inositol has been researched along with Brain Neoplasms in 53 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study was to evaluate the uptake of [(18)F]-1-deoxy-1-fluoro-scyllo-inositol ([(18)F]-scyllo-inositol) in human breast cancer (BC) and glioma xenografts, as well as in inflammatory tissue, in immunocompromised mice." | 7.77 | Comparisons of [18F]-1-deoxy-1-fluoro-scyllo-inositol with [18F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic mice. ( Chan, C; Guha, A; Houle, S; McLarty, K; McLaurin, J; Moran, MD; Mukherjee, J; Nitz, M; Reilly, RM; Sabha, N; Scollard, DA; Vasdev, N; Wilson, AA, 2011) |
| "Inositol uptake was measured at concentrations of 25, 40 and 50 microM in human astrocytoma cell cultures treated for 1-3 weeks with pharmacologically relevant concentrations of LiCl, valproic acid or carbamazepine as well as in control cultures that had not been treated with any drug." | 7.70 | Chronic treatment of human astrocytoma cells with lithium, carbamazepine or valproic acid decreases inositol uptake at high inositol concentrations but increases it at low inositol concentrations. ( Belmaker, RH; Bersudsky, Y; Hertz, L; Simkin, M; Wolfson, M; Zinger, E, 2000) |
| "Myoinositol (MI) is an organic osmolyte, with intracellular concentration changes depending on the extracellular osmolality." | 5.43 | Myoinositol as a Biomarker in Recurrent Glioblastoma Treated with Bevacizumab: A 1H-Magnetic Resonance Spectroscopy Study. ( Bähr, O; Hattingen, E; Pilatus, U; Ronellenfitsch, MW; Steidl, E; Steinbach, JP; Zanella, F, 2016) |
| "Hemangiopericytomas are a rare type of brain tumor that are very similar to meningiomas in appearance and symptoms but require different treatment." | 5.31 | Magnetic resonance spectroscopy of brain hemangiopericytomas: high myoinositol concentrations and discrimination from meningiomas. ( Arús, C; Baquero, M; Barba, I; Cabañas, ME; Capdevila, A; Martinez-Pérez, I; Moreno, A; Tate, AR, 2001) |
| " There are a number of metabolites that can be identified by standard brain proton MRS but only a few of them has a clinical significance in diagnosis of gliomas including N-acetylaspartate, choline, creatine, myo-inositol, lactate, and lipids." | 4.89 | Potential of MR spectroscopy for assessment of glioma grading. ( Bulik, M; Jancalek, R; Mechl, M; Skoch, A; Vanicek, J, 2013) |
| " This biochemical information can be processed and presented as density maps of several metabolites, among them N-acetylaspartate (marker of neuronal viability), choline (marker of membrane turnover), creatine (related to the energy state of the cells), myo-Inositol (exclusively found in astrocytes), lipids and lactate (observed in necrosis and other pathological processes) which mean relevant information in the context of brain tumors." | 4.85 | Proton magnetic resonance spectroscopy imaging in the study of human brain cancer. ( Celda, B; Martínez-Bisbal, MC, 2009) |
