Page last updated: 2024-10-19

inositol and Brain Injuries

inositol has been researched along with Brain Injuries in 16 studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.

Research Excerpts

ExcerptRelevanceReference
" We also did not find a correlation between the amount of Glx and the initial Glasgow Coma Scale score, duration of coma, nor with changes in spectral metabolites, including N-acetyl aspartate, choline, and myoinositol."3.72Proton MR spectroscopy detected glutamate/glutamine is increased in children with traumatic brain injury. ( Ashwal, S; Gross, M; Holshouser, B; Kido, D; Osterdock, R; Serna, T; Tong, K, 2004)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (12.50)18.2507
2000's9 (56.25)29.6817
2010's5 (31.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kierans, AS1
Kirov, II3
Gonen, O3
Haemer, G1
Nisenbaum, E1
Babb, JS2
Grossman, RI3
Lui, YW3
Sajja, VS1
Perrine, SA1
Ghoddoussi, F1
Hall, CS1
Galloway, MP1
VandeVord, PJ1
Grossman, EJ1
Novikov, DS1
Davitz, MS1
Inglese, M1
Fieremans, E1
Semenova, NA1
Akhadov, TA1
Petryaykin, AV1
Sidorin, SS1
Lukovenkov, AV1
Varfolomeev, SD1
Tal, A1
Schuhmann, MU1
Stiller, D1
Skardelly, M1
Bernarding, J1
Klinge, PM1
Samii, A1
Samii, M1
Brinker, T1
Ashwal, S3
Holshouser, B2
Tong, K2
Serna, T2
Osterdock, R2
Gross, M2
Kido, D2
Shutter, L1
Tong, KA1
Holshouser, BA2
Babikian, T1
Freier, MC1
Riggs, ML1
Burley, T1
Pascual, JM1
Solivera, J1
Prieto, R1
Barrios, L1
López-Larrubia, P1
Cerdán, S1
Roda, JM1
Danielsen, ER1
Michaelis, T1
Ross, BD1
Yamashita, T1
Shimada, S1
Yamauchi, A1
Guo, W1
Kohmura, E1
Hayakawa, T1
Tohyama, M1
Brooks, WM1
Stidley, CA1
Petropoulos, H1
Jung, RE1
Weers, DC1
Friedman, SD1
Barlow, MA1
Sibbitt, WL1
Yeo, RA1
Garnett, MR1
Blamire, AM1
Corkill, RG1
Cadoux-Hudson, TA1
Rajagopalan, B1
Styles, P1
Khiat, A1
Yared, Z1
Bard, C1
Lacroix, A1
Boulanger, Y1

Trials

1 trial available for inositol and Brain Injuries

ArticleYear
Early proton magnetic resonance spectroscopy in normal-appearing brain correlates with outcome in patients following traumatic brain injury.
    Brain : a journal of neurology, 2000, Volume: 123 ( Pt 10)

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Chemistry; Brain Injuries; Choline; Creatine; Disabili

2000

Other Studies

15 other studies available for inositol and Brain Injuries

ArticleYear
Myoinositol and glutamate complex neurometabolite abnormality after mild traumatic brain injury.
    Neurology, 2014, Feb-11, Volume: 82, Issue:6

    Topics: Adult; Aspartic Acid; Brain Injuries; Case-Control Studies; Caudate Nucleus; Choline; Corpus Striatu

2014
Blast neurotrauma impairs working memory and disrupts prefrontal myo-inositol levels in rats.
    Molecular and cellular neurosciences, 2014, Volume: 59

    Topics: Animals; Betaine; Blast Injuries; Brain Injuries; Creatine; Ethanolamines; gamma-Aminobutyric Acid;

2014
N-acetyl-aspartate levels correlate with intra-axonal compartment parameters from diffusion MRI.
    NeuroImage, 2015, Volume: 118

    Topics: Adult; Aspartic Acid; Axons; Brain; Brain Injuries; Choline; Creatine; Diffusion Magnetic Resonance

2015
Metabolic dysfunction and relationship in human frontoparietal cortex in severe traumatic brain injury: single-voxel (1)H magnetic resonance spectroscopy study.
    Biochemistry. Biokhimiia, 2012, Volume: 77, Issue:4

    Topics: Adolescent; Aspartic Acid; Brain; Brain Injuries; Cerebral Cortex; Child; Child, Preschool; Choline;

2012
Diffuse axonal injury in mild traumatic brain injury: a 3D multivoxel proton MR spectroscopy study.
    Journal of neurology, 2013, Volume: 260, Issue:1

    Topics: Adolescent; Adult; Aspartic Acid; Brain Injuries; Brain Mapping; Choline; Creatine; Diffuse Axonal I

2013
Metabolic changes in the vicinity of brain contusions: a proton magnetic resonance spectroscopy and histology study.
    Journal of neurotrauma, 2003, Volume: 20, Issue:8

    Topics: Animals; Aspartic Acid; Biomarkers; Brain Injuries; Choline; Creatine; Functional Laterality; Glutam

2003
Proton spectroscopy detected myoinositol in children with traumatic brain injury.
    Pediatric research, 2004, Volume: 56, Issue:4

    Topics: Adolescent; Biomarkers; Brain; Brain Injuries; Child; Child, Preschool; Gliosis; Glutamic Acid; Glut

2004
Proton MR spectroscopy detected glutamate/glutamine is increased in children with traumatic brain injury.
    Journal of neurotrauma, 2004, Volume: 21, Issue:11

    Topics: Adolescent; Age Factors; Aspartic Acid; Brain; Brain Injuries; Child; Child, Preschool; Choline; Com

2004
Proton MRS in acute traumatic brain injury: role for glutamate/glutamine and choline for outcome prediction.
    Journal of neurotrauma, 2004, Volume: 21, Issue:12

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Injuries; Cerebral Cortex; Choline; Creatinine; Evoked

2004
MR spectroscopy: predicting long-term neuropsychological outcome following pediatric TBI.
    Journal of magnetic resonance imaging : JMRI, 2006, Volume: 24, Issue:4

    Topics: Adolescent; Aspartic Acid; Brain Injuries; Child; Child, Preschool; Creatine; Female; Glutamic Acid;

2006
Time course of early metabolic changes following diffuse traumatic brain injury in rats as detected by (1)H NMR spectroscopy.
    Journal of neurotrauma, 2007, Volume: 24, Issue:6

    Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Chemistry; Brain Injuries; Creatine; Diffuse Axona

2007
Three methods of calibration in quantitative proton MR spectroscopy.
    Journal of magnetic resonance. Series B, 1995, Volume: 106, Issue:3

    Topics: Adult; Aspartic Acid; Body Water; Brain; Brain Chemistry; Brain Injuries; Calibration; Choline; Crea

1995
Induction of Na+/myo-inositol co-transporter mRNA after rat cryogenic injury.
    Brain research. Molecular brain research, 1997, Volume: 46, Issue:1-2

    Topics: Animals; Biological Transport; Brain Injuries; Cerebral Cortex; In Situ Hybridization; Inositol; Ion

1997
Metabolic and cognitive response to human traumatic brain injury: a quantitative proton magnetic resonance study.
    Journal of neurotrauma, 2000, Volume: 17, Issue:8

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Injuries; Choline; Cognition Disorders; Creatinine; Cr

2000
Long-term brain metabolic alterations in exogenous Cushing's syndrome as monitored by proton magnetic resonance spectroscopy.
    Brain research, 2001, Aug-24, Volume: 911, Issue:2

    Topics: Adult; Aspartic Acid; Brain; Brain Diseases, Metabolic; Brain Injuries; Cell Membrane; Choline; Crea

2001