inositol and Cataract studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)

Research Excerpts

Excerpt	Relevance	Reference
"Lens fiber swelling and related cataractous outgrowth positively correlated to the degree of lens bSMIT gene expression and intralenticular myo-inositol content."	7.70	A transgenic animal model of osmotic cataract. Part 1: over-expression of bovine Na+/myo-inositol cotransporter in lens fibers. ( Cammarata, PR; Chen, G; Kuszak, JR; Reeves, RE; Robinson, ML; Singh, I; Zhou, C, 1999)
" This study was performed to investigate whether high levels of myo-inositol, one of the major organic osmolytes in the lens, would lead to cataract development."	7.70	Overexpression of Na(+)-dependent myo-inositol transporter gene in mouse lens led to congenital cataract. ( Cammarata, PR; Chung, SK; Chung, SS; Jiang, Z; Zhou, C, 2000)
"The effect of myoinositol on in vitro peroxidation induced by hydrogen peroxide in human erythrocytes and human cataractous lenses has been investigated."	7.69	Myoinositol and peroxidation--an in vitro study on human cataractous lens and human erythrocytes. ( Devi, CS; Raj, DG; Ramakrishnan, S, 1995)
"To develop and characterize a new model of galactose-induced cataract formation in young, 3- to 4-week-old Hartley guinea pigs."	7.69	Galactose-induced cataract formation in guinea pigs: morphologic changes and accumulation of galactitol. ( Bekhor, I; Kannan, R; Mackic, JB; McComb, JG; Ross-Cisneros, FN; Weiss, MH; Zlokovic, BV, 1994)
"It was reported previously that dietary ascorbate (ASC) delays the development of galactose-induced cataract in guinea pigs compared to the rate which is observed in ASC-deficient animals."	7.69	A physiological level of ascorbate inhibits galactose cataract in guinea pigs by decreasing polyol accumulation in the lens epithelium: a dehydroascorbate-linked mechanism. ( Giblin, FJ; Reddy, VN; Sasaki, H; Yokoyama, T, 1994)
"It has been postulated that the accumulation of sugar alcohol, galactitol, from milk induces cataract in the eye lens through an osmotic mechanism."	7.68	Galactitol is not a cause of senile cataract. ( Aine, E; Arola, H; Isokoski, M; Koivula, T; Sillanaukee, P, 1992)
"The lens myo-inositol (MI) content is known to be depleted during initial cataractogenesis in both streptozocin (STZ)-induced diabetic and 50% galactose-maintained rats."	7.67	Dietary myo-inositol effect on sugar cataractogenesis. ( Beyer-Mears, A; Bucci, FA; Cruz, E; Del Val, M, 1989)
"The myo-inositol uptake system was studied in lenses of normal and hereditary cataract mouse."	7.66	A defect of the myo-inositol maintenance mechanism in the lens of hereditary cataract mice. ( Takenawa, T; Tsumita, T; Wada, E, 1979)
"Lens fiber swelling and related cataractous outgrowth positively correlated to the degree of lens bSMIT gene expression and intralenticular myo-inositol content."	3.70	A transgenic animal model of osmotic cataract. Part 1: over-expression of bovine Na+/myo-inositol cotransporter in lens fibers. ( Cammarata, PR; Chen, G; Kuszak, JR; Reeves, RE; Robinson, ML; Singh, I; Zhou, C, 1999)
" This study was performed to investigate whether high levels of myo-inositol, one of the major organic osmolytes in the lens, would lead to cataract development."	3.70	Overexpression of Na(+)-dependent myo-inositol transporter gene in mouse lens led to congenital cataract. ( Cammarata, PR; Chung, SK; Chung, SS; Jiang, Z; Zhou, C, 2000)
