inositol has been researched along with Brain Disorders in 28 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recent in vivo studies using proton magnetic resonance (1H-MR) spectroscopy showed low levels of myo-inositol in the brain in hepatic encephalopathy; the pathogenetic relevance of this observation is unclear." | 7.69 | Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy. ( Bayer, S; Ernst, T; Gerok, W; Häussinger, D; Hennig, J; Langer, M; Laubenberger, J; vom Dahl, S, 1994) |
| " This biochemical information can be processed and presented as density maps of several metabolites, among them N-acetylaspartate (marker of neuronal viability), choline (marker of membrane turnover), creatine (related to the energy state of the cells), myo-Inositol (exclusively found in astrocytes), lipids and lactate (observed in necrosis and other pathological processes) which mean relevant information in the context of brain tumors." | 4.85 | Proton magnetic resonance spectroscopy imaging in the study of human brain cancer. ( Celda, B; Martínez-Bisbal, MC, 2009) |
| " The enzymatic activity of IMPase is inhibited by lithium, a drug used for the treatment of mood swings seen in bipolar disorder." | 3.80 | Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis. ( Gondo, Y; Hida, A; Iwayama, Y; Mishima, K; Murata, T; Ohba, H; Ohnishi, T; Watanabe, A; Yoshikawa, T, 2014) |
| "Higher triglyceride and lower HDL levels statistically account for the association between BMI and myo-inositol, pointing toward a potentially critical role for dyslipidemia in the development of cerebral neurochemical alterations in obesity." | 3.79 | Dyslipidemia links obesity to early cerebral neurochemical alterations. ( Gonzales, MM; Haley, AP; Tanaka, H; Tarumi, T, 2013) |
| "Compared with healthy subjects, patients with myotonic dystrophy had elevated levels of myoinositol (+19% in the occipital region and +12." | 3.70 | Proton spectroscopy in myotonic dystrophy: correlations with CTG repeats. ( Chang, L; Ernst, T; Leonido-Yee, M; Osborn, D; Poland, RE; Seltzer, W, 1998) |
| "Recent in vivo studies using proton magnetic resonance (1H-MR) spectroscopy showed low levels of myo-inositol in the brain in hepatic encephalopathy; the pathogenetic relevance of this observation is unclear." | 3.69 | Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy. ( Bayer, S; Ernst, T; Gerok, W; Häussinger, D; Hennig, J; Langer, M; Laubenberger, J; vom Dahl, S, 1994) |
| "Lipopolysaccharide (LPS)-induced encephalopathy induces neuroinflammation." | 1.51 | Anti-inflammatory agent, OKN-007, reverses long-term neuroinflammatory responses in a rat encephalopathy model as assessed by multi-parametric MRI: implications for aging-associated neuroinflammation. ( Gulej, R; Lawrence, B; McKenzie, T; Morton, KA; Saunders, D; Smith, N; Towner, RA, 2019) |
| "Active demyelination or increased myelin turnover might contribute to the hitherto unexplained WMD of this rare disorder." | 1.33 | White-matter disease in 18q deletion (18q-) syndrome: magnetic resonance spectroscopy indicates demyelination or increased myelin turnover rather than dysmyelination. ( Anhuf, D; Häusler, M; Möller-Hartmann, W; Ramaekers, VT; Schüler, H; Thron, A; Zerres, K, 2005) |
