inositol has been researched along with Aging in 98 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previously reported MRS findings in the aging brain include lower N-acetylaspartate (NAA) and higher myo-inositol (mI), total creatine (Cr) and choline-containing compound (Cho) concentrations." | 7.80 | Effects of normal aging and SCN1A risk-gene expression on brain metabolites: evidence for an association between SCN1A and myo-inositol. ( Brusniak, W; Demirakca, T; Diener, C; Ende, G; Matthäus, F; Meier, S; Sack, M; Schulze, TG; Tunc-Skarka, N; Weber-Fahr, W; Wolf, I, 2014) |
| " Concentrations of glutamate + glutamin (Glx), cholin (Cho), myoinositol (mIns), N-acetyl aspartate (NAA) expressed as ratio with creatine (Cr) and NAA were correlated with markers of disease activity (RIO score), Multiple Sclerosis Severity Scale (MSSS), Depressive-Severity Status Scale and Simple Numerical Fatigue Scale." | 3.85 | Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue. ( Baranovičová, E; Bittšanský, M; Čierny, D; Hnilicová, P; Kantorová, E; Kurča, E; Nosáľ, V; Poláček, H; Sivák, Š; Zeleňák, K, 2017) |
| "In a healthy aging normal population, choline/creatine and myo-inositol/creatine ratios were significantly increased in APOE E4 carriers, suggesting the presence of neuroinflammatory processes and greater membrane turnover in older carriers." | 3.80 | APOE genotype modulates proton magnetic resonance spectroscopy metabolites in the aging brain. ( Buthorn, JJ; Christen, E; Conejero-Goldberg, C; Davies, P; Dickinson, D; Goldberg, TE; Gomar, JJ; Gordon, ML; Huet, S; Keehlisen, L; Kingsley, PB; Koppel, J; Uluğ, AM, 2014) |
| " We used structural magnetic resonance imaging (sMRI) to measure the volume of the AHC, and magnetic resonance spectroscopy ((1)H-MRS) to measure concentrations of N-acetyl aspartate (NAA), creatine+phosphocreatine (Cr+PCr), myo-inositol (mI) and choline (Cho)." | 3.76 | Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging. ( Baird, G; Bolton, P; Conroy, RM; Curran, S; Daly, E; Foy, C; Hallahan, B; Murphy, DG; Murphy, KC; O'Brien, FM; O'Gorman, RL; Page, L; Robertson, D; Sharma, A, 2010) |
| "Long- and short-echo proton spectroscopic imaging were used to investigate concentrations and R2 relaxation rates of N-acetyl aspartate (NAA) + N-acetyl aspartyl glutamate (NAAG), choline (Cho), creatine (Cr), and myoinositol (mI) in the white matter of the centrum semiovale of 106 healthy volunteers aged 50-90 years; usable data were obtained from 79 subjects." | 3.74 | Long and short echo time proton magnetic resonance spectroscopic imaging of the healthy aging brain. ( Charlton, RA; Howe, FA; Markus, HS; McIntyre, DJ, 2007) |
| "Compared with seronegative controls, HIV-positive subjects showed additional and marked increases in the concentration of glial markers, choline-containing compounds (seronegative controls +2%/decade; HIV-positive subjects +10%/decade) and myoinositol (seronegative controls +3%/decade; HIV-positive subjects +12%/decade), with aging in the frontal white matter." | 3.72 | Effect of aging on brain metabolism in antiretroviral-naive HIV patients. ( Chang, L; Ernst, T, 2004) |
| "myo-Inositol (MI) plays an essential role in several important processes of cell physiology, is involved in the neural system, and provides an effective treatment for some psychiatric disorders." | 1.37 | Sodium/myo-inositol cotransporter 1 and myo-inositol are essential for osteogenesis and bone formation. ( Chan, AW; Chung, SK; Dai, Z; Kung, AW; Lau, KS; Miao, D, 2011) |
