inositol has been researched along with Autoimmune Diabetes in 30 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To improve insulin sensitivity, insulin-sensitizing drugs such as metformin are commonly used in overweight and obese T1D patients." | 9.24 | A pilot study of D-chiro-inositol plus folic acid in overweight patients with type 1 diabetes. ( Defeudis, G; Del Toro, R; Fioriti, E; Guglielmi, C; Kyanvash, S; Maggi, D; Manfrini, S; Maurizi, AR; Menduni, M; Pantano, AL; Pozzilli, P, 2017) |
| "Authors would like to demonstrate the beneficial effect of myo-inositol supplementation in a pregnant woman with insulin-dependent type 2 diabetes mellitus and polycystic ovary syndrome." | 7.85 | [The myo-inositol is beneficial in the therapy of pregnancy with insulin-dependent type 2 diabetes and polycystic ovary syndrome]. ( Kun, A; Tornóczky, J, 2017) |
| "To improve insulin sensitivity, insulin-sensitizing drugs such as metformin are commonly used in overweight and obese T1D patients." | 5.24 | A pilot study of D-chiro-inositol plus folic acid in overweight patients with type 1 diabetes. ( Defeudis, G; Del Toro, R; Fioriti, E; Guglielmi, C; Kyanvash, S; Maggi, D; Manfrini, S; Maurizi, AR; Menduni, M; Pantano, AL; Pozzilli, P, 2017) |
| "Authors would like to demonstrate the beneficial effect of myo-inositol supplementation in a pregnant woman with insulin-dependent type 2 diabetes mellitus and polycystic ovary syndrome." | 3.85 | [The myo-inositol is beneficial in the therapy of pregnancy with insulin-dependent type 2 diabetes and polycystic ovary syndrome]. ( Kun, A; Tornóczky, J, 2017) |
| "Nocturnal hypoglycemia is one of the serious complications of intensive insulin therapy in patients with insulin-dependent diabetes mellitus (IDDM; type 1 DM)." | 2.69 | Voglibose administration before the evening meal improves nocturnal hypoglycemia in insulin-dependent diabetic patients with intensive insulin therapy. ( Komiya, I; Taira, M; Taira, T; Takasu, N; Tanaka, H, 2000) |
| "Sorbinil treatment reduced the elevated sorbitol levels in the diabetic patients to normal or slightly below normal, but did not affect the erythrocyte myo-inositol concentration." | 2.65 | myo-Inositol and sorbitol in erythrocytes from diabetic patients before and after sorbinil treatment. ( Lomecky-Janousek, MZ; Popp-Snijders, C; Schouten, JA; van der Veen, EA, 1984) |
| "The brain metabolites of 17 men with type 1 diabetes and 12 age-matched non-diabetic men (22-43 years old) were studied after an overnight fast (plasma glucose 9." | 1.35 | Hyperglycaemia is associated with changes in the regional concentrations of glucose and myo-inositol within the brain. ( Groop, PH; Heikkilä, O; Heikkinen, S; Lundbom, N; Mäkimattila, S; Timonen, M, 2009) |
| "Myo-inositol was even more elevated in patients with polyneuropathy (p = 0." | 1.32 | Alterations of cerebral metabolism in patients with diabetes mellitus studied by proton magnetic resonance spectroscopy. ( Feuerbach, S; Fründ, R; Geissler, A; Schölmerich, J; Zietz, B, 2003) |
| "Several autoantibodies related to Type 1 diabetes mellitus and their corresponding autoantigens have been previously identified." | 1.30 | Sera from children with type 1 diabetes mellitus react against a new group of antigens composed of lysophospholipids. ( Bleich, D; Chen, S; Lévy-Marchal, C; Polak, M; Swiderek, KM, 1999) |