| "Most of the brain tumors were characterized by strongly reduced total N-acetylaspartyl compounds and marked increases of myo-inositol and choline-containing compounds, consistent with a lack of neuroaxonal tissue and a proliferation of glial cells." | 1.31 | Quantitative proton magnetic resonance spectroscopy of focal brain lesions. ( Dechent, P; Frahm, J; Hanefeld, F; Herms, J; Markakis, E; Maxton, C; Wilken, B, 2000) |
| "Also, patients with Wilson disease and portosystemic shunting had lower myo-inositol-creatine ratios than did patients with Wilson disease and no portosystemic shunting (P < ." | 1.30 | Differentiation between portal-systemic encephalopathy and neurodegenerative disorders in patients with Wilson disease: H-1 MR spectroscopy. ( Hoogenraad, TU; Mali, WP; Van Den Heuvel, AG; Van der Grond, J; Van Rooij, LG; Van Wassenaer-van Hall, HN, 1997) |
| "Late juvenile neuronal ceroid lipofuscinosis (NCL) is a lysosomal neurodegenerative disorder caused by the accumulation of lipopigment in neurons." | 1.30 | MR imaging and localized proton MR spectroscopy in late infantile neuronal ceroid lipofuscinosis. ( Grodd, W; Klose, U; Nägele, T; Schwab, A; Seeger, U; Seitz, D, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.14) | 18.7374 |
| 1990's | 8 (28.57) | 18.2507 |
| 2000's | 12 (42.86) | 29.6817 |
| 2010's | 5 (17.86) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Mueller, C | 1 |
| Baird, JF | 1 |
| Motl, RW | 1 |
| Towner, RA | 1 |
| Saunders, D | 1 |
| Smith, N | 1 |
| Gulej, R | 1 |
| McKenzie, T | 1 |
| Lawrence, B | 1 |
| Morton, KA | 1 |
| Haley, AP | 1 |
| Gonzales, MM | 1 |
| Tarumi, T | 1 |
| Tanaka, H | 1 |
| Ohnishi, T | 1 |
| Murata, T | 1 |
| Watanabe, A | 1 |
| Hida, A | 1 |
| Ohba, H | 1 |
| Iwayama, Y | 1 |
| Mishima, K | 1 |
| Gondo, Y | 1 |
| Yoshikawa, T | 1 |
| Liu, TB | 1 |
| Subbian, S | 1 |
| Pan, W | 1 |
| Eugenin, E | 1 |
| Xie, J | 1 |
| Xue, C | 1 |
| Lin, YW | 1 |
| Yu, CY | 1 |
| Martínez-Bisbal, MC | 1 |
| Celda, B | 1 |
| Terek, D | 1 |
| Koroglu, O | 1 |
| Yalaz, M | 1 |
| Gokben, S | 1 |
| Calli, C | 1 |
| Coker, M | 1 |
| Kultursay, N | 1 |
| TSUCHIYAMA, H | 1 |
| NISHIDA, T | 1 |
| KUMMEROW, FA | 1 |
| Bachert, P | 1 |
| Schröder, L | 1 |
| Häusler, M | 1 |
| Anhuf, D | 1 |
| Schüler, H | 1 |
| Ramaekers, VT | 1 |
| Thron, A | 1 |
| Zerres, K | 1 |
| Möller-Hartmann, W | 1 |
| Chang, L | 3 |
| Ernst, T | 4 |
| Speck, O | 1 |
| Grob, CS | 1 |
| Briellmann, RS | 1 |
| Wellard, RM | 1 |
| Jackson, GD | 1 |
| Groeschel, S | 1 |
| Brockmann, K | 1 |
| Dechent, P | 2 |
| Wilichowski, E | 1 |
| Frahm, J | 3 |
| Hanefeld, F | 2 |
| Taylor, MJ | 1 |
| Schweinsburg, BC | 1 |
| Alhassoon, OM | 1 |
| Gongvatana, A | 1 |
| Brown, GG | 1 |
| Young-Casey, C | 1 |
| Letendre, SL | 1 |
| Grant, I | 1 |
| Nitkunan, A | 1 |
| Charlton, RA | 1 |
| McIntyre, DJ | 1 |
| Barrick, TR | 1 |
| Howe, FA | 2 |
| Markus, HS | 1 |
| Dezortova, M | 1 |
| Hajek, M | 1 |
| Miller, BL | 1 |
| McBride, D | 1 |
| Cornford, M | 1 |
| Oropilla, G | 1 |
| Buchthal, S | 1 |
| Chiang, F | 1 |
| Aronow, H | 1 |
| Beck, CK | 1 |
| Häussinger, D | 1 |
| Laubenberger, J | 2 |
| vom Dahl, S | 1 |
| Bayer, S | 2 |
| Langer, M | 2 |
| Gerok, W | 1 |