| "The aim of the study was to evaluate the uptake of [(18)F]-1-deoxy-1-fluoro-scyllo-inositol ([(18)F]-scyllo-inositol) in human breast cancer (BC) and glioma xenografts, as well as in inflammatory tissue, in immunocompromised mice." | 3.77 | Comparisons of [18F]-1-deoxy-1-fluoro-scyllo-inositol with [18F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic mice. ( Chan, C; Guha, A; Houle, S; McLarty, K; McLaurin, J; Moran, MD; Mukherjee, J; Nitz, M; Reilly, RM; Sabha, N; Scollard, DA; Vasdev, N; Wilson, AA, 2011) |
| " MRS of normal brain parenchyma displays 4 main metabolites: N-acetyl aspartate (neuronal marker), creatine (cellular density marker), choline (membrane activity marker) and myoinositol (glial marker); pathological processes lead to variations of the level of these metabolites and/or the appearance of abnormal metabolites (lactate), following different patterns according to pathological process involved: glioma, meningioma, metastasis, bacterial or toxoplasmic abscess, radionecrosis." | 3.71 | [Contribution of magnetic resonance spectrometry to the diagnosis of intracranial tumors]. ( Confort-Gouny, S; Cozzone, PJ; Dufour, H; Galanaud, D; Le Fur, Y; Nicoli, F; Peragut, JC; Ranjeva, JP; Roche, P; Viout, P, 2002) |
| "Inositol uptake was measured at concentrations of 25, 40 and 50 microM in human astrocytoma cell cultures treated for 1-3 weeks with pharmacologically relevant concentrations of LiCl, valproic acid or carbamazepine as well as in control cultures that had not been treated with any drug." | 3.70 | Chronic treatment of human astrocytoma cells with lithium, carbamazepine or valproic acid decreases inositol uptake at high inositol concentrations but increases it at low inositol concentrations. ( Belmaker, RH; Bersudsky, Y; Hertz, L; Simkin, M; Wolfson, M; Zinger, E, 2000) |
| "Ketoconazole, cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate, and gossypol are reported inhibitors of the lipoxygenase (LO) and cytochrome P-450 enzyme systems and are potent blockers of swelling-activated efflux of organic osmolytes and volume-sensitive anion channels in C6 glioma cells." | 3.69 | Ketoconazole blocks organic osmolyte efflux independently of its effect on arachidonic acid conversion. ( Jackson, P; McManus, M; Serhan, C; Strange, K, 1994) |
| "Glycine (Gly) has been implicated in several neurological disorders, including malignant brain tumors." | 1.46 | Measurement of glycine in healthy and tumorous brain by triple-refocusing MRS at 3 T in vivo. ( An, Z; Baxter, J; Choi, C; Ganji, SK; Maher, EA; Mickey, BE; Pan, E; Patel, TR; Pinho, MC; Tiwari, V, 2017) |
| "Myoinositol (MI) is an organic osmolyte, with intracellular concentration changes depending on the extracellular osmolality." | 1.43 | Myoinositol as a Biomarker in Recurrent Glioblastoma Treated with Bevacizumab: A 1H-Magnetic Resonance Spectroscopy Study. ( Bähr, O; Hattingen, E; Pilatus, U; Ronellenfitsch, MW; Steidl, E; Steinbach, JP; Zanella, F, 2016) |
| "Glycine is a key metabolic intermediate required for the synthesis of proteins, nucleic acids, and other molecules, and its detection in cancer could, therefore, provide biologically relevant information about the growth of the tumor." | 1.37 | Measurement of glycine in the human brain in vivo by 1H-MRS at 3 T: application in brain tumors. ( Bachoo, R; Choi, C; DeBerardinis, RJ; Dimitrov, IE; Ganji, SK; Maher, EA; Malloy, CR; Mickey, BE; Pascual, JM, 2011) |
