Page last updated: 2024-10-19

inositol and Aging

inositol has been researched along with Aging in 98 studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Previously reported MRS findings in the aging brain include lower N-acetylaspartate (NAA) and higher myo-inositol (mI), total creatine (Cr) and choline-containing compound (Cho) concentrations."7.80Effects of normal aging and SCN1A risk-gene expression on brain metabolites: evidence for an association between SCN1A and myo-inositol. ( Brusniak, W; Demirakca, T; Diener, C; Ende, G; Matthäus, F; Meier, S; Sack, M; Schulze, TG; Tunc-Skarka, N; Weber-Fahr, W; Wolf, I, 2014)
" Concentrations of glutamate + glutamin (Glx), cholin (Cho), myoinositol (mIns), N-acetyl aspartate (NAA) expressed as ratio with creatine (Cr) and NAA were correlated with markers of disease activity (RIO score), Multiple Sclerosis Severity Scale (MSSS), Depressive-Severity Status Scale and Simple Numerical Fatigue Scale."3.85Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue. ( Baranovičová, E; Bittšanský, M; Čierny, D; Hnilicová, P; Kantorová, E; Kurča, E; Nosáľ, V; Poláček, H; Sivák, Š; Zeleňák, K, 2017)
"In a healthy aging normal population, choline/creatine and myo-inositol/creatine ratios were significantly increased in APOE E4 carriers, suggesting the presence of neuroinflammatory processes and greater membrane turnover in older carriers."3.80APOE genotype modulates proton magnetic resonance spectroscopy metabolites in the aging brain. ( Buthorn, JJ; Christen, E; Conejero-Goldberg, C; Davies, P; Dickinson, D; Goldberg, TE; Gomar, JJ; Gordon, ML; Huet, S; Keehlisen, L; Kingsley, PB; Koppel, J; Uluğ, AM, 2014)
" We used structural magnetic resonance imaging (sMRI) to measure the volume of the AHC, and magnetic resonance spectroscopy ((1)H-MRS) to measure concentrations of N-acetyl aspartate (NAA), creatine+phosphocreatine (Cr+PCr), myo-inositol (mI) and choline (Cho)."3.76Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging. ( Baird, G; Bolton, P; Conroy, RM; Curran, S; Daly, E; Foy, C; Hallahan, B; Murphy, DG; Murphy, KC; O'Brien, FM; O'Gorman, RL; Page, L; Robertson, D; Sharma, A, 2010)
"Long- and short-echo proton spectroscopic imaging were used to investigate concentrations and R2 relaxation rates of N-acetyl aspartate (NAA) + N-acetyl aspartyl glutamate (NAAG), choline (Cho), creatine (Cr), and myoinositol (mI) in the white matter of the centrum semiovale of 106 healthy volunteers aged 50-90 years; usable data were obtained from 79 subjects."3.74Long and short echo time proton magnetic resonance spectroscopic imaging of the healthy aging brain. ( Charlton, RA; Howe, FA; Markus, HS; McIntyre, DJ, 2007)
"Compared with seronegative controls, HIV-positive subjects showed additional and marked increases in the concentration of glial markers, choline-containing compounds (seronegative controls +2%/decade; HIV-positive subjects +10%/decade) and myoinositol (seronegative controls +3%/decade; HIV-positive subjects +12%/decade), with aging in the frontal white matter."3.72Effect of aging on brain metabolism in antiretroviral-naive HIV patients. ( Chang, L; Ernst, T, 2004)
"myo-Inositol (MI) plays an essential role in several important processes of cell physiology, is involved in the neural system, and provides an effective treatment for some psychiatric disorders."1.37Sodium/myo-inositol cotransporter 1 and myo-inositol are essential for osteogenesis and bone formation. ( Chan, AW; Chung, SK; Dai, Z; Kung, AW; Lau, KS; Miao, D, 2011)
"Patients with late-life major depressive disorder had a significantly lower NAA/creatine ratio in the left frontal white matter, and higher Cho/creatine and myo-inositol/creatine ratios in the left basal ganglia when compared with the control subjects."1.35Proton magnetic resonance spectroscopy of late-life major depressive disorder. ( Chen, CS; Chiang, IC; Hsieh, TJ; Kuo, YT; Li, CW; Lin, HF; Lin, WC; Liu, GC; Lu, CY, 2009)
"Inositol-4-phosphate was stable in the young rats but increased in the frontal cortex and the hippocampus in the old rats."1.29Sustained effects of pilocarpine-induced convulsions on brain inositol and inositol monophosphate levels and brain morphology in young and old male rats. ( Hirvonen, MR; Paljärvi, L; Savolainen, KM, 1993)
"Senile cataract was observed on six lenses of 12 rats aged 28-32 months."1.27Ageing and compositional changes of rat lens. ( Tsumita, T; Wada, E, 1984)
" Comparison of the dependence of the turnover on carbamoylcholine concentration revealed that in neonates, the dose-response curve was shifted to the left, giving a half-maximal effect at concentrations approximately tenfold lower than that in the adult."1.27Enhanced coupling of neonatal muscarinic receptors in rat brain to phosphoinositide turnover. ( Agranoff, BW; Fisher, SK; Heacock, AM, 1987)
"Inositol incorporation was also measurable, whereas [14C]serine incorporation was low or undetectable."1.27Renewal of the membrane complex of Schistosoma mansoni is closely associated with lipid metabolism. ( Ancelin, ML; Capron, A; Torpier, G; Vial, HJ, 1985)

Research

Studies (98)

TimeframeStudies, this research(%)All Research%
pre-199024 (24.49)18.7374
1990's16 (16.33)18.2507
2000's20 (20.41)29.6817
2010's27 (27.55)24.3611
2020's11 (11.22)2.80

