inositol and Alloxan Diabetes studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Research Excerpts

Excerpt	Relevance	Reference
" The present experiment was designed to determine: 1) if hyperglycemia-induced membrane injury is associated with intracellular and/or extracellular lipid disturbances; 2) if supplemental myo-inositol therapy prevents hyperglycemia-induced embryopathy; 3) if a correlation exists between dietary myo-inositol, serum and tissue levels of myo-inositol, and conceptus development; and 4) the cellular content of arachidonic acid following myo-inositol supplementation."	7.70	Dietary myo-inositol therapy in hyperglycemia-induced embryopathy. ( Borenstein, M; Khandelwal, M; Reece, EA; Wu, YK, 1998)
" The current investigation was undertaken to assess the use of dietary myo-inositol supplementation as a pharmacologic prophylaxis to obviate the teratogenic effects of hyperglycemia in an in vivo study."	7.69	Dietary intake of myo-inositol and neural tube defects in offspring of diabetic rats. ( Borenstein, M; Khandelwal, M; Reece, EA; Wu, YK, 1997)
"The acute effects of administration of D-chiroinositol (D-CI), a component of a putative mediator of insulin action, on plasma glucose were examined in low dose streptozotocin-treated rats and normal rats given a glucose load and the effects on plasma glucose and insulin were determined in five obese rhesus monkeys with varying degrees of spontaneous insulin resistance."	7.68	Chiroinositol deficiency and insulin resistance. II. Acute effects of D-chiroinositol administration in streptozotocin-diabetic rats, normal rats given a glucose load, and spontaneously insulin-resistant rhesus monkeys. ( Hansen, BC; Huang, LC; Larner, J; Ortmeyer, HK; Zhang, L, 1993)
"The lens myo-inositol (MI) content is known to be depleted during initial cataractogenesis in both streptozocin (STZ)-induced diabetic and 50% galactose-maintained rats."	7.67	Dietary myo-inositol effect on sugar cataractogenesis. ( Beyer-Mears, A; Bucci, FA; Cruz, E; Del Val, M, 1989)
" Body weight, blood glucose, glycated haemoglobin, insulin, serum leptin, HOMA-insulin resistance scores, intestinal amylase activity, serum and faecal lipids and food and fluid consumption were measured."	3.83	The effect of combined inositol hexakisphosphate and inositol supplement in streptozotocin-induced type 2 diabetic rats. ( Bustamante, J; Dilworth, LL; Foster, SR; Lindo, RL; Omoruyi, FO, 2016)
"Peripheral hyperglycemia was associated with significant increases in brain sorbitol (7."	3.74	Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory. ( Chong, L; Diamond, DM; Hanna, S; Malone, JI; Mervis, RF; Park, CR; Saporta, S, 2008)
" The present experiment was designed to determine: 1) if hyperglycemia-induced membrane injury is associated with intracellular and/or extracellular lipid disturbances; 2) if supplemental myo-inositol therapy prevents hyperglycemia-induced embryopathy; 3) if a correlation exists between dietary myo-inositol, serum and tissue levels of myo-inositol, and conceptus development; and 4) the cellular content of arachidonic acid following myo-inositol supplementation."	3.70	Dietary myo-inositol therapy in hyperglycemia-induced embryopathy. ( Borenstein, M; Khandelwal, M; Reece, EA; Wu, YK, 1998)
" The current investigation was undertaken to assess the use of dietary myo-inositol supplementation as a pharmacologic prophylaxis to obviate the teratogenic effects of hyperglycemia in an in vivo study."	3.69	Dietary intake of myo-inositol and neural tube defects in offspring of diabetic rats. ( Borenstein, M; Khandelwal, M; Reece, EA; Wu, YK, 1997)
