Page last updated: 2024-10-19

inositol and Cardiovascular Diseases

inositol has been researched along with Cardiovascular Diseases in 20 studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.

Research Excerpts

ExcerptRelevanceReference
"We enrolled 47 Japanese patients with type 2 diabetes, with HbA1c levels with 7."2.79Switching α-glucosidase inhibitors to miglitol reduced glucose fluctuations and circulating cardiovascular disease risk factors in type 2 diabetic Japanese patients. ( Fuchigami, M; Goda, T; Hariya, N; Inoue, S; Mochizuki, K; Osonoi, T; Saito, M, 2014)
"Myo-inositol has documented in clinical studies its effectiveness in improving the metabolic syndrome in post menopausal women."2.50Resveratrol, inositol, vitamin D and K in the prevention of cardiovascular and osteoporotic risk: a novel approach in peri- and postmenopause. ( Parazzini, F, 2014)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19908 (40.00)18.7374
1990's0 (0.00)18.2507
2000's3 (15.00)29.6817
2010's9 (45.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hedrington, MS1
Davis, SN1
Asakura, M1
Kim, J1
Asanuma, H1
Hamasaki, T1
Tsukahara, K1
Higashino, Y1
Ishikawa, T1
Nakama, Y1
Koba, S1
Maruyama, Y1
Tsujimoto, M1
Himeno, H1
Ohkusa, T1
Fujino, S1
Shimizu, M1
Endo, T1
Yoda, S1
Muroya, T1
Murohara, T1
Ohte, N1
Suzuki, H1
Kohno, T1
Fukui, K1
Shiono, T1
Takase, H1
Uzui, H1
Nagai, Y1
Hashimoto, Y1
Ikeda, S1
Mizuno, S1
Tamita, K1
Fujita, M1
Satake, K1
Kinoshita, Y1
Nunohiro, T1
Sakagami, S1
Higaki, J1
Morii, I1
Sawada, R1
Hiasa, Y1
Shigemasa, T1
Nakahama, M1
Sata, M1
Doi, O1
Ueda, T1
Yamada, T1
Yamanouchi, T1
Yamaguchi, H1
Morita, Y1
Hayashi, H1
Kitakaze, M1
Ferrer, MD1
Ketteler, M1
Tur, F1
Tur, E1
Isern, B1
Salcedo, C1
Joubert, PH1
Behets, GJ1
Neven, E1
D'Haese, PC1
Perelló, J1
Minozzi, M1
Nordio, M1
Pajalich, R1
Unfer, V1
Porcaro, G1
Hariya, N1
Mochizuki, K1
Inoue, S1
Saito, M1
Fuchigami, M1
Goda, T1
Osonoi, T1
Parazzini, F1
Kawamori, R2
Tajima, N1
Iwamoto, Y1
Kashiwagi, A1
Shimamoto, K1
Kaku, K1
Napoli, C1
Sessa, M1
Infante, T1
Casamassimi, A1
Standl, E1
Schnell, O1
SCHOGER, GA3
SCHOGER-VON SCHOLZ, I1
Kadowaki, T1
Ishida, H1
Kim, JI1
Kim, JC1
Kang, MJ1
Lee, MS1
Kim, JJ1
Cha, IJ1
Holub, BJ1
Radhakrishnamurthy, B1
Berenson, GS1
Pargaonkar, PS1
Voors, AW1
Srinivasan, SR1
Plavidal, F1
Dolan, P1
Dalferes, ER1
Richard, A1
Schütz, E1
Brandt, H1
Fromm, H1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Japan Working Group for the Assessment That the Alpha-glucosidase Inhibitor Blocks Cardiac Events in Patients With Myocardial Infarction and IGT[NCT00212017]3,000 participants (Actual)Interventional2005-04-30Terminated (stopped due to We obtained the final results due to the interim analysis.)
Evaluation of Quercetin in Type 2 Diabetes: Impact on Glucose Tolerance and Postprandial Endothelial Function.[NCT01839344]Phase 219 participants (Actual)Interventional2013-05-31Completed
Novel Fiber Effects on Glucose Metabolism and Insulin Sensitivity for Individuals at High Risk for Diabetes: a Randomized, Placebo-controlled, Double-blind, Parallel Group Clinical Trial[NCT00820807]60 participants (Anticipated)Interventional2009-01-31Terminated (stopped due to Stopped due to a non-safety-related issue with the beverage (test vehicle).)
Effects of Different Doses of Pinitol on Carbohydrate Metabolism Parameters in Healthy Subjects: a Randomized Cross-over Placebo-controlled Study[NCT01738763]30 participants (Actual)Interventional2011-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for inositol and Cardiovascular Diseases