| "Patients with late-life major depressive disorder had a significantly lower NAA/creatine ratio in the left frontal white matter, and higher Cho/creatine and myo-inositol/creatine ratios in the left basal ganglia when compared with the control subjects." | 1.35 | Proton magnetic resonance spectroscopy of late-life major depressive disorder. ( Chen, CS; Chiang, IC; Hsieh, TJ; Kuo, YT; Li, CW; Lin, HF; Lin, WC; Liu, GC; Lu, CY, 2009) |
| "Inositol-4-phosphate was stable in the young rats but increased in the frontal cortex and the hippocampus in the old rats." | 1.29 | Sustained effects of pilocarpine-induced convulsions on brain inositol and inositol monophosphate levels and brain morphology in young and old male rats. ( Hirvonen, MR; Paljärvi, L; Savolainen, KM, 1993) |
| "Senile cataract was observed on six lenses of 12 rats aged 28-32 months." | 1.27 | Ageing and compositional changes of rat lens. ( Tsumita, T; Wada, E, 1984) |
| " Comparison of the dependence of the turnover on carbamoylcholine concentration revealed that in neonates, the dose-response curve was shifted to the left, giving a half-maximal effect at concentrations approximately tenfold lower than that in the adult." | 1.27 | Enhanced coupling of neonatal muscarinic receptors in rat brain to phosphoinositide turnover. ( Agranoff, BW; Fisher, SK; Heacock, AM, 1987) |
| "Inositol incorporation was also measurable, whereas [14C]serine incorporation was low or undetectable." | 1.27 | Renewal of the membrane complex of Schistosoma mansoni is closely associated with lipid metabolism. ( Ancelin, ML; Capron, A; Torpier, G; Vial, HJ, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (24.49) | 18.7374 |
| 1990's | 16 (16.33) | 18.2507 |
| 2000's | 20 (20.41) | 29.6817 |
| 2010's | 27 (27.55) | 24.3611 |
| 2020's | 11 (11.22) | 2.80 |
| Authors | Studies |
|---|---|
| Li, XL | 2 |
| Yu, F | 2 |
| Fu, CL | 2 |
| Yu, X | 2 |
| Xu, M | 2 |
| Cheng, M | 2 |
| Hone-Blanchet, A | 1 |
| Bohsali, A | 1 |
| Krishnamurthy, LC | 1 |
| Shahid, S | 1 |
| Lin, Q | 1 |
| Zhao, L | 1 |
| Loring, D | 1 |
| Goldstein, F | 1 |
| John, SE | 1 |
| Fleischer, CC | 1 |
| Levey, A | 1 |
| Lah, J | 1 |
| Qiu, D | 1 |
| Crosson, B | 1 |
| Rodríguez-Nieto, G | 1 |
| Levin, O | 2 |
| Hermans, L | 1 |
| Weerasekera, A | 1 |
| Sava, AC | 1 |
| Haghebaert, A | 1 |
| Huybrechts, A | 1 |
| Cuypers, K | 1 |
| Mantini, D | 1 |
| Himmelreich, U | 2 |
| Swinnen, SP | 1 |
| Vints, WAJ | 1 |
| Ziv, G | 1 |
| Katkutė, G | 1 |
| Kušleikienė, S | 1 |
| Valatkevičienė, K | 1 |
| Sheoran, S | 1 |
| Drozdova-Statkevičienė, M | 1 |
| Gleiznienė, R | 1 |
| Pääsuke, M | 1 |
| Dudonienė, V | 1 |
| Česnaitienė, VJ | 1 |
| Masiulis, N | 1 |
| Deelchand, DK | 2 |
| Eberly, LE | 2 |
| McCarten, JR | 2 |
| Hemmy, LS | 2 |
| Auerbach, EJ | 2 |
| Marjańska, M | 2 |
| Mahmoudi, N | 1 |
| Dadak, M | 1 |
| Bronzlik, P | 1 |
| Maudsley, AA | 1 |
| Sheriff, S | 1 |
| Lanfermann, H | 1 |
| Ding, XQ | 1 |
| Pericuesta, E | 1 |
| Laguna-Barraza, R | 1 |
| Ramos-Ibeas, P | 1 |
| Gutierrez-Arroyo, JL | 1 |
| Navarro, JA | 1 |
| Vera, K | 1 |
| Sanjuan, C | 1 |
| Baixeras, E | 1 |
| de Fonseca, FR | 1 |
| Gutierrez-Adan, A | 1 |
| Yang, S | 1 |
| Fang, G | 1 |
| Zhang, A | 1 |
| Ruan, B | 1 |
| Jiang, H | 1 |
| Ding, S | 1 |
| Liu, C | 1 |
| Zhang, Y | 1 |
| Jaha, N | 1 |
| Hu, P | 1 |
| Xu, Z | 1 |
| Gao, Z | 1 |
| Wang, J | 1 |
| Qian, Q | 1 |
| Shi, D | 1 |
| Xia, X | 1 |
| Cui, A | 1 |
| Xiong, Z | 1 |
| Yan, Y | 1 |
| Luo, J | 1 |
| Chen, G | 1 |
| Zeng, Y | 1 |
| Cai, D | 1 |
| Hou, L | 1 |
| McDermott, J | 1 |
| Li, Y | 1 |
| Zhang, H | 1 |
| Han, JJ | 1 |
| Gao, HQ | 1 |
| Sporn, L | 1 |
| MacMillan, EL | 1 |
| Ge, R | 1 |
| Greenway, K | 1 |
| Vila-Rodriguez, F | 1 |
| Laule, C | 1 |
| Fried, PJ | 1 |