| "Using 36 biopsies from patients with brain tumors [12 glioblastoma multiforme (GBM); 10 low-grade (LG), including 7 schwannoma and 3 pylocytic astrocytoma; 7 meningioma (MN); 7 brain metastases (MT), including 3 adenocarcinoma and 4 breast cancer] and 9 control biopsies from patients undergoing surgery for epilepsy, we tested the hypothesis that the presence of glycine may distinguish among these brain tumor types." | 1.36 | High-resolution magic angle spinning magnetic resonance spectroscopy detects glycine as a biomarker in brain tumors. ( Andronesi, OC; Black, PM; Mintzopoulos, D; Righi, V; Tzika, AA, 2010) |
| "Desmoplastic infantile gangliogliomas (DIG) are rare benign intracranial neoplasms of early childhood with involvement of superficial cerebral cortex and leptomeninges." | 1.35 | Imaging of desmoplastic infantile ganglioglioma: a spectroscopic viewpoint. ( Balaji, R; Ramachandran, K, 2009) |
| "Most of the brain tumors were characterized by strongly reduced total N-acetylaspartyl compounds and marked increases of myo-inositol and choline-containing compounds, consistent with a lack of neuroaxonal tissue and a proliferation of glial cells." | 1.31 | Quantitative proton magnetic resonance spectroscopy of focal brain lesions. ( Dechent, P; Frahm, J; Hanefeld, F; Herms, J; Markakis, E; Maxton, C; Wilken, B, 2000) |
| "Hemangiopericytomas are a rare type of brain tumor that are very similar to meningiomas in appearance and symptoms but require different treatment." | 1.31 | Magnetic resonance spectroscopy of brain hemangiopericytomas: high myoinositol concentrations and discrimination from meningiomas. ( Arús, C; Baquero, M; Barba, I; Cabañas, ME; Capdevila, A; Martinez-Pérez, I; Moreno, A; Tate, AR, 2001) |
| "Total creatine was decreased in all brain tumors in comparison with normal brain tissues, but was relatively higher in neuroectodermal tumors than in other brain tumors." | 1.29 | Proton magnetic resonance spectroscopy of brain tumors: an in vitro study. ( Kajiwara, H; Kinoshita, Y; Koga, Y; Yokota, A, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.89) | 18.7374 |
| 1990's | 9 (16.98) | 18.2507 |
| 2000's | 25 (47.17) | 29.6817 |
| 2010's | 14 (26.42) | 24.3611 |
| 2020's | 4 (7.55) | 2.80 |
| Authors | Studies |
|---|---|
| El-Abtah, ME | 1 |
| Wenke, MR | 1 |
| Talati, P | 1 |
| Fu, M | 1 |
| Kim, D | 1 |
| Weerasekera, A | 1 |
| He, J | 1 |
| Vaynrub, A | 1 |
| Vangel, M | 1 |
| Rapalino, O | 1 |
| Andronesi, O | 1 |
| Arrillaga-Romany, I | 1 |
| Forst, DA | 1 |
| Yen, YF | 1 |
| Rosen, B | 1 |
| Batchelor, TT | 1 |
| Gonzalez, RG | 2 |
| Dietrich, J | 1 |
| Gerstner, ER | 1 |
| Ratai, EM | 2 |
| Autry, AW | 1 |
| Lafontaine, M | 1 |
| Jalbert, L | 1 |
| Phillips, E | 1 |
| Phillips, JJ | 2 |
| Villanueva-Meyer, J | 1 |
| Berger, MS | 1 |
| Chang, SM | 2 |
| Li, Y | 1 |
| Flores-Alvarez, E | 1 |
| Anselmo Rios Piedra, E | 1 |
| Cruz-Priego, GA | 1 |
| Durand-Muñoz, C | 1 |
