Page last updated: 2024-10-19

inositol and Age-Related Memory Disorders

inositol has been researched along with Age-Related Memory Disorders in 12 studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Research Excerpts

ExcerptRelevanceReference
"Peripheral hyperglycemia was associated with significant increases in brain sorbitol (7."3.74Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory. ( Chong, L; Diamond, DM; Hanna, S; Malone, JI; Mervis, RF; Park, CR; Saporta, S, 2008)
"Epilepsy is a severe neurological disease characterized by spontaneous recurrent seizures (SRS)."1.72Myo-Inositol Limits Kainic Acid-Induced Epileptogenesis in Rats. ( Burjanadze, M; Dashniani, M; Gamkrelidze, G; Kandashvili, M; Kokaia, M; Lagani, V; Lepsveridze, E; Lordkipanidze, T; Solomonia, R; Tsverava, L, 2022)
"Despite progress in defining a pathogenic role for amyloid beta protein (Abeta) in Alzheimer's disease, orally bioavailable compounds that prevent its effects on hippocampal synaptic plasticity and cognitive function have not yet emerged."1.33Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers. ( Cleary, JP; Hofmeister, J; Lesne, S; Mehta, T; O'Hare, E; Selkoe, DJ; Townsend, M; Walsh, DM, 2006)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19901 (8.33)18.7374
1990's1 (8.33)18.2507
2000's6 (50.00)29.6817
2010's3 (25.00)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Kandashvili, M1
Gamkrelidze, G1
Tsverava, L1
Lordkipanidze, T1
Lepsveridze, E1
Lagani, V1
Burjanadze, M1
Dashniani, M1
Kokaia, M1
Solomonia, R1
Shan, Y1
Jia, Y1
Zhong, S1
Li, X1
Zhao, H1
Chen, J1
Lu, Q1
Zhang, L1
Li, Z1
Lai, S1
Wang, Y1
Lee, BH1
Lee, CC1
Wu, SC1
Mazgaj, R1
Tal, A1
Goetz, R1
Lazar, M1
Rothman, K1
Messinger, JW1
Malaspina, D1
Gonen, O1
Malone, JI1
Hanna, S1
Saporta, S1
Mervis, RF1
Park, CR1
Chong, L1
Diamond, DM1
Weiss, U1
Bacher, R1
Vonbank, H1
Kemmler, G1
Lingg, A1
Marksteiner, J1
Frederick, BD1
Lyoo, IK1
Satlin, A1
Ahn, KH1
Kim, MJ1
Yurgelun-Todd, DA1
Cohen, BM1
Renshaw, PF1
Metastasio, A1
Rinaldi, P1
Tarducci, R2
Mariani, E1
Feliziani, FT1
Cherubini, A1
Pelliccioli, GP2
Gobbi, G2
Senin, U2
Mecocci, P1
Townsend, M1
Cleary, JP1
Mehta, T1
Hofmeister, J1
Lesne, S1
O'Hare, E1
Walsh, DM1
Selkoe, DJ1
Parnetti, L1
Lowenthal, DT1
Presciutti, O1
Palumbo, R1
Chiarini, P1
Palumbo, B1
Lin, A1
Nguy, CH1
Shic, F1
Ross, BD1
Ritschel, WA1
Wagensonner, D1
Heringer, EA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Open-label Exploratory Study With Memantine: Correlation Between Proton Magnetic Resonance Spectroscopy, Cerebrospinal Fluid Biomarkers, and Cognition in Patients With Mild to Moderate Alzheimer's Disease[NCT00551161]Phase 412 participants (Actual)Interventional2007-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Changes in the Metabolite Ratios of N-acetylaspartate (NAA) to Creatine (Cr), Myo-inositol (mI) to Cr, Choline (Cho) to Cr, NAA to Cho, and NAA to mI, on Cholinesterase Monotherapy vs Combination of Memantine and Cholinesterase Inhibitor

Ratios of myo-inositol (mI), N-acetylaspartate (NAA), total creatine (Cr), and choline (Cho) by single voxel 1H MRS (proton magnetic resonance spectroscopy). Mean (± SD) metabolite levels (normalized to T2-corrected water signal intensity) and metabolite ratios for Alzheimer's disease subjects at baseline (t0), after 24 weeks of ongoing monotherapy with stable-dose cholinesterase inhibitor (t1), and after another 24 weeks of combination therapy with memantine in addition to stable-dose cholinesterase inhibitor (t2). The Wilcoxon signed-rank test was used to examine whether the change between t0 and t1 differed from the change between t1 and t2 [(t2 - t1) - (t1 - t0)]. (NCT00551161)
Timeframe: Baseline, 24 weeks, and 48 weeks

