inositol has been researched along with Astrocytoma in 15 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inositol uptake was measured at concentrations of 25, 40 and 50 microM in human astrocytoma cell cultures treated for 1-3 weeks with pharmacologically relevant concentrations of LiCl, valproic acid or carbamazepine as well as in control cultures that had not been treated with any drug." | 7.70 | Chronic treatment of human astrocytoma cells with lithium, carbamazepine or valproic acid decreases inositol uptake at high inositol concentrations but increases it at low inositol concentrations. ( Belmaker, RH; Bersudsky, Y; Hertz, L; Simkin, M; Wolfson, M; Zinger, E, 2000) |
| "The coupling of muscarinic receptor-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis by phospholipase C to resynthesis of phosphatidylinositol (PtdIns) and the ability of Li+ to inhibit this after cellular inositol depletion were studied in 1321N1 astrocytoma cells cultured in medium +/- inositol (40 microM)." | 7.69 | The mechanism of muscarinic receptor-stimulated phosphatidylinositol resynthesis in 1321N1 astrocytoma cells and its inhibition by Li+. ( Batty, IH; Downes, CP, 1995) |
| "The uptake of inositol into 1321N1 astrocytoma cells was studied by measurement of the accumulation of free [3H]inositol within the intracellular pool." | 7.68 | The characteristics, capacity and receptor regulation of inositol uptake in 1321N1 astrocytoma cells. ( Batty, IH; Downes, CP; Fennel, M; Michie, A, 1993) |
| "In an inositol-depleted 1321 N1 astrocytoma cell line, propranolol at 0." | 7.68 | Subcellular distribution of agonist-stimulated phosphatidylinositol synthesis in 1321 N1 astrocytoma cells. ( Downes, CP; Sillence, DJ, 1993) |
| "The compartmentation of inositol phospholipids was examined by using a combination of radiolabelling approaches in intact and permeabilized 1321N1 astrocytoma cells." | 3.70 | Evidence for a model of integrated inositol phospholipid pools implies an essential role for lipid transport in the maintenance of receptor-mediated phospholipase C activity in 1321N1 cells. ( Batty, IH; Currie, RA; Downes, CP, 1998) |
| "Inositol uptake was measured at concentrations of 25, 40 and 50 microM in human astrocytoma cell cultures treated for 1-3 weeks with pharmacologically relevant concentrations of LiCl, valproic acid or carbamazepine as well as in control cultures that had not been treated with any drug." | 3.70 | Chronic treatment of human astrocytoma cells with lithium, carbamazepine or valproic acid decreases inositol uptake at high inositol concentrations but increases it at low inositol concentrations. ( Belmaker, RH; Bersudsky, Y; Hertz, L; Simkin, M; Wolfson, M; Zinger, E, 2000) |
| "The coupling of muscarinic receptor-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis by phospholipase C to resynthesis of phosphatidylinositol (PtdIns) and the ability of Li+ to inhibit this after cellular inositol depletion were studied in 1321N1 astrocytoma cells cultured in medium +/- inositol (40 microM)." | 3.69 | The mechanism of muscarinic receptor-stimulated phosphatidylinositol resynthesis in 1321N1 astrocytoma cells and its inhibition by Li+. ( Batty, IH; Downes, CP, 1995) |
| "The uptake of inositol into 1321N1 astrocytoma cells was studied by measurement of the accumulation of free [3H]inositol within the intracellular pool." | 3.68 | The characteristics, capacity and receptor regulation of inositol uptake in 1321N1 astrocytoma cells. ( Batty, IH; Downes, CP; Fennel, M; Michie, A, 1993) |
| "In an inositol-depleted 1321 N1 astrocytoma cell line, propranolol at 0." | 3.68 | Subcellular distribution of agonist-stimulated phosphatidylinositol synthesis in 1321 N1 astrocytoma cells. ( Downes, CP; Sillence, DJ, 1993) |
| "myo-Inositol plays a key role in signal transduction and osmotic regulation events in the CNS." | 1.30 | Differentiated human NT2-N neurons possess a high intracellular content of myo-inositol. ( Agranoff, BW; Fisher, SK; Novak, JE; Turner, RS, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 8 (53.33) | 18.2507 |
| 2000's | 6 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Murphy, M | 2 |
| Loosemore, A | 1 |
| Clifton, AG | 1 |
| Howe, FA | 2 |
| Tate, AR | 1 |
| Cudlip, SA | 2 |
| Wilkins, PR | 1 |
| Griffiths, JR | 2 |
| Bell, BA | 2 |
| Barton, SJ | 1 |
| Stubbs, M | 1 |