"The effect of myoinositol on in vitro peroxidation induced by hydrogen peroxide in human erythrocytes and human cataractous lenses has been investigated."	3.69	Myoinositol and peroxidation--an in vitro study on human cataractous lens and human erythrocytes. ( Devi, CS; Raj, DG; Ramakrishnan, S, 1995)
"To develop and characterize a new model of galactose-induced cataract formation in young, 3- to 4-week-old Hartley guinea pigs."	3.69	Galactose-induced cataract formation in guinea pigs: morphologic changes and accumulation of galactitol. ( Bekhor, I; Kannan, R; Mackic, JB; McComb, JG; Ross-Cisneros, FN; Weiss, MH; Zlokovic, BV, 1994)
"It was reported previously that dietary ascorbate (ASC) delays the development of galactose-induced cataract in guinea pigs compared to the rate which is observed in ASC-deficient animals."	3.69	A physiological level of ascorbate inhibits galactose cataract in guinea pigs by decreasing polyol accumulation in the lens epithelium: a dehydroascorbate-linked mechanism. ( Giblin, FJ; Reddy, VN; Sasaki, H; Yokoyama, T, 1994)
"It has been postulated that the accumulation of sugar alcohol, galactitol, from milk induces cataract in the eye lens through an osmotic mechanism."	3.68	Galactitol is not a cause of senile cataract. ( Aine, E; Arola, H; Isokoski, M; Koivula, T; Sillanaukee, P, 1992)
"It has been suggested that sugar cataracts associated with diabetes mellitus result from the accumulation of excess sorbitol within lens fibrils."	3.68	Nonosmotic diabetic cataracts. ( Cook, WR; Lowitt, S; Malone, JI, 1990)
"Circulating glycosylated hemoglobin (Hb A1) and/or fasting blood glucose (FBG) levels, measures of the extent to which diabetes is clinically controlled, were correlated with the contents of fructose, sorbitol, glucose, and inositol in 27 cataracts removed by intracapsular extraction."	3.67	Polyol pathway metabolites in human cataracts. Correlation of circulating glycosylated hemoglobin content and fasting blood glucose levels. ( Lerner, BC; Richards, RD; Varma, SD, 1984)
"The cataractogenic effect of a galactose diet was studied in male and female pigs in relation to the daily galactose intake."	3.67	The effects of 5% and 25% galactose diets on lens polyols, glutathione and protein glycation in male and female pigs. ( Alloussi, S; Birlouez-Aragon, I; Fevrier, C; Morawiec, M, 1989)
"The lens myo-inositol (MI) content is known to be depleted during initial cataractogenesis in both streptozocin (STZ)-induced diabetic and 50% galactose-maintained rats."	3.67	Dietary myo-inositol effect on sugar cataractogenesis. ( Beyer-Mears, A; Bucci, FA; Cruz, E; Del Val, M, 1989)
"The myo-inositol uptake system was studied in lenses of normal and hereditary cataract mouse."	3.66	A defect of the myo-inositol maintenance mechanism in the lens of hereditary cataract mice. ( Takenawa, T; Tsumita, T; Wada, E, 1979)
"Cataract is one of the most prevalent protein aggregation disorders and still the most common cause of vision loss worldwide."	1.72	A native chemical chaperone in the human eye lens. ( Chowdhury, S; Klevit, RE; McClelland, AA; Serebryany, E; Shakhnovich, EI; Thorn, DC; Watson, NE; Woods, CN, 2022)
" The purpose of this study was to investigate metabolic changes in the rabbit lens after long-term dexamethasone treatment in combination with UVB exposure, using high-resolution magic angle spinning proton nuclear magnetic resonance (HR-MAS (1)H NMR) spectroscopy to analyse intact lens tissues."	1.32	High-resolution magic angle spinning 1H NMR spectroscopy of metabolic changes in rabbit lens after treatment with dexamethasone combined with UVB exposure. ( Cejková, J; Krane, J; Midelfart, A; Risa, O; Saether, O, 2004)