Authors

AuthorsStudies
Li, XL2
Yu, F2
Fu, CL2
Yu, X2
Xu, M2
Cheng, M2
Hone-Blanchet, A1
Bohsali, A1
Krishnamurthy, LC1
Shahid, S1
Lin, Q1
Zhao, L1
Loring, D1
Goldstein, F1
John, SE1
Fleischer, CC1
Levey, A1
Lah, J1
Qiu, D1
Crosson, B1
Rodríguez-Nieto, G1
Levin, O2
Hermans, L1
Weerasekera, A1
Sava, AC1
Haghebaert, A1
Huybrechts, A1
Cuypers, K1
Mantini, D1
Himmelreich, U2
Swinnen, SP1
Vints, WAJ1
Ziv, G1
Katkutė, G1
Kušleikienė, S1
Valatkevičienė, K1
Sheoran, S1
Drozdova-Statkevičienė, M1
Gleiznienė, R1
Pääsuke, M1
Dudonienė, V1
Česnaitienė, VJ1
Masiulis, N1
Deelchand, DK2
Eberly, LE2
McCarten, JR2
Hemmy, LS2
Auerbach, EJ2
Marjańska, M2
Mahmoudi, N1
Dadak, M1
Bronzlik, P1
Maudsley, AA1
Sheriff, S1
Lanfermann, H1
Ding, XQ1
Pericuesta, E1
Laguna-Barraza, R1
Ramos-Ibeas, P1
Gutierrez-Arroyo, JL1
Navarro, JA1
Vera, K1
Sanjuan, C1
Baixeras, E1
de Fonseca, FR1
Gutierrez-Adan, A1
Yang, S1
Fang, G1
Zhang, A1
Ruan, B1
Jiang, H1
Ding, S1
Liu, C1
Zhang, Y1
Jaha, N1
Hu, P1
Xu, Z1
Gao, Z1
Wang, J1
Qian, Q1
Shi, D1
Xia, X1
Cui, A1
Xiong, Z1
Yan, Y1
Luo, J1
Chen, G1
Zeng, Y1
Cai, D1
Hou, L1
McDermott, J1
Li, Y1
Zhang, H1
Han, JJ1
Gao, HQ1
Sporn, L1
MacMillan, EL1
Ge, R1
Greenway, K1
Vila-Rodriguez, F1
Laule, C1
Fried, PJ1
Pascual-Leone, A1
Bolo, NR1
Zhang, X2
Wu, J1
Liu, H1
Menezes, TL1
Andrade-Valença, LP1
Valença, MM1
Chiu, PW1
Mak, HK1
Yau, KK1
Chan, Q1
Chang, RC1
Chu, LW1
Gomar, JJ1
Gordon, ML1
Dickinson, D1
Kingsley, PB1
Uluğ, AM1
Keehlisen, L1
Huet, S1
Buthorn, JJ1
Koppel, J1
Christen, E1
Conejero-Goldberg, C1
Davies, P1
Goldberg, TE1
Mori, T1
Mori, K1
Ito, H1
Goji, A1
Miyazaki, M1
Harada, M1
Kurosawa, K1
Kagami, S1
Tunc-Skarka, N1
Meier, S1
Demirakca, T1
Sack, M1
Weber-Fahr, W1
Brusniak, W1
Wolf, I1
Matthäus, F1
Schulze, TG1
Diener, C1
Ende, G1
Bolognin, S1
Buffelli, M1
Puoliväli, J1
Iqbal, K1
Chang, L3
Jiang, C1
Cunningham, E1
Buchthal, S1
Douet, V1
Andres, M1
Ernst, T3
Mazgaj, R1
Tal, A1
Goetz, R1
Lazar, M1
Rothman, K1
Messinger, JW1
Malaspina, D1
Gonen, O2
Yang, ZY1
Yue, Q1
Xing, HY1
Tan, QY1
Sun, HQ1
Gong, QY1
Tan, ZJ1
Quan, H1
Tsili, AC1
Astrakas, LG1
Ntorkou, A1
Giannakis, D1
Stavrou, S1
Maliakas, V1
Sofikitis, N1
Argyropoulou, MI1
Brandt, AS1
Unschuld, PG1
Pradhan, S1
Lim, IA1
Churchill, G1
Harris, AD1
Hua, J1
Barker, PB2
Ross, CA1
van Zijl, PC1
Edden, RA1
Margolis, RL1
Kantorová, E1
Poláček, H1
Bittšanský, M1
Baranovičová, E1
Hnilicová, P1
Čierny, D1
Sivák, Š1
Nosáľ, V1
Zeleňák, K1
Kurča, E1
SanGiovanni, JP1
Mehta, S2
Horská, A1
Farage, L1
Bibat, G1
Nagae, LM1
Kaufmann, WE1
Naidu, S1
Chen, CS1
Chiang, IC1
Li, CW1
Lin, WC1
Lu, CY1
Hsieh, TJ1
Liu, GC1
Lin, HF1
Kuo, YT1
Ronen, I1
Fan, X1
Schettler, S1
Jain, S1
Murray, D1
Kim, DS1
Killiany, R1
Rosene, D1
Chen, SQ2
Wang, PJ2
Ten, GJ1
Zhan, W1
Li, MH1
Zang, FC2
Raininko, R1
Mattsson, P1
Cosker, KE1
Segal, RA1
Dai, Z1
Chung, SK1
Miao, D1
Lau, KS1
Chan, AW1
Kung, AW1
O'Brien, FM1
Page, L1
O'Gorman, RL1
Bolton, P1
Sharma, A1
Baird, G1
Daly, E1
Hallahan, B1
Conroy, RM1
Foy, C1
Curran, S1
Robertson, D1
Murphy, KC1