| Pascual-Leone, A | 1 |
| Bolo, NR | 1 |
| Zhang, X | 2 |
| Wu, J | 1 |
| Liu, H | 1 |
| Menezes, TL | 1 |
| Andrade-Valença, LP | 1 |
| Valença, MM | 1 |
| Chiu, PW | 1 |
| Mak, HK | 1 |
| Yau, KK | 1 |
| Chan, Q | 1 |
| Chang, RC | 1 |
| Chu, LW | 1 |
| Gomar, JJ | 1 |
| Gordon, ML | 1 |
| Dickinson, D | 1 |
| Kingsley, PB | 1 |
| Uluğ, AM | 1 |
| Keehlisen, L | 1 |
| Huet, S | 1 |
| Buthorn, JJ | 1 |
| Koppel, J | 1 |
| Christen, E | 1 |
| Conejero-Goldberg, C | 1 |
| Davies, P | 1 |
| Goldberg, TE | 1 |
| Mori, T | 1 |
| Mori, K | 1 |
| Ito, H | 1 |
| Goji, A | 1 |
| Miyazaki, M | 1 |
| Harada, M | 1 |
| Kurosawa, K | 1 |
| Kagami, S | 1 |
| Tunc-Skarka, N | 1 |
| Meier, S | 1 |
| Demirakca, T | 1 |
| Sack, M | 1 |
| Weber-Fahr, W | 1 |
| Brusniak, W | 1 |
| Wolf, I | 1 |
| Matthäus, F | 1 |
| Schulze, TG | 1 |
| Diener, C | 1 |
| Ende, G | 1 |
| Bolognin, S | 1 |
| Buffelli, M | 1 |
| Puoliväli, J | 1 |
| Iqbal, K | 1 |
| Chang, L | 3 |
| Jiang, C | 1 |
| Cunningham, E | 1 |
| Buchthal, S | 1 |
| Douet, V | 1 |
| Andres, M | 1 |
| Ernst, T | 3 |
| Mazgaj, R | 1 |
| Tal, A | 1 |
| Goetz, R | 1 |
| Lazar, M | 1 |
| Rothman, K | 1 |
| Messinger, JW | 1 |
| Malaspina, D | 1 |
| Gonen, O | 2 |
| Yang, ZY | 1 |
| Yue, Q | 1 |
| Xing, HY | 1 |
| Tan, QY | 1 |
| Sun, HQ | 1 |
| Gong, QY | 1 |
| Tan, ZJ | 1 |
| Quan, H | 1 |
| Tsili, AC | 1 |
| Astrakas, LG | 1 |
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| Giannakis, D | 1 |
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| Argyropoulou, MI | 1 |
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| Unschuld, PG | 1 |
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| Lim, IA | 1 |
| Churchill, G | 1 |
| Harris, AD | 1 |
| Hua, J | 1 |
| Barker, PB | 2 |
| Ross, CA | 1 |
| van Zijl, PC | 1 |
| Edden, RA | 1 |
| Margolis, RL | 1 |
| Kantorová, E | 1 |
| Poláček, H | 1 |
| Bittšanský, M | 1 |
| Baranovičová, E | 1 |
| Hnilicová, P | 1 |
| Čierny, D | 1 |
| Sivák, Š | 1 |
| Nosáľ, V | 1 |
| Zeleňák, K | 1 |
| Kurča, E | 1 |
| SanGiovanni, JP | 1 |
| Mehta, S | 2 |
| Horská, A | 1 |
| Farage, L | 1 |
| Bibat, G | 1 |
| Nagae, LM | 1 |
| Kaufmann, WE | 1 |
| Naidu, S | 1 |
| Chen, CS | 1 |
| Chiang, IC | 1 |
| Li, CW | 1 |
| Lin, WC | 1 |
| Lu, CY | 1 |
| Hsieh, TJ | 1 |
| Liu, GC | 1 |
| Lin, HF | 1 |
| Kuo, YT | 1 |
| Ronen, I | 1 |
| Fan, X | 1 |
| Schettler, S | 1 |
| Jain, S | 1 |
| Murray, D | 1 |
| Kim, DS | 1 |
| Killiany, R | 1 |
| Rosene, D | 1 |
| Chen, SQ | 2 |
| Wang, PJ | 2 |
| Ten, GJ | 1 |
| Zhan, W | 1 |
| Li, MH | 1 |
| Zang, FC | 2 |
| Raininko, R | 1 |
| Mattsson, P | 1 |
| Cosker, KE | 1 |
| Segal, RA | 1 |
| Dai, Z | 1 |
| Chung, SK | 1 |
| Miao, D | 1 |
| Lau, KS | 1 |
| Chan, AW | 1 |
| Kung, AW | 1 |
| O'Brien, FM | 1 |
| Page, L | 1 |
| O'Gorman, RL | 1 |
| Bolton, P | 1 |
| Sharma, A | 1 |
| Baird, G | 1 |
| Daly, E | 1 |
| Hallahan, B | 1 |
| Conroy, RM | 1 |
| Foy, C | 1 |
| Curran, S | 1 |
| Robertson, D | 1 |
| Murphy, KC | 1 |
| Murphy, DG | 1 |
| Chakraborty, A | 1 |
| Koldobskiy, MA | 1 |
| Bello, NT | 1 |
| Maxwell, M | 1 |
| Potter, JJ | 1 |
| Juluri, KR | 1 |
| Maag, D | 1 |
| Kim, S | 1 |
| Huang, AS | 1 |
| Dailey, MJ | 1 |
| Saleh, M | 1 |
| Snowman, AM | 1 |
| Moran, TH | 1 |
| Mezey, E | 1 |
| Snyder, SH | 1 |
| Reyngoudt, H | 1 |
| Claeys, T | 1 |
| Vlerick, L | 1 |
| Verleden, S | 1 |
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| Babb, JS | 1 |
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2 reviews available for inositol and Aging
| Article | Year |
|---|---|
Variation in lipid-associated genes as they relate to risk of advanced age-related macular degeneration.