| "Myoinositol influx was significantly but negatively correlated with the serum very low density lipoprotein (VLDL) cholesterol concentration in patients with and without neuropathy but not in the controls." | 1.29 | Relationship between myoinositol influx and lipids in diabetic neuropathy. ( Bomford, J; Ng, LL; Simmons, D, 1993) |
| "Erythromelalgia is a syndrome characterized by erythema, burning pain and increased skin temperature of the affected extremities." | 1.27 | Erythromelalgia associated with acute diabetic neuropathy: an unusual condition. ( Bosch, X; Esmatjes, E; Goday, A; Gomis, R; Nubiola, A; Vendrell, J; Vilardell, E, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (23.33) | 18.7374 |
| 1990's | 11 (36.67) | 18.2507 |
| 2000's | 9 (30.00) | 29.6817 |
| 2010's | 3 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kun, A | 1 |
| Tornóczky, J | 1 |
| Zhang, H | 1 |
| Huang, M | 1 |
| Gao, L | 1 |
| Lei, H | 1 |
| Maurizi, AR | 1 |
| Menduni, M | 1 |
| Del Toro, R | 1 |
| Kyanvash, S | 1 |
| Maggi, D | 1 |
| Guglielmi, C | 1 |
| Pantano, AL | 1 |
| Defeudis, G | 1 |
| Fioriti, E | 1 |
| Manfrini, S | 1 |
| Pozzilli, P | 1 |
| Heikkilä, O | 1 |
| Lundbom, N | 1 |
| Timonen, M | 1 |
| Groop, PH | 1 |
| Heikkinen, S | 1 |
| Mäkimattila, S | 1 |
| Watanabe, K | 1 |
| Kawamori, R | 1 |
| Geissler, A | 1 |
| Fründ, R | 1 |
| Schölmerich, J | 1 |
| Feuerbach, S | 1 |
| Zietz, B | 1 |
| Jung, TS | 1 |
| Hahm, JR | 1 |
| Kim, JJ | 1 |
| Jung, JH | 1 |
| Kang, MY | 1 |
| Moon, SW | 1 |
| Lee, KW | 1 |
| Kim, HC | 1 |
| Lee, JD | 1 |
| Kim, JH | 1 |
| Kim, DR | 1 |
| Chung, SI | 1 |
| Rankins, D | 1 |
| Wellard, RM | 1 |
| Cameron, F | 1 |
| McDonnell, C | 1 |
| Northam, E | 1 |
| Kawashima, S | 1 |
| Kaneto, H | 1 |
| Sakamoto, K | 1 |
| Yasuda, T | 1 |
| Kuroda, A | 1 |
| Shiraiwa, T | 1 |
| Yamamoto, K | 1 |
| Kasami, R | 1 |
| Matsuoka, TA | 1 |
| Yamasaki, Y | 1 |
| Matsuhisa, M | 1 |
| Merimee, TJ | 1 |
| Misbin, RI | 1 |
| Gold, L | 1 |
| Greene, DA | 2 |
| Varma, SD | 1 |
| Richards, RD | 1 |
| Popp-Snijders, C | 1 |
| Lomecky-Janousek, MZ | 1 |
| Schouten, JA | 1 |
| van der Veen, EA | 1 |
| Dyck, PJ | 1 |
| Sherman, WR | 2 |
| Hallcher, LM | 1 |
| Service, FJ | 1 |
| O'Brien, PC | 1 |
| Grina, LA | 1 |
| Palumbo, PJ | 1 |
| Swanson, CJ | 1 |
| Dayhaw-Barker, P | 1 |
| Hacibekiroğlu, M | 1 |
| Akçay, T | 1 |
| Simmons, D | 2 |
| Ng, LL | 2 |
| Bomford, J | 2 |
| Ostlund, RE | 1 |
| McGill, JB | 1 |
| Herskowitz, I | 1 |
| Kipnis, DM | 1 |
| Santiago, JV | 1 |
| Larner, J | 2 |
| Craig, JW | 1 |
| Bleich, D | 1 |
| Polak, M | 1 |
| Chen, S | 1 |
| Swiderek, KM | 1 |
| Lévy-Marchal, C | 1 |
| Taira, M | 1 |
| Takasu, N | 1 |
| Komiya, I | 1 |
| Taira, T | 1 |
| Tanaka, H | 1 |
| Sundkvist, G | 1 |
| Dahlin, LB | 1 |
| Nilsson, H | 1 |
| Eriksson, KF | 1 |
| Lindgärde, F | 1 |
| Rosén, I | 1 |
| Lattimer, SA | 1 |
| Sima, AA | 2 |
| Sullivan, K | 1 |
| Chakrabarti, S | 1 |
| Hotta, N | 1 |
| Sano, T | 1 |
| Moller, DE | 1 |
| Moses, AC | 1 |
| Loy, A | 1 |
| Lurie, KG | 1 |
| Ghosh, A | 1 |
| Wilson, JM | 1 |
| MacGregor, LC | 1 |
| Matschinsky, FM | 1 |
| Airey, CM | 1 |
| Price, DE | 1 |
| Kemp, JV | 1 |
| Perkins, CM | 1 |
| Wales, JK | 1 |
| Vendrell, J | 1 |
| Nubiola, A | 1 |