Interventionratio (normalized to T2-corrected water (Mean)
Change in NAA [(t2-t1) - (t1-t0)]Change in Cr [(t2-t1) - (t1-t0)]Change in Cho [(t2-t1) - (t1-t0)]Change in mI [(t2-t1) - (t1-t0)]Change in NAA/Cr [(t2-t1) - (t1-t0)]Change in Cho/Cr [(t2-t1) - (t1-t0)]Change in mI/Cr [(t2-t1) - (t1-t0)]Change in NAA/Cho [(t2-t1) - (t1-t0)]Change in NAA/mI [(t2-t1) - (t1-t0)]
Memantine-54-2916-0.090.020.04-0.26-0.35

Trials

2 trials available for inositol and Age-Related Memory Disorders

ArticleYear
Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy.
    Toxicology letters, 2001, Sep-15, Volume: 123, Issue:2-3

    Topics: Administration, Oral; Adult; Aged; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Dimethy

2001
[Statistical evaluation of the effect of 3 stimulants of cellular metabolism].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1970, Sep-08, Volume: 59, Issue:36

    Topics: Adult; Aged; Aminobutyrates; Ascorbic Acid; Attention; Calcium; Depression; Emotions; Fatigue; Feedi

1970

Other Studies

10 other studies available for inositol and Age-Related Memory Disorders

ArticleYear
Myo-Inositol Limits Kainic Acid-Induced Epileptogenesis in Rats.
    International journal of molecular sciences, 2022, Jan-21, Volume: 23, Issue:3

    Topics: Animals; Antinematodal Agents; Disease Models, Animal; Epilepsy; Inositol; Kainic Acid; Male; Memory

2022
Correlations between working memory impairment and neurometabolites of prefrontal cortex and lenticular nucleus in patients with major depressive disorder.
    Journal of affective disorders, 2018, Volume: 227

    Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Corpus Striatum; Creatine; Depressive Disorder,

2018
Ice plant (Mesembryanthemum crystallinum) improves hyperglycaemia and memory impairments in a Wistar rat model of streptozotocin-induced diabetes.
    Journal of the science of food and agriculture, 2014, Volume: 94, Issue:11

    Topics: Acetylcholinesterase; Animals; Avoidance Learning; Blood Glucose; Brain; Cholinesterase Inhibitors;

2014
Hypo-metabolism of the rostral anterior cingulate cortex associated with working memory impairment in 18 cases of schizophrenia.
    Brain imaging and behavior, 2016, Volume: 10, Issue:1

    Topics: Adult; Aging; Aspartic Acid; Creatine; Female; Gliosis; Gyrus Cinguli; Humans; Inositol; Intelligenc

2016
Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory.
    Pediatric diabetes, 2008, Volume: 9, Issue:6

    Topics: Animals; Brain Chemistry; Cerebral Cortex; Dendrites; Dendritic Spines; Diabetes Mellitus, Experimen

2008
Cognitive impairment: assessment with brain magnetic resonance imaging and proton magnetic resonance spectroscopy.
    The Journal of clinical psychiatry, 2003, Volume: 64, Issue:3

    Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition Disorders; Creati

2003
In vivo proton magnetic resonance spectroscopy of the temporal lobe in Alzheimer's disease.
    Progress in neuro-psychopharmacology & biological psychiatry, 2004, Volume: 28, Issue:8

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain Mapping; Case

2004
Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy.
    Neurobiology of aging, 2006, Volume: 27, Issue:7

    Topics: Aged; Amnesia; Aspartic Acid; Cerebral Cortex; Choline; Cognition Disorders; Creatine; Dementia; Dis

2006
Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers.
    Annals of neurology, 2006, Volume: 60, Issue:6

    Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Disease Models, Anim

2006
1H-MRS, MRI-based hippocampal volumetry, and 99mTc-HMPAO-SPECT in normal aging, age-associated memory impairment, and probable Alzheimer's disease.
    Journal of the American Geriatrics Society, 1996, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Case-Control Stud

1996