Topics: Aging; Diet; Docosahexaenoic Acids; Fatty Acids; Fatty Acids, Omega-3; Genetic Predisposition to Dis | 2009 |
Acute and chronic complications of diabetes mellitus in older patients.
Topics: Adult; Aged; Aging; Blood Pressure; Diabetes Complications; Diabetes Mellitus; Diabetic Coma; Diabet | 1986 |
3 trials available for inositol and Aging
| Article | Year |
|---|---|
Scyllo-inositol in normal aging human brain: 1H magnetic resonance spectroscopy study at 4 Tesla.
Topics: Adaptation, Physiological; Adult; Aged; Aging; Brain; Female; Humans; Inositol; Internal Capsule; Ma | 2005 |
Aging alters regional multichemical profile of the human brain: an in vivo 1H-MRS study of young versus middle-aged subjects.
Topics: Adult; Age Factors; Aging; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; gamma-A | 2001 |
Aging alters the multichemical networking profile of the human brain: an in vivo (1)H-MRS study of young versus middle-aged subjects.
Topics: Adult; Aging; Analysis of Variance; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female | 2001 |
93 other studies available for inositol and Aging
| Article | Year |
|---|---|
Phosphoproteomics analysis of diabetic cardiomyopathy in aging-accelerated mice and effects of D-pinitol.
Topics: Aging; Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Disease Model | 2022 |
Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Biomarkers; Cognition; Creatine; Fem | 2022 |
Organization of neurochemical interactions in young and older brains as revealed with a network approach: Evidence from proton magnetic resonance spectroscopy (
Topics: Aged; Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Inositol; Motor Cortex; Prefrontal Cor | 2023 |
Neurometabolic correlates of posturography in normal aging and older adults with mild cognitive impairment: Evidence from a
Topics: Aged; Aging; Aspartic Acid; Choline; Cognitive Dysfunction; Creatine; Glutamine; Humans; Inositol; P | 2023 |
Scyllo-inositol: Transverse relaxation time constant at 3 T and concentration changes associated with aging and alcohol use.
Topics: Adult; Aged; Aging; Alcohol Drinking; Brain; Humans; Infant, Newborn; Inositol; Young Adult | 2023 |
Microstructural and Metabolic Changes in Normal Aging Human Brain Studied with Combined Whole-Brain MR Spectroscopic Imaging and Quantitative MR Imaging.
Topics: Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Inositol; Magnetic Resonance Imaging; Magnet | 2023 |
Changes in the intracellular microenvironment in the aging human brain.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Brain Chemistry; Cellular M | 2020 |
D-Chiro-Inositol Treatment Affects Oocyte and Embryo Quality and Improves Glucose Intolerance in Both Aged Mice and Mouse Models of Polycystic Ovarian Syndrome.
Topics: Aging; Animals; Blastocyst; Cumulus Cells; Dihydrotestosterone; Disease Models, Animal; Female; Gene | 2020 |
Rice EARLY SENESCENCE 2, encoding an inositol polyphosphate kinase, is involved in leaf senescence.
Topics: Aging; China; Gene Expression Regulation, Plant; Genes, Plant; Inositol; Oryza; Phosphotransferases | 2020 |
The precursor of PI(3,4,5)P
Topics: Aging; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegans Protei | 2020 |
Effects of D-pinitol on myocardial apoptosis and fibrosis in streptozocin-induced aging-accelerated mice.
Topics: Aged; Aging; Animals; Apoptosis; Diabetes Mellitus, Experimental; Fibrosis; Humans; Inositol; Mice; | 2021 |
Longer Repetition Time Proton MR Spectroscopy Shows Increasing Hippocampal and Parahippocampal Metabolite Concentrations with Aging.