"Lens galactose accumulation was low (3 mumol/g wet wt) up to 7 days; however, it was rapidly increased after 7 days."	1.28	Myo-inositol transport in the lens of galactose-maintained rats. ( Beyer-Mears, A; Cruz, E; Diecke, FP; Mistry, K, 1992)
"Inositol was not detectable from stage I."	1.27	Studies on diabetic cataract in rats induced by streptozotocin. II. Biochemical examinations of rat lenses in relation to cataract stages. ( Fukuda, M; Kuriyama, H; Sasaki, K, 1983)
"Senile cataract was observed on six lenses of 12 rats aged 28-32 months."	1.27	Ageing and compositional changes of rat lens. ( Tsumita, T; Wada, E, 1984)
"Both diabetic hyperglycemia and galactosemia caused the prolongation of peak latencies and in some cases a reduction in the amplitudes of oscillatory potentials on the b-wave."	1.27	The development of electroretinogram abnormalities and the possible role of polyol pathway activity in diabetic hyperglycemia and galactosemia. ( Fujimori, S; Hirata, Y; Okada, K; Segawa, M, 1988)
"After 160 days, no cataract is revealed in the T and P groups."	1.26	[Reactions in the rats from prolonged consumption of lactose or hydrolyzed lactose. 3. Crystalline lens]. ( Adrian, J; David, C; Frangne, R; Manent, PJ; Poiffait, A, 1982)

Timeframe	Studies, this research(%)	All Research%
pre-1990	34 (66.67)	18.7374
1990's	11 (21.57)	18.2507
2000's	4 (7.84)	29.6817
2010's	1 (1.96)	24.3611
2020's	1 (1.96)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Myo-inositol for the Management of Poor Ovarian Responders: A Prospective Randomized Controlled Trial[NCT04273256]	Phase 2/Phase 3	226 participants (Anticipated)	Interventional	2020-02-11	Recruiting
Effect of Myoinositol on Serum Asprosin Levels in Pregnant Women[NCT05943158]		40 participants (Actual)	Interventional	2021-06-01	Completed
Different Effects of Inositol Stereoisomers on Insulin Sensitivity in Women With Gestational Diabetes[NCT02097069]		80 participants (Anticipated)	Interventional	2014-04-30	Not yet recruiting
Effects of a Supplementation With Zinc and Myo-inositol in Paediatric Obesity[NCT03283813]	Phase 4	60 participants (Anticipated)	Interventional	2018-02-05	Recruiting
Reduction of Insulin Therapy Under Myo-inositol for the Treatment of Gestational Diabetes Mellitus: a Randomized Multicenter and Prospective Trial. MYO-GDM Study[NCT03875755]		1,080 participants (Anticipated)	Interventional	2020-03-04	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie, 2013, Volume: 95, Issue:10 Topics: Animals; Blood Glucose; Cataract; Diabetes, Gestational; Diabetic Nephropathies; Diet; Female; Human	2013
Galactose cataract: a review. Experimental eye research, 1971, Volume: 11, Issue:3 Topics: Age Factors; Alcohol Oxidoreductases; Aminoisobutyric Acids; Animals; Cataract; Dairy Products; Gala	1971

Article	Year
[Statistical analysis of conservative cataract therapy based on a controlled clinical study of the effectiveness of Phakan/Phakolen]. Fortschritte der Ophthalmologie : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1984, Volume: 81, Issue:4 Topics: Amino Acids; Ascorbic Acid; Cataract; Clinical Trials as Topic; Drug Combinations; Humans; Inositol;	1984
[Controlled clinical study on the efficacy of Phakan as an anticataract drug]. Fortschritte der Ophthalmologie : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1982, Volume: 79, Issue:3 Topics: Adult; Aged; Amino Acids; Ascorbic Acid; Cataract; Clinical Trials as Topic; Double-Blind Method; Dr	1982