"The acute effects of administration of D-chiroinositol (D-CI), a component of a putative mediator of insulin action, on plasma glucose were examined in low dose streptozotocin-treated rats and normal rats given a glucose load and the effects on plasma glucose and insulin were determined in five obese rhesus monkeys with varying degrees of spontaneous insulin resistance."	3.68	Chiroinositol deficiency and insulin resistance. II. Acute effects of D-chiroinositol administration in streptozotocin-diabetic rats, normal rats given a glucose load, and spontaneously insulin-resistant rhesus monkeys. ( Hansen, BC; Huang, LC; Larner, J; Ortmeyer, HK; Zhang, L, 1993)
"Concentrations of vitamins, biopterin, free inositol and acid-soluble carnitine were determined in cyclosporine A induced renal adenocarcinoma and uninvaded renal tissue from streptozotocin diabetic rats."	3.68	Vitamin and micronutrient concentrations in cyclosporine-induced renal tumor from diabetic rats. ( Baker, H; DeAngelis, B; Frank, O; Jyothirmayi, GN; Kabaria, V; Reddi, AS, 1991)
" Untreated alloxan diabetes reduced endoneurial sodium-gradient dependent uptake of the nonmetabolized amino acid 2-aminoisobutyric acid by greater than 50%."	3.68	A defect in sodium-dependent amino acid uptake in diabetic rabbit peripheral nerve. Correction by an aldose reductase inhibitor or myo-inositol administration. ( Carroll, PB; Fernstrom, JD; Finegold, DN; Greene, DA; Lattimer, SA, 1990)
"It has been suggested that sugar cataracts associated with diabetes mellitus result from the accumulation of excess sorbitol within lens fibrils."	3.68	Nonosmotic diabetic cataracts. ( Cook, WR; Lowitt, S; Malone, JI, 1990)
" Furthermore, insulin but not myoinositol treatment normalized blood glucose and insulin levels, maintained normal prostate and body weight-gain, and prevented the decrease in the density, i."	3.68	Beta adrenergic receptor alterations in diabetic rat prostate: effects of insulin and dietary myoinositol. ( Gousse, A; Latifpour, J; Weiss, RM; Yoshida, M, 1991)
"The lens myo-inositol (MI) content is known to be depleted during initial cataractogenesis in both streptozocin (STZ)-induced diabetic and 50% galactose-maintained rats."	3.67	Dietary myo-inositol effect on sugar cataractogenesis. ( Beyer-Mears, A; Bucci, FA; Cruz, E; Del Val, M, 1989)
" Half of the diabetic rats were given the aldose reductase inhibitor, sorbinil (mean dose 30 mg/kg/day body weight by dietary admixture) over the entire protocol."	3.67	Substance P levels in peripheral nerve, skin, atrial myocardium and gastrointestinal tract of rats with long-term diabetes mellitus. Effects of aldose reductase inhibition. ( Calcutt, NA; Compton, AM; Keen, P; Tomlinson, DR; Willars, GB, 1989)
" One group received no additional treatment whilst the other was given the aldose reductase inhibitor, sorbinil, by dietary admixture (approximate dose was 30 mg/day/kg body weight)."	3.67	Effects of sorbinil treatment in rats with chronic streptozotocin-diabetes; changes in lens and in substance P and catecholamines in the iris. ( Calcutt, NA; Clarke, HE; Compton, AM; Keen, P; Macdonald, IA; Tomlinson, DR; Willars, GB, 1989)
"Patients with type 2 diabetes mellitus (T2DM) have a higher incidence of cardiovascular (CV) events."	2.87	Effects of a Carob-Pod-Derived Sweetener on Glucose Metabolism. ( Badimon, L; Cubedo, J; Hernández-Mijares, A; Lambert, C; López-Bernal, S; Padró, T; Rocha, M; Vilahur, G, 2018)