Topics: Adolescent; Adult; Aging; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Glutamine; Hippoc | 2019 |
Diabetes and the link between neuroplasticity and glutamate in the aging human motor cortex.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Creatine; Diabetes Mellitus, Type 2; Female; Glucose; | 2019 |
Age- and gender-related metabonomic alterations in striatum and cerebellar cortex in rats.
Topics: Aging; Animals; Cerebellar Cortex; Corpus Striatum; Creatine; Female; Glutamic Acid; Inositol; Lacti | 2013 |
Magnetic resonance imaging study cannot individually distinguish individuals with mild cognitive impairment, mild Alzheimer's disease, and normal aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Di | 2013 |
Metabolic changes in the anterior and posterior cingulate cortices of the normal aging brain: proton magnetic resonance spectroscopy study at 3 T.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain Chemistry; China; Choline; Creatine; Fem | 2014 |
APOE genotype modulates proton magnetic resonance spectroscopy metabolites in the aging brain.
Topics: Aged; Aged, 80 and over; Aging; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Brain; Chol | 2014 |
Age-related changes in a patient with Pelizaeus-Merzbacher disease determined by repeated 1H-magnetic resonance spectroscopy.
Topics: Aging; Aspartic Acid; Case-Control Studies; Child, Preschool; Creatine; gamma-Aminobutyric Acid; Glu | 2014 |
Effects of normal aging and SCN1A risk-gene expression on brain metabolites: evidence for an association between SCN1A and myo-inositol.
Topics: Adult; Aged; Aged, 80 and over; Aging; Animals; Brain; Evidence-Based Medicine; Female; Gene Express | 2014 |
Rescue of cognitive-aging by administration of a neurogenic and/or neurotrophic compound.
Topics: Administration, Oral; Aging; Alzheimer Disease; Animals; Ciliary Neurotrophic Factor; Cognition Diso | 2014 |
Effects of APOE ε4, age, and HIV on glial metabolites and cognitive deficits.
Topics: Adult; Aging; Apolipoprotein E4; Choline; Cognition Disorders; Cross-Sectional Studies; Female; Fron | 2014 |
Hypo-metabolism of the rostral anterior cingulate cortex associated with working memory impairment in 18 cases of schizophrenia.
Topics: Adult; Aging; Aspartic Acid; Creatine; Female; Gliosis; Gyrus Cinguli; Humans; Inositol; Intelligenc | 2016 |
A quantitative analysis of (1)H-MR spectroscopy at 3.0 T of three brain regions from childhood to middle age.
Topics: Adolescent; Adult; Aging; Analysis of Variance; Aspartic Acid; Brain; Child; Creatinine; Female; Glu | 2015 |
MR Spectra of Normal Adult Testes and Variations with Age: Preliminary Observations.
Topics: Adult; Age Factors; Aged; Aging; Choline; Creatine; Humans; Inositol; Magnetic Resonance Spectroscop | 2016 |
Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A (1)H MRS Study at 7 Tesla.
Topics: Adult; Aging; Antipsychotic Agents; Aspartic Acid; Choline; Creatine; Dipeptides; Female; gamma-Amin | 2016 |
Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue.
Topics: Adult; Aging; Aspartic Acid; Case-Control Studies; Choline; Creatine; Cross-Sectional Studies; Depre | 2017 |
Brain metabolism in Rett syndrome: age, clinical, and genotype correlations.
Topics: Adolescent; Aging; Analysis of Variance; Aspartic Acid; Case-Control Studies; Child; Child, Preschoo | 2009 |
Proton magnetic resonance spectroscopy of late-life major depressive disorder.
Topics: Aged; Aging; Aspartic Acid; Basal Ganglia; Biomarkers; Brain; Choline; Cognition; Creatine; Depressi | 2009 |
Regional age-related effects in the monkey brain measured with 1H magnetic resonance spectroscopy.
Topics: Aging; Animals; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Humans; Image Processing, Co | 2011 |
Role of myo-inositol by magnetic resonance spectroscopy in early diagnosis of Alzheimer's disease in APP/PS1 transgenic mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Apolipoproteins E; Biomarkers; Brain Chemi | 2009 |
Metabolite concentrations in supraventricular white matter from teenage to early old age: A short echo time 1H magnetic resonance spectroscopy (MRS) study.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Fe | 2010 |
The longer U(T)R, the further you go.
Topics: 3' Untranslated Regions; Aging; Animals; Cell Enlargement; Gene Expression; Gene Expression Profilin | 2010 |
Sodium/myo-inositol cotransporter 1 and myo-inositol are essential for osteogenesis and bone formation.
Topics: Aging; Animals; Bone and Bones; Cell Count; Cell Differentiation; Cell Line; Embryo, Mammalian; Gene | 2011 |
Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging.