Murphy, DG1
Chakraborty, A1
Koldobskiy, MA1
Bello, NT1
Maxwell, M1
Potter, JJ1
Juluri, KR1
Maag, D1
Kim, S1
Huang, AS1
Dailey, MJ1
Saleh, M1
Snowman, AM1
Moran, TH1
Mezey, E1
Snyder, SH1
Reyngoudt, H1
Claeys, T1
Vlerick, L1
Verleden, S1
Acou, M1
Deblaere, K1
De Deene, Y1
Audenaert, K1
Goethals, I1
Achten, E1
Kirov, II1
George, IC1
Jayawickrama, N1
Babb, JS1
Perry, NN1
Fenili, D1
Weng, YQ1
Aubert, I1
Nitz, M1
McLaurin, J1
Cai, Q1
Shen, YY1
Teng, GJ1
Zhang, W1
Tisell, A1
Leinhard, OD1
Warntjes, JB1
Lundberg, P1
Morgan, JJ1
Kleven, GA1
Tulbert, CD1
Olson, J1
Horita, DA1
Ronca, AE1
PIRIE, A1
VANHEYNINGEN, R1
Kaiser, LG1
Schuff, N1
Cashdollar, N1
Weiner, MW1
Pears, MR1
Cooper, JD1
Mitchison, HM1
Mortishire-Smith, RJ1
Pearce, DA1
Griffin, JL1
Girard, N1
Fogliarini, C1
Viola, A1
Confort-Gouny, S1
Fur, YL1
Viout, P1
Chapon, F1
Levrier, O1
Cozzone, P1
Ross, AJ1
Sachdev, PS1
Wen, W1
Brodaty, H1
Williams, RE1
Lenz, EM1
Lowden, JS1
Rantalainen, M1
Wilson, ID1
McIntyre, DJ1
Charlton, RA1
Markus, HS1
Howe, FA1
Yiannoutsos, CT1
Nakas, CT1
Navia, BA1
Serkova, NJ1
Gamito, EJ1
Jones, RH1
O'Donnell, C1
Brown, JL1
Green, S1
Sullivan, H1
Hedlund, T1
Crawford, ED1
Wada, E1
Tsumita, T1
Stokes, CE1
Gillon, KR1
Hawthorne, JN1
Ogawa, K1
McLaren, J1
Schacht, J1
Hirvonen, MR1
Paljärvi, L1
Savolainen, KM1
Hirano, F1
Tanaka, H1
Okamoto, K1
Makino, Y1
Inaba, M1
Nomura, Y1
Fukawa, E1
Miura, T1
Tani, T1
Makino, I1
Parnetti, L1
Lowenthal, DT1
Presciutti, O1
Pelliccioli, GP2
Palumbo, R1
Gobbi, G2
Chiarini, P1
Palumbo, B1
Tarducci, R2
Senin, U2
Poland, RE1
Jenden, DJ1
Schoepp, DD1
Salhoff, CR1
Wright, RA1
Johnson, BG1
Burnett, JP1
Mayne, NG1
Belagaje, R1
Wu, S1
Monn, JA1
Liu, L1
Moor, RM1
Marchell, NL1
Uchida, Y1
Brown, BE1
Elias, PM1
Holleran, WM1
Facchinetti, MM1
Boland, R1
de Boland, AR1
Herndon, JG1
Constantinidis, I1
Moss, MB1
Perron, JT1
Tyson, RL1
Sutherland, GR1
Koyama, M1
Wada, R1
Mizukami, H1
Sakuraba, H1
Odaka, H1
Ikeda, H1
Yagihashi, S1
Leary, SM1
Brex, PA1
MacManus, DG1
Parker, GJ1
Barker, GJ1
Miller, DH1
Thompson, AJ1
Tabata, H1
Ikegami, H1
Kariya, K1
Grachev, ID2
Apkarian, AV2
Swarnkar, A1
Szeverenyi, NM1
Ramachandran, TS1
Catani, M1
Cherubini, A1
Howard, R1
Piccirilli, M1
Mecocci, P1
Isaacks, RE1
Harkness, DR1
Sampsell, RN1
Adler, JL1
Kim, CY1
Goldman, PH1
Bartlett, GR1
Rana, RS1
Munkres, KD1
Ruenwongsa, P1
Singh, H1
Jungalwala, FB1
Laitinen, JT1
Vakkuri, O1
Saavedra, JM1
DasGupta, K1
Weiler, MH1
Gombos, G1
Levy, O1
de Barry, J1
Bry, K1
Hallman, M1
Dupuis, BA1
Suzuki, K1
Yen-Chung, H1
Toyota, T1
Goto, Y1
Hirata, Y1
Okada, K1
Greene, DA1
Heagerty, AM1
Ollerenshaw, JD1
Swales, JD1
Heacock, AM1
Fisher, SK1
Agranoff, BW1
Adhikari, J1
Majumder, AL1
Vial, HJ1
Torpier, G1
Ancelin, ML1
Capron, A1
Broekhuyse, RM2
Wells, WW1
McIntyre, JP1
Schlichter, DJ1
Wacholtz, MC1
Spieker, SE1
Weinhold, PA1
Sanders, RD1
Hochschild, R1
Sullivan, JL1
Debusk, AG1
Bruce, A2
Svennerholm, L1
Takaku, I1
Hasegawa, K1
Kimura, R1
Watanabe, Y1
Charlton, JM1
van Heyningen, R1
Horrocks, LA1
Gaitonde, MK1
Richter, D1