| Hennig, J | 2 |
| Hirvonen, MR | 1 |
| Paljärvi, L | 1 |
| Savolainen, KM | 1 |
| Tourbah, A | 1 |
| Stievenart, JL | 1 |
| Iba-Zizen, MT | 1 |
| Zannoli, G | 1 |
| Lyon-Caen, O | 1 |
| Cabanis, EA | 1 |
| Van Den Heuvel, AG | 1 |
| Van der Grond, J | 1 |
| Van Rooij, LG | 1 |
| Van Wassenaer-van Hall, HN | 1 |
| Hoogenraad, TU | 1 |
| Mali, WP | 1 |
| Osborn, D | 1 |
| Seltzer, W | 1 |
| Leonido-Yee, M | 1 |
| Poland, RE | 1 |
| Thiel, T | 1 |
| Seitz, D | 1 |
| Grodd, W | 1 |
| Schwab, A | 1 |
| Seeger, U | 1 |
| Klose, U | 1 |
| Nägele, T | 1 |
| Wilken, B | 1 |
| Herms, J | 1 |
| Maxton, C | 1 |
| Markakis, E | 1 |
| Axford, JS | 1 |
| Heron, C | 1 |
| Griffiths, JR | 1 |
| Bruhn, H | 1 |
| Gyngell, ML | 1 |
| Merboldt, KD | 1 |
| Hänicke, W | 1 |
| Sauter, R | 1 |
| Hamburger, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Combination of 11C-MET PET and MRS in the Diagnosis of Glioma.[NCT03009318] | 100 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| Role of Magnetic Resonance Imaging in Detection of Minimal Hepatic Encephalopathy[NCT04131205] | 40 participants (Anticipated) | Observational | 2019-06-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for inositol and Brain Disorders
| Article | Year |
|---|---|
Proton magnetic resonance spectroscopy imaging in the study of human brain cancer.
Topics: Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Glioblastoma; Humans; In | 2009 |
Seizure-associated abnormalities in epilepsy: evidence from MR imaging.
Topics: Adult; Aspartic Acid; Atrophy; Brain; Brain Diseases; Brain Edema; Choline; Creatine; Diffusion Magn | 2005 |
(1)H MR spectroscopy in pediatrics.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Diseases; Child; Child, Preschool; Choline; Creatine; G | 2008 |
25 other studies available for inositol and Brain Disorders
| Article | Year |
|---|---|
Whole-Brain Metabolic Abnormalities Are Associated With Mobility in Older Adults With Multiple Sclerosis.
Topics: Aged; Aspartic Acid; Brain; Brain Diseases; Choline; Creatine; Humans; Inositol; Magnetic Resonance | 2022 |
Anti-inflammatory agent, OKN-007, reverses long-term neuroinflammatory responses in a rat encephalopathy model as assessed by multi-parametric MRI: implications for aging-associated neuroinflammation.
Topics: Animals; Anti-Inflammatory Agents; Aspartic Acid; Benzenesulfonates; Brain Diseases; Cerebral Cortex | 2019 |
Dyslipidemia links obesity to early cerebral neurochemical alterations.
Topics: Adult; Aspartic Acid; Blood Glucose; Blood Pressure; Body Mass Index; Brain; Brain Diseases; Cholest | 2013 |
Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Bipolar Disorder; Brain; Brain Diseases; Circadian R | 2014 |
Cryptococcus inositol utilization modulates the host protective immune response during brain infection.
Topics: Animals; Brain Diseases; Cryptococcosis; Cryptococcus neoformans; Female; Gene Expression Profiling; | 2014 |
Reversible focal splenium lesion--MRS study of a different etiology.
Topics: Adult; Aspartic Acid; Brain Diseases; Brain Mapping; Corpus Callosum; Diffusion Magnetic Resonance I | 2009 |
Diagnostic tools of early brain disturbances in an asymptomatic neonate with maple syrup urine disease.
