inositol has been researched along with Breast Neoplasms in 24 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A supplementation with Boswellia, betaine and myo-inositol reduces fibroadenoma dimension in young women." | 9.22 | A randomized trial of Boswellia in association with betaine and myo-inositol in the management of breast fibroadenomas. ( Alwasel, SH; Bizzarri, M; Cucina, A; Dinicola, S; Giuliani, A; Harrath, AH; Pasta, V; Tartaglia, F, 2016) |
| "Inositol has been reported to improve insulin sensitivity since it works as a second messenger achieving insulin-like effects on metabolic enzymes." | 9.17 | Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial. ( Botti, G; Brillante, G; Capasso, I; Cavalcanti, E; Ciliberto, G; Crispo, A; D'Aiuto, G; D'Aiuto, M; De Laurentiis, M; Esposito, E; Esposito, G; Frasci, G; Fucito, A; Grimaldi, M; Maurea, N; Montella, M, 2013) |
| "The aim of the study was to evaluate the uptake of [(18)F]-1-deoxy-1-fluoro-scyllo-inositol ([(18)F]-scyllo-inositol) in human breast cancer (BC) and glioma xenografts, as well as in inflammatory tissue, in immunocompromised mice." | 7.77 | Comparisons of [18F]-1-deoxy-1-fluoro-scyllo-inositol with [18F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic mice. ( Chan, C; Guha, A; Houle, S; McLarty, K; McLaurin, J; Moran, MD; Mukherjee, J; Nitz, M; Reilly, RM; Sabha, N; Scollard, DA; Vasdev, N; Wilson, AA, 2011) |
| "Inositol lipid turnover has been implicated in the action of oestradiol 17 beta and bombesin-related peptides on the human breast cancer cell line MCF-7." | 7.68 | Heterologous regulation of inositol lipid hydrolysis in human breast cancer cells by oestradiol 17 beta, bombesin and fluoroaluminate. ( Furlong, MM; Holt, JR; Patel, KV; Schrey, MP, 1992) |
| "Women with breast cancer were all treated with chemotherapy." | 6.78 | Elevated prefrontal myo-inositol and choline following breast cancer chemotherapy. ( Kesler, SR; Koovakkattu, D; Lee, C; Mahaffey, ML; O'Hara, R; Watson, C; Wefel, JS, 2013) |
| "Breast cancer is the leading cause of cancer death among women in worldwide and France." | 5.72 | Inositol (1,4,5)-Trisphosphate Receptors in Invasive Breast Cancer: A New Prognostic Tool? ( Brabencova, E; Foulon, A; Jonckheere, N; Ouadid-Ahidouch, H; Rodat-Despoix, L; Rybarczyk, P; Sevestre, H, 2022) |
| "Inositol displays multi-targeted effects on many biochemical pathways involved in epithelial-mesenchymal transition (EMT)." | 5.43 | Inositol induces mesenchymal-epithelial reversion in breast cancer cells through cytoskeleton rearrangement. ( Alwasel, SH; Bizzarri, M; Catizone, A; Cucina, A; Dinicola, S; Fabrizi, G; Harrath, AH; Masiello, MG; Minini, M; Palombo, A; Proietti, S; Ricci, G, 2016) |
| "Imaging of Y1R expression in breast cancer is still a challenging task." | 5.42 | Synthesis and in vitro and in vivo evaluation of an (18)F-labeled neuropeptide Y analogue for imaging of breast cancer by PET. ( Beck-Sickinger, AG; Hofmann, S; Kuwert, T; Maschauer, S; Prante, O, 2015) |
| "Proliferation of MCF-7 human breast cancer cells, which also respond to EGF and estrogens, was stimulated by LiCl (1-5 mM) within the concentration range that is encountered during human therapy with lithium." | 5.29 | Lithium-stimulated proliferation and alteration of phosphoinositide metabolites in MCF-7 human breast cancer cells. ( Curran, EM; Engler, KS; Grady, LH; Taylor, JA; Welshons, WV, 1995) |
