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inositol and Astrocytoma

inositol has been researched along with Astrocytoma in 15 studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)

Research Excerpts

ExcerptRelevanceReference
"Inositol uptake was measured at concentrations of 25, 40 and 50 microM in human astrocytoma cell cultures treated for 1-3 weeks with pharmacologically relevant concentrations of LiCl, valproic acid or carbamazepine as well as in control cultures that had not been treated with any drug."7.70Chronic treatment of human astrocytoma cells with lithium, carbamazepine or valproic acid decreases inositol uptake at high inositol concentrations but increases it at low inositol concentrations. ( Belmaker, RH; Bersudsky, Y; Hertz, L; Simkin, M; Wolfson, M; Zinger, E, 2000)
"The coupling of muscarinic receptor-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis by phospholipase C to resynthesis of phosphatidylinositol (PtdIns) and the ability of Li+ to inhibit this after cellular inositol depletion were studied in 1321N1 astrocytoma cells cultured in medium +/- inositol (40 microM)."7.69The mechanism of muscarinic receptor-stimulated phosphatidylinositol resynthesis in 1321N1 astrocytoma cells and its inhibition by Li+. ( Batty, IH; Downes, CP, 1995)
"The uptake of inositol into 1321N1 astrocytoma cells was studied by measurement of the accumulation of free [3H]inositol within the intracellular pool."7.68The characteristics, capacity and receptor regulation of inositol uptake in 1321N1 astrocytoma cells. ( Batty, IH; Downes, CP; Fennel, M; Michie, A, 1993)
"In an inositol-depleted 1321 N1 astrocytoma cell line, propranolol at 0."7.68Subcellular distribution of agonist-stimulated phosphatidylinositol synthesis in 1321 N1 astrocytoma cells. ( Downes, CP; Sillence, DJ, 1993)
"The compartmentation of inositol phospholipids was examined by using a combination of radiolabelling approaches in intact and permeabilized 1321N1 astrocytoma cells."3.70Evidence for a model of integrated inositol phospholipid pools implies an essential role for lipid transport in the maintenance of receptor-mediated phospholipase C activity in 1321N1 cells. ( Batty, IH; Currie, RA; Downes, CP, 1998)
"Inositol uptake was measured at concentrations of 25, 40 and 50 microM in human astrocytoma cell cultures treated for 1-3 weeks with pharmacologically relevant concentrations of LiCl, valproic acid or carbamazepine as well as in control cultures that had not been treated with any drug."3.70Chronic treatment of human astrocytoma cells with lithium, carbamazepine or valproic acid decreases inositol uptake at high inositol concentrations but increases it at low inositol concentrations. ( Belmaker, RH; Bersudsky, Y; Hertz, L; Simkin, M; Wolfson, M; Zinger, E, 2000)
"The coupling of muscarinic receptor-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis by phospholipase C to resynthesis of phosphatidylinositol (PtdIns) and the ability of Li+ to inhibit this after cellular inositol depletion were studied in 1321N1 astrocytoma cells cultured in medium +/- inositol (40 microM)."3.69The mechanism of muscarinic receptor-stimulated phosphatidylinositol resynthesis in 1321N1 astrocytoma cells and its inhibition by Li+. ( Batty, IH; Downes, CP, 1995)
"The uptake of inositol into 1321N1 astrocytoma cells was studied by measurement of the accumulation of free [3H]inositol within the intracellular pool."3.68The characteristics, capacity and receptor regulation of inositol uptake in 1321N1 astrocytoma cells. ( Batty, IH; Downes, CP; Fennel, M; Michie, A, 1993)
"In an inositol-depleted 1321 N1 astrocytoma cell line, propranolol at 0."3.68Subcellular distribution of agonist-stimulated phosphatidylinositol synthesis in 1321 N1 astrocytoma cells. ( Downes, CP; Sillence, DJ, 1993)
"myo-Inositol plays a key role in signal transduction and osmotic regulation events in the CNS."1.30Differentiated human NT2-N neurons possess a high intracellular content of myo-inositol. ( Agranoff, BW; Fisher, SK; Novak, JE; Turner, RS, 1999)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.67)18.7374
1990's8 (53.33)18.2507
2000's6 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Murphy, M2
Loosemore, A1
Clifton, AG1
Howe, FA2
Tate, AR1
Cudlip, SA2
Wilkins, PR1
Griffiths, JR2
Bell, BA2
Barton, SJ1
Stubbs, M1
Saunders, DE1
Wilkins, P1
Opstad, KS1
Doyle, VL1
McLean, MA1
Bowen, BC1
Londoño, A1
Castillo, M2
Armao, D1
Kwock, L2
Suzuki, K1
Hagberg, G1
Burlina, AP1
Mader, I1
Roser, W1
Radue, EW1
Seelig, J1
Batty, IH3
Downes, CP4
Heuillet, E1
Ménager, J1
Fardin, V1
Flamand, O1
Bock, M1
Garret, C1
Crespo, A1
Fallourd, AM1
Doble, A1
Michie, A1
Fennel, M1
Sillence, DJ1
Currie, RA1
Novak, JE1
Turner, RS1
Agranoff, BW1
Fisher, SK1
Wolfson, M1
Bersudsky, Y1
Zinger, E1
Simkin, M1
Belmaker, RH1
Hertz, L1
Smith, JK1
Nakahata, N1
Abe, MT1
Nakanishi, H1
Masters, SB1
Quinn, MT1
Brown, JH1