[Supplement to the clinical study on the effectiveness of an anticataract preparation]. Fortschritte der Ophthalmologie : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1985, Volume: 82, Issue:3 Topics: Amino Acids; Ascorbic Acid; Cataract; Clinical Trials as Topic; Densitometry; Drug Combinations; Hum	1985
[Results of clinical studies on drug modification of progressive lens opacities]. Klinische Monatsblatter fur Augenheilkunde, 1985, Volume: 186, Issue:6 Topics: Amino Acids; Ascorbic Acid; Cataract; Clinical Trials as Topic; Densitometry; Double-Blind Method; D	1985

Article	Year
A native chemical chaperone in the human eye lens. eLife, 2022, 06-20, Volume: 11 Topics: Cataract; Humans; Inositol; Lens, Crystalline; Molecular Chaperones; Protein Aggregates	2022
THE EFFECT OF DIABETES ON THE CONTENT OF SORBITOL, GLUCOSE, FRUCTOSE AND INOSITOL IN THE HUMAN LENS. Experimental eye research, 1964, Volume: 3 Topics: Aging; Cataract; Diabetes Mellitus; Fructose; Geriatrics; Glucose; Humans; Inositol; Lens, Crystalli	1964
EPIDEMIOLOGICAL AND BIOCHEMICAL STUDIES OF CATARACT AND DIABETES. Investigative ophthalmology, 1965, Volume: 4 Topics: Carbohydrate Metabolism; Cataract; Cataract Extraction; Diabetes Mellitus; England; Epidemiology; Fr	1965
High-resolution magic angle spinning 1H NMR spectroscopy of metabolic changes in rabbit lens after treatment with dexamethasone combined with UVB exposure. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2004, Volume: 242, Issue:12 Topics: Administration, Topical; Animals; Cataract; Combined Modality Therapy; Dexamethasone; Glucocorticoid	2004
Postnatal biochemical changes in rat lens: an important factor in cataract models. Current eye research, 2007, Volume: 32, Issue:2 Topics: Amino Acids; Animals; Cataract; Crystallins; Disease Models, Animal; Energy Metabolism; Inositol; Le	2007
The effect of single and repeated UVB radiation on rabbit lens. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2008, Volume: 246, Issue:4 Topics: Alanine; Animals; Cataract; Glutathione; Inositol; Lens, Crystalline; Nuclear Magnetic Resonance, Bi	2008
Studies on diabetic cataract in rats induced by streptozotocin. II. Biochemical examinations of rat lenses in relation to cataract stages. Ophthalmic research, 1983, Volume: 15, Issue:4 Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Fructose; Inositol; Lens, Crystalline; Male; Pot	1983
Etiology of cataracts in diabetics. International ophthalmology clinics, 1984,Winter, Volume: 24, Issue:4 Topics: Adolescent; Adult; Aldehyde Reductase; Animals; Blood Glucose; Cataract; Child; Child, Preschool; Di	1984
Ageing and compositional changes of rat lens. Mechanisms of ageing and development, 1984, Oct-31, Volume: 27, Issue:3 Topics: Aging; Animals; Carbohydrate Metabolism; Cataract; Fatty Acids; Female; Inositol; Lens, Crystalline;	1984
[Is there hope for drug therapy of cataracts?]. Therapeutische Umschau. Revue therapeutique, 1984, Volume: 41, Issue:4 Topics: Aged; Amino Acids; Ascorbic Acid; Cataract; Drug Combinations; Humans; Inositol; Iodine; Pyridoxine	1984
Polyol pathway metabolites in human cataracts. Correlation of circulating glycosylated hemoglobin content and fasting blood glucose levels. Archives of ophthalmology (Chicago, Ill. : 1960), 1984, Volume: 102, Issue:6 Topics: Blood Glucose; Carbohydrates; Cataract; Fructose; Glucose; Glycated Hemoglobin; Humans; Inositol; Le	1984