ArticleYear
Considerations when using alpha-glucosidase inhibitors in the treatment of type 2 diabetes.
    Expert opinion on pharmacotherapy, 2019, Volume: 20, Issue:18

    Topics: 1-Deoxynojirimycin; Acarbose; Aged; Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type

2019
Updates on the myo-inositol plus D-chiro-inositol combined therapy in polycystic ovary syndrome.
    Expert review of clinical pharmacology, 2014, Volume: 7, Issue:5

    Topics: Animals; Cardiovascular Diseases; Drug Therapy, Combination; Female; Humans; Inositol; Insulin Resis

2014
Resveratrol, inositol, vitamin D and K in the prevention of cardiovascular and osteoporotic risk: a novel approach in peri- and postmenopause.
    Minerva ginecologica, 2014, Volume: 66, Issue:5

    Topics: Animals; Cardiovascular Diseases; Cell Line; Female; Humans; Inositol; Mice; Osteoporosis, Postmenop

2014
Unraveling framework of the ancestral Mediator complex in human diseases.
    Biochimie, 2012, Volume: 94, Issue:3

    Topics: Animals; Cardiovascular Diseases; Catechols; Humans; Inositol; Mediator Complex; Metabolic Diseases;

2012
Alpha-glucosidase inhibitors 2012 - cardiovascular considerations and trial evaluation.
    Diabetes & vascular disease research, 2012, Volume: 9, Issue:3

    Topics: 1-Deoxynojirimycin; Acarbose; Cardiovascular Diseases; Diabetes Complications; Glycoside Hydrolase I

2012
The nutritional significance, metabolism, and function of myo-inositol and phosphatidylinositol in health and disease.
    Advances in nutritional research, 1982, Volume: 4

    Topics: 6-Phytase; Animals; Biological Transport; Birds; Brain Chemistry; Cardiovascular Diseases; Chemical

1982

Trials

4 trials available for inositol and Cardiovascular Diseases

ArticleYear
Does Treatment of Impaired Glucose Tolerance Improve Cardiovascular Outcomes in Patients with Previous Myocardial Infarction?
    Cardiovascular drugs and therapy, 2017, Volume: 31, Issue:4

    Topics: Aged; Cardiovascular Diseases; Female; Glucose Intolerance; Glycoside Hydrolase Inhibitors; Humans;

2017
Switching α-glucosidase inhibitors to miglitol reduced glucose fluctuations and circulating cardiovascular disease risk factors in type 2 diabetic Japanese patients.
    Drugs in R&D, 2014, Volume: 14, Issue:3

    Topics: 1-Deoxynojirimycin; Acarbose; Aged; Asian People; Blood Glucose; Cardiovascular Diseases; Chemokine

2014
[Alpha-glucosidase inhibitor for the prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese subjects with impaired glucose tolerance].
    Nihon rinsho. Japanese journal of clinical medicine, 2009, Volume: 67, Issue:9

    Topics: Asian People; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Disease Progression; Enzyme Inhibi

2009
Effects of pinitol isolated from soybeans on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus: a randomized controlled study.
    European journal of clinical nutrition, 2005, Volume: 59, Issue:3

    Topics: Blood Glucose; Cardiovascular Diseases; Cholesterol; Diabetes Mellitus, Type 2; Double-Blind Method;

