inositol has been researched along with Blood Pressure, High in 34 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, our knowledge regarding the effects of G6PD deficiency on pathogenesis of vascular diseases caused by factors, like angiotensin II (Ang-II), which stimulate synthesis of inflammatory cytokines and vascular inflammation, is lacking." | 8.12 | Mediterranean G6PD variant rats are protected from Angiotensin II-induced hypertension and kidney damage, but not from inflammation and arterial stiffness. ( D'Addiaro, C; De Miguel, C; Gupte, R; Gupte, SA; Matsumura, S; Miano, JM; Slivano, OJ; Stier, C, 2022) |
| "Inositols (INOs) supplementation during pregnancy, specifically the combination of myo-inositol (MI) and D-chiro-inositol (DCI), has been reported to improve vascular parameters in women with gestational diabetes mellitus." | 7.91 | Vascular and metabolic profiles in offspring born to pregnant mice with metabolic syndrome treated with inositols. ( Alrais, M; Blackwell, SC; Facchinetti, F; Ferrari, F; Longo, M; Refuerzo, JS; Sibai, BM; Tamayo, EH, 2019) |
| "To determine the blood concentrations of myo-inositol, glucose and zinc before, during and after normal pregnancy." | 7.73 | Myo-inositol, glucose and zinc concentrations determined in the preconceptional period, during and after pregnancy. ( Groenen, PM; Merkus, HM; Peer, PG; Roes, EM; Steegers, EA; Steegers-Theunissen, RP, 2006) |
| "Myo-inositol and D-chiro-inositol are capable of improving the ovarian function and metabolism of polycystic ovary syndrome (PCOS) patients." | 5.19 | Comparison between effects of myo-inositol and D-chiro-inositol on ovarian function and metabolic factors in women with PCOS. ( Barbaro, L; Laganà, AS; Pizzo, A, 2014) |
| " However, our knowledge regarding the effects of G6PD deficiency on pathogenesis of vascular diseases caused by factors, like angiotensin II (Ang-II), which stimulate synthesis of inflammatory cytokines and vascular inflammation, is lacking." | 4.12 | Mediterranean G6PD variant rats are protected from Angiotensin II-induced hypertension and kidney damage, but not from inflammation and arterial stiffness. ( D'Addiaro, C; De Miguel, C; Gupte, R; Gupte, SA; Matsumura, S; Miano, JM; Slivano, OJ; Stier, C, 2022) |
| "Inositols (INOs) supplementation during pregnancy, specifically the combination of myo-inositol (MI) and D-chiro-inositol (DCI), has been reported to improve vascular parameters in women with gestational diabetes mellitus." | 3.91 | Vascular and metabolic profiles in offspring born to pregnant mice with metabolic syndrome treated with inositols. ( Alrais, M; Blackwell, SC; Facchinetti, F; Ferrari, F; Longo, M; Refuerzo, JS; Sibai, BM; Tamayo, EH, 2019) |
| "To determine the blood concentrations of myo-inositol, glucose and zinc before, during and after normal pregnancy." | 3.73 | Myo-inositol, glucose and zinc concentrations determined in the preconceptional period, during and after pregnancy. ( Groenen, PM; Merkus, HM; Peer, PG; Roes, EM; Steegers, EA; Steegers-Theunissen, RP, 2006) |
| "In this study, cognitively intact chronic hypertensive older patients had a higher white matter myoinositol/creatine ratio compared with healthy older subjects, suggesting that myoinositol may be a sensitive marker of the effects of chronic hypertension on the brain." | 3.71 | Proton magnetic resonance spectroscopy reveals similar white matter biochemical changes in patients with chronic hypertension and early Alzheimer's disease. ( Benedetti, C; Catani, M; Cherubini, A; Howard, R; Mariani, E; Mecocci, P; Metastasio, A; Pelliccioli, GP; Senin, U; Tarducci, R, 2002) |