Topics: Adolescent; Adult; Age Factors; Aging; Amygdala; Aspartic Acid; Asperger Syndrome; Brain Mapping; Ch | 2010 |
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain.
Topics: Adipogenesis; Aging; Animals; Cell Culture Techniques; Diet; Diphosphates; Inositol; Inositol Phosph | 2010 |
Age-related differences in metabolites in the posterior cingulate cortex and hippocampus of normal ageing brain: a 1H-MRS study.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Analysis of Variance; Aspartic Acid; Choline; Creatine; | 2012 |
Longitudinal inter- and intra-individual human brain metabolic quantification over 3 years with proton MR spectroscopy at 3 T.
Topics: Aging; Algorithms; Aspartic Acid; Brain; Choline; Creatine; Humans; Inositol; Longitudinal Studies; | 2012 |
Sodium/myo-Inositol transporters: substrate transport requirements and regional brain expression in the TgCRND8 mouse model of amyloid pathology.
Topics: Aging; Alzheimer Disease; Amyloid; Animals; Biological Transport; Brain; Gene Expression Regulation, | 2011 |
Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Cholin | 2012 |
Procedure for quantitative (1)H magnetic resonance spectroscopy and tissue characterization of human brain tissue based on the use of quantitative magnetic resonance imaging.
Topics: Adolescent; Adult; Aged; Aging; Creatine; Female; Humans; Inositol; Magnetic Resonance Imaging; Magn | 2013 |
Longitudinal 1H MRS of rat forebrain from infancy to adulthood reveals adolescence as a distinctive phase of neurometabolite development.
Topics: Aging; Animals; Aspartic Acid; Dipeptides; Glutamic Acid; Inositol; Magnetic Resonance Spectroscopy; | 2013 |
THE EFFECT OF DIABETES ON THE CONTENT OF SORBITOL, GLUCOSE, FRUCTOSE AND INOSITOL IN THE HUMAN LENS.
Topics: Aging; Cataract; Diabetes Mellitus; Fructose; Geriatrics; Glucose; Humans; Inositol; Lens, Crystalli | 1964 |
Effect of aging on brain metabolism in antiretroviral-naive HIV patients.
Topics: Adolescent; Adult; Aging; Aspartic Acid; Basal Ganglia; Brain; Choline; Creatinine; Female; Frontal | 2004 |
High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease.
Topics: Aging; Animals; Aspartic Acid; Brain; Cerebellum; Cerebral Cortex; Creatine; Disease Models, Animal; | 2005 |
MRS of normal and impaired fetal brain development.
Topics: Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Fetal Development; Fetus; gamma-Aminobutyric | 2006 |
Longitudinal changes during aging using proton magnetic resonance spectroscopy.
Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Aspartic Acid; Brain; Chi-Square Distribution; | 2006 |
The metabonomics of aging and development in the rat: an investigation into the effect of age on the profile of endogenous metabolites in the urine of male rats using 1H NMR and HPLC-TOF MS.
Topics: Aging; Animals; Chromatography, High Pressure Liquid; Citrates; Creatinine; Energy Metabolism; Hippu | 2005 |
Long and short echo time proton magnetic resonance spectroscopic imaging of the healthy aging brain.
Topics: Aged; Aged, 80 and over; Aging; Artifacts; Aspartic Acid; Brain; Choline; Creatine; Dipeptides; Fema | 2007 |
Assessing multiple-group diagnostic problems with multi-dimensional receiver operating characteristic surfaces: application to proton MR Spectroscopy (MRS) in HIV-related neurological injury.
Topics: Adult; Aging; AIDS Dementia Complex; Algorithms; Aspartic Acid; Basal Ganglia; Brain; Brain Chemistr | 2008 |
The metabolites citrate, myo-inositol, and spermine are potential age-independent markers of prostate cancer in human expressed prostatic secretions.
Topics: Adult; Aged; Aging; Area Under Curve; Biomarkers, Tumor; Body Fluids; Citric Acid; Humans; Inositol; | 2008 |
Ageing and compositional changes of rat lens.
Topics: Aging; Animals; Carbohydrate Metabolism; Cataract; Fatty Acids; Female; Inositol; Lens, Crystalline; | 1984 |
Free and total lipid myo-inositol concentrations decrease with age in human brain.
Topics: Adult; Aged; Aging; Brain Chemistry; Humans; Inositol; Lipid Metabolism; Middle Aged | 1983 |
Effect of aging on myo-inositol and phosphoinositide metabolism in the cochlear and vestibular sensory epithelia of the rat.
Topics: Adenosine Triphosphate; Aging; Animals; Binding Sites; Carbachol; Cochlea; Epithelium; Hydrolysis; I | 1994 |
Sustained effects of pilocarpine-induced convulsions on brain inositol and inositol monophosphate levels and brain morphology in young and old male rats.