2005
Effects of pinitol isolated from soybeans on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus: a randomized controlled study.
    European journal of clinical nutrition, 2005, Volume: 59, Issue:3

    Topics: Blood Glucose; Cardiovascular Diseases; Cholesterol; Diabetes Mellitus, Type 2; Double-Blind Method;

2005
Effects of pinitol isolated from soybeans on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus: a randomized controlled study.
    European journal of clinical nutrition, 2005, Volume: 59, Issue:3

    Topics: Blood Glucose; Cardiovascular Diseases; Cholesterol; Diabetes Mellitus, Type 2; Double-Blind Method;

2005
Effects of pinitol isolated from soybeans on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus: a randomized controlled study.
    European journal of clinical nutrition, 2005, Volume: 59, Issue:3

    Topics: Blood Glucose; Cardiovascular Diseases; Cholesterol; Diabetes Mellitus, Type 2; Double-Blind Method;

2005

Other Studies

10 other studies available for inositol and Cardiovascular Diseases

ArticleYear
Characterization of SNF472 pharmacokinetics and efficacy in uremic and non-uremic rats models of cardiovascular calcification.
    PloS one, 2018, Volume: 13, Issue:5

    Topics: Animals; Calcinosis; Cardiovascular Diseases; Cholecalciferol; Disease Models, Animal; Disease Progr

2018
The Combined therapy myo-inositol plus D-Chiro-inositol, in a physiological ratio, reduces the cardiovascular risk by improving the lipid profile in PCOS patients.
    European review for medical and pharmacological sciences, 2013, Volume: 17, Issue:4

    Topics: Adult; Cardiovascular Diseases; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female;

2013
[Results of inositol-nicotinic acid therapy in the treatment of blood circulation disorders].
    Zeitschrift fur Rheumaforschung, 1959, Volume: 18

    Topics: Cardiovascular Diseases; Inositol; Niacin; Nicotinic Acids; Peripheral Vascular Diseases; Vascular D

1959
[On the appropriate treatment of peripheral circulation disorders in private practice].
    Therapie der Gegenwart, 1960, Volume: 99

    Topics: Cardiovascular Diseases; Inositol; Niacin; Nicotinic Acids; Peripheral Vascular Diseases; Private Pr

1960
[Achieving better control of blood sugar--understanding of oral hypoglycemic agents according to their characteristics in pharmacological action mechanism (discussion)].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62, Issue:4

    Topics: Administration, Oral; Cardiovascular Diseases; Cyclohexanes; Diabetes Complications; Diabetes Mellit

2004
Serum-free and protein-bound sugars and cardiovascular complications in diabetes mellitus.
    Laboratory investigation; a journal of technical methods and pathology, 1976, Volume: 34, Issue:2

    Topics: Adult; Age Factors; Aged; Analysis of Variance; Blood Glucose; Blood Pressure; Cardiovascular Diseas

1976
[Indications for Veno-Hexanicit in surgical practice].
    Therapie der Gegenwart, 1971, Volume: 110, Issue:11

    Topics: Aged; Amino Alcohols; Cardiovascular Diseases; Drug Combinations; Female; Fractures, Bone; Humans; I

1971
[Effective and without side effects blood circulation therapy with Vascunicol].
    Deutsches medizinisches Journal, 1971, Mar-20, Volume: 22, Issue:6

    Topics: Cardiovascular Diseases; Cerebrovascular Disorders; Ethanolamines; Female; Humans; Inositol; Male; M

1971
[Drug therapy of peripheral and central vascular diseases].
    Deutsches medizinisches Journal, 1970, Dec-20, Volume: 21, Issue:24

    Topics: Cardiovascular Diseases; Humans; Inositol; Nicotinic Acids; Regional Blood Flow; Vascular Diseases

1970
[On the uptake and effect of hexanicotinic acid-esters of meso-inosit in the body].
    Deutsches medizinisches Journal, 1966, Mar-20, Volume: 17, Issue:6

    Topics: Cardiovascular Diseases; Humans; Injections, Intravenous; Inositol; Nicotinic Acids

1966