Reviews

2 reviews available for inositol and Aging

ArticleYear
Variation in lipid-associated genes as they relate to risk of advanced age-related macular degeneration.
    World review of nutrition and dietetics, 2009, Volume: 99

    Topics: Aging; Diet; Docosahexaenoic Acids; Fatty Acids; Fatty Acids, Omega-3; Genetic Predisposition to Dis

2009
Acute and chronic complications of diabetes mellitus in older patients.
    The American journal of medicine, 1986, May-16, Volume: 80, Issue:5A

    Topics: Adult; Aged; Aging; Blood Pressure; Diabetes Complications; Diabetes Mellitus; Diabetic Coma; Diabet

1986

Trials

3 trials available for inositol and Aging

ArticleYear
Scyllo-inositol in normal aging human brain: 1H magnetic resonance spectroscopy study at 4 Tesla.
    NMR in biomedicine, 2005, Volume: 18, Issue:1

    Topics: Adaptation, Physiological; Adult; Aged; Aging; Brain; Female; Humans; Inositol; Internal Capsule; Ma

2005
Aging alters regional multichemical profile of the human brain: an in vivo 1H-MRS study of young versus middle-aged subjects.
    Journal of neurochemistry, 2001, Volume: 76, Issue:2

    Topics: Adult; Age Factors; Aging; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; gamma-A

2001
Aging alters the multichemical networking profile of the human brain: an in vivo (1)H-MRS study of young versus middle-aged subjects.
    Journal of neurochemistry, 2001, Volume: 77, Issue:1

    Topics: Adult; Aging; Analysis of Variance; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female

2001

Other Studies

93 other studies available for inositol and Aging

ArticleYear
Phosphoproteomics analysis of diabetic cardiomyopathy in aging-accelerated mice and effects of D-pinitol.
    Proteomics. Clinical applications, 2022, Volume: 16, Issue:1

    Topics: Aging; Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Disease Model

2022
Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.
    Neurobiology of aging, 2022, Volume: 109

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Biomarkers; Cognition; Creatine; Fem

2022
Organization of neurochemical interactions in young and older brains as revealed with a network approach: Evidence from proton magnetic resonance spectroscopy (
    NeuroImage, 2023, 02-01, Volume: 266

    Topics: Aged; Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Inositol; Motor Cortex; Prefrontal Cor

2023
Neurometabolic correlates of posturography in normal aging and older adults with mild cognitive impairment: Evidence from a
    NeuroImage. Clinical, 2023, Volume: 37

    Topics: Aged; Aging; Aspartic Acid; Choline; Cognitive Dysfunction; Creatine; Glutamine; Humans; Inositol; P

2023
Scyllo-inositol: Transverse relaxation time constant at 3 T and concentration changes associated with aging and alcohol use.
    NMR in biomedicine, 2023, Volume: 36, Issue:8

    Topics: Adult; Aged; Aging; Alcohol Drinking; Brain; Humans; Infant, Newborn; Inositol; Young Adult

2023
Microstructural and Metabolic Changes in Normal Aging Human Brain Studied with Combined Whole-Brain MR Spectroscopic Imaging and Quantitative MR Imaging.
    Clinical neuroradiology, 2023, Volume: 33, Issue:4

    Topics: Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Inositol; Magnetic Resonance Imaging; Magnet

2023
Changes in the intracellular microenvironment in the aging human brain.
    Neurobiology of aging, 2020, Volume: 95

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Brain Chemistry; Cellular M

2020
D-Chiro-Inositol Treatment Affects Oocyte and Embryo Quality and Improves Glucose Intolerance in Both Aged Mice and Mouse Models of Polycystic Ovarian Syndrome.
    International journal of molecular sciences, 2020, Aug-22, Volume: 21, Issue:17

    Topics: Aging; Animals; Blastocyst; Cumulus Cells; Dihydrotestosterone; Disease Models, Animal; Female; Gene

2020
Rice EARLY SENESCENCE 2, encoding an inositol polyphosphate kinase, is involved in leaf senescence.
    BMC plant biology, 2020, Aug-26, Volume: 20, Issue:1

    Topics: Aging; China; Gene Expression Regulation, Plant; Genes, Plant; Inositol; Oryza; Phosphotransferases

2020
The precursor of PI(3,4,5)P
    Nature communications, 2020, 09-08, Volume: 11, Issue:1

    Topics: Aging; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegans Protei

2020
Effects of D-pinitol on myocardial apoptosis and fibrosis in streptozocin-induced aging-accelerated mice.
    Journal of food biochemistry, 2021, Volume: 45, Issue:4

    Topics: Aged; Aging; Animals; Apoptosis; Diabetes Mellitus, Experimental; Fibrosis; Humans; Inositol; Mice;

2021
Longer Repetition Time Proton MR Spectroscopy Shows Increasing Hippocampal and Parahippocampal Metabolite Concentrations with Aging.
    Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2019, Volume: 29, Issue:5

    Topics: Adolescent; Adult; Aging; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Glutamine; Hippoc

2019
Diabetes and the link between neuroplasticity and glutamate in the aging human motor cortex.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2019, Volume: 130, Issue:9

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Creatine; Diabetes Mellitus, Type 2; Female; Glucose;

2019
Age- and gender-related metabonomic alterations in striatum and cerebellar cortex in rats.
    Brain research, 2013, Apr-24, Volume: 1507

    Topics: Aging; Animals; Cerebellar Cortex; Corpus Striatum; Creatine; Female; Glutamic Acid; Inositol; Lacti

2013
Magnetic resonance imaging study cannot individually distinguish individuals with mild cognitive impairment, mild Alzheimer's disease, and normal aging.
    Arquivos de neuro-psiquiatria, 2013, Volume: 71, Issue:4

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Di

2013
Metabolic changes in the anterior and posterior cingulate cortices of the normal aging brain: proton magnetic resonance spectroscopy study at 3 T.
    Age (Dordrecht, Netherlands), 2014, Volume: 36, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain Chemistry; China; Choline; Creatine; Fem

2014
APOE genotype modulates proton magnetic resonance spectroscopy metabolites in the aging brain.
    Biological psychiatry, 2014, May-01, Volume: 75, Issue:9

    Topics: Aged; Aged, 80 and over; Aging; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Brain; Chol

