 |
| Knopf, L | 1 |
| Towbin, KE | 1 |
| Pine, DS | 1 |
| Leibenluft, E | 1 |
| Cucinotta, D | 1 |
| Silvestrini, C | 1 |
| Mancini, M | 1 |
| Maini, C | 1 |
| Passeri, M | 1 |
| Fürst, P | 1 |
| Alvestrand, A | 1 |
| Bergström, J | 1 |
| Levine, J | 1 |
| Rapaport, A | 1 |
| Lev, L | 1 |
| Bersudsky, Y | 1 |
| Kofman, O | 1 |
| Belmaker, RH | 1 |
| Shapiro, J | 1 |
| Shimizu, T | 1 |
| Shibata, M | 1 |
| Wakisaka, S | 1 |
| Inoue, T | 1 |
| Mashimo, T | 1 |
| Yoshiya, I | 1 |
| Grachev, ID | 1 |
| Fredrickson, BE | 1 |
| Apkarian, VA | 1 |
| Soupart, A | 1 |
| Silver, S | 1 |
| Schroöeder, B | 1 |
| Sterns, R | 1 |
| Decaux, G | 1 |
| Trznadel, K | 1 |
| Kidawa, Z | 1 |
| Walasek, L | 1 |
| Lutz, W | 1 |
| Pitkänen, E | 1 |
| Bultitude, FW | 1 |
| Newham, SJ | 1 |
| Kreis, R | 2 |
| Ross, BD | 2 |
| Borejszo, I | 1 |
| Sappey-Marinier, D | 1 |
| Calabrese, G | 1 |
| Hetherington, HP | 1 |
| Fisher, SN | 1 |
| Deicken, R | 1 |
| Van Dyke, C | 1 |
| Fein, G | 1 |
| Weiner, MW | 1 |
| Farrow, N | 1 |
| Reddi, AS | 1 |
| Jyothirmayi, GN | 1 |
| DeAngelis, B | 1 |
| Frank, O | 1 |
| Baker, H | 1 |
| Zawalich, WS | 1 |
| Zawalich, KC | 1 |
| Shulman, GI | 1 |
| Rossetti, L | 1 |
| Lien, YH | 1 |
| Shapiro, JI | 1 |
| Chan, L | 1 |
| Lohr, JW | 1 |
| McReynolds, J | 1 |
| Grimaldi, T | 1 |
| Acara, M | 1 |
| Chlumský, J | 1 |
| Hyncík, V | 1 |
| Anderson, W | 1 |
| Hollins, JG | 1 |
| Bond, PS | 1 |
3 reviews available for inositol and Chronic Disease
| Article | Year |
|---|---|
Brain volume regulation in response to hypo-osmolality and its correction.
Topics: Acute Disease; Animals; Brain; Brain Edema; Chronic Disease; Demyelinating Diseases; Humans; Hyponat | 2006 |
Recent advances in the pathogenesis and nutritional treatment of chronic uremia.
Topics: Amino Acids; Amino Acids, Essential; Arteriosclerosis; Choline; Chronic Disease; Cyclic AMP; Dietary | 1982 |
[Role of the polyol cycle and disturbances of myoinositol metabolism in pathogenesis of chronic complications in diabetes mellitus].
Topics: Ampholyte Mixtures; Animals; Chronic Disease; Diabetes Complications; Humans; Inositol; Periodicity; | 1992 |
3 trials available for inositol and Chronic Disease
| Article | Year |
|---|---|
Proton magnetic resonance spectroscopy in youth with severe mood dysregulation.
Topics: Antimanic Agents; Arousal; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Bipolar Dis | 2008 |
[Experience with the medical treatment of chronic cerebrovascular insufficiency: bamethan and inositol nicotinate versus placebo].
Topics: Aged; Brain Ischemia; Chronic Disease; Clinical Trials as Topic; Ethanolamines; Female; Humans; Inos | 1981 |
Inositol treatment raises CSF inositol levels.
Topics: Adult; Chronic Disease; Female; Follow-Up Studies; Humans; Inositol; Male; Middle Aged; Schizophreni | 1993 |
30 other studies available for inositol and Chronic Disease
| Article | Year |
|---|---|
Brain metabolites in chronic migraine patients with medication overuse headache.
Topics: Adult; Brain; Chronic Disease; Female; Headache Disorders, Secondary; Humans; Inositol; Magnetic Res | 2020 |
Neurochemical changes in the medial wall of the brain in chronic migraine.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Brain Mapping; Chronic Disease; Correlation of Data; C | 2018 |
[1H NMR based metabonomics study on the antidepressant effect of genipin in rat hippocampus].
Topics: Alanine; Animals; Antidepressive Agents; Aspartic Acid; Behavior, Animal; Chronic Disease; Depressio | 2014 |
Yeast bioassay for identification of inositol depleting compounds.
Topics: Anticonvulsants; Antimanic Agents; Biological Assay; Bipolar Disorder; Brain; Carboxylic Acids; Cell | 2009 |
Uncoupling between CD1d upregulation induced by retinoic acid and conduritol-B-epoxide and iNKT cell responsiveness.
Topics: Antigens, CD1d; Antineoplastic Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell | 2010 |
Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Caffeine; Central Nervous System Stimulants; Chronic Disease; Diabetes Melli | 2009 |
Proton magnetic resonance spectroscopy reveals similar white matter biochemical changes in patients with chronic hypertension and early Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Choline; Chronic Disease; Creatine | 2002 |
[Clinical experience with a new hormone combination in tonic therapy].