"Type 2 diabetes was induced in three groups using high-fat diet combined with a single dose of streptozotocin (35mg/kg body weight, intraperitoneally)."	1.46	Pancreatic and renal function in streptozotocin-induced type 2 diabetic rats administered combined inositol hexakisphosphate and inositol supplement. ( Alexander-Lindo, RL; Dilworth, LL; Foster, SR; Omoruyi, FO; Thompson, R, 2017)
"In this investigation, a model of type 2 diabetes mellitus (T2DM) was used on Sprague-Dawley (SD) rats to clarify more details of the mechanism in the therapy of T2DM."	1.43	Hypoglycemic effect of D-chiro-inositol in type 2 diabetes mellitus rats through the PI3K/Akt signaling pathway. ( Ai, RD; Gao, YF; Wang, TX; Wu, TC; Zhang, MN; Zhang, ZS, 2016)
"Diabetic nephropathy is a serious complication of diabetes mellitus with a pressing need for effective metabolic markers to detect renal impairment."	1.42	The diabetic rat kidney mediates inosituria and selective urinary partitioning of D-chiro-inositol. ( Chang, HH; Choong, B; Loomes, KM; Phillips, AR, 2015)
"Pioglitazone was used as a hypoglycemic drug for comparison."	1.38	Antioxidant and anti-inflammatory effects of a hypoglycemic fraction from Cucurbita ficifolia Bouché in streptozotocin-induced diabetes mice. ( Alarcon-Aguilar, FJ; Almanza-Perez, JC; Angeles-Mejia, S; Banderas-Dorantes, TR; Blancas-Flores, G; Diaz-Flores, M; Fortis-Barrera, A; Gomez, J; Jasso, I; Roman-Ramos, R; Zamilpa-Alvarez, A, 2012)
"The implication of MIOX expression in diabetic nephropathy, however, has not been revealed."	1.35	Increased expression of myo-inositol oxygenase is involved in the tubulointerstitial injury of diabetic nephropathy. ( Liu, C; Lu, Y; Miao, X; Wu, X; Xu, K, 2009)
" Chronic administration of D-pinitol (100 mg kg(-1) i."	1.31	Insulin-like effect of pinitol. ( Bailey, CJ; Bates, SH; Jones, RB, 2000)
"Sorbinil treatment essentially corrected diabetes-induced sorbitol and fructose accumulation, myo-inositol depletion, decrease in free cytosolic NAD+:NADH ratio and energy deficiency."	1.31	Evaluation of an aldose reductase inhibitor on lens metabolism, ATPases and antioxidative defense in streptozotocin-diabetic rats: an intervention study. ( Fathallah, L; Obrosova, IG, 2000)
"After 6 weeks of untreated streptozotocin diabetes, rats were treated for 2 weeks."	1.30	Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats. ( Basso, M; Cameron, NE; Cotter, MA; Hohman, TC, 1997)
" This last observation could explain at least part of the specificity of PP-56 for normalizing platelet aggregation in diabetic animals after long-term administration in vivo."	1.29	In vitro effect of D-myo-inositol 1,2,6-trisphosphate (PP-56) on aggregation of platelets from normal and diabetic rats: relationship to malondialdehyde release and phosphoinositide pathway. ( Ciavatti, M; Gustafsson, T; Renaud, S; Ruf, JC, 1994)
" Following 2-months untreated diabetes, examination of 1 month ZD5522 treatment dose-response relationships for correction of nerve sorbitol and fructose accumulations and reduction in myo-inositol concentration, sciatic motor and saphenous sensory conduction velocity and sciatic blood flow by laser-Doppler flowmetry revealed poor agreement between nerve function and biochemical indices."	1.29	Aldose reductase inhibition, nerve perfusion, oxygenation and function in streptozotocin-diabetic rats: dose-response considerations and independence from a myo-inositol mechanism. ( Cameron, NE; Carey, F; Cotter, MA; Dines, KC; Maxfield, EK; Mirrlees, DJ, 1994)
"Primaquine treatment did not affect diabetic rats."	1.29	Anti-oxidant and pro-oxidant effects on nerve conduction velocity, endoneurial blood flow and oxygen tension in non-diabetic and streptozotocin-diabetic rats. ( Archibald, V; Cameron, NE; Cotter, MA; Dines, KC; Maxfield, EK, 1994)
