inositol has been researched along with Brain Swelling in 14 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Excerpt | Relevance | Reference |
---|---|---|
"Brain myo-inositol, an organic osmolyte, is decreased in cirrhotic patients with hepatic encephalopathy but appears unchanged in fulminant hepatic failure." | 7.69 | Glutamine, myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: implications for ammonia-induced brain edema. ( Blei, AT; Cordoba, J; Gottstein, J, 1996) |
"In hepatic encephalopathy (HE), osmotic stressors promoting brain edema result in a compensatory drop in the astrocyte metabolite myo-inositol (mI)." | 3.96 | Brain MR Spectroscopy Markers of Encephalopathy Due to Nonalcoholic Steatohepatitis. ( Cole, S; Csete, M; King, KS; Mena, E; Tran, TT; Wei, K, 2020) |
"Brain myo-inositol, an organic osmolyte, is decreased in cirrhotic patients with hepatic encephalopathy but appears unchanged in fulminant hepatic failure." | 3.69 | Glutamine, myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: implications for ammonia-induced brain edema. ( Blei, AT; Cordoba, J; Gottstein, J, 1996) |
"Myo-inositol levels were strongly decreased already at 3h after treatment with NH4Cl; other intracellular osmolytes, such as hypotaurine and choline-containing compounds were also decreased, along with a concomitant increase of both the total concentration and the amount of newly synthesized glutamine, alanine, and glutathione." | 1.33 | Ammonia toxicity under hyponatremic conditions in astrocytes: de novo synthesis of amino acids for the osmoregulatory response. ( Leibfritz, D; Zwingmann, C, 2005) |
"Myo-inositol accumulation was associated with 4-5-fold (peak rate) and 1." | 1.29 | Osmoregulatory changes in myo-inositol content and Na+/myo-inositol cotransport in rat cortical astrocytes. ( Emma, F; Morrison, R; Paredes, A; Strange, K, 1994) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (7.14) | 18.7374 |
1990's | 5 (35.71) | 18.2507 |
2000's | 6 (42.86) | 29.6817 |
2010's | 1 (7.14) | 24.3611 |
2020's | 1 (7.14) | 2.80 |
Authors | Studies |
---|---|
Tran, TT | 1 |
Wei, K | 1 |
Cole, S | 1 |
Mena, E | 1 |
Csete, M | 1 |
King, KS | 1 |
Righi, V | 1 |
Tugnoli, V | 1 |
Mucci, A | 1 |
Bacci, A | 1 |
Bonora, S | 1 |
Schenetti, L | 1 |
Rumpel, H | 1 |
Lim, WE | 1 |
Chang, HM | 1 |
Chan, LL | 1 |
Ho, GL | 1 |
Wong, MC | 1 |
Tan, KP | 1 |
Zwingmann, C | 2 |
Chatauret, N | 1 |
Rose, C | 1 |
Leibfritz, D | 2 |
Butterworth, RF | 1 |
Briellmann, RS | 1 |
Wellard, RM | 1 |
Jackson, GD | 1 |
Sterns, RH | 1 |
Silver, SM | 1 |
Chernov, MF | 1 |
Ono, Y | 1 |
Kubo, O | 1 |
Hori, T | 1 |
Norenberg, MD | 1 |
Bender, AS | 1 |
Strange, K | 1 |
Emma, F | 1 |
Paredes, A | 1 |
Morrison, R | 1 |
Gyngell, ML | 1 |
Els, T | 1 |
Hoehn-Berlage, M | 1 |
Hossmann, KA | 1 |
Cordoba, J | 2 |
Gottstein, J | 1 |
Blei, AT | 1 |
Prockop, LD | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Phase 2a Study to Evaluate the Safety and Tolerability of OCR-002 (Ornithine Phenylacetate) in the Treatment of Patients With Acute Liver Failure/Severe Acute Liver Injury[NCT01548690] | Phase 2 | 47 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
To evaluate the effect of OCR-002 on ammonia levels in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: Baseline and 72 Hours
Intervention | Percent Change (Mean) |
---|---|
Maximum Dose Level 3.33 g/24h | 41.2 |
Maximum Dose Level 6.65 g/24h | 16.6 |
Maximum Dose Level 10 g/24h | 41.8 |
Maximum Dose Level 20g/24h | 38.4 |
To evaluate the steady state pharmacokinetic and pharmacodynamic profile of OCR-002 in patients with impaired and intact renal function using urinary phenylacetylglutamine (PAGN) as a surrogate marker (NCT01548690)
Timeframe: 24 Hours after last infusion
Intervention | micrograms per millileter (Mean) |
---|---|
Maximum Dose Level 3.33 g/24h | 65.6 |
Maximum Dose Level 6.65 g/24h | 32.2 |
Maximum Dose Level 10 g/24h | 33.4 |
Maximum Dose Level 20g/24h | 104.9 |
The orientation log focuses on orientation to place, time, and circumstance. There are 10 items on the orientation log, which are scored 0-3. A spontaneous correct response is awarded 3 points. A spontaneous response that is lacking or incorrect, but a correct response is provided following a logical cue is awarded 2 points. A score of 1 is given if spontaneous and cued responses are lacking or incorrect, but a correct response is provided in a recognition format. A score of 0 is given if the spontaneous, cued, or recognition format does not generate a correct answer. Scores from the 10 items are summed and the final score ranges from 0 to 30. (NCT01548690)