Topics: Aspartic Acid; Brain Diseases; Brain Waves; Consanguinity; Developmental Disabilities; Diet; Diet, C | 2013 |
Pathology of chick encephalomalacia. Peroxides or vitamin E deficiency as causes.
Topics: Animals; Ascorbic Acid; Brain; Brain Diseases; Chickens; Diet; Encephalomalacia; Fatty Acids; Inosit | 1962 |
[Magnetic resonance imaging spectroscopy. Part 1: Basics].
Topics: Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Choline; Energy Metabolism; Humans; Image Enh | 2003 |
White-matter disease in 18q deletion (18q-) syndrome: magnetic resonance spectroscopy indicates demyelination or increased myelin turnover rather than dysmyelination.
Topics: Aspartic Acid; Brain Diseases; Choline; Chromosome Deletion; Chromosomes, Human, Pair 18; Demyelinat | 2005 |
Additive effects of HIV and chronic methamphetamine use on brain metabolite abnormalities.
Topics: Adult; Amphetamine-Related Disorders; Aspartic Acid; Basal Ganglia; Brain; Brain Diseases; Choline; | 2005 |
Magnetic resonance imaging and proton magnetic resonance spectroscopy of megalencephaly and dilated Virchow-Robin spaces.
Topics: Aspartic Acid; Brain Diseases; Child; Child, Preschool; Choline; Creatine; Dilatation, Pathologic; D | 2006 |
Effects of human immunodeficiency virus and methamphetamine on cerebral metabolites measured with magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Basal Ganglia; Brain; Brain Diseases; CD4 Lymphocyte Count; Central Nervous Sy | 2007 |
Diffusion tensor imaging and MR spectroscopy in hypertension and presumed cerebral small vessel disease.
Topics: Aged; Aspartic Acid; Brain Diseases; Brain Ischemia; Case-Control Studies; Cerebrovascular Circulati | 2008 |
Brain lesions in patients with AIDS: H-1 MR spectroscopy.
Topics: Abscess; Adult; AIDS Dementia Complex; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Crea | 1995 |
Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Brain Chemistry; Brain Diseases; Female; Glutamine; | 1994 |
Malaoxon-induced neurotoxicity in old rats: alterations in cerebral inositol lipid signalling, brain tissue calcium levels and early neuronal injury.
Topics: Animals; Behavior, Animal; Brain; Brain Diseases; Calcium; Inositol; Inositol Phosphates; Insecticid | 1993 |
In vivo localized NMR proton spectroscopy of normal appearing white matter in patients with multiple sclerosis.
Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Brain Diseases; Choline; Clinical Trials as Topic | 1996 |
Differentiation between portal-systemic encephalopathy and neurodegenerative disorders in patients with Wilson disease: H-1 MR spectroscopy.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Diseases; Choline; Creatinine; Diagnosis, Differential; Fem | 1997 |
Proton spectroscopy in myotonic dystrophy: correlations with CTG repeats.
Topics: Adult; Brain Chemistry; Brain Diseases; Choline; Creatinine; Female; Humans; Inositol; Magnetic Reso | 1998 |
[Clinical uses of proton magnetic resonance spectroscopy of the brain].
Topics: AIDS Dementia Complex; Alzheimer Disease; Animals; Aspartic Acid; Brain; Brain Diseases; Brain Disea | 1998 |
MR imaging and localized proton MR spectroscopy in late infantile neuronal ceroid lipofuscinosis.
Topics: Aspartic Acid; Brain; Brain Diseases; Case-Control Studies; Cerebellum; Cerebral Ventricles; Child; | 1998 |
Quantitative proton magnetic resonance spectroscopy of focal brain lesions.
Topics: Adolescent; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Abscess; Brain Diseases; Brain Neoplasms; | 2000 |
Sensitivity of quantitative (1)H magnetic resonance spectroscopy of the brain in detecting early neuronal damage in systemic lupus erythematosus.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Diseases; Case-Control Studies; Choline; Creatine; Fem | 2001 |
Noninvasive differentiation of tumors with use of localized H-1 MR spectroscopy in vivo: initial experience in patients with cerebral tumors.
Topics: Adult; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Cysts; | 1989 |