| "Postprandial hyperglycemia is frequently associated with visceral obesity which plays a key role in metabolic abnormalities such as dyslipidemia and hypertension." | 2.42 | [Pharmacological treatment of postprandial hyperglycemia in hypertensive patients with type 2 diabetes mellitus]. ( Yamada, K, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (67.65) | 18.7374 |
| 1990's | 1 (2.94) | 18.2507 |
| 2000's | 4 (11.76) | 29.6817 |
| 2010's | 3 (8.82) | 24.3611 |
| 2020's | 3 (8.82) | 2.80 |
| Authors | Studies |
|---|---|
| Matsumura, S | 1 |
| D'Addiaro, C | 1 |
| Slivano, OJ | 1 |
| De Miguel, C | 1 |
| Stier, C | 1 |
| Gupte, R | 1 |
| Miano, JM | 1 |
| Gupte, SA | 1 |
| Menichini, D | 1 |
| Alrais, M | 2 |
| Liu, C | 1 |
| Xia, Y | 1 |
| Blackwell, SC | 2 |
| Facchinetti, F | 2 |
| Sibai, BM | 2 |
| Longo, M | 2 |
| Hashemi Tari, S | 1 |
| Sohouli, MH | 1 |
| Lari, A | 1 |
| Fatahi, S | 1 |
| Rahideh, ST | 1 |
| Tamayo, EH | 1 |
| Ferrari, F | 1 |
| Refuerzo, JS | 1 |
| Pizzo, A | 1 |
| Laganà, AS | 1 |
| Barbaro, L | 1 |
| Chang, HH | 1 |
| Chao, HN | 1 |
| Walker, CS | 1 |
| Choong, SY | 1 |
| Phillips, A | 1 |
| Loomes, KM | 1 |
| Catani, M | 1 |
| Mecocci, P | 1 |
| Tarducci, R | 1 |
| Howard, R | 1 |
| Pelliccioli, GP | 1 |
| Mariani, E | 1 |
| Metastasio, A | 1 |
| Benedetti, C | 1 |
| Senin, U | 1 |
| Cherubini, A | 1 |
| Yamada, K | 1 |
| BOYD, LJ | 1 |
| LOMBARDI, AA | 1 |
| SVIGALS, CS | 1 |
| CARERE-COMES, O | 1 |
| SAVELLI, G | 1 |
| SODO, D | 1 |
| BERNSTEIN, LM | 1 |
| IVY, AC | 1 |
| MENEGHINI, P | 1 |
| AVANZI, G | 1 |
| STROBBIA, R | 1 |
| DONATELLI, L | 1 |
| SPIGLIATI, P | 1 |
| ZABBAN, M | 1 |
| SELLERI, R | 1 |
| BARBARO FORLEO, G | 2 |
| SERPI, L | 2 |
| BARICALLA, A | 1 |
| Groenen, PM | 1 |
| Roes, EM | 1 |
| Peer, PG | 1 |
| Merkus, HM | 1 |
| Steegers, EA | 1 |
| Steegers-Theunissen, RP | 1 |
| Nitkunan, A | 1 |
| Charlton, RA | 1 |
| McIntyre, DJ | 1 |
| Barrick, TR | 1 |
| Howe, FA | 1 |
| Markus, HS | 1 |
| Russo-Marie, F | 1 |
| Duval, D | 1 |
| Felix, G | 1 |
| Otrzonsek, G | 1 |
| Windsheimer, F | 1 |
| Schneider, B | 1 |
| Jaillard, J | 1 |
| Krämer, KD | 2 |
| Ghabussi, P | 2 |
| Hochrein, H | 2 |
| Schnicke, M | 1 |
| Olschowka, U | 1 |
| Rezori, R | 1 |
| Lehmann, HU | 1 |
| Hotta, N | 1 |
| Sano, T | 1 |
| Minenko, A | 1 |
| Gabrysiak, B | 1 |
| Oehme, P | 1 |
| Resink, TJ | 1 |
| Scott-Burden, T | 1 |
| Baur, U | 1 |
| Bühler, FR | 1 |
| Buck, SH | 1 |
| Nabika, T | 1 |
| Lovenberg, W | 1 |
| Heagerty, AM | 1 |
| Ollerenshaw, JD | 1 |
| Swales, JD | 1 |
| Ortega Mata, R | 1 |
| Guglielmi, G | 1 |
| Barlattani, M | 1 |
| Wardemann, H | 1 |
| Hesseling, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Inositols on Insulin Resistance in Children With Obesity (ONIRICO Trial)[NCT05701813] | 56 participants (Anticipated) | Interventional | 2023-02-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for inositol and Blood Pressure, High
| Article | Year |
|---|---|
The effect of inositol supplementation on blood pressure: A systematic review and meta-analysis of randomized-controlled trials.