| Goday, A | 1 |
| Bosch, X | 1 |
| Esmatjes, E | 1 |
| Gomis, R | 1 |
| Vilardell, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study of D-Chiro-Inositol Plus Folic Acid in Overweight Patients With Type 1 Diabetes[NCT02730949] | Phase 3 | 26 participants (Actual) | Interventional | 2014-03-31 | Completed | ||
| Effects of a Supplementation With Zinc and Myo-inositol in Paediatric Obesity[NCT03283813] | Phase 4 | 60 participants (Anticipated) | Interventional | 2018-02-05 | Recruiting | ||
| [NCT01514942] | Phase 4 | 0 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for inositol and Autoimmune Diabetes
| Article | Year |
|---|---|
[Combination therapy with insulin and alpha-glucosidase inhibitor].
Topics: Acarbose; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Drug Thera | 2002 |
Mechanisms of pathogenesis in diabetes mellitus.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Histocompatibilit | 1995 |
4 trials available for inositol and Autoimmune Diabetes
| Article | Year |
|---|---|
A pilot study of D-chiro-inositol plus folic acid in overweight patients with type 1 diabetes.
Topics: Adolescent; Adult; Blood Glucose; Diabetes Mellitus, Type 1; Female; Folic Acid; Humans; Inositol; I | 2017 |
myo-Inositol and sorbitol in erythrocytes from diabetic patients before and after sorbinil treatment.
Topics: Adult; Aldehyde Reductase; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabetes Mellitus, T | 1984 |
Voglibose administration before the evening meal improves nocturnal hypoglycemia in insulin-dependent diabetic patients with intensive insulin therapy.
Topics: Adolescent; Adult; Aged; Blood Glucose; Circadian Rhythm; Diabetes Mellitus, Type 1; Drug Administra | 2000 |
The effect of aldose reductase inhibition on erythrocyte polyols and galactitol accumulation in diabetic patients.
Topics: Aldehyde Reductase; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, | 1989 |
24 other studies available for inositol and Autoimmune Diabetes
| Article | Year |
|---|---|
[The myo-inositol is beneficial in the therapy of pregnancy with insulin-dependent type 2 diabetes and polycystic ovary syndrome].
Topics: Adult; Diabetes Mellitus, Type 1; Female; Humans; Infant, Newborn; Inositol; Polycystic Ovary Syndro | 2017 |
Region-specific cerebral metabolic alterations in streptozotocin-induced type 1 diabetic rats: an in vivo proton magnetic resonance spectroscopy study.
Topics: Animals; Aspartic Acid; Blood Glucose; Brain Chemistry; Corpus Striatum; Diabetes Mellitus, Experime | 2015 |
Hyperglycaemia is associated with changes in the regional concentrations of glucose and myo-inositol within the brain.
Topics: Adult; Blood Glucose; Blood Pressure; Body Mass Index; Brain; C-Reactive Protein; Cholesterol, HDL; | 2009 |
Alterations of cerebral metabolism in patients with diabetes mellitus studied by proton magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Blood Glucose; Brain; Chlorides; Choline; Creatinine; Diabetes Mellitus, Type | 2003 |
Determination of urinary Myo-/chiro-inositol ratios from Korean diabetes patients.
Topics: Adult; Aged; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Inositol; Insulin | 2005 |
The impact of acute hypoglycemia on neuropsychological and neurometabolite profiles in children with type 1 diabetes.
