Page last updated: 2024-10-19

inositol and Acrania

inositol has been researched along with Acrania in 35 studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Research Excerpts

ExcerptRelevanceReference
"Although peri-conceptional folic acid (FA) supplementation can prevent a proportion of neural tube defects (NTD), there is increasing evidence that many NTD are FA non-responsive."9.22Inositol for the prevention of neural tube defects: a pilot randomised controlled trial. ( Burren, K; Chitty, LS; Copp, AJ; Gay, V; Greene, ND; Leung, KY; Mills, K, 2016)
" Maternal periconceptional supplementation with folic acid significantly reduces the risk of an NTD-affected pregnancy, but does not prevent all NTDs, and "folic acid non-responsive" NTDs continue to occur."8.95Inositol, neural tube closure and the prevention of neural tube defects. ( Copp, AJ; Greene, ND; Leung, KY, 2017)
"Although inositol dietary deficiency in the general population has not been demonstrated at the serum level, several findings are emerging regarding the impact of inositol supplementation in periconceptional period and in early phases of pregnancy."8.93Preventive and Therapeutic Role of Dietary Inositol Supplementation in Periconceptional Period and During Pregnancy: A Summary of Evidences and Future Applications. ( Abdulrahim, B; Borgato, S; Gizzo, S; Noventa, M; Quaranta, M; Vitagliano, A, 2016)
"Although up to 70% of neural tube defects (NTDs) can be prevented by adequate folate consumption, some NTDs are unrelated to folate, myo-inositol was found to reduce the incidence of spinal NTDs that are unrelated to folate in curly tail mice."8.79Inositol prevents expression of a genetic model of neural tube defects in mice. ( , 1997)
"Supplementation with myo-inositol during the periconceptional period of pregnancy may ameliorate the recurrence risk of having a fetus affected by a neural tube defect (NTD; e."8.02Maternal Inositol Status and Neural Tube Defects: A Role for the Human Yolk Sac in Embryonic Inositol Delivery? ( Copp, AJ; D'Souza, SW; Glazier, JD; Greene, NDE, 2021)
"Our study aims to demonstrate that the use in the preconceptional period until the 24th week of pregnancy of inositol and folic acid, first of all, preserves the product of conception from neural tube defects (NTDs) and then, thanks to inositol supplementation, it possibly counteracts and prevents the onset of maternal gestational diabetes (GDM)."7.85Prevention of neural tube defects and maternal gestational diabetes through the inositol supplementation: preliminary results. ( Allegretti, A; Benedetto, M; Capalbo, A; D'Apice, MR; Dell'Edera, D; Epifania, AA; Lupo, MG; Sarlo, F; Simone, F, 2017)
"Neural tube defects (NTDs) are classified as folate sensitive (about 70%) and folate resistant (about 30%); although folic acid is able to prevent the former, several data have shown that inositol may prevent the latter."7.78Myo-inositol soft gel capsules may prevent the risk of coffee-induced neural tube defects. ( Carlomagno, G; Cavalli, P; De Grazia, S; Unfer, V, 2012)
"Neural tube defects (NTDs), most commonly spina bifida and anencephaly, can be prevented with periconceptional intake of folic acid in about 70% of cases."7.77Effects of inositol supplementation in a cohort of mothers at risk of producing an NTD pregnancy. ( Cavalli, P; Grosso, E; Poggiani, C; Tonni, G, 2011)
"Among mouse genetic mutants that develop neural tube defects (NTDs), some respond to folic acid administration during early pregnancy, whereas NTDs in other mutants are not prevented."7.71D-chiro-inositol is more effective than myo-inositol in preventing folate-resistant mouse neural tube defects. ( Allan, G; Cogram, P; Copp, AJ; Greene, ND; Tesh, J; Tesh, S; Wade, A, 2002)