| "A supplementation with Boswellia, betaine and myo-inositol reduces fibroadenoma dimension in young women." | 5.22 | A randomized trial of Boswellia in association with betaine and myo-inositol in the management of breast fibroadenomas. ( Alwasel, SH; Bizzarri, M; Cucina, A; Dinicola, S; Giuliani, A; Harrath, AH; Pasta, V; Tartaglia, F, 2016) |
| "Inositol has been reported to improve insulin sensitivity since it works as a second messenger achieving insulin-like effects on metabolic enzymes." | 5.17 | Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial. ( Botti, G; Brillante, G; Capasso, I; Cavalcanti, E; Ciliberto, G; Crispo, A; D'Aiuto, G; D'Aiuto, M; De Laurentiis, M; Esposito, E; Esposito, G; Frasci, G; Fucito, A; Grimaldi, M; Maurea, N; Montella, M, 2013) |
| "The antagonistic effects of Inositol-C2-PAF on cell migration and proliferation are indicative for its potential for breast cancer therapy, alone or in combination with other cytostatic drugs." | 3.88 | Inositol-C2-PAF acts as a biological response modifier and antagonizes cancer-relevant processes in mammary carcinoma cells. ( Bintig, W; Danker, K; Eickholt, B; Häckel, S; Hildmann, A; Klein, A; Lucka, L; Mrawietz, G; Pelz, C; Schrötter, S; Semini, G; Shmanai, V; Stricker, S, 2018) |
| "The aim of the study was to evaluate the uptake of [(18)F]-1-deoxy-1-fluoro-scyllo-inositol ([(18)F]-scyllo-inositol) in human breast cancer (BC) and glioma xenografts, as well as in inflammatory tissue, in immunocompromised mice." | 3.77 | Comparisons of [18F]-1-deoxy-1-fluoro-scyllo-inositol with [18F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic mice. ( Chan, C; Guha, A; Houle, S; McLarty, K; McLaurin, J; Moran, MD; Mukherjee, J; Nitz, M; Reilly, RM; Sabha, N; Scollard, DA; Vasdev, N; Wilson, AA, 2011) |
| " The specific objectives of this investigation were: (1) to develop a ceramic delivery system for the novel purpose of releasing sustained levels of the anti-cancer drug combination inositol hexaphosphate (IP6) + inositol (I) in a tissue culture setting; (2) to assess the proliferation rate and viability of HTB 122 Intraductile Breast Cancer (IBC) cells exposed to sustained levels of IP6 + I compared to conventional means of drug delivery (dissolved in media); (3) to evaluate the morphological changes associated with this treatment process." | 3.70 | Development of sustained delivery system as a novel technique for tissue culture. ( Benghuzzi, H; Higdon, KK; Hughes, JL; Puckett, A; Scott, A; Tucci, M, 2000) |
| "Inositol lipid turnover has been implicated in the action of oestradiol 17 beta and bombesin-related peptides on the human breast cancer cell line MCF-7." | 3.68 | Heterologous regulation of inositol lipid hydrolysis in human breast cancer cells by oestradiol 17 beta, bombesin and fluoroaluminate. ( Furlong, MM; Holt, JR; Patel, KV; Schrey, MP, 1992) |
| "Myo-inositol is a six-fold alcohol of cyclohexane, has already been proved to modulate different pathways: inflammatory, metabolic, oxidative and endocrine processes, in a wide array of human diseases, including cancer and the genesis of mammary gland and breast diseases, like fibrosis, as well as metabolic and endocrine cues." | 2.80 | An association of boswellia, betaine and myo-inositol (Eumastós) in the treatment of mammographic breast density: a randomized, double-blind study. ( Alwasel, SH; Bizzarri, M; Cucina, A; Giuliani, A; Gullo, G; Harrath, AH; Pasta, V; Tartaglia, F, 2015) |
| "Women with breast cancer were all treated with chemotherapy." | 2.78 | Elevated prefrontal myo-inositol and choline following breast cancer chemotherapy. ( Kesler, SR; Koovakkattu, D; Lee, C; Mahaffey, ML; O'Hara, R; Watson, C; Wefel, JS, 2013) |