"Methylguanidine was only approximately 7% as effective as aminoguanidine as an inhibitor of AGE formation from L-lysine and G6P; both compounds were poor inhibitors of AR."	1.29	Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation. ( Chang, K; Corbett, JA; Currie, MG; Hasan, KS; McDaniel, ML; Misko, TP; Moore, WM; Petrash, JM; Smith, SR; Tilton, RG, 1993)
"Inositol was diminished in diabetes to 0."	1.28	Myocardial inositol and sodium in diabetes. ( Beyer-Mears, A; Fusilli, LD; Regan, TJ; Torres, R, 1992)
"The effect of streptozotocin diabetes of 4-week duration on the adrenergic motor transmission and on the nonadrenergic, noncholinergic, inhibitory transmission in the rat anococcygeus was investigated by recording contractile and relaxant activity of isolated muscle preparations taken from diabetic and age-matched control animals."	1.28	Effect of streptozotocin diabetes on motor and inhibitory transmission in rat anococcygeus. ( Luheshi, GN; Zar, MA, 1992)
"Myo-inositol levels were 18% decreased by diabetes."	1.28	Effects of aminoguanidine on peripheral nerve function and polyol pathway metabolites in streptozotocin-diabetic rats. ( Cameron, NE; Cotter, MA; Dines, K; Love, A, 1992)
"Myo-inositol concentration was decreased in liver, heart and kidney but not in brain, pancreas and skeletal muscle."	1.28	Effect of short- and long-term diabetes on carnitine and myo-inositol in rats. ( Baker, H; DeAngelis, B; Frank, O; Jyothirmayi, GN; Reddi, AS, 1991)
"Iloprost was administered intraperitoneally to streptozotocin-induced diabetic rats at a dose of 10 micrograms/kg/day for a month."	1.28	Effect of a prostaglandin I2 derivative (iloprost) on peripheral neuropathy of diabetic rats. ( Ito, H; Kanazawa, A; Miwa, T; Ohno, A; Tanaka, A, 1992)
"Myo-inositol (650 mg/kg) was administered by gavage daily for 1 and 2 weeks after induction of diabetes."	1.28	Effect of myo-inositol on renal Na-K-ATPase in experimental diabetes. ( Cohen, RA; Epstein, FH; MacGregor, LC; Silva, P; Spokes, KC, 1990)
"Myo-inositol was reduced approximately 50%."	1.28	[Alterations in the sorbitol pathway and Na(+)-K(+)-ATPase activity of peripheral nerve of alloxan-induced diabetic rats]. ( Lu, KM; Zhong, XL; Zhu, QY; Zhu, XX, 1990)
"Myo-inositol treatment could not improve Ca2(+)-uptake activity in diabetic rats."	1.28	Calcium uptake activity of cardiac sarcoplasmic reticulum in myo-inositol-treated diabetic rats. ( McNeill, JH; Xiang, H, 1990)
"Inositol is a major component of the intracellular mediators of insulin action."	1.28	Low urinary chiro-inositol excretion in non-insulin-dependent diabetes mellitus. ( Bogardus, C; Craig, J; Hansen, BC; Hill, CR; Kennington, AS; Larner, J; Ortmeyer, HK; Raz, I; Romero, G, 1990)
"Free inositol content was highest in brain and lowest in skeletal muscle of CBL and db/db mice; diabetes or ETOH intake did not affect tissue inositol content."	1.28	Effect of genetic diabetes and alcohol on tissue carnitine and inositol concentrations in mice. ( Baker, H; DeAngelis, B; Frank, O; Jyothirmayi, GN; Leevy, CB; Reddi, AS, 1990)
"Myo-inositol treatment also partially prevented the rise in adrenal adrenaline."	1.28	Tissue noradrenaline and the polyol pathway in experimentally diabetic rats. ( Lucas, PD; Qirbi, A, 1989)
"Myo-inositol treatment did not affect nerve levels."	1.28	The effect of aldose reductase inhibition on the pattern of nerve conduction deficits in diabetic rats. ( Cameron, NE; Cotter, MA; Robertson, S, 1989)