| Saunders, DE | 1 |
| Wilkins, P | 1 |
| Opstad, KS | 1 |
| Doyle, VL | 1 |
| McLean, MA | 1 |
| Bowen, BC | 1 |
| Londoño, A | 1 |
| Castillo, M | 2 |
| Armao, D | 1 |
| Kwock, L | 2 |
| Suzuki, K | 1 |
| Hagberg, G | 1 |
| Burlina, AP | 1 |
| Mader, I | 1 |
| Roser, W | 1 |
| Radue, EW | 1 |
| Seelig, J | 1 |
| Batty, IH | 3 |
| Downes, CP | 4 |
| Heuillet, E | 1 |
| Ménager, J | 1 |
| Fardin, V | 1 |
| Flamand, O | 1 |
| Bock, M | 1 |
| Garret, C | 1 |
| Crespo, A | 1 |
| Fallourd, AM | 1 |
| Doble, A | 1 |
| Michie, A | 1 |
| Fennel, M | 1 |
| Sillence, DJ | 1 |
| Currie, RA | 1 |
| Novak, JE | 1 |
| Turner, RS | 1 |
| Agranoff, BW | 1 |
| Fisher, SK | 1 |
| Wolfson, M | 1 |
| Bersudsky, Y | 1 |
| Zinger, E | 1 |
| Simkin, M | 1 |
| Belmaker, RH | 1 |
| Hertz, L | 1 |
| Smith, JK | 1 |
| Nakahata, N | 1 |
| Abe, MT | 1 |
| Nakanishi, H | 1 |
| Masters, SB | 1 |
| Quinn, MT | 1 |
| Brown, JH | 1 |
15 other studies available for inositol and Astrocytoma
| Article | Year |
|---|---|
The contribution of proton magnetic resonance spectroscopy (1HMRS) to clinical brain tumour diagnosis.
Topics: Adolescent; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatinine; Humans; Inositol; Magn | 2002 |
Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy.
Topics: Alanine; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Glioblastoma; Humans; Inosi | 2003 |
Glial neoplasms without elevated choline-creatine ratios.
Topics: Astrocytoma; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Humans; I | 2003 |
Unusual MR spectroscopic imaging pattern of an astrocytoma: lack of elevated choline and high myo-inositol and glycine levels.
Topics: Adult; Astrocytoma; Brain Neoplasms; Choline; Glycine; Humans; Inositol; Magnetic Resonance Spectros | 2003 |
In vivo proton MR spectroscopy of human gliomas: definition of metabolic coordinates for multi-dimensional classification.
Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Cluster Analysis; Creatine; Discriminan | 1995 |
The mechanism of muscarinic receptor-stimulated phosphatidylinositol resynthesis in 1321N1 astrocytoma cells and its inhibition by Li+.
Topics: Astrocytoma; CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase; Enzyme Activation; Inositol; Lit | 1995 |
Characterization of a human NK1 tachykinin receptor in the astrocytoma cell line U 373 MG.
Topics: Astrocytoma; Binding Sites; Humans; Inositol; Inositol Phosphates; Receptors, Neurokinin-2; Receptor | 1993 |
The characteristics, capacity and receptor regulation of inositol uptake in 1321N1 astrocytoma cells.
Topics: Astrocytoma; Carrier Proteins; Inositol; Kinetics; Receptors, Cell Surface; Receptors, Muscarinic; S | 1993 |
Subcellular distribution of agonist-stimulated phosphatidylinositol synthesis in 1321 N1 astrocytoma cells.
Topics: Astrocytoma; Carbachol; Humans; Inositol; Lithium; Phosphatidylinositols; Propranolol; Tumor Cells, | 1993 |
Evidence for a model of integrated inositol phospholipid pools implies an essential role for lipid transport in the maintenance of receptor-mediated phospholipase C activity in 1321N1 cells.
Topics: Astrocytoma; Carbachol; Cell Compartmentation; Cell Membrane Permeability; Cytosol; Guanosine 5'-O-( | 1998 |
Differentiated human NT2-N neurons possess a high intracellular content of myo-inositol.
Topics: Antineoplastic Agents; Astrocytoma; Biological Transport; Cell Differentiation; Cells, Cultured; Hum | 1999 |
Chronic treatment of human astrocytoma cells with lithium, carbamazepine or valproic acid decreases inositol uptake at high inositol concentrations but increases it at low inositol concentrations.
Topics: Antimanic Agents; Astrocytoma; Bipolar Disorder; Brain; Brain Neoplasms; Carbamazepine; Dose-Respons | 2000 |
Correlation of myo-inositol levels and grading of cerebral astrocytomas.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Child; Chil | 2000 |
PGJ2 and delta 12PGJ2 inhibit cell growth accompanied with inhibition of phosphoinositide turnover in human astrocytoma cells.
Topics: Astrocytoma; Carbachol; Cell Division; Cyclic AMP; DNA; GTP-Binding Proteins; Histamine; Humans; Ino | 1990 |
Agonist-induced desensitization of muscarinic receptor-mediated calcium efflux without concomitant desensitization of phosphoinositide hydrolysis.
Topics: Astrocytoma; Calcium; Carbachol; Cell Line; Chromatography, Ion Exchange; Humans; Hydrolysis; Inosit | 1985 |