| "Breast cancer is the leading cause of cancer death among women in worldwide and France." | 1.72 | Inositol (1,4,5)-Trisphosphate Receptors in Invasive Breast Cancer: A New Prognostic Tool? ( Brabencova, E; Foulon, A; Jonckheere, N; Ouadid-Ahidouch, H; Rodat-Despoix, L; Rybarczyk, P; Sevestre, H, 2022) |
| "Inositol displays multi-targeted effects on many biochemical pathways involved in epithelial-mesenchymal transition (EMT)." | 1.43 | Inositol induces mesenchymal-epithelial reversion in breast cancer cells through cytoskeleton rearrangement. ( Alwasel, SH; Bizzarri, M; Catizone, A; Cucina, A; Dinicola, S; Fabrizi, G; Harrath, AH; Masiello, MG; Minini, M; Palombo, A; Proietti, S; Ricci, G, 2016) |
| "Imaging of Y1R expression in breast cancer is still a challenging task." | 1.42 | Synthesis and in vitro and in vivo evaluation of an (18)F-labeled neuropeptide Y analogue for imaging of breast cancer by PET. ( Beck-Sickinger, AG; Hofmann, S; Kuwert, T; Maschauer, S; Prante, O, 2015) |
| "Human breast cancer cells were treated with different concentrations of D-pinitol and cytotoxicity was measured by MTT and LDH assays." | 1.40 | D-pinitol promotes apoptosis in MCF-7 cells via induction of p53 and Bax and inhibition of Bcl-2 and NF-κB. ( Balasubramanian, MP; Haribabu, L; Nandakumar, N; Nishigaki, I; Rajendran, P; Rengarajan, T, 2014) |
| "In the breast cancer cell lines MCF-7 (estrogen receptor positive) and MDA-MB-468 (estrogen receptor negative), C4-PI had no effect on the uptake of D-myo-inositol but severely inhibited its incorporation into PI." | 1.30 | Effects of a water-soluble antitumor ether phosphonoinositide, D-myo-inositol 4-(hexadecyloxy)-3(S)-methoxybutanephosphonate (C4-PI), on inositol lipid metabolism in breast epithelial cancer cell lines. ( Arthur, G; Bae, YS; Bittman, R; Leung, LW; Lin, W, 1999) |
| "Proliferation of MCF-7 human breast cancer cells, which also respond to EGF and estrogens, was stimulated by LiCl (1-5 mM) within the concentration range that is encountered during human therapy with lithium." | 1.29 | Lithium-stimulated proliferation and alteration of phosphoinositide metabolites in MCF-7 human breast cancer cells. ( Curran, EM; Engler, KS; Grady, LH; Taylor, JA; Welshons, WV, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.17) | 18.7374 |
| 1990's | 6 (25.00) | 18.2507 |
| 2000's | 2 (8.33) | 29.6817 |
| 2010's | 12 (50.00) | 24.3611 |
| 2020's | 3 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Foulon, A | 1 |
| Rybarczyk, P | 1 |
| Jonckheere, N | 1 |
| Brabencova, E | 1 |
| Sevestre, H | 1 |
| Ouadid-Ahidouch, H | 1 |
| Rodat-Despoix, L | 1 |
| Dai, C | 1 |
| Charlestin, V | 1 |
| Wang, M | 1 |
| Walker, ZT | 1 |
| Miranda-Vergara, MC | 1 |
| Facchine, BA | 1 |
| Wu, J | 1 |
| Kaliney, WJ | 1 |
| Dovichi, NJ | 1 |
| Li, J | 1 |
| Littlepage, LE | 1 |
| Minini, M | 2 |
| Senni, A | 1 |
| He, X | 1 |
| Proietti, S | 2 |
| Liguoro, D | 1 |
| Catizone, A | 2 |
| Giuliani, A | 3 |
| Mancini, R | 1 |
| Fuso, A | 1 |
| Cucina, A | 4 |
| Cao, Y | 1 |
| Bizzarri, M | 4 |
| Collet, C | 1 |
| Schmitt, S | 1 |
| Maskali, F | 1 |
| Clément, A | 1 |
| Chrétien, F | 1 |
| Karcher, G | 1 |
| Marie, PY | 1 |
| Poussier, S | 1 |
| Lamandé-Langle, S | 1 |
| Farjon, J | 1 |
| Milande, C | 1 |
| Martineau, E | 1 |
| Akoka, S | 1 |
| Giraudeau, P | 1 |
| Pelz, C | 1 |
| Häckel, S | 1 |
| Semini, G | 1 |
| Schrötter, S | 1 |
| Bintig, W | 1 |
| Stricker, S | 1 |
| Mrawietz, G | 1 |