2014
Age-related changes in a patient with Pelizaeus-Merzbacher disease determined by repeated 1H-magnetic resonance spectroscopy.
    Journal of child neurology, 2014, Volume: 29, Issue:2

    Topics: Aging; Aspartic Acid; Case-Control Studies; Child, Preschool; Creatine; gamma-Aminobutyric Acid; Glu

2014
Effects of normal aging and SCN1A risk-gene expression on brain metabolites: evidence for an association between SCN1A and myo-inositol.
    NMR in biomedicine, 2014, Volume: 27, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Animals; Brain; Evidence-Based Medicine; Female; Gene Express

2014
Rescue of cognitive-aging by administration of a neurogenic and/or neurotrophic compound.
    Neurobiology of aging, 2014, Volume: 35, Issue:9

    Topics: Administration, Oral; Aging; Alzheimer Disease; Animals; Ciliary Neurotrophic Factor; Cognition Diso

2014
Effects of APOE ε4, age, and HIV on glial metabolites and cognitive deficits.
    Neurology, 2014, Jun-17, Volume: 82, Issue:24

    Topics: Adult; Aging; Apolipoprotein E4; Choline; Cognition Disorders; Cross-Sectional Studies; Female; Fron

2014
Hypo-metabolism of the rostral anterior cingulate cortex associated with working memory impairment in 18 cases of schizophrenia.
    Brain imaging and behavior, 2016, Volume: 10, Issue:1

    Topics: Adult; Aging; Aspartic Acid; Creatine; Female; Gliosis; Gyrus Cinguli; Humans; Inositol; Intelligenc

2016
A quantitative analysis of (1)H-MR spectroscopy at 3.0 T of three brain regions from childhood to middle age.
    The British journal of radiology, 2015, Volume: 88, Issue:1052

    Topics: Adolescent; Adult; Aging; Analysis of Variance; Aspartic Acid; Brain; Child; Creatinine; Female; Glu

2015
MR Spectra of Normal Adult Testes and Variations with Age: Preliminary Observations.
    European radiology, 2016, Volume: 26, Issue:7

    Topics: Adult; Age Factors; Aged; Aging; Choline; Creatine; Humans; Inositol; Magnetic Resonance Spectroscop

2016
Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A (1)H MRS Study at 7 Tesla.
    Schizophrenia research, 2016, Volume: 172, Issue:1-3

    Topics: Adult; Aging; Antipsychotic Agents; Aspartic Acid; Choline; Creatine; Dipeptides; Female; gamma-Amin

2016
Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue.
    Neurological research, 2017, Volume: 39, Issue:4

    Topics: Adult; Aging; Aspartic Acid; Case-Control Studies; Choline; Creatine; Cross-Sectional Studies; Depre

2017
Brain metabolism in Rett syndrome: age, clinical, and genotype correlations.
    Annals of neurology, 2009, Volume: 65, Issue:1

    Topics: Adolescent; Aging; Analysis of Variance; Aspartic Acid; Case-Control Studies; Child; Child, Preschoo

2009
Proton magnetic resonance spectroscopy of late-life major depressive disorder.
    Psychiatry research, 2009, Jun-30, Volume: 172, Issue:3

    Topics: Aged; Aging; Aspartic Acid; Basal Ganglia; Biomarkers; Brain; Choline; Cognition; Creatine; Depressi

2009
Regional age-related effects in the monkey brain measured with 1H magnetic resonance spectroscopy.
    Neurobiology of aging, 2011, Volume: 32, Issue:6

    Topics: Aging; Animals; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Humans; Image Processing, Co

2011
Role of myo-inositol by magnetic resonance spectroscopy in early diagnosis of Alzheimer's disease in APP/PS1 transgenic mice.
    Dementia and geriatric cognitive disorders, 2009, Volume: 28, Issue:6

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Apolipoproteins E; Biomarkers; Brain Chemi

2009
Metabolite concentrations in supraventricular white matter from teenage to early old age: A short echo time 1H magnetic resonance spectroscopy (MRS) study.
    Acta radiologica (Stockholm, Sweden : 1987), 2010, Volume: 51, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Aging; Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Fe

2010
The longer U(T)R, the further you go.
    Nature neuroscience, 2010, Volume: 13, Issue:3

    Topics: 3' Untranslated Regions; Aging; Animals; Cell Enlargement; Gene Expression; Gene Expression Profilin

2010
Sodium/myo-inositol cotransporter 1 and myo-inositol are essential for osteogenesis and bone formation.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011, Volume: 26, Issue:3

    Topics: Aging; Animals; Bone and Bones; Cell Count; Cell Differentiation; Cell Line; Embryo, Mammalian; Gene

2011
Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging.
    Psychiatry research, 2010, Nov-30, Volume: 184, Issue:2

    Topics: Adolescent; Adult; Age Factors; Aging; Amygdala; Aspartic Acid; Asperger Syndrome; Brain Mapping; Ch

2010
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain.
    Cell, 2010, Dec-10, Volume: 143, Issue:6

    Topics: Adipogenesis; Aging; Animals; Cell Culture Techniques; Diet; Diphosphates; Inositol; Inositol Phosph

2010
Age-related differences in metabolites in the posterior cingulate cortex and hippocampus of normal ageing brain: a 1H-MRS study.
    European journal of radiology, 2012, Volume: 81, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Aging; Analysis of Variance; Aspartic Acid; Choline; Creatine;

2012
Longitudinal inter- and intra-individual human brain metabolic quantification over 3 years with proton MR spectroscopy at 3 T.
    Magnetic resonance in medicine, 2012, Volume: 67, Issue:1

    Topics: Aging; Algorithms; Aspartic Acid; Brain; Choline; Creatine; Humans; Inositol; Longitudinal Studies;