Topics: Androgens; Arthritis; Arthritis, Rheumatoid; Chronic Disease; Infections; Inositol; Prednisolone | 1958 |
Drug-induced parkinsonism in relation to choline-containing compounds measured by 1H-MR spectroscopy in putamen of chronically medicated patients with schizophrenia.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Basal Ganglia Diseases; Choline; Chronic Disease; Creati | 2003 |
A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDS.
Topics: Acute Disease; AIDS Dementia Complex; Animals; Aspartic Acid; Brain; Choline; Chronic Disease; Creat | 2004 |
Additive effects of HIV and chronic methamphetamine use on brain metabolite abnormalities.
Topics: Adult; Amphetamine-Related Disorders; Aspartic Acid; Basal Ganglia; Brain; Brain Diseases; Choline; | 2005 |
Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T.
Topics: Acute Disease; Adult; Brain; Choline; Chronic Disease; Female; Glutamic Acid; Humans; Inositol; Magn | 2005 |
Inhibition of chronic ulcerative colitis associated adenocarcinoma development in mice by inositol compounds.
Topics: Adenocarcinoma; Animals; Body Weight; Chronic Disease; Colitis, Ulcerative; Colorectal Neoplasms; Fe | 2007 |
Abnormal glucose tolerance contributes to the progression of chronic heart failure in patients with dilated cardiomyopathy.
Topics: Cardiomyopathy, Dilated; Chronic Disease; Disease Progression; Echocardiography; Female; Glucose Int | 2006 |
In vivo 1H magnetic resonance spectroscopy-derived metabolite variations between acute-on-chronic liver failure and acute liver failure.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Case-Control Studies; Choline; Chronic Disease; Creat | 2008 |
Intrathecal lithium reduces neuropathic pain responses in a rat model of peripheral neuropathy.
Topics: Animals; Chronic Disease; Cold Temperature; Drug Interactions; Hot Temperature; Hyperalgesia; Inject | 2000 |
Abnormal brain chemistry in chronic back pain: an in vivo proton magnetic resonance spectroscopy study.
Topics: Adult; Anxiety; Aspartic Acid; Back Pain; Brain Chemistry; Choline; Chronic Disease; Creatine; Femal | 2000 |
Rapid (24-hour) reaccumulation of brain organic osmolytes (particularly myo-inositol) in azotemic rats after correction of chronic hyponatremia.
Topics: Animals; Body Water; Brain; Chronic Disease; Hyponatremia; Inositol; Male; Mercuric Chloride; Potass | 2002 |
[A comparison of the efficiency of eliminating middle-weight molecules and myoinositol from plasma during hemoperfusion and hemodialysis in cases of chronic uremia].
Topics: Chronic Disease; Hemoperfusion; Humans; Inositol; Renal Dialysis; Toxins, Biological; Uremia | 1978 |
Changes in serum and urinary myo-inositol levels in chronic glomerulonephritis.
Topics: Chronic Disease; Creatinine; Diabetes Mellitus; Glomerulonephritis; Humans; Inositol; Kidney Disease | 1976 |
Identification of some abnormal metabolites in plasma from uremic subjects.
Topics: Autoanalysis; Chromatography, Gas; Chromatography, Gel; Chronic Disease; Erythritol; Glycerol; Human | 1975 |
Cerebral metabolic disturbances in patients with subacute and chronic diabetes mellitus: detection with proton MR spectroscopy.
Topics: Adult; Aged; Brain; Chronic Disease; Diabetes Mellitus; Diabetic Ketoacidosis; Female; Glucose; Huma | 1992 |
Proton magnetic resonance spectroscopy of human brain: applications to normal white matter, chronic infarction, and MRI white matter signal hyperintensities.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Chemistry; Brain Ischemia; Cerebral Infarction; | 1992 |
Localized 1H NMR spectroscopy in patients with chronic hepatic encephalopathy. Analysis of changes in cerebral glutamine, choline and inositols.
Topics: Aged; Brain; Choline; Chronic Disease; Data Interpretation, Statistical; Electronic Data Processing; | 1991 |
Effect of short- and long-term diabetes on carnitine and myo-inositol in rats.
Topics: Acute Disease; Animals; Blood Glucose; Body Weight; Carnitine; Chronic Disease; Diabetes Mellitus, E | 1991 |
Chronic in vivo hyperglycemia impairs phosphoinositide hydrolysis and insulin release in isolated perifused rat islets.
Topics: Animals; Blood Glucose; Chronic Disease; Glucose; Hydrolysis; Hyperglycemia; In Vitro Techniques; In | 1990 |
Effects of hypernatremia on organic brain osmoles.
Topics: Acute Disease; Amino Acids; Animals; Body Water; Brain; Chronic Disease; Hypernatremia; Inositol; Ma | 1990 |
Effect of acute and chronic hypernatremia on myoinositol and sorbitol concentration in rat brain and kidney.
Topics: Acute Disease; Animals; Body Water; Brain; Chronic Disease; Hypernatremia; Inositol; Kidney; Male; O | 1988 |
[Problem of active therapeutic procedure in chronic liver disease].
Topics: Adenine; Adult; Aged; Chronic Disease; Diet Therapy; Female; Humans; Inositol; Liver Diseases; Male; | 1972 |
The composition of tea infusions examined in relation to the association between mortality and water hardness.
Topics: Caffeine; Calcium; Calcium, Dietary; Chronic Disease; England; Humans; Inositol; Metals; Mortality; | 1971 |