[Reactions in the rats from prolonged consumption of lactose or hydrolyzed lactose. 3. Crystalline lens]. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1982, Volume: 52, Issue:4 Topics: Animals; Cataract; Crystallins; Galactitol; Galactosephosphates; Hydrolysis; Inositol; Lactose; Lens	1982
[Sugars, polyols and electrolytes in human cataractous lens (author's transl)]. Nippon Ganka Gakkai zasshi, 1980, Oct-10, Volume: 84, Issue:10 Topics: Aged; Cataract; Glucose; Humans; Inositol; Lens, Crystalline; Middle Aged; Potassium; Sodium; Sorbit	1980
Myoinositol and peroxidation--an in vitro study on human cataractous lens and human erythrocytes. Indian journal of biochemistry & biophysics, 1995, Volume: 32, Issue:2 Topics: Cataract; Erythrocytes; Humans; In Vitro Techniques; Inositol; Lipid Peroxidation	1995
Galactose-induced cataract formation in guinea pigs: morphologic changes and accumulation of galactitol. Investigative ophthalmology & visual science, 1994, Volume: 35, Issue:3 Topics: Animals; Cataract; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; Galactitol;	1994
A physiological level of ascorbate inhibits galactose cataract in guinea pigs by decreasing polyol accumulation in the lens epithelium: a dehydroascorbate-linked mechanism. Experimental eye research, 1994, Volume: 58, Issue:2 Topics: Animals; Aqueous Humor; Ascorbic Acid; Cataract; Cells, Cultured; Dehydroascorbic Acid; Dogs; Female	1994
Sugar alcohols in the lens epithelium of age-related cataract. Experimental eye research, 1993, Volume: 56, Issue:1 Topics: Aged; Blood Glucose; Cataract; Diabetes Mellitus; Epithelium; Female; Humans; Inositol; Lens, Crysta	1993
Effect of pyruvate on lens myo-inositol transport and polyol formation in diabetic cataract. Pharmacology, 1997, Volume: 55, Issue:2 Topics: Animals; Biological Transport; Carbohydrates; Cataract; Culture Media; Culture Techniques; Diabetes	1997
Effects of sorbitol dehydrogenase deficiency on nerve conduction in experimental diabetic mice. Diabetes, 1998, Volume: 47, Issue:6 Topics: Animals; Brain; Cataract; Diabetes Mellitus, Experimental; Fructose; Glucose; Inositol; Introns; Kid	1998
Fructose induced deactivation of glucose-6-phosphate dehydrogenase activity and its prevention by pyruvate: implications in cataract prevention. Free radical research, 1998, Volume: 29, Issue:4 Topics: Animals; Catalase; Cataract; Cytochrome c Group; Diabetes Complications; Dose-Response Relationship,	1998
A transgenic animal model of osmotic cataract. Part 1: over-expression of bovine Na+/myo-inositol cotransporter in lens fibers. Investigative ophthalmology & visual science, 1999, Volume: 40, Issue:8 Topics: Animals; Carrier Proteins; Cataract; Cell Differentiation; Chromatography, Ion Exchange; Disease Mod	1999
Overexpression of Na(+)-dependent myo-inositol transporter gene in mouse lens led to congenital cataract. Investigative ophthalmology & visual science, 2000, Volume: 41, Issue:6 Topics: Aldehyde Reductase; Animals; Blotting, Northern; Carrier Proteins; Cataract; Dietary Carbohydrates;	2000
Implications of aldose reductase in cataracts in human diabetes. Investigative ophthalmology & visual science, 1979, Volume: 18, Issue:3 Topics: Aldehyde Reductase; Blood Glucose; Cataract; Diabetes Mellitus; Fructose; Glucose; Humans; Inositol;	1979
The effect of an unsaturated-fat diet on cataract formation in streptozotocin-induced diabetic rats. The British journal of nutrition, 1976, Volume: 36, Issue:2 Topics: Animals; Aqueous Humor; Carbohydrate Metabolism; Cataract; Diabetes Mellitus; Dietary Fats; Eye; Fat	1976