2012
Sodium/myo-Inositol transporters: substrate transport requirements and regional brain expression in the TgCRND8 mouse model of amyloid pathology.
    PloS one, 2011, Volume: 6, Issue:8

    Topics: Aging; Alzheimer Disease; Amyloid; Animals; Biological Transport; Brain; Gene Expression Regulation,

2011
Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice.
    Behavioural brain research, 2012, Nov-01, Volume: 235, Issue:1

    Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Cholin

2012
Procedure for quantitative (1)H magnetic resonance spectroscopy and tissue characterization of human brain tissue based on the use of quantitative magnetic resonance imaging.
    Magnetic resonance in medicine, 2013, Volume: 70, Issue:4

    Topics: Adolescent; Adult; Aged; Aging; Creatine; Female; Humans; Inositol; Magnetic Resonance Imaging; Magn

2013
Longitudinal 1H MRS of rat forebrain from infancy to adulthood reveals adolescence as a distinctive phase of neurometabolite development.
    NMR in biomedicine, 2013, Volume: 26, Issue:6

    Topics: Aging; Animals; Aspartic Acid; Dipeptides; Glutamic Acid; Inositol; Magnetic Resonance Spectroscopy;

2013
THE EFFECT OF DIABETES ON THE CONTENT OF SORBITOL, GLUCOSE, FRUCTOSE AND INOSITOL IN THE HUMAN LENS.
    Experimental eye research, 1964, Volume: 3

    Topics: Aging; Cataract; Diabetes Mellitus; Fructose; Geriatrics; Glucose; Humans; Inositol; Lens, Crystalli

1964
Effect of aging on brain metabolism in antiretroviral-naive HIV patients.
    AIDS (London, England), 2004, Jan-01, Volume: 18 Suppl 1

    Topics: Adolescent; Adult; Aging; Aspartic Acid; Basal Ganglia; Brain; Choline; Creatinine; Female; Frontal

2004
High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease.
    The Journal of biological chemistry, 2005, Dec-30, Volume: 280, Issue:52

    Topics: Aging; Animals; Aspartic Acid; Brain; Cerebellum; Cerebral Cortex; Creatine; Disease Models, Animal;

2005
MRS of normal and impaired fetal brain development.
    European journal of radiology, 2006, Volume: 57, Issue:2

    Topics: Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Fetal Development; Fetus; gamma-Aminobutyric

2006
Longitudinal changes during aging using proton magnetic resonance spectroscopy.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2006, Volume: 61, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Aspartic Acid; Brain; Chi-Square Distribution;

2006
The metabonomics of aging and development in the rat: an investigation into the effect of age on the profile of endogenous metabolites in the urine of male rats using 1H NMR and HPLC-TOF MS.
    Molecular bioSystems, 2005, Volume: 1, Issue:2

    Topics: Aging; Animals; Chromatography, High Pressure Liquid; Citrates; Creatinine; Energy Metabolism; Hippu

2005
Long and short echo time proton magnetic resonance spectroscopic imaging of the healthy aging brain.
    Journal of magnetic resonance imaging : JMRI, 2007, Volume: 26, Issue:6

    Topics: Aged; Aged, 80 and over; Aging; Artifacts; Aspartic Acid; Brain; Choline; Creatine; Dipeptides; Fema

2007
Assessing multiple-group diagnostic problems with multi-dimensional receiver operating characteristic surfaces: application to proton MR Spectroscopy (MRS) in HIV-related neurological injury.
    NeuroImage, 2008, Mar-01, Volume: 40, Issue:1

    Topics: Adult; Aging; AIDS Dementia Complex; Algorithms; Aspartic Acid; Basal Ganglia; Brain; Brain Chemistr

2008
The metabolites citrate, myo-inositol, and spermine are potential age-independent markers of prostate cancer in human expressed prostatic secretions.
    The Prostate, 2008, May-01, Volume: 68, Issue:6

    Topics: Adult; Aged; Aging; Area Under Curve; Biomarkers, Tumor; Body Fluids; Citric Acid; Humans; Inositol;

2008
Ageing and compositional changes of rat lens.
    Mechanisms of ageing and development, 1984, Oct-31, Volume: 27, Issue:3

    Topics: Aging; Animals; Carbohydrate Metabolism; Cataract; Fatty Acids; Female; Inositol; Lens, Crystalline;

1984
Free and total lipid myo-inositol concentrations decrease with age in human brain.
    Biochimica et biophysica acta, 1983, Aug-29, Volume: 753, Issue:1

    Topics: Adult; Aged; Aging; Brain Chemistry; Humans; Inositol; Lipid Metabolism; Middle Aged

1983
Effect of aging on myo-inositol and phosphoinositide metabolism in the cochlear and vestibular sensory epithelia of the rat.
    Hearing research, 1994, Volume: 73, Issue:2

    Topics: Adenosine Triphosphate; Aging; Animals; Binding Sites; Carbachol; Cochlea; Epithelium; Hydrolysis; I

1994
Sustained effects of pilocarpine-induced convulsions on brain inositol and inositol monophosphate levels and brain morphology in young and old male rats.
    Toxicology and applied pharmacology, 1993, Volume: 122, Issue:2

    Topics: Aging; Animals; Brain; Inositol; Inositol Phosphates; Male; Neurons; Pilocarpine; Rats; Rats, Wistar

1993
Natural course of diabetic peripheral neuropathy in spontaneous-onset diabetic Chinese hamsters.
    Diabetes research and clinical practice, 1995, Volume: 28, Issue:3

    Topics: Aging; Animals; Cricetinae; Cricetulus; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Electrophy

1995
1H-MRS, MRI-based hippocampal volumetry, and 99mTc-HMPAO-SPECT in normal aging, age-associated memory impairment, and probable Alzheimer's disease.
    Journal of the American Geriatrics Society, 1996, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Case-Control Stud