"Myo-inositol treatment leads to a normalization of blood-brain barrier permeability; it is suggested that myo-inositol exerts a restituting effect upon Na+/K+-ATPase activity of the cerebral endothelial cells."	1.28	Myo-inositol normalizes decreased sodium permeability of the blood-brain barrier in streptozotocin diabetes. ( Barry, DI; Compton, AM; Jakobsen, J; Knudsen, GM; Tomlinson, DR, 1989)
"When sorbinil was added raising medium glucose did not alter the ability of 70 mumol/l medium myoinositol to maintain the (Na+, K+)-ATPase activity that requires medium myo-inositol."	1.28	Mechanism of glucose-induced (Na+, K+)-ATPase inhibition in aortic wall of rabbits. ( Simmons, DA; Winegrad, AI, 1989)
"Myo-Inositol treatment at 650 mg ."	1.27	Myo-inositol and sorbitol metabolism in relation to peripheral nerve function in experimental diabetes in the rat: the effect of aldose reductase inhibition. ( Gillon, KR; Hawthorne, JN; Tomlinson, DR, 1983)
"Inositol was not detectable from stage I."	1.27	Studies on diabetic cataract in rats induced by streptozotocin. II. Biochemical examinations of rat lenses in relation to cataract stages. ( Fukuda, M; Kuriyama, H; Sasaki, K, 1983)
"This study examined the effect of streptozotocin diabetes of 5 weeks duration on the profile of slow orthogradely transported radiolabelled protein in rat sciatic motoneurones."	1.27	Slow orthograde axonal transport of radiolabelled protein in sciatic motoneurones of rats with short-term experimental diabetes: effects of treatment with an aldose reductase inhibitor or myo-inositol. ( Mayer, JH; McLean, WG; Tomlinson, DR, 1984)
"Treatment with Sorbinil (25 mg/kg/day, p."	1.27	Prevention and reversal of defective axonal transport and motor nerve conduction velocity in rats with experimental diabetes by treatment with the aldose reductase inhibitor Sorbinil. ( Mayer, JH; Moriarty, RJ; Tomlinson, DR, 1984)
"Sorbinil treatment prevented the 10-fold increase in nerve sorbitol found with diabetes."	1.27	The effects of sorbinil on peripheral nerve conduction velocity, polyol concentrations and morphology in the streptozotocin-diabetic rat. ( Cameron, NE; Leonard, MB; Ross, IS; Whiting, PH, 1986)
"Sorbinil treatment, initiated after 8 weeks of diabetes, and without effect on sciatic nerve glucose levels, normalized sorbitol concentrations following 4, 8, or 12 weeks of treatment but only partially reversed the accumulation of fructose by 368, 161 and 199%, compared to age-matched non-diabetic control values, at the above times, respectively."	1.27	Increased nerve polyol levels in experimental diabetes and their reversal by Sorbinil. ( Ross, IS; Whiting, PH, 1988)
"myo-inositol treatment partially improved cardiac performance in STZ-D rats."	1.27	Effect of myo-inositol and T3 on myocardial lipids and cardiac function in streptozocin-induced diabetic rats. ( Heyliger, CE; McNeill, JH; Xiang, H, 1988)
"Both diabetic hyperglycemia and galactosemia caused the prolongation of peak latencies and in some cases a reduction in the amplitudes of oscillatory potentials on the b-wave."	1.27	The development of electroretinogram abnormalities and the possible role of polyol pathway activity in diabetic hyperglycemia and galactosemia. ( Fujimori, S; Hirata, Y; Okada, K; Segawa, M, 1988)
"A more mild degree of galactosemia, induced by 5 or 21 days of feeding a diet containing 10% galactose to nondiabetic rats, provoked an increase in nerve water content associated with polyol levels of a similar order to those seen in diabetes."	1.27	Does galactose feeding provide a valid model of consequences of exaggerated polyol-pathway flux in peripheral nerve in experimental diabetes? ( Lambourne, JE; Tomlinson, DR; Willars, GB, 1987)