A defect of the myo-inositol maintenance mechanism in the lens of hereditary cataract mice. Biochimica et biophysica acta, 1979, Jun-13, Volume: 554, Issue:1 Topics: Animals; Biological Transport; Cataract; Inositol; Kinetics; Lens, Crystalline; Male; Mannitol; Mice	1979
Myo-inositol content of the lens in hereditary cataract mice. Experimental eye research, 1978, Volume: 26, Issue:1 Topics: Animals; Cataract; Female; Inositol; Lens, Crystalline; Lipid Metabolism; Male; Mice	1978
Gas chromatographic study of free polyols and aldoses in cataractous human lens tissue. Journal of chromatography, 1976, Nov-03, Volume: 126 Topics: Cataract; Chromatography, Gas; Diabetes Mellitus; Galactose; Glucose; Humans; Inositol; Lens, Crysta	1976
Sorbitol and other polyols in lens, adipose tissue and urine in diabetes mellitus. Clinica chimica acta; international journal of clinical chemistry, 1975, Aug-18, Volume: 63, Issue:1 Topics: Adipose Tissue; Cataract; Chromatography, Gas; Diabetes Mellitus; Fructose; Glucose; Humans; Inosito	1975
Myo-inositol transport in the lens of galactose-maintained rats. Current eye research, 1992, Volume: 11, Issue:1 Topics: Animals; Biological Transport, Active; Carbohydrate Metabolism; Cataract; Cell Membrane Permeability	1992
Galactitol is not a cause of senile cataract. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1992, Volume: 230, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Animals; Cataract; Cataract Extraction; Chromatography, Gas; Female;	1992
Nonosmotic diabetic cataracts. Pediatric research, 1990, Volume: 27, Issue:3 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines;	1990
The effects of 5% and 25% galactose diets on lens polyols, glutathione and protein glycation in male and female pigs. Current eye research, 1989, Volume: 8, Issue:5 Topics: Animals; Cataract; Chromatography, Gas; Chromatography, High Pressure Liquid; Diet; Female; Galactit	1989
Lens hexitols and cataract formation during lactation in a woman heterozygote for galactosaemia. Journal of inherited metabolic disease, 1989, Volume: 12 Suppl 2 Topics: Adult; Cataract; Female; Galactitol; Galactokinase; Galactosemias; Genetic Carrier Screening; Humans	1989
Dietary myo-inositol effect on sugar cataractogenesis. Pharmacology, 1989, Volume: 39, Issue:1 Topics: Animals; Carbohydrates; Cataract; Chromatography, Gas; Diabetes Mellitus, Experimental; Diet; Galact	1989
The accumulation of myoinositol and rubidium ions in galactose-exposed rat lens. Investigative ophthalmology & visual science, 1986, Volume: 27, Issue:10 Topics: Aldehyde Reductase; Animals; Cataract; Galactose; Hypertonic Solutions; Imidazoles; Imidazolidines;	1986
The development of electroretinogram abnormalities and the possible role of polyol pathway activity in diabetic hyperglycemia and galactosemia. Metabolism: clinical and experimental, 1988, Volume: 37, Issue:5 Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Electroretinography; Galactitol; Galactosemias;	1988
Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor. Diabetes, 1985, Volume: 34, Issue:1 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Glucose; Imidazoles; Imidazo	1985
Composition and metabolism of phospholipids in cataract. Experimental eye research, 1969, Volume: 8, Issue:2 Topics: Aging; Animals; Cataract; Humans; Inositol; Lens, Crystalline; Phosphatidylcholines; Phosphatidyleth	1969
Lipids in tissues of the eye. V. Phospholipid metabolism in normal and cataractous lens. Biochimica et biophysica acta, 1971, Mar-16, Volume: 231, Issue:2 Topics: Aging; Albumins; Alcohols; Alloxan; Animals; Cataract; Cattle; Cytosine Nucleotides; Diabetes Mellit	1971