1996
In vivo proton magnetic resonance spectroscopy of the normal aging human brain.
    Life sciences, 1996, Volume: 58, Issue:22

    Topics: Adult; Aged; Aging; Body Water; Brain; Choline; Creatine; Glutamic Acid; Glutamine; Humans; Inositol

1996
The novel metabotropic glutamate receptor agonist 2R,4R-APDC potentiates stimulation of phosphoinositide hydrolysis in the rat hippocampus by 3,5-dihydroxyphenylglycine: evidence for a synergistic interaction between group 1 and group 2 receptors.
    Neuropharmacology, 1996, Volume: 35, Issue:12

    Topics: Aging; Animals; Animals, Newborn; Brain; Cloning, Molecular; Colforsin; Cyclic AMP; Cycloleucine; Dr

1996
Factors affecting electrical activation of porcine oocyte matured in vitro.
    Animal reproduction science, 1997, Volume: 48, Issue:1

    Topics: Aging; Animals; Cell Cycle; Cell Division; Cells, Cultured; Coculture Techniques; Culture Media; Ele

1997
Glucosylceramides stimulate mitogenesis in aged murine epidermis.
    The Journal of investigative dermatology, 1998, Volume: 110, Issue:4

    Topics: Administration, Topical; Aging; Animals; Animals, Newborn; DNA; Enzyme Inhibitors; Epidermal Cells;

1998
Age-related loss of calcitriol stimulation of phosphoinositide hydrolysis in rat skeletal muscle.
    Molecular and cellular endocrinology, 1998, Jan-15, Volume: 136, Issue:2

    Topics: Aging; Animals; Arachidonic Acid; Calcitriol; Calcium; Cell Membrane; Diglycerides; GTP-Binding Prot

1998
Age-related brain changes in rhesus monkeys: a magnetic resonance spectroscopic study.
    Neuroreport, 1998, Jun-22, Volume: 9, Issue:9

    Topics: Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition; Creatine; Female; Inosito

1998
Maintenance of tricarboxylic acid cycle kinetics in Brown-Norway Fischer 344 rats may translate to longevity.
    Neuroscience letters, 2000, Mar-10, Volume: 281, Issue:2-3

    Topics: Aging; Amino Acids; Animals; Citric Acid Cycle; Glucose; Glycolysis; Hippocampus; Inositol; Kinetics

2000
Inhibition of progressive reduction of islet beta-cell mass in spontaneously diabetic Goto-Kakizaki rats by alpha-glucosidase inhibitor.
    Metabolism: clinical and experimental, 2000, Volume: 49, Issue:3

    Topics: Aging; Animals; Body Weight; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glycoside Hydrolase Inhib

2000
A (1)H magnetic resonance spectroscopy study of aging in parietal white matter: implications for trials in multiple sclerosis.
    Magnetic resonance imaging, 2000, Volume: 18, Issue:4

    Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; I

2000
Spontaneous age-related peripheral neuropathy in B6C3F1 mice.
    The Journal of toxicological sciences, 2000, Volume: 25, Issue:2

    Topics: Aging; Animals; Axons; Blood Glucose; Body Temperature; Cell Division; Female; Glycated Hemoglobin;

2000
(1)H-MR spectroscopy differentiates mild cognitive impairment from normal brain aging.
    Neuroreport, 2001, Aug-08, Volume: 12, Issue:11

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Choline; Cognitio

2001
Studies on avian erythrocyte metabolism-IV. relationship between the major phosphorylated metabolic intermediates and oxygen affinity of whole blood in adults and embryos in several galliformes.
    Comparative biochemistry and physiology. A, Comparative physiology, 1976, Volume: 55, Issue:1

    Topics: Adenine Nucleotides; Aging; Animals; Birds; Diphosphoglyceric Acids; Embryo, Nonmammalian; Erythrocy

1976
Phosphate compounds in red cells of reptiles, amphibians and fish.
    Comparative biochemistry and physiology. A, Comparative physiology, 1976, Volume: 55, Issue:3

    Topics: Aging; Alligators and Crocodiles; Animals; Diphosphoglyceric Acids; Embryo, Nonmammalian; Erythrocyt

1976
Ageing of Neurospora crassa. V. Lipid peroxidation and decay of respiratory enzymes in an inositol auxotroph.
    Mechanisms of ageing and development, 1978, Volume: 7, Issue:4

    Topics: Aging; Antioxidants; Catechols; Cytochrome Reductases; Electron Transport Complex IV; Hydrocortisone

1978
Protein-catalyzed exchange of phosphatidylinositol between rat brain microsomes and myelin.
    The Journal of biological chemistry, 1979, Oct-10, Volume: 254, Issue:19

    Topics: Aging; Animals; Brain; Inositol; Kinetics; Microsomes; Myelin Sheath; Nerve Tissue Proteins; Phospha

1979
Pineal muscarinic phosphoinositide responses: age-associated sensitization, agonist-induced desensitization and increase in melatonin release from cultured pineal glands.
    Neuroendocrinology, 1992, Volume: 55, Issue:5

    Topics: Aging; Animals; Carbachol; Culture Techniques; Inositol; Kinetics; Male; Melatonin; Phosphatidylinos

1992
Age-related differences in the phosphoinositide system in rat neostriatum.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1992, Volume: 7, Issue:2

    Topics: Aging; Animals; Corpus Striatum; In Vitro Techniques; Inositol; Lithium; Male; Oxotremorine; Phospha

1992
Developmental changes of EAA metabotropic receptor activity in rat cerebellum.
    Neuroreport, 1992, Volume: 3, Issue:10

    Topics: Aging; Animals; Cerebellum; Cycloleucine; Hydrolysis; Inositol; Inositol Phosphates; Rats; Rats, Wis

1992
Perinatal development of inositol synthesis and catabolism in rabbit kidney.
    Biology of the neonate, 1991, Volume: 60, Issue:3-4