| Moreno-Jimenez, S | 1 |
| Roldan-Valadez, E | 1 |
| Kumon, M | 1 |
| Nakae, S | 1 |
| Murayama, K | 1 |
| Kato, T | 1 |
| Ohba, S | 1 |
| Inamasu, J | 1 |
| Yamada, S | 1 |
| Abe, M | 1 |
| Sasaki, H | 1 |
| Ohno, Y | 1 |
| Hasegawa, M | 1 |
| Kurahashi, H | 1 |
| Hirose, Y | 1 |
| Tiwari, V | 1 |
| An, Z | 1 |
| Ganji, SK | 2 |
| Baxter, J | 1 |
| Patel, TR | 1 |
| Pan, E | 1 |
| Mickey, BE | 2 |
| Maher, EA | 2 |
| Pinho, MC | 1 |
| Choi, C | 2 |
| Nagashima, H | 1 |
| Sasayama, T | 1 |
| Tanaka, K | 1 |
| Kyotani, K | 1 |
| Sato, N | 1 |
| Maeyama, M | 1 |
| Kohta, M | 1 |
| Sakata, J | 1 |
| Yamamoto, Y | 1 |
| Hosoda, K | 1 |
| Itoh, T | 1 |
| Sasaki, R | 1 |
| Kohmura, E | 1 |
| Carlin, D | 1 |
| Babourina-Brooks, B | 1 |
| Arvanitis, TN | 1 |
| Wilson, M | 1 |
| Peet, AC | 1 |
| Bruggers, CS | 1 |
| Moore, K | 1 |
| Gilberto González, R | 1 |
| Steidl, E | 1 |
| Pilatus, U | 2 |
| Hattingen, E | 2 |
| Steinbach, JP | 1 |
| Zanella, F | 1 |
| Ronellenfitsch, MW | 1 |
| Bähr, O | 1 |
| Guillevin, R | 1 |
| Menuel, C | 1 |
| Sanson, M | 1 |
| Hoang-Xuan, K | 1 |
| Chiras, J | 2 |
| Balaji, R | 1 |
| Ramachandran, K | 1 |
| Kallenberg, K | 1 |
| Bock, HC | 1 |
| Helms, G | 1 |
| Jung, K | 1 |
| Wrede, A | 1 |
| Buhk, JH | 1 |
| Giese, A | 1 |
| Frahm, J | 4 |
| Strik, H | 1 |
| Dechent, P | 2 |
| Knauth, M | 1 |
| Martínez-Bisbal, MC | 1 |
| Celda, B | 1 |
| Righi, V | 1 |
| Andronesi, OC | 1 |
| Mintzopoulos, D | 1 |
| Black, PM | 1 |
| Tzika, AA | 2 |
| Clarençon, F | 1 |
| Bonneville, F | 1 |
| Rousseau, A | 1 |
| Galanaud, D | 2 |
| Kujas, M | 1 |
| Naggara, O | 1 |
| Cornu, P | 1 |
| Srinivasan, R | 1 |
| Vandenberg, SR | 1 |
| Polley, MY | 1 |
| Bourne, G | 1 |
| Au, A | 1 |
| Pirzkall, A | 1 |
| Cha, S | 1 |
| Nelson, SJ | 2 |
| DeBerardinis, RJ | 1 |
| Dimitrov, IE | 1 |
| Pascual, JM | 1 |
| Bachoo, R | 1 |
| Malloy, CR | 1 |
| McLarty, K | 1 |
| Moran, MD | 1 |
| Scollard, DA | 1 |
| Chan, C | 1 |
| Sabha, N | 1 |
| Mukherjee, J | 1 |
| Guha, A | 1 |
| McLaurin, J | 1 |
| Nitz, M | 1 |
| Houle, S | 1 |
| Wilson, AA | 1 |
| Reilly, RM | 1 |
| Vasdev, N | 1 |
| Kozić, D | 1 |
| Ostojić, J | 1 |
| Bjelan, M | 1 |
| Koprivšek, K | 1 |
| Pascual-Castroviejo, I | 1 |
| Pascual-Pascual, SI | 1 |
| Velazquez-Fragua, R | 1 |
| Viaño, J | 1 |
| Bulik, M | 1 |
| Jancalek, R | 1 |
| Vanicek, J | 1 |
| Skoch, A | 1 |
| Mechl, M | 1 |
| Murphy, M | 2 |
| Loosemore, A | 1 |
| Clifton, AG | 1 |
| Howe, FA | 2 |
| Tate, AR | 2 |
| Cudlip, SA | 2 |
| Wilkins, PR | 1 |
| Griffiths, JR | 2 |
| Bell, BA | 2 |
| Barton, SJ | 1 |
| Stubbs, M | 1 |
| Saunders, DE | 1 |
| Wilkins, P | 1 |
| Opstad, KS | 1 |
| Doyle, VL | 1 |
| McLean, MA | 1 |
| Rijpkema, M | 1 |
| Schuuring, J | 1 |
| van der Meulen, Y | 1 |
| van der Graaf, M | 2 |
| Bernsen, H | 1 |
| Boerman, R | 1 |
| van der Kogel, A | 1 |
| Heerschap, A | 2 |
| Nicoli, F | 1 |
| Le Fur, Y | 1 |
| Roche, P | 1 |
| Confort-Gouny, S | 1 |
| Dufour, H | 1 |
| Ranjeva, JP | 1 |
| Peragut, JC | 1 |
| Viout, P | 1 |
| Cozzone, PJ | 1 |
| Bowen, BC | 2 |
| Saraf-Lavi, E | 1 |
| Pattany, PM | 1 |
| Sklar, EM | 1 |