" Comparison between the values before and with up to nine weeks of dosing revealed no alteration in conduction velocity."	1.26	Influence of dietary myoinositol on nerve conduction and inositol phospholipids in normal and diabetic rats. ( Jefferys, JG; Palmano, KP; Sharma, AK; Thomas, PK, 1978)

Timeframe	Studies, this research(%)	All Research%
pre-1990	111 (42.86)	18.7374
1990's	85 (32.82)	18.2507
2000's	27 (10.42)	29.6817
2010's	27 (10.42)	24.3611
2020's	9 (3.47)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Symptomatic Diabetic Neuropathy (SYDNEY 2) Randomised, Double-blind,Placebo-controlled Multicentre Trial With 4 Parallel Groups[NCT00328601]			Phase 3	170 participants	Interventional	2005-02-28	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Defects of axonal transport in diabetes mellitus--a possible contribution to the aetiology of diabetic neuropathy. Journal of autonomic pharmacology, 1984, Volume: 4, Issue:1 Topics: Animals; Axonal Transport; Body Temperature; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dia	1984
[Physiological aspects of phosphoinositide metabolism]. Uspekhi sovremennoi biologii, 1981, Volume: 91, Issue:2 Topics: Animals; Calcium; Cell Membrane Permeability; Cyclization; Diabetes Mellitus; Diabetes Mellitus, Exp	1981
The nutritional significance, metabolism, and function of myo-inositol and phosphatidylinositol in health and disease. Advances in nutritional research, 1982, Volume: 4 Topics: 6-Phytase; Animals; Biological Transport; Birds; Brain Chemistry; Cardiovascular Diseases; Chemical	1982
The axonopathy of diabetic neuropathy. Diabetes, 1982, Volume: 31, Issue:4 Pt 1 Topics: Animals; Axons; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Edem	1982
Aldose reductase inhibitors: an approach to the treatment of diabetic nerve damage. Diabetes/metabolism reviews, 1993, Volume: 9, Issue:3 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Neuropathi	1993
Inositol and phospholipid metabolism in diabetic nerve. Diabetic medicine : a journal of the British Diabetic Association, 1993, Volume: 10 Suppl 2 Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Humans; Inositol; Inositol Phosphat	1993
Advances in the understanding of diabetic embryopathy: signal transduction. Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy, 1996, Volume: 2, Issue:2 Topics: Animals; Arachidonic Acid; Congenital Abnormalities; Diabetes Mellitus, Experimental; Embryo, Mammal	1996
[Diabetic neuropathy--a review of pathological studies]. Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49 Suppl Topics: Adolescent; Adult; Aged; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Mo	1991
Peripheral nerve biochemistry in diabetes. Clinical physiology (Oxford, England), 1985, Volume: 5 Suppl 5 Topics: Animals; Axonal Transport; Carbohydrate Metabolism; CDP-Diacylglycerol-Inositol 3-Phosphatidyltransf	1985
Metabolic correlates and axonal transport in nerves during experimental diabetes. Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985), 1986, Volume: 9, Issue:2-4 Topics: Animals; Axonal Transport; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Inositol; Periphe	1986
Axonal transport of choline acetyltransferase and 6-phosphofructokinase activities in genetically diabetic mice. Muscle & nerve, 1988, Volume: 11, Issue:12 Topics: Animals; Axonal Transport; Choline O-Acetyltransferase; Diabetes Mellitus, Experimental; Female; Fru	1988