    Topics: Aging; Amniotic Fluid; Animals; Animals, Newborn; Betamethasone; Female; Fetus; Inositol; Inositol O

1991
[Calcium antagonists and vascular aging].
    Annales de cardiologie et d'angeiologie, 1991, Volume: 40, Issue:6

    Topics: Aging; Animals; Blood Vessels; Calcium; Calcium Channel Blockers; Humans; Inositol; Lipid Metabolism

1991
The significance of nerve sugar levels for the peripheral nerve impairment of spontaneously diabetic GK (Goto-Kakizaki) rats.
    Diabetes research (Edinburgh, Scotland), 1990, Volume: 14, Issue:1

    Topics: Aging; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Fructose; Glucose; Inos

1990
Abnormal vascular phosphoinositide hydrolysis in the spontaneously hypertensive rat.
    British journal of pharmacology, 1986, Volume: 89, Issue:4

    Topics: Aging; Animals; Hydrolysis; Hypertension; Inositol; Male; Muscle, Smooth, Vascular; Phosphatidylinos

1986
Enhanced coupling of neonatal muscarinic receptors in rat brain to phosphoinositide turnover.
    Journal of neurochemistry, 1987, Volume: 48, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Carbachol; Cerebral Cortex; Inositol; Phosphatidylinositols; Quinu

1987
L-myo-inositol-1-phosphate synthase from mammalian brain: partial purification and characterisation of the fetal and adult enzyme.
    Indian journal of biochemistry & biophysics, 1988, Volume: 25, Issue:5

    Topics: Aging; Brain; Carbohydrate Epimerases; Humans; Inositol; Myo-Inositol-1-Phosphate Synthase

1988
Renewal of the membrane complex of Schistosoma mansoni is closely associated with lipid metabolism.
    Molecular and biochemical parasitology, 1985, Volume: 17, Issue:2

    Topics: Aging; Animals; Biomphalaria; Carbon Radioisotopes; Choline; Ethanolamine; Ethanolamines; Female; Gl

1985
Composition and metabolism of phospholipids in cataract.
    Experimental eye research, 1969, Volume: 8, Issue:2

    Topics: Aging; Animals; Cataract; Humans; Inositol; Lens, Crystalline; Phosphatidylcholines; Phosphatidyleth

1969
Studies on myo-inositol metabolism in galactosemia.
    Annals of the New York Academy of Sciences, 1969, Oct-17, Volume: 165, Issue:2

    Topics: Adenosine Triphosphate; Aging; Alcohols; Alkaline Phosphatase; Animals; Brain; Carbon Isotopes; Diet

1969
Phospholipid metabolism during the development of the liver. The incorporation of [1,2-14C]ethanolamine, [2-3H]myo-inositol and L-[U-14C]serine into phospholipids by liver slices.
    Biochemistry, 1971, Mar-16, Volume: 10, Issue:6

    Topics: Aging; Amino Alcohols; Animals; Carbon Isotopes; Cholesterol; Fatty Acids; Female; Glycerides; Glyce

1971
Lipids in tissues of the eye. V. Phospholipid metabolism in normal and cataractous lens.
    Biochimica et biophysica acta, 1971, Mar-16, Volume: 231, Issue:2

    Topics: Aging; Albumins; Alcohols; Alloxan; Animals; Cataract; Cattle; Cytosine Nucleotides; Diabetes Mellit

1971
Effect of membrane stabilizing drugs on mortality in Drosophila melanogaster.
    Experimental gerontology, 1971, Volume: 6, Issue:2

    Topics: Adrenal Cortex Hormones; Aging; Analgesics; Animals; Cell Membrane; Central Nervous System Stimulant

1971
Inositol-less death in Neurospora and cellular ageing.
    Nature: New biology, 1973, May-16, Volume: 243, Issue:124

    Topics: Aging; Carbon Isotopes; Cell Membrane; Fungal Proteins; Glucosephosphate Dehydrogenase; Glutamate De

1973
Skeletal muscle lipids. II. Changes in phospholipid composition in man from fetal to middle age.
    Journal of lipid research, 1974, Volume: 15, Issue:2

    Topics: Adolescent; Adult; Aging; Brain; Cardiolipins; Child; Child, Preschool; Chromatography, DEAE-Cellulo

1974
Skeletal muscle lipids. I. Changes in fatty acid composition of lecithin in man during growth.
    Biochimica et biophysica acta, 1971, Sep-01, Volume: 239, Issue:3

    Topics: Abortion, Legal; Adolescent; Adult; Aging; Amino Alcohols; Child, Preschool; Chromatography, Gas; Ch

1971
[Biochemical characteristics of the cataract lens. 1. Comparison of water content and concentration of sorbitol, inositol, glutathione and sialic acid in the young and adult rat lens].
    Nippon Ganka Gakkai zasshi, 1967, Volume: 71, Issue:7

    Topics: Aging; Animals; Cataract; Glutathione; Inositol; Lens, Crystalline; Neuraminic Acids; Rats; Sorbitol

1967
An investigation into the loss of proteins of low molecular size from the lens in senile cataract.
    Experimental eye research, 1968, Volume: 7, Issue:1

    Topics: Aged; Aging; Animals; Autoradiography; Carbon Isotopes; Cataract; Cattle; Chromatography, Gel; Cryst

1968
Composition of mouse brain myelin during development.
    Journal of neurochemistry, 1968, Volume: 15, Issue:6

    Topics: Aging; Amino Alcohols; Animals; Brain; Brain Chemistry; Cholesterol; Galactose; Glycerylphosphorylch

1968
Changes with age in the utilization of glucose carbon in liver and brain.
    Journal of neurochemistry, 1966, Volume: 13, Issue:12

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Brain; Carbon; Carbon Isotopes; Centri

1966