Other Studies

15 other studies available for inositol and Astrocytoma

ArticleYear
The contribution of proton magnetic resonance spectroscopy (1HMRS) to clinical brain tumour diagnosis.
    British journal of neurosurgery, 2002, Volume: 16, Issue:4

    Topics: Adolescent; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatinine; Humans; Inositol; Magn

2002
Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy.
    Magnetic resonance in medicine, 2003, Volume: 49, Issue:2

    Topics: Alanine; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Glioblastoma; Humans; Inosi

2003
Glial neoplasms without elevated choline-creatine ratios.
    AJNR. American journal of neuroradiology, 2003, Volume: 24, Issue:5

    Topics: Astrocytoma; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Humans; I

2003
Unusual MR spectroscopic imaging pattern of an astrocytoma: lack of elevated choline and high myo-inositol and glycine levels.
    AJNR. American journal of neuroradiology, 2003, Volume: 24, Issue:5

    Topics: Adult; Astrocytoma; Brain Neoplasms; Choline; Glycine; Humans; Inositol; Magnetic Resonance Spectros

2003
In vivo proton MR spectroscopy of human gliomas: definition of metabolic coordinates for multi-dimensional classification.
    Magnetic resonance in medicine, 1995, Volume: 34, Issue:2

    Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Cluster Analysis; Creatine; Discriminan

1995
The mechanism of muscarinic receptor-stimulated phosphatidylinositol resynthesis in 1321N1 astrocytoma cells and its inhibition by Li+.
    Journal of neurochemistry, 1995, Volume: 65, Issue:5

    Topics: Astrocytoma; CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase; Enzyme Activation; Inositol; Lit

1995
Characterization of a human NK1 tachykinin receptor in the astrocytoma cell line U 373 MG.
    Journal of neurochemistry, 1993, Volume: 60, Issue:3

    Topics: Astrocytoma; Binding Sites; Humans; Inositol; Inositol Phosphates; Receptors, Neurokinin-2; Receptor

1993
The characteristics, capacity and receptor regulation of inositol uptake in 1321N1 astrocytoma cells.
    The Biochemical journal, 1993, Aug-15, Volume: 294 ( Pt 1)

    Topics: Astrocytoma; Carrier Proteins; Inositol; Kinetics; Receptors, Cell Surface; Receptors, Muscarinic; S

1993
Subcellular distribution of agonist-stimulated phosphatidylinositol synthesis in 1321 N1 astrocytoma cells.
    The Biochemical journal, 1993, Mar-01, Volume: 290 ( Pt 2)

    Topics: Astrocytoma; Carbachol; Humans; Inositol; Lithium; Phosphatidylinositols; Propranolol; Tumor Cells,

1993
Evidence for a model of integrated inositol phospholipid pools implies an essential role for lipid transport in the maintenance of receptor-mediated phospholipase C activity in 1321N1 cells.
    The Biochemical journal, 1998, Mar-15, Volume: 330 ( Pt 3)

    Topics: Astrocytoma; Carbachol; Cell Compartmentation; Cell Membrane Permeability; Cytosol; Guanosine 5'-O-(

1998
Differentiated human NT2-N neurons possess a high intracellular content of myo-inositol.
    Journal of neurochemistry, 1999, Volume: 72, Issue:4

    Topics: Antineoplastic Agents; Astrocytoma; Biological Transport; Cell Differentiation; Cells, Cultured; Hum

1999
Chronic treatment of human astrocytoma cells with lithium, carbamazepine or valproic acid decreases inositol uptake at high inositol concentrations but increases it at low inositol concentrations.
    Brain research, 2000, Feb-07, Volume: 855, Issue:1

    Topics: Antimanic Agents; Astrocytoma; Bipolar Disorder; Brain; Brain Neoplasms; Carbamazepine; Dose-Respons

2000
Correlation of myo-inositol levels and grading of cerebral astrocytomas.
    AJNR. American journal of neuroradiology, 2000, Volume: 21, Issue:9

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Child; Chil

2000
PGJ2 and delta 12PGJ2 inhibit cell growth accompanied with inhibition of phosphoinositide turnover in human astrocytoma cells.
    Prostaglandins, 1990, Volume: 40, Issue:4

    Topics: Astrocytoma; Carbachol; Cell Division; Cyclic AMP; DNA; GTP-Binding Proteins; Histamine; Humans; Ino

1990
Agonist-induced desensitization of muscarinic receptor-mediated calcium efflux without concomitant desensitization of phosphoinositide hydrolysis.
    Molecular pharmacology, 1985, Volume: 27, Issue:3

    Topics: Astrocytoma; Calcium; Carbachol; Cell Line; Chromatography, Ion Exchange; Humans; Hydrolysis; Inosit

1985