Current aspects of research on the pathogenesis of diabetic neuropathy. Diabete & metabolisme, 1986, Volume: 12, Issue:6 Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Humans; Inositol; Microcirculation;	1986
Altered sorbitol and myo-inositol metabolism as the basis for defective protein kinase C and (Na,K)-ATPase regulation in diabetic neuropathy. Annals of the New York Academy of Sciences, 1986, Volume: 488 Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Humans; Inositol; Peripheral Nerves	1986

inositol and Alloxan Diabetes

Research Excerpts

Research

Studies (259)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Li, XL	2
Yu, F	2
Fu, CL	2
Yu, X	2
Xu, M	2
Cheng, M	2
Saldanha, LL	1
Quintiliano Delgado, A	1
Marcourt, L	1
de Paula Camaforte, NA	1
Ponce Vareda, PM	1
Nejad Ebrahimi, S	1
Vilegas, W	1
Dokkedal, AL	1
Queiroz, EF	1
Wolfender, JL	1
Bosqueiro, JR	1
Fan, C	1
Zhang, D	1
Zhang, J	1
Li, J	1
Wang, Y	1
Gao, L	2
Han, S	1
Sousa, LGF	1
Cortez, LUAS	1
Evangelista, JSAM	1
Xavier-Júnior, FAF	1
Heimark, DB	5
Fonteles, MC	6
Santos, CF	3
Nascimento, NRF	2
Nepal, MR	1
Kang, MJ	1
Kim, GH	1
Cha, DH	1
Kim, JH	1
Jeong, TC	1
Shah, P	1
Chavda, V	1
Patel, S	1
Bhadada, S	1
Ashraf, GM	1
Guimarães, VHD	1
Basilio Silva, JN	1
de Freitas, DF	1
Filho, OC	1
da Silveira, LH	1
Marinho, BM	1
de Paula, AMB	1
Melo, GA	1
Santos, SHS	1
Gao, HQ	1
Hanafy, MM	1
Lindeque, JZ	1
El-Maraghy, SA	1
Abdel-Hamid, AZ	1
Shahin, NN	1
Foster, SR	3
Dilworth, LL	3
Thompson, RK	1
Alexander-Lindo, RL	2
Omoruyi, FO	3
Thompson, R	1
Lambert, C	1
Cubedo, J	1
Padró, T	1
Vilahur, G	1
López-Bernal, S	1
Rocha, M	1
Hernández-Mijares, A	1
Badimon, L	1
Sathialingam, M	1
Saidian, M	1
Zhang, S	1
Flores, A	1
Alexander, M	1
Lakey, JR	1
Villalba, H	1
Shah, K	1
Albekairi, TH	1
Sifat, AE	1
Vaidya, B	1
Abbruscato, TJ	1
Farias, VX	2
Uchoa, PN	1
Aquino, CP	1
Britto, LRG	1
Leal-Cardoso, JH	2
Silva-Alves, KS	1
Havt, A	1
Prata, MMG	1
Chen, XP	1
Yang, JR	3
Li, XW	3
Hao, W	3
Liu, Y	4
Zhang, JX	1
Lee, BH	1
Lee, CC	1
Wu, SC	1
Suzuki, S	1
Suzuki, C	1
Hinokio, Y	1
Ishigaki, Y	1
Katagiri, H	1
Kanzaki, M	1
Azev, VN	1
Chakraborty, N	1
d'Alarcao, M	1
Chang, HH	2
Choong, B	1
Phillips, AR	1
Loomes, KM	2
Zhang, H	1
Huang, M	1
Lei, H	1
Chao, HN	1
Walker, CS	1
Choong, SY	1
Phillips, A	1
Freeman, OJ	1
Unwin, RD	1
Dowsey, AW	1
Begley, P	1
Ali, S	1
Hollywood, KA	1
Rustogi, N	1
Petersen, RS	1
Dunn, WB	1
Cooper, GJ	1
Gardiner, NJ	1
Gao, YF	1
Zhang, MN	1
Wang, TX	1
Wu, TC	1
Ai, RD	1
Zhang, ZS	1
Chukwuma, CI	1
Ibrahim, MA	1
Islam, MS	1
Bustamante, J	1
Lindo, RL	1
Antony, PJ	1
Gandhi, GR	1
Stalin, A	1
Balakrishna, K	1
Toppo, E	1
Sivasankaran, K	1
Ignacimuthu, S	1
Al-Dhabi, NA	1
Plows, JF	1
Budin, F	1
Andersson, RA	1
Mills, VJ	1
Mace, K	1
Davidge, ST	1
Vickers, MH	1
Baker, PN	1
Silva-Zolezzi, I	1
Stanley, JL	1
Lu, Y	1
Liu, C	2
Miao, X	1
Xu, K	1
Wu, X	1
Malone, JI	2
Hanna, S	1
Saporta, S	1
Mervis, RF	1
Park, CR	1
Chong, L	1
Diamond, DM	1
Moritoh, Y	2
Takeuchi, K	2
Hazama, M	2
Duarte, JM	1
Carvalho, RA	1
Cunha, RA	1
Gruetter, R	1
Kobayashi, T	1
Taguchi, K	1
Nemoto, S	1
Nogami, T	1
Matsumoto, T	1
Kamata, K	1
Sivakumar, S	4
Subramanian, SP	4
Palsamy, P	2
Macêdo, FH	1
Oquendo, MB	1
Tomé, AR	1
Báo, SN	1
Cintra, DO	1
Albuquerque, AA	1
Larner, J	9
Nascimento, NR	1
Shen, H	1
Shao, M	1
Cho, KW	1
Wang, S	1
Chen, Z	1
Sheng, L	1
Wang, T	1
Rui, L	1
Roman-Ramos, R	1
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Fortis-Barrera, A	1
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Zamilpa-Alvarez, A	1
Diaz-Flores, M	1
Jasso, I	1
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Gomez, J	1
Alarcon-Aguilar, FJ	1
González Mosquera, DM	1
Hernandez Ortega, Y	1