| Klein, A | 1 |
| Lucka, L | 1 |
| Shmanai, V | 1 |
| Eickholt, B | 1 |
| Hildmann, A | 1 |
| Danker, K | 1 |
| Kesler, SR | 1 |
| Watson, C | 1 |
| Koovakkattu, D | 1 |
| Lee, C | 1 |
| O'Hara, R | 1 |
| Mahaffey, ML | 1 |
| Wefel, JS | 1 |
| Capasso, I | 1 |
| Esposito, E | 1 |
| Maurea, N | 1 |
| Montella, M | 1 |
| Crispo, A | 1 |
| De Laurentiis, M | 1 |
| D'Aiuto, M | 1 |
| Frasci, G | 1 |
| Botti, G | 1 |
| Grimaldi, M | 1 |
| Cavalcanti, E | 1 |
| Esposito, G | 1 |
| Fucito, A | 1 |
| Brillante, G | 1 |
| D'Aiuto, G | 1 |
| Ciliberto, G | 1 |
| Rengarajan, T | 1 |
| Nandakumar, N | 1 |
| Rajendran, P | 1 |
| Haribabu, L | 1 |
| Nishigaki, I | 1 |
| Balasubramanian, MP | 1 |
| Hofmann, S | 1 |
| Maschauer, S | 1 |
| Kuwert, T | 1 |
| Beck-Sickinger, AG | 1 |
| Prante, O | 1 |
| Pasta, V | 2 |
| Gullo, G | 1 |
| Harrath, AH | 3 |
| Alwasel, SH | 3 |
| Tartaglia, F | 2 |
| Dinicola, S | 2 |
| Fabrizi, G | 1 |
| Masiello, MG | 1 |
| Palombo, A | 1 |
| Ricci, G | 1 |
| Kitatani, K | 1 |
| Sheldon, K | 1 |
| Anelli, V | 1 |
| Jenkins, RW | 1 |
| Sun, Y | 1 |
| Grabowski, GA | 1 |
| Obeid, LM | 1 |
| Hannun, YA | 1 |
| McLarty, K | 1 |
| Moran, MD | 1 |
| Scollard, DA | 1 |
| Chan, C | 1 |
| Sabha, N | 1 |
| Mukherjee, J | 1 |
| Guha, A | 1 |
| McLaurin, J | 1 |
| Nitz, M | 1 |
| Houle, S | 1 |
| Wilson, AA | 1 |
| Reilly, RM | 1 |
| Vasdev, N | 2 |
| Carroll, L | 1 |
| Perumal, M | 1 |
| Robins, E | 1 |
| Aboagye, EO | 1 |
| Welshons, WV | 1 |
| Engler, KS | 1 |
| Taylor, JA | 1 |
| Grady, LH | 1 |
| Curran, EM | 1 |
| Gribbestad, IS | 1 |
| Petersen, SB | 1 |
| Fjøsne, HE | 1 |
| Kvinnsland, S | 1 |
| Krane, J | 1 |
| Speckter, H | 1 |
| Blümich, B | 1 |
| Just, M | 1 |
| Trömel, U | 1 |
| Mitze, M | 1 |
| Thelen, M | 1 |
| Williams, CM | 1 |
| Maunder, K | 1 |
| Higdon, KK | 1 |
| Scott, A | 1 |
| Benghuzzi, H | 1 |
| Tucci, M | 1 |
| Puckett, A | 1 |
| Hughes, JL | 1 |
| Lin, W | 1 |
| Leung, LW | 1 |
| Bae, YS | 1 |
| Bittman, R | 1 |
| Arthur, G | 1 |
| Schrey, MP | 1 |
| Furlong, MM | 1 |
| Holt, JR | 1 |
| Patel, KV | 1 |
| Lyon, RC | 1 |
| Cohen, JS | 1 |
| Faustino, PJ | 1 |
| Megnin, F | 1 |
| Myers, CE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Inositol Alone or Associated With Alpha-lipoic Acid in Polycystic Ovary Syndrome Treatment[NCT04881851] | 90 participants (Anticipated) | Interventional | 2015-05-07 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for inositol and Breast Neoplasms
| Article | Year |
|---|---|
Elevated prefrontal myo-inositol and choline following breast cancer chemotherapy.
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Choline; Cognition; Female; Humans; Inositol; | 2013 |
Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial.
Topics: Aged; Biomarkers; Blood Glucose; Body Mass Index; Breast Neoplasms; Caloric Restriction; Cholesterol | 2013 |
An association of boswellia, betaine and myo-inositol (Eumastós) in the treatment of mammographic breast density: a randomized, double-blind study.
Topics: Adult; Betaine; Boswellia; Breast; Breast Density; Breast Neoplasms; Double-Blind Method; Drug Thera | 2015 |
A randomized trial of Boswellia in association with betaine and myo-inositol in the management of breast fibroadenomas.
Topics: Adult; Betaine; Boswellia; Breast Neoplasms; Female; Fibroadenoma; Humans; Inositol; Neoplasm Recurr | 2016 |
20 other studies available for inositol and Breast Neoplasms
| Article | Year |
|---|---|
Inositol (1,4,5)-Trisphosphate Receptors in Invasive Breast Cancer: A New Prognostic Tool?