Topics: Acute Disease; Aspartic Acid; Attention; Blood Glucose; Child; Diabetes Mellitus, Type 1; Female; Fo | 2005 |
Acute progression of severe insulin edema accompanied by pericardial and pleural effusion in a patient with type 2 diabetes.
Topics: Administration, Oral; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Disease Progression; Ede | 2008 |
Elevated L-xylulose concentrations in serum: a difference between type I and type II diabetes.
Topics: Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glucuronates; Glucuronic Acid; | 1984 |
Metabolic abnormalities in diabetic peripheral nerve: relation to impaired function.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Energy Metabolism; Female; Gluc | 1983 |
Etiology of cataracts in diabetics.
Topics: Adolescent; Adult; Aldehyde Reductase; Animals; Blood Glucose; Cataract; Child; Child, Preschool; Di | 1984 |
Human diabetic endoneurial sorbitol, fructose, and myo-inositol related to sural nerve morphometry.
Topics: Diabetes Mellitus, Type 1; Diabetic Neuropathies; Fructose; Humans; Inositol; Middle Aged; Periphera | 1980 |
The role of plasma, erythrocyte and platelet myo-inositol levels in the development of diabetic microangiopathy.
Topics: Adult; Blood Platelets; Creatinine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic A | 1994 |
Relationship between myoinositol influx and lipids in diabetic neuropathy.
Topics: Blood Glucose; Blood Pressure; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; D | 1993 |
D-chiro-inositol metabolism in diabetes mellitus.
Topics: Adult; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gas Chromatography-M | 1993 |
Urinary myo-inositol-to-chiro-inositol ratios and insulin resistance.
Topics: Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gas Chromatography-Mass Spectrometry; Humans; | 1996 |
Sera from children with type 1 diabetes mellitus react against a new group of antigens composed of lysophospholipids.
Topics: Autoantibodies; Child; Diabetes Mellitus, Type 1; Female; Gas Chromatography-Mass Spectrometry; Huma | 1999 |
Sorbitol and myo-inositol levels and morphology of sural nerve in relation to peripheral nerve function and clinical neuropathy in men with diabetic, impaired, and normal glucose tolerance.
Topics: Diabetes Mellitus, Type 1; Diabetic Neuropathies; Glucose Intolerance; Glucose Tolerance Test; Human | 2000 |
D-chiro-inositol--its functional role in insulin action and its deficit in insulin resistance.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 1; Glycogen Synthase; Inositol; Insulin; Insulin Res | 2002 |
D-chiro-inositol--its functional role in insulin action and its deficit in insulin resistance.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 1; Glycogen Synthase; Inositol; Insulin; Insulin Res | 2002 |
D-chiro-inositol--its functional role in insulin action and its deficit in insulin resistance.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 1; Glycogen Synthase; Inositol; Insulin; Insulin Res | 2002 |
D-chiro-inositol--its functional role in insulin action and its deficit in insulin resistance.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 1; Glycogen Synthase; Inositol; Insulin; Insulin Res | 2002 |
The effect of myo-inositol treatment on basement membrane thickening in the BB/W-rat retina.
Topics: Animals; Basement Membrane; Blood Glucose; Capillaries; Diabetes Mellitus, Type 1; Diabetic Angiopat | 1992 |
Abnormal myoinositol influx in human leucocytes in diabetes but not specifically in diabetic neuropathy.
Topics: Biological Transport; Blood Glucose; Blood Pressure; Carbon Radioisotopes; Diabetes Mellitus, Type 1 | 1992 |
[Risk factors of developing diabetic complications].
Topics: Animals; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetic Retinopathy; Female; Glycoprotei | 1991 |
Advances in the diagnosis and pathogenesis of diabetes mellitus and its complications.
Topics: Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Dia | 1990 |
Diabetes and the myo-inositol paradox.
Topics: Animals; Aqueous Humor; Blood Glucose; Cornea; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 1990 |
Erythromelalgia associated with acute diabetic neuropathy: an unusual condition.
Topics: Acute Disease; Adult; Carbamazepine; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Erythromelalg | 1988 |