| Murdoch, JB | 1 |
| Petito, CK | 1 |
| Londoño, A | 1 |
| Castillo, M | 2 |
| Armao, D | 1 |
| Kwock, L | 2 |
| Suzuki, K | 1 |
| Simonetti, AW | 1 |
| Melssen, WJ | 1 |
| Postma, GJ | 1 |
| Buydens, LM | 1 |
| Bachert, P | 1 |
| Schröder, L | 1 |
| McKnight, TR | 1 |
| Grand, S | 1 |
| Tropres, I | 1 |
| Hoffmann, D | 1 |
| Ziegler, A | 1 |
| Le Bas, JF | 1 |
| Bodensteiner, JB | 1 |
| Kerrigan, JF | 1 |
| Johnsen, SD | 1 |
| Kim, JH | 1 |
| Chang, KH | 1 |
| Na, DG | 1 |
| Song, IC | 1 |
| Kwon, BJ | 1 |
| Han, MH | 1 |
| Kim, K | 1 |
| Raab, P | 1 |
| Franz, K | 1 |
| Zanella, FE | 1 |
| Lanfermann, H | 1 |
| Alimenti, A | 1 |
| Delavelle, J | 1 |
| Lazeyras, F | 1 |
| Yilmaz, H | 1 |
| Dietrich, PY | 1 |
| de Tribolet, N | 1 |
| Lövblad, KO | 1 |
| Chernov, MF | 1 |
| Ono, Y | 1 |
| Kubo, O | 1 |
| Hori, T | 1 |
| Zacharia, TT | 1 |
| Law, M | 1 |
| Naidich, TP | 1 |
| Leeds, NE | 1 |
| Hagberg, G | 1 |
| Burlina, AP | 1 |
| Mader, I | 1 |
| Roser, W | 1 |
| Radue, EW | 1 |
| Seelig, J | 1 |
| Chang, L | 1 |
| Miller, BL | 1 |
| McBride, D | 1 |
| Cornford, M | 1 |
| Oropilla, G | 1 |
| Buchthal, S | 1 |
| Chiang, F | 1 |
| Aronow, H | 1 |
| Beck, CK | 1 |
| Ernst, T | 1 |
| McManus, M | 1 |
| Serhan, C | 1 |
| Jackson, P | 1 |
| Strange, K | 1 |
| Kinoshita, Y | 1 |
| Kajiwara, H | 1 |
| Yokota, A | 1 |
| Koga, Y | 1 |
| Gyngell, ML | 2 |
| Els, T | 1 |
| Hoehn-Berlage, M | 1 |
| Hossmann, KA | 1 |
| Vigneron, DB | 1 |
| Dunn, RS | 1 |
| Ball, WS | 1 |
| Cheng, LL | 1 |
| Chang, IW | 1 |
| Louis, DN | 1 |
| Pouwels, PJ | 1 |
| Brockmann, K | 1 |
| Kruse, B | 1 |
| Wilken, B | 2 |
| Wick, M | 1 |
| Hanefeld, F | 2 |
| Gutowski, NJ | 1 |
| Gómez-Ansón, B | 1 |
| Torpey, N | 1 |
| Revesz, T | 1 |
| Miller, D | 1 |
| Rudge, P | 1 |
| Wolfson, M | 1 |
| Bersudsky, Y | 1 |
| Zinger, E | 1 |
| Simkin, M | 1 |
| Belmaker, RH | 1 |
| Hertz, L | 1 |
| Herms, J | 1 |
| Maxton, C | 1 |
| Markakis, E | 1 |
| Smith, JK | 1 |
| Barba, I | 1 |
| Moreno, A | 1 |
| Martinez-Pérez, I | 1 |
| Cabañas, ME | 1 |
| Baquero, M | 1 |
| Capdevila, A | 1 |
| Arús, C | 1 |
| Bruhn, H | 1 |
| Merboldt, KD | 1 |
| Hänicke, W | 1 |
| Sauter, R | 1 |
| Hamburger, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Monitoring Anti-angiogenic Therapy in Brain Tumors by Advanced MRI[NCT02843230] | 30 participants (Actual) | Observational | 2016-08-01 | Completed | |||
| Combination of 11C-MET PET and MRS in the Diagnosis of Glioma.[NCT03009318] | 100 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| Treatment Development of Triheptanoin for Glucose Transporter Type I Deficiency[NCT02021526] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2015-12-31 | Withdrawn (stopped due to NIH funding resulted in new clinical trial) | ||
| Role of Glutamate-mediate Excitotoxicity in Invasion and Progression Processes of Glioblastoma Multiforme[NCT05775458] | 50 participants (Anticipated) | Observational | 2020-06-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for inositol and Brain Neoplasms
| Article | Year |
|---|---|
Clinical magnetic resonance spectroscopy of the central nervous system.