Topics: Aging; Animals; Brain; Inositol; Inositol Phosphates; Male; Neurons; Pilocarpine; Rats; Rats, Wistar | 1993 |
Natural course of diabetic peripheral neuropathy in spontaneous-onset diabetic Chinese hamsters.
Topics: Aging; Animals; Cricetinae; Cricetulus; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Electrophy | 1995 |
1H-MRS, MRI-based hippocampal volumetry, and 99mTc-HMPAO-SPECT in normal aging, age-associated memory impairment, and probable Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Case-Control Stud | 1996 |
In vivo proton magnetic resonance spectroscopy of the normal aging human brain.
Topics: Adult; Aged; Aging; Body Water; Brain; Choline; Creatine; Glutamic Acid; Glutamine; Humans; Inositol | 1996 |
The novel metabotropic glutamate receptor agonist 2R,4R-APDC potentiates stimulation of phosphoinositide hydrolysis in the rat hippocampus by 3,5-dihydroxyphenylglycine: evidence for a synergistic interaction between group 1 and group 2 receptors.
Topics: Aging; Animals; Animals, Newborn; Brain; Cloning, Molecular; Colforsin; Cyclic AMP; Cycloleucine; Dr | 1996 |
Factors affecting electrical activation of porcine oocyte matured in vitro.
Topics: Aging; Animals; Cell Cycle; Cell Division; Cells, Cultured; Coculture Techniques; Culture Media; Ele | 1997 |
Glucosylceramides stimulate mitogenesis in aged murine epidermis.
Topics: Administration, Topical; Aging; Animals; Animals, Newborn; DNA; Enzyme Inhibitors; Epidermal Cells; | 1998 |
Age-related loss of calcitriol stimulation of phosphoinositide hydrolysis in rat skeletal muscle.
Topics: Aging; Animals; Arachidonic Acid; Calcitriol; Calcium; Cell Membrane; Diglycerides; GTP-Binding Prot | 1998 |
Age-related brain changes in rhesus monkeys: a magnetic resonance spectroscopic study.
Topics: Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition; Creatine; Female; Inosito | 1998 |
Maintenance of tricarboxylic acid cycle kinetics in Brown-Norway Fischer 344 rats may translate to longevity.
Topics: Aging; Amino Acids; Animals; Citric Acid Cycle; Glucose; Glycolysis; Hippocampus; Inositol; Kinetics | 2000 |
Inhibition of progressive reduction of islet beta-cell mass in spontaneously diabetic Goto-Kakizaki rats by alpha-glucosidase inhibitor.
Topics: Aging; Animals; Body Weight; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glycoside Hydrolase Inhib | 2000 |
A (1)H magnetic resonance spectroscopy study of aging in parietal white matter: implications for trials in multiple sclerosis.
Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; I | 2000 |
Spontaneous age-related peripheral neuropathy in B6C3F1 mice.
Topics: Aging; Animals; Axons; Blood Glucose; Body Temperature; Cell Division; Female; Glycated Hemoglobin; | 2000 |
(1)H-MR spectroscopy differentiates mild cognitive impairment from normal brain aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Choline; Cognitio | 2001 |
Studies on avian erythrocyte metabolism-IV. relationship between the major phosphorylated metabolic intermediates and oxygen affinity of whole blood in adults and embryos in several galliformes.
Topics: Adenine Nucleotides; Aging; Animals; Birds; Diphosphoglyceric Acids; Embryo, Nonmammalian; Erythrocy | 1976 |
Phosphate compounds in red cells of reptiles, amphibians and fish.
Topics: Aging; Alligators and Crocodiles; Animals; Diphosphoglyceric Acids; Embryo, Nonmammalian; Erythrocyt | 1976 |
Ageing of Neurospora crassa. V. Lipid peroxidation and decay of respiratory enzymes in an inositol auxotroph.
Topics: Aging; Antioxidants; Catechols; Cytochrome Reductases; Electron Transport Complex IV; Hydrocortisone | 1978 |
Protein-catalyzed exchange of phosphatidylinositol between rat brain microsomes and myelin.
Topics: Aging; Animals; Brain; Inositol; Kinetics; Microsomes; Myelin Sheath; Nerve Tissue Proteins; Phospha | 1979 |
Pineal muscarinic phosphoinositide responses: age-associated sensitization, agonist-induced desensitization and increase in melatonin release from cultured pineal glands.
Topics: Aging; Animals; Carbachol; Culture Techniques; Inositol; Kinetics; Male; Melatonin; Phosphatidylinos | 1992 |
Age-related differences in the phosphoinositide system in rat neostriatum.
Topics: Aging; Animals; Corpus Striatum; In Vitro Techniques; Inositol; Lithium; Male; Oxotremorine; Phospha | 1992 |
Developmental changes of EAA metabotropic receptor activity in rat cerebellum.