The absence of cataracts in mice with congenital hyperglycemia. Experimental eye research, 1974, Volume: 19, Issue:6 Topics: Alcohol Oxidoreductases; Animals; Cataract; Diabetes Mellitus; Diet; Fructose; Galactitol; Galactose	1974
Changes in the levels of free amino acids and myo-inositol in the galactose-exposed lens. Investigative ophthalmology, 1969, Volume: 8, Issue:6 Topics: Alcohol Oxidoreductases; Amino Acids; Animals; Carbohydrates; Cataract; Culture Techniques; Diet; Fe	1969
[Biochemical characteristics of the cataract lens. 1. Comparison of water content and concentration of sorbitol, inositol, glutathione and sialic acid in the young and adult rat lens]. Nippon Ganka Gakkai zasshi, 1967, Volume: 71, Issue:7 Topics: Aging; Animals; Cataract; Glutathione; Inositol; Lens, Crystalline; Neuraminic Acids; Rats; Sorbitol	1967
An investigation into the loss of proteins of low molecular size from the lens in senile cataract. Experimental eye research, 1968, Volume: 7, Issue:1 Topics: Aged; Aging; Animals; Autoradiography; Carbon Isotopes; Cataract; Cattle; Chromatography, Gel; Cryst	1968
Inositol in normal lenses and cataracts. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1968, Volume: 3, Issue:3 Topics: Animals; Biological Assay; Carbon Isotopes; Cataract; Cats; Humans; Inositol; Lens, Crystalline; Spe	1968
Changes in myo-inositol permeability in the lens due to cataractous conditions. Biochimica et biophysica acta, 1968, Sep-17, Volume: 163, Issue:2 Topics: Alcohols; Animals; Cataract; Diabetes Complications; Female; Galactosemias; Inositol; Lens, Crystall	1968

inositol and Cataract

Research Excerpts

Research

Studies (51)

Authors

Clinical Trials (5)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Serebryany, E	1
Chowdhury, S	1
Woods, CN	1
Thorn, DC	1
Watson, NE	1
McClelland, AA	1
Klevit, RE	1
Shakhnovich, EI	1
Croze, ML	1
Soulage, CO	1
PIRIE, A	2
VANHEYNINGEN, R	1
Saether, O	1
Risa, O	1
Cejková, J	2
Krane, J	1
Midelfart, A	3
Fris, M	2
Kuriyama, H	1
Sasaki, K	1
Fukuda, M	1
Pau, H	1
Varma, SD	5
Richards, RD	3
Wada, E	3
Tsumita, T	3
Koch, HR	1
Lerner, BC	1
Hockwin, O	2
Weigelin, E	3
Baur, M	2
Boutros, G	1
Poiffait, A	1
Frangne, R	1
David, C	1
Manent, PJ	1
Adrian, J	1
Funahashi, M	1
Ono, H	1
Hayano, S	1
Komori, T	1
Raj, DG	1
Ramakrishnan, S	1
Devi, CS	1
Mackic, JB	1
Ross-Cisneros, FN	1
McComb, JG	1
Bekhor, I	1
Weiss, MH	1
Kannan, R	1
Zlokovic, BV	1
Yokoyama, T	1
Sasaki, H	1
Giblin, FJ	1
Reddy, VN	1
Belpoliti, M	1
Maraini, G	1
Beyer-Mears, A	4
Diecke, FP	2
Mistry, K	2
Ellison, C	1
Cruz, E	4
Ng, TF	1
Lee, FK	1
Song, ZT	1
Calcutt, NA	1
Lee, AY	1
Chung, SS	2
Chung, SK	2
Ng, DT	1
Lee, LW	1
Zhao, W	1
Devamanoharan, PS	1
Cammarata, PR	2
Zhou, C	2
Chen, G	1
Singh, I	1
Reeves, RE	1
Kuszak, JR	1
Robinson, ML	1
Jiang, Z	1
Schocket, SS	1
Hutton, JC	1
Schofield, PH	1
Williams, JF	1
Regtop, HL	1
Hollows, FC	1
Takenawa, T	2
Matsuzawa, A	1
Pfaffenberger, CD	1
Szafranek, J	1
Horning, EC	1
Heaf, DJ	1
Galton, DJ	1
Arola, H	1
Sillanaukee, P	1
Aine, E	1
Koivula, T	1
Isokoski, M	1
Malone, JI	1
Lowitt, S	1
Cook, WR	1
Birlouez-Aragon, I	1
Alloussi, S	1
Morawiec, M	1
Fevrier, C	1
Brivet, M	1
Migayron, F	1
Roger, J	1
Cheron, G	1
Lemonnier, A	1
Bucci, FA	1
Del Val, M	1
Kawaba, T	1
Cheng, HM	1
Kinoshita, JH	3
Segawa, M	1
Hirata, Y	1
Fujimori, S	1
Okada, K	1
Broekhuyse, RM	3
Van Heyningen, R	2
Barber, GW	1
Merola, LO	1
Tung, B	1
Takaku, I	1
Hasegawa, K	1
Kimura, R	1
Watanabe, Y	1
Charlton, JM	1
Oliver, GL	1
Gardiner, RJ	1
Rossiter, RJ	1