Topics: Aspartic Acid; Brain Chemistry; Brain Neoplasms; Central Nervous System; Choline; Creatine; Glutamic | 2016 |
Proton magnetic resonance spectroscopy imaging in the study of human brain cancer.
Topics: Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Glioblastoma; Humans; In | 2009 |
The role of MR spectroscopy in neurooncology.
Topics: Aspartic Acid; Biomarkers, Tumor; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Humans; Inosi | 2012 |
[Corpus callosum tumor as the presenting symptom of neurofibromatosis type 1 in a patient and literature review].
Topics: Brain Neoplasms; Brain Stem Neoplasms; Cerebellar Neoplasms; Child, Preschool; Choline; Corpus Callo | 2012 |
Potential of MR spectroscopy for assessment of glioma grading.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Inositol; Lactates; Lipid Metabol | 2013 |
Proton magnetic resonance spectroscopic evaluation of brain tumor metabolism.
Topics: Alanine; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glutamic Acid; Glutamine; Humans | 2004 |
1 trial available for inositol and Brain Neoplasms
| Article | Year |
|---|---|
Characterization of oligodendrogliomas using short echo time 1H MR spectroscopic imaging.
Topics: Adult; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Dipeptides; Female; Glutamic Acid | 2003 |
46 other studies available for inositol and Brain Neoplasms
| Article | Year |
|---|---|
Myo-Inositol Levels Measured with MR Spectroscopy Can Help Predict Failure of Antiangiogenic Treatment in Recurrent Glioblastoma.
Topics: Angiogenesis Inhibitors; Bevacizumab; Biomarkers, Tumor; Brain Neoplasms; Female; Glioblastoma; Huma | 2022 |
Spectroscopic imaging of D-2-hydroxyglutarate and other metabolites in pre-surgical patients with IDH-mutant lower-grade gliomas.
Topics: Brain Neoplasms; Glioma; Glutarates; Humans; Inositol; Isocitrate Dehydrogenase; Magnetic Resonance | 2022 |
Correlations between DTI-derived metrics and MRS metabolites in tumour regions of glioblastoma: a pilot study.
Topics: Anisotropy; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Contrast Media; Creatine; Di | 2020 |
Myoinositol to Total Choline Ratio in Glioblastomas as a Potential Prognostic Factor in Preoperative Magnetic Resonance Spectroscopy.
Topics: Brain Neoplasms; Choline; Glioblastoma; Humans; Inositol; Isocitrate Dehydrogenase; Magnetic Resonan | 2021 |
Measurement of glycine in healthy and tumorous brain by triple-refocusing MRS at 3 T in vivo.
Topics: Adult; Brain; Brain Neoplasms; Female; Glycine; Gray Matter; Humans; Inositol; Linear Models; Magnet | 2017 |
Myo-inositol concentration in MR spectroscopy for differentiating high grade glioma from primary central nervous system lymphoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Brain Neoplasms; Glioma; Humans; Imag | 2018 |
Short-acquisition-time JPRESS and its application to paediatric brain tumours.
Topics: Adult; Biomarkers, Tumor; Brain; Brain Neoplasms; Child; Female; Glycine; Healthy Volunteers; Humans | 2019 |
Magnetic resonance imaging spectroscopy in pediatric atypical teratoid rhabdoid tumors of the brain.
Topics: Brain; Brain Neoplasms; Child, Preschool; Choline; Chromosomal Proteins, Non-Histone; Creatine; Diag | 2014 |
Myoinositol as a Biomarker in Recurrent Glioblastoma Treated with Bevacizumab: A 1H-Magnetic Resonance Spectroscopy Study.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Agents; Bevacizumab; Biomarkers, Tumor; Brain N | 2016 |
[The advantage of photon magnetic resonance spectroscopy in brain tumors].