Topics: Breast Neoplasms; Calcium; Endoplasmic Reticulum; Female; Humans; Inositol; Inositol 1,4,5-Trisphosp | 2022 |
Aquaporin-7 Regulates the Response to Cellular Stress in Breast Cancer.
Topics: Adipocytes; Animals; Aquaporins; Breast Neoplasms; Carbohydrate Metabolism; Cell Movement; Female; G | 2020 |
miR-125a-5p impairs the metastatic potential in breast cancer via IP
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transi | 2021 |
Synthesis and preliminary in vivo evaluation of new [
Topics: Animals; Breast Neoplasms; Disease Models, Animal; Female; Fluorine Radioisotopes; Humans; Inositol; | 2017 |
The FAQUIRE Approach: FAst, QUantitative, hIghly Resolved and sEnsitivity Enhanced
Topics: Amino Acids; Breast Neoplasms; Carbon Isotopes; Cell Line, Tumor; Choline; Female; Humans; Hydrogen; | 2018 |
Inositol-C2-PAF acts as a biological response modifier and antagonizes cancer-relevant processes in mammary carcinoma cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female | 2018 |
D-pinitol promotes apoptosis in MCF-7 cells via induction of p53 and Bax and inhibition of Bcl-2 and NF-κB.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cell Line, Tumor; Ce | 2014 |
Synthesis and in vitro and in vivo evaluation of an (18)F-labeled neuropeptide Y analogue for imaging of breast cancer by PET.
Topics: Animals; Breast Neoplasms; Chemistry, Pharmaceutical; Chlorocebus aethiops; COS Cells; Drug Design; | 2015 |
Inositol induces mesenchymal-epithelial reversion in breast cancer cells through cytoskeleton rearrangement.
Topics: Amyloid Precursor Protein Secretases; beta Catenin; Breast Neoplasms; Cadherins; Carrier Proteins; C | 2016 |
Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid.
Topics: Blotting, Western; Breast Neoplasms; Carcinogens; Cell Line, Tumor; Ceramides; Enzyme-Linked Immunos | 2009 |
Comparisons of [18F]-1-deoxy-1-fluoro-scyllo-inositol with [18F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic mice.
Topics: Animals; Biological Transport; Brain Neoplasms; Breast Neoplasms; Cell Line, Tumor; Female; Fluorode | 2011 |
Radiosynthesis and in vivo tumor uptake of 2-deoxy-2-[(18)F]fluoro-myo-inositol.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Inositol; Mice; Neoplasms, Experimental | 2012 |
Lithium-stimulated proliferation and alteration of phosphoinositide metabolites in MCF-7 human breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Cell Survival; Epidermal Growth Factor; Growth Substances; Humans; | 1995 |
1H NMR spectroscopic characterization of perchloric acid extracts from breast carcinomas and non-involved breast tissue.
Topics: Breast; Breast Neoplasms; Carbohydrates; Humans; Inositol; Magnetic Resonance Spectroscopy; Perchlor | 1994 |
[In vitro NMR spectroscopy of healthy, pathologically changed and carcinomatous breast tissue samples correlated with histological findings].
Topics: Breast; Breast Diseases; Breast Neoplasms; Diagnosis, Differential; Fatty Acids; Female; Glucose; Gl | 1994 |
Fatty acid compositions of inositol and choline phospholipids of breast tumours and normal breast tissue.
Topics: Adult; Body Weight; Breast; Breast Neoplasms; Erythrocytes; Fatty Acids; Female; Humans; Inositol; M | 1993 |
Development of sustained delivery system as a novel technique for tissue culture.
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Culture Techniques | 2000 |
Effects of a water-soluble antitumor ether phosphonoinositide, D-myo-inositol 4-(hexadecyloxy)-3(S)-methoxybutanephosphonate (C4-PI), on inositol lipid metabolism in breast epithelial cancer cell lines.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line; Epithelial Cells; Humans; Inositol; Organophosph | 1999 |
Heterologous regulation of inositol lipid hydrolysis in human breast cancer cells by oestradiol 17 beta, bombesin and fluoroaluminate.
Topics: Aluminum; Bombesin; Breast Neoplasms; Estradiol; Female; Fluorine; Humans; Hydrolysis; Inositol; Ino | 1992 |
Glucose metabolism in drug-sensitive and drug-resistant human breast cancer cells monitored by magnetic resonance spectroscopy.
Topics: Antineoplastic Agents; Azides; Breast Neoplasms; Carbon Isotopes; Cell Line; Female; Glucose; Glutam | 1988 |