Timeframe: 30 Days
Intervention | units on a scale (Mean) |
---|---|
Maximum Dose Level 3.33 g/24h | 23.8 |
Maximum Dose Level 6.65 g/24h | 24.0 |
Maximum Dose Level 10 g/24h | 24.0 |
Maximum Dose Level 20g/24h | 24.0 |
The West Haven Criteria (WHC) for Hepatic Encephalopathy measures the severity of encephalopathy and patient's level of consciousness. The scale ranges from 0 to 4; a minimum score of 0 represents a better outcome, and a maximum total score of 4 represents a worse outcome. A score of 0 corresponds to normal consciousness and behavior and normal neurological examination. A score of 1 corresponds to mild lack of awareness, shortened attention span, and impaired addition or subtraction; mild asterixis or tremor. A score of 2 corresponds to lethargy, disorientated or inappropriate behavior, obvious asterixis; slurred speech. A score of 3 corresponds to somnolent but arousable, gross disorientation or bizarre behavior, muscle rigidity and clonus; hyperreflexia. A score of 4 corresponds to coma and decerebrate posturing. (NCT01548690)
Timeframe: 120 hours from start of infusion
Intervention | units on a scale (Mean) |
---|---|
Maximum Dose Level 3.33 g/24h | 2.4 |
Maximum Dose Level 6.65 g/24h | 3.2 |
Maximum Dose Level 10 g/24h | 1.6 |
Maximum Dose Level 20g/24h | 1.8 |
To evaluate the safety and tolerability of OCR-002 in patients with acute liver failure/severe acute liver injury (NCT01548690)
Timeframe: 30 Days
Intervention | Participants (Count of Participants) |
---|---|
Maximum Dose Level 3.33 g/24h | 0 |
Maximum Dose Level 6.65 g/24h | 0 |
Maximum Dose Level 10 g/24h | 0 |
Maximum Dose Level 20g/24h | 0 |
2 reviews available for inositol and Brain Swelling
Article | Year |
---|---|
Seizure-associated abnormalities in epilepsy: evidence from MR imaging.
Topics: Adult; Aspartic Acid; Atrophy; Brain; Brain Diseases; Brain Edema; Choline; Creatine; Diffusion Magn | 2005 |
Brain volume regulation in response to hypo-osmolality and its correction.
Topics: Acute Disease; Animals; Brain; Brain Edema; Chronic Disease; Demyelinating Diseases; Humans; Hyponat | 2006 |
12 other studies available for inositol and Brain Swelling
Article | Year |
---|---|
Brain MR Spectroscopy Markers of Encephalopathy Due to Nonalcoholic Steatohepatitis.
Topics: Aged; Biomarkers; Brain; Brain Edema; Female; Glutamine; Hepatic Encephalopathy; Humans; Inositol; M | 2020 |
MRS study of meningeal hemangiopericytoma and edema: a comparison with meningothelial meningioma.
Topics: 3-Hydroxybutyric Acid; Alanine; Aspartic Acid; Brain Edema; Choline; Creatine; Glutamic Acid; Glutat | 2012 |
Is myo-inositol a measure of glial swelling after stroke? A magnetic resonance study.
Topics: Aged; Aged, 80 and over; Brain Edema; Creatine; Female; Humans; Inositol; Magnetic Resonance Imaging | 2003 |
Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia.
Topics: Animals; Brain Edema; Disease Models, Animal; Glutamine; Hepatic Encephalopathy; Hypothermia, Induce | 2004 |
Ammonia toxicity under hyponatremic conditions in astrocytes: de novo synthesis of amino acids for the osmoregulatory response.
Topics: Alanine; Amino Acids; Ammonia; Ammonium Chloride; Animals; Animals, Newborn; Astrocytes; Brain Edema | 2005 |
Comparison of 1H-MRS-detected metabolic characteristics in single metastatic brain tumors of different origin.
Topics: Aged; Brain Chemistry; Brain Edema; Brain Neoplasms; False Negative Reactions; False Positive Reacti | 2006 |
Astrocyte swelling in liver failure: role of glutamine and benzodiazepines.
Topics: Ammonia; Animals; Animals, Newborn; Astrocytes; Brain Edema; Cells, Cultured; Cerebral Cortex; Chlor | 1994 |
Osmoregulatory changes in myo-inositol content and Na+/myo-inositol cotransport in rat cortical astrocytes.
Topics: Animals; Astrocytes; Biological Transport; Blotting, Northern; Brain Edema; Carrier Proteins; Cells, | 1994 |
Proton MR spectroscopy of experimental brain tumors in vivo.
Topics: Animals; Aspartic Acid; Blood Glucose; Brain Edema; Brain Neoplasms; Caudate Nucleus; Cell Line; Cho | 1994 |
Glutamine, myo-inositol, and brain edema in acute liver failure.
Topics: Brain; Brain Edema; Glutamine; Hepatic Encephalopathy; Humans; Inositol | 1996 |
Glutamine, myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: implications for ammonia-induced brain edema.
Topics: Ammonia; Animals; Blood Pressure; Body Water; Body Weight; Brain; Brain Edema; Cerebral Cortex; Glut | 1996 |
Hyperglycemia, polyol accumulation, and increased intracranial pressure.
Topics: Animals; Brain; Brain Edema; Cerebrospinal Fluid Proteins; Diabetic Ketoacidosis; Disease Models, An | 1971 |