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Vicet Muro, L	1
Saucedo Hernandez, Y	1
Grau Ábalos, R	1
Dehaen, W	1
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Price, JD	1
Heimark, D	1
Smith, L	1
Rule, G	1
Piccariello, T	1
Pontes, C	1
Vale, D	1
Huang, L	1
Kawa, JM	1
Przybylski, R	1
Taylor, CG	1
DAUGHADAY, WH	1
HOUGHTON, E	1
Schmidt, RE	3
Dorsey, DA	1
Beaudet, LN	1
Parvin, CA	1
Yarasheski, KE	1
Smith, SR	2
Williamson, JR	9
Peterson, RG	3
Oates, PJ	2
Brautigan, DL	1
Brown, M	1
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Chinigo, G	1
Kruszewski, A	1
Lukasik, SM	1
Bushweller, JH	1
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Price, J	1
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Ho, EC	1
Lam, KS	1
Chen, YS	1
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Yamagishi, S	1
Yagihashi, S	4
Ellery, CA	1
Chung, SS	2
Chung, SK	2
Xia, T	1
Wang, Q	1
Lakshmi, V	1
Gupta, P	1
Tiwari, P	1
Srivastava, AK	1
Greene, DA	21
Lattimer, SA	13
Mayer, JH	6
Tomlinson, DR	24
Moriarty, RJ	1
McLean, WG	2
Kuriyama, H	1
Sasaki, K	1
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Ford, WC	1
Hamilton, DW	1
Clements, RS	2
Stockard, CR	1
Gulak, PV	1
Holub, BJ	1
Finegold, D	1
Nolle, S	1
Bernstein, M	1
Gillon, KR	2
Hawthorne, JN	6
Beyer-Mears, A	5
Ku, L	1
Cohen, MP	2
Varma, SD	1
Richards, RD	1
Yue, DK	2
Hanwell, MA	1
Satchell, PM	1
Handelsman, DJ	1
Turtle, JR	2
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Wells, WW	1
MacGregor, LC	6
Matschinsky, FM	6
Sidenius, P	2
Hinton, BT	1
Howards, SS	1
Lewis, RA	1
Brown, MJ	1
Thomas, PK	4
Jefferys, JG	2
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Koh, N	3
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Nakamura, J	3
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Mori, K	1
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Yorek, MA	7
Spanheimer, RG	1
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Tilton, RG	5
Chang, K	5
Hasan, KS	1
Petrash, JM	1
Misko, TP	1
Moore, WM	1
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Corbett, JA	1
McDaniel, ML	1
Jethmalani, SM	1
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Chang, KC	1
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Corr, PB	1
Cameron, NE	9
Cotter, MA	8
Dines, KC	2
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Zhu, X	2
Wiese, TJ	2
Davidson, EP	5
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Stefani, MR	1
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Huang, LC	2
Zhang, L	1
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Houston, DB	1
Zhang, C	1
Berti-Mattera, L	1
Day, N	1
Hohman, TC	2
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Wu, YK	3
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Lee, AY	1
Ng, DT	1
Lee, LW	1
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Yao, JK	1
Zollman, PJ	1
Nickander, KK	1
Tritschler, HJ	1
Low, PA	1
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Wentzel, CR	1
Gäreskog, MB	1
Eriksson, UJ	1
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Sun, TH	1
Nguygen, T	1
Nadler, JL	1
Hothersall, JS	1
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Whiting, PH	4
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Winegrad, AI	3
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Tanaka, A	1
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Leevy, CB	2
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Stevens, EJ	1
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Taniguchi, Y	1
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Filliatreau, G	1
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