Topics: Abnormalities, Radiation-Induced; Aspartic Acid; Brain Neoplasms; Cell Proliferation; Choline; Creat | 2008 |
Imaging of desmoplastic infantile ganglioglioma: a spectroscopic viewpoint.
Topics: Aspartic Acid; Brain; Brain Neoplasms; Child; Choline; Creatine; Diagnosis, Differential; Gangliogli | 2009 |
Untreated glioblastoma multiforme: increased myo-inositol and glutamine levels in the contralateral cerebral hemisphere at proton MR spectroscopy.
Topics: Aged; Brain Neoplasms; Case-Control Studies; Female; Glioblastoma; Glutamine; Humans; Inositol; Magn | 2009 |
High-resolution magic angle spinning magnetic resonance spectroscopy detects glycine as a biomarker in brain tumors.
Topics: Adolescent; Adult; Biomarkers, Tumor; Brain Neoplasms; Glioblastoma; Glycine; Humans; Inositol; Magn | 2010 |
Intracranial solitary fibrous tumor: imaging findings.
Topics: Adult; Brain Neoplasms; Choline; Contrast Media; Diffusion Magnetic Resonance Imaging; Female; Heter | 2011 |
Ex vivo MR spectroscopic measure differentiates tumor from treatment effects in GBM.
Topics: Biomarkers, Tumor; Brain Neoplasms; Choline; Glioblastoma; Humans; Image Interpretation, Computer-As | 2010 |
Measurement of glycine in the human brain in vivo by 1H-MRS at 3 T: application in brain tumors.
Topics: Brain Chemistry; Brain Neoplasms; Glioblastoma; Glycine; Humans; Imaging, Three-Dimensional; Inosito | 2011 |
Comparisons of [18F]-1-deoxy-1-fluoro-scyllo-inositol with [18F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic mice.
Topics: Animals; Biological Transport; Brain Neoplasms; Breast Neoplasms; Cell Line, Tumor; Female; Fluorode | 2011 |
The contribution of proton magnetic resonance spectroscopy (1HMRS) to clinical brain tumour diagnosis.
Topics: Adolescent; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatinine; Humans; Inositol; Magn | 2002 |
Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy.
Topics: Alanine; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Glioblastoma; Humans; Inosi | 2003 |
[Contribution of magnetic resonance spectrometry to the diagnosis of intracranial tumors].
Topics: Aspartic Acid; Biomarkers; Brain Abscess; Brain Neoplasms; Choline; Computer Graphics; Creatine; Dia | 2002 |
Glial neoplasms without elevated choline-creatine ratios.
Topics: Astrocytoma; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Humans; I | 2003 |
Proton MR spectroscopy of gliomatosis cerebri: case report of elevated myoinositol with normal choline levels.
Topics: Aged; Brain Neoplasms; Choline; Creatine; Female; Humans; Inositol; Magnetic Resonance Spectroscopy; | 2003 |
Unusual MR spectroscopic imaging pattern of an astrocytoma: lack of elevated choline and high myo-inositol and glycine levels.
Topics: Adult; Astrocytoma; Brain Neoplasms; Choline; Glycine; Humans; Inositol; Magnetic Resonance Spectros | 2003 |
A chemometric approach for brain tumor classification using magnetic resonance imaging and spectroscopy.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Cerebrospinal Fluid; Choline; Creatine; Disc | 2003 |
[Magnetic resonance imaging spectroscopy. Part 1: Basics].
Topics: Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Choline; Energy Metabolism; Humans; Image Enh | 2003 |
[Proton magnetic resonance spectroscopy (1H-MRS) for the diagnosis of brain tumors and the evaluation of treatment].
Topics: Acetates; Alanine; Amino Acids; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Glutami | 2005 |
Leukoencephalopathy with bilateral anterior temporal lobe cysts.
Topics: Adolescent; Aspartic Acid; Brain Neoplasms; Central Nervous System Cysts; Child; Child, Preschool; F | 2006 |
3T 1H-MR spectroscopy in grading of cerebral gliomas: comparison of short and intermediate echo time sequences.
Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Echo-Planar Imaging; Female; Glioma; | 2006 |
Myo-inositol: a marker of reactive astrogliosis in glial tumors?
Topics: Adolescent; Adult; Biomarkers; Brain Neoplasms; Female; Glioma; Humans; Image Interpretation, Comput | 2008 |
Monovoxel 1H magnetic resonance spectroscopy in the progression of gliomas.
Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Disease Progression; Female; Glioma; | 2007 |
Comparison of 1H-MRS-detected metabolic characteristics in single metastatic brain tumors of different origin.
Topics: Aged; Brain Chemistry; Brain Edema; Brain Neoplasms; False Negative Reactions; False Positive Reacti | 2006 |
Central nervous system lymphoma characterization by diffusion-weighted imaging and MR spectroscopy.
Topics: Adult; Aged; Aspartic Acid; Biopsy; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis, Differenti | 2008 |
In vivo proton MR spectroscopy of human gliomas: definition of metabolic coordinates for multi-dimensional classification.
Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Cluster Analysis; Creatine; Discriminan | 1995 |
Brain lesions in patients with AIDS: H-1 MR spectroscopy.
Topics: Abscess; Adult; AIDS Dementia Complex; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Crea | 1995 |
Ketoconazole blocks organic osmolyte efflux independently of its effect on arachidonic acid conversion.
Topics: Animals; Anions; Arachidonic Acid; Brain Neoplasms; Chromatography, High Pressure Liquid; Eicosanoid | 1994 |
Proton magnetic resonance spectroscopy of brain tumors: an in vitro study.
Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Neoplasms; Child; C | 1994 |
Proton MR spectroscopy of experimental brain tumors in vivo.
Topics: Animals; Aspartic Acid; Blood Glucose; Brain Edema; Brain Neoplasms; Caudate Nucleus; Cell Line; Cho | 1994 |
Intracranial tumors in children: small single-voxel proton MR spectroscopy using short- and long-echo sequences.
Topics: Adolescent; Aspartic Acid; Brain Neoplasms; Child; Child, Preschool; Choline; Creatinine; Female; Gl | 1996 |
Correlation of high-resolution magic angle spinning proton magnetic resonance spectroscopy with histopathology of intact human brain tumor specimens.
Topics: Amino Acids; Brain; Brain Neoplasms; Glioblastoma; Humans; Inositol; Lipid Metabolism; Magnetic Reso | 1998 |
Regional age dependence of human brain metabolites from infancy to adulthood as detected by quantitative localized proton MRS.
Topics: Adolescent; Age Factors; Aspartic Acid; Basal Ganglia; Brain; Brain Neoplasms; Cerebellum; Child; Ch | 1999 |
Oligodendroglial gliomatosis cerebri: (1)H-MRS suggests elevated glycine/inositol levels.
Topics: Adult; Aspartic Acid; Biopsy, Needle; Brain Neoplasms; Glycine; Humans; Inositol; Magnetic Resonance | 1999 |
Chronic treatment of human astrocytoma cells with lithium, carbamazepine or valproic acid decreases inositol uptake at high inositol concentrations but increases it at low inositol concentrations.
Topics: Antimanic Agents; Astrocytoma; Bipolar Disorder; Brain; Brain Neoplasms; Carbamazepine; Dose-Respons | 2000 |
Quantitative proton magnetic resonance spectroscopy of focal brain lesions.
Topics: Adolescent; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Abscess; Brain Diseases; Brain Neoplasms; | 2000 |
Correlation of myo-inositol levels and grading of cerebral astrocytomas.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Child; Chil | 2000 |
Magnetic resonance spectroscopy of brain hemangiopericytomas: high myoinositol concentrations and discrimination from meningiomas.
Topics: Brain Neoplasms; Diagnosis, Differential; Hemangiopericytoma; Humans; Inositol; Magnetic Resonance S | 2001 |
Noninvasive differentiation of tumors with use of localized H-1 MR spectroscopy in vivo: initial experience in patients with cerebral tumors.
Topics: Adult; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Cysts; | 1989 |