Topics: Blood Pressure; Dietary Supplements; Humans; Hypertension; Inositol; Randomized Controlled Trials as | 2021 |
[Pharmacological treatment of postprandial hyperglycemia in hypertensive patients with type 2 diabetes mellitus].
Topics: Acarbose; Cyclohexanes; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 2; Enzyme | 2003 |
5 trials available for inositol and Blood Pressure, High
| Article | Year |
|---|---|
Comparison between effects of myo-inositol and D-chiro-inositol on ovarian function and metabolic factors in women with PCOS.
Topics: Adolescent; Adult; Amenorrhea; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follicl | 2014 |
[Long-term antihypertensive therapy with Etozoline].
Topics: Adult; Drug Evaluation; Female; Humans; Hypertension; Inositol; Male; Mefruside; Middle Aged; Reserp | 1980 |
[Antihypertensive combination-therapy with inositol nicotinate in essential hypertension].
Topics: Adult; Aged; Blood Pressure; Cholesterol; Clinical Trials as Topic; Drug Therapy, Combination; Femal | 1977 |
[Mild and medium severe hypertension. Treatment of mild and medium severe hypertension with bendigon mite].
Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Drug Combinations; Drug Evaluation; Female; Humans | 1979 |
[Dose-effect comparison of antihypertensive combinations with and without alpha-methyldopa].
Topics: Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Dose-Response Relationship, | 1975 |
27 other studies available for inositol and Blood Pressure, High
| Article | Year |
|---|---|
Mediterranean G6PD variant rats are protected from Angiotensin II-induced hypertension and kidney damage, but not from inflammation and arterial stiffness.
Topics: Actins; Angiotensin II; Animals; Glucosephosphate Dehydrogenase Deficiency; Humans; Hypertension; In | 2022 |
Maternal Supplementation of Inositols, Fucoxanthin, and Hydroxytyrosol in Pregnant Murine Models of Hypertension.
Topics: Animals; Antioxidants; Dietary Supplements; Disease Models, Animal; Drug Evaluation, Preclinical; Dr | 2020 |
Vascular and metabolic profiles in offspring born to pregnant mice with metabolic syndrome treated with inositols.
Topics: Animals; Biomarkers; Drug Administration Schedule; Female; Hypertension; Inositol; Male; Metabolic S | 2019 |
Renal depletion of myo-inositol is associated with its increased degradation in animal models of metabolic disease.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Hypertension; Inositol; Inositol O | 2015 |
Proton magnetic resonance spectroscopy reveals similar white matter biochemical changes in patients with chronic hypertension and early Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Choline; Chronic Disease; Creatine | 2002 |
The use of hexa-nitro-mesoinositol in renal hypertension.
Topics: Hexosaminidase A; Hypertension; Hypertension, Renal; Inositol | 1952 |
[Nitroadenol therapy of arterial hypertension and especially of hypertensive myocardiosclerosis].
Topics: Adenosine Triphosphate; Cardiomyopathies; Disease; Heart Diseases; Humans; Hypertension; Inositol; M | 1954 |
Inositol and mannitol hexanitrates in hypertension management.
Topics: Disease Management; Hypertension; Inositol; Mannitol; Nitrites | 1955 |
[INDIRECT FIBRINOLYTIC AND ANTICOAGULANT TREATMENT OF THROMBOSIS].