Topics: Aging; Animals; Cerebellum; Cycloleucine; Hydrolysis; Inositol; Inositol Phosphates; Rats; Rats, Wis | 1992 |
Perinatal development of inositol synthesis and catabolism in rabbit kidney.
Topics: Aging; Amniotic Fluid; Animals; Animals, Newborn; Betamethasone; Female; Fetus; Inositol; Inositol O | 1991 |
[Calcium antagonists and vascular aging].
Topics: Aging; Animals; Blood Vessels; Calcium; Calcium Channel Blockers; Humans; Inositol; Lipid Metabolism | 1991 |
The significance of nerve sugar levels for the peripheral nerve impairment of spontaneously diabetic GK (Goto-Kakizaki) rats.
Topics: Aging; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Fructose; Glucose; Inos | 1990 |
Abnormal vascular phosphoinositide hydrolysis in the spontaneously hypertensive rat.
Topics: Aging; Animals; Hydrolysis; Hypertension; Inositol; Male; Muscle, Smooth, Vascular; Phosphatidylinos | 1986 |
Enhanced coupling of neonatal muscarinic receptors in rat brain to phosphoinositide turnover.
Topics: Aging; Animals; Animals, Newborn; Carbachol; Cerebral Cortex; Inositol; Phosphatidylinositols; Quinu | 1987 |
L-myo-inositol-1-phosphate synthase from mammalian brain: partial purification and characterisation of the fetal and adult enzyme.
Topics: Aging; Brain; Carbohydrate Epimerases; Humans; Inositol; Myo-Inositol-1-Phosphate Synthase | 1988 |
Renewal of the membrane complex of Schistosoma mansoni is closely associated with lipid metabolism.
Topics: Aging; Animals; Biomphalaria; Carbon Radioisotopes; Choline; Ethanolamine; Ethanolamines; Female; Gl | 1985 |
Composition and metabolism of phospholipids in cataract.
Topics: Aging; Animals; Cataract; Humans; Inositol; Lens, Crystalline; Phosphatidylcholines; Phosphatidyleth | 1969 |
Studies on myo-inositol metabolism in galactosemia.
Topics: Adenosine Triphosphate; Aging; Alcohols; Alkaline Phosphatase; Animals; Brain; Carbon Isotopes; Diet | 1969 |
Phospholipid metabolism during the development of the liver. The incorporation of [1,2-14C]ethanolamine, [2-3H]myo-inositol and L-[U-14C]serine into phospholipids by liver slices.
Topics: Aging; Amino Alcohols; Animals; Carbon Isotopes; Cholesterol; Fatty Acids; Female; Glycerides; Glyce | 1971 |
Lipids in tissues of the eye. V. Phospholipid metabolism in normal and cataractous lens.
Topics: Aging; Albumins; Alcohols; Alloxan; Animals; Cataract; Cattle; Cytosine Nucleotides; Diabetes Mellit | 1971 |
Effect of membrane stabilizing drugs on mortality in Drosophila melanogaster.
Topics: Adrenal Cortex Hormones; Aging; Analgesics; Animals; Cell Membrane; Central Nervous System Stimulant | 1971 |
Inositol-less death in Neurospora and cellular ageing.
Topics: Aging; Carbon Isotopes; Cell Membrane; Fungal Proteins; Glucosephosphate Dehydrogenase; Glutamate De | 1973 |
Skeletal muscle lipids. II. Changes in phospholipid composition in man from fetal to middle age.
Topics: Adolescent; Adult; Aging; Brain; Cardiolipins; Child; Child, Preschool; Chromatography, DEAE-Cellulo | 1974 |
Skeletal muscle lipids. I. Changes in fatty acid composition of lecithin in man during growth.
Topics: Abortion, Legal; Adolescent; Adult; Aging; Amino Alcohols; Child, Preschool; Chromatography, Gas; Ch | 1971 |
[Biochemical characteristics of the cataract lens. 1. Comparison of water content and concentration of sorbitol, inositol, glutathione and sialic acid in the young and adult rat lens].
Topics: Aging; Animals; Cataract; Glutathione; Inositol; Lens, Crystalline; Neuraminic Acids; Rats; Sorbitol | 1967 |
An investigation into the loss of proteins of low molecular size from the lens in senile cataract.
Topics: Aged; Aging; Animals; Autoradiography; Carbon Isotopes; Cataract; Cattle; Chromatography, Gel; Cryst | 1968 |
Composition of mouse brain myelin during development.
Topics: Aging; Amino Alcohols; Animals; Brain; Brain Chemistry; Cholesterol; Galactose; Glycerylphosphorylch | 1968 |
Changes with age in the utilization of glucose carbon in liver and brain.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Brain; Carbon; Carbon Isotopes; Centri | 1966 |