Topics: Anticoagulants; Arteriosclerosis Obliterans; Arteritis; Coronary Disease; Diabetic Angiopathies; Eth | 1964 |
[Clinical and experimental research on hexanitromesoinositol in arterial hypertension and vascular spasm].
Topics: Blood Pressure; Blood Pressure Determination; Humans; Hypertension; Inositol; Spasm; Vascular Diseas | 1950 |
[Nicotinic hexaester of m-inositol (esantene), new synthetic hypotensive drug with prolonged action].
Topics: Blood Pressure; Humans; Hypertension; Hypotension; Inositol | 1951 |
[Arterial hypertension; treatment with a new nitroderivative compound].
Topics: Humans; Hypertension; Inositol | 1951 |
[Arterial hypertension; treatment with a new nitroderivative preparation].
Topics: Hypertension; Inositol | 1951 |
[Effect of nicotinic hexa-ester of m-inosite (Exantene) in menopausal hypertension].
Topics: Climacteric; Female; Hexosaminidase A; Humans; Hypertension; Inositol; Menopause; Niacin; Nicotinic | 1952 |
Myo-inositol, glucose and zinc concentrations determined in the preconceptional period, during and after pregnancy.
Topics: Adult; Blood Glucose; Erythrocytes; Female; Humans; Hypertension; Inositol; Linear Models; Longitudi | 2006 |
Diffusion tensor imaging and MR spectroscopy in hypertension and presumed cerebral small vessel disease.
Topics: Aged; Aspartic Acid; Brain Diseases; Brain Ischemia; Case-Control Studies; Cerebrovascular Circulati | 2008 |
Dexamethasone-induced inhibition of prostaglandin production dose not result from a direct action on phospholipase activities but is mediated through a steroid-inducible factor.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Dexamethasone; Hypertension; Inositol | 1982 |
[Clinical experimentation with tensid (apropos of 60 cases)].
Topics: Adult; Aged; Diuretics; Drug Combinations; Drug Evaluation; Female; Humans; Hypertension; Inositol; | 1976 |
[Risk factors of developing diabetic complications].
Topics: Animals; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetic Retinopathy; Female; Glycoprotei | 1991 |
Decreased SP-stimulated diesteratic hydrolysis of inositol phospholipids in adrenal medulla slices from spontaneously hypertensive rats.
Topics: Adrenal Medulla; Animals; Hydrolysis; Hypertension; Inositol; Male; Phosphates; Phosphatidic Acids; | 1988 |
Increased proliferation fate and phosphoinositide turnover in cultured smooth muscle cells from spontaneously hypertensive rats.
Topics: Animals; Cell Division; Cells, Cultured; Hypertension; Inositol; Inositol Phosphates; Male; Muscle, | 1987 |
Mn++-stimulated 3H-inositol incorporation in cultured vascular smooth muscle cells: deficiency in cells from spontaneously hypertensive rats.
Topics: Animals; Cells, Cultured; Hypertension; Inositol; Manganese; Muscle, Smooth, Vascular; Phosphatidyli | 1985 |
Abnormal vascular phosphoinositide hydrolysis in the spontaneously hypertensive rat.
Topics: Aging; Animals; Hydrolysis; Hypertension; Inositol; Male; Muscle, Smooth, Vascular; Phosphatidylinos | 1986 |
[Treatment of arterial hypertension with a new preparation, Bay Mc 4540 (Bendigon)].
Topics: Adult; Aged; Diuretics; Drug Combinations; Female; Furans; Humans; Hypertension; Inositol; Male; Mid | 1973 |
[Clinico-therapeutic controls of the antihypertensive drugs and compounds effective on the regulation of the regional circulation].
Topics: Aged; Antihypertensive Agents; Blood Circulation; Blood Pressure; Female; Humans; Hypertension; Inos | 1971 |
[Clinical studies with a new antihypertensive agent, Bendigon].
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Diuretics; Drug Combinations; Drug Synergism; | 1970 |
[Clinical tests with a new antihypertensive combination (Bendigon)].
Topics: Adult; Aged; Antihypertensive Agents; Diuretics; Drug Combinations; Drug Synergism; Evaluation Studi | 1970 |