" The present experiment was designed to determine: 1) if hyperglycemia-induced membrane injury is associated with intracellular and/or extracellular lipid disturbances; 2) if supplemental myo-inositol therapy prevents hyperglycemia-induced embryopathy; 3) if a correlation exists between dietary myo-inositol, serum and tissue levels of myo-inositol, and conceptus development; and 4) the cellular content of arachidonic acid following myo-inositol supplementation."7.70Dietary myo-inositol therapy in hyperglycemia-induced embryopathy. ( Borenstein, M; Khandelwal, M; Reece, EA; Wu, YK, 1998)
" It has been reported that a substantial proportion of NTD in humans can be prevented by folic acid (FA) supplementation prior to conception and during the first months of pregnancy, and myo-inositol (MI) was shown to reduce the incidence of NTD in curly tail mice which are not prevented by FA."7.70Folic acid supplementation of pregnant mice suppresses heat-induced neural tube defects in the offspring. ( Shin, JH; Shiota, K, 1999)
"Clinical trials demonstrate that up to 70% of neural tube defects (NTDs) can be prevented by folic acid supplementation in early pregnancy, whereas the remaining NTDs are resistant to folate."7.69Inositol prevents folate-resistant neural tube defects in the mouse. ( Copp, AJ; Greene, ND, 1997)
" The current investigation was undertaken to assess the use of dietary myo-inositol supplementation as a pharmacologic prophylaxis to obviate the teratogenic effects of hyperglycemia in an in vivo study."7.69Dietary intake of myo-inositol and neural tube defects in offspring of diabetic rats. ( Borenstein, M; Khandelwal, M; Reece, EA; Wu, YK, 1997)
"Although peri-conceptional folic acid (FA) supplementation can prevent a proportion of neural tube defects (NTD), there is increasing evidence that many NTD are FA non-responsive."5.22Inositol for the prevention of neural tube defects: a pilot randomised controlled trial. ( Burren, K; Chitty, LS; Copp, AJ; Gay, V; Greene, ND; Leung, KY; Mills, K, 2016)
" Maternal periconceptional supplementation with folic acid significantly reduces the risk of an NTD-affected pregnancy, but does not prevent all NTDs, and "folic acid non-responsive" NTDs continue to occur."4.95Inositol, neural tube closure and the prevention of neural tube defects. ( Copp, AJ; Greene, ND; Leung, KY, 2017)
"Although inositol dietary deficiency in the general population has not been demonstrated at the serum level, several findings are emerging regarding the impact of inositol supplementation in periconceptional period and in early phases of pregnancy."4.93Preventive and Therapeutic Role of Dietary Inositol Supplementation in Periconceptional Period and During Pregnancy: A Summary of Evidences and Future Applications. ( Abdulrahim, B; Borgato, S; Gizzo, S; Noventa, M; Quaranta, M; Vitagliano, A, 2016)
"Neural tube defects can be prevented by folic acid, although the mechanism of this action is unclear."4.80Prevention of neural tube defects: vitamins, enzymes and genes. ( Copp, AJ, 1998)
"Although up to 70% of neural tube defects (NTDs) can be prevented by adequate folate consumption, some NTDs are unrelated to folate, myo-inositol was found to reduce the incidence of spinal NTDs that are unrelated to folate in curly tail mice."4.79Inositol prevents expression of a genetic model of neural tube defects in mice. ( , 1997)
"Inositol is closely related to the occurrence of neural tube defects (NTDs)."4.31Genetic Effects of ITPK1 Polymorphisms on the Risk of Neural Tube Defects: a Population-Based Study. ( Guan, Z; Li, S; Liang, Y; Wang, J; Wang, X; Yang, A; Zhu, Z, 2023)
"Supplementation with myo-inositol during the periconceptional period of pregnancy may ameliorate the recurrence risk of having a fetus affected by a neural tube defect (NTD; e."4.02Maternal Inositol Status and Neural Tube Defects: A Role for the Human Yolk Sac in Embryonic Inositol Delivery? ( Copp, AJ; D'Souza, SW; Glazier, JD; Greene, NDE, 2021)
"Our study aims to demonstrate that the use in the preconceptional period until the 24th week of pregnancy of inositol and folic acid, first of all, preserves the product of conception from neural tube defects (NTDs) and then, thanks to inositol supplementation, it possibly counteracts and prevents the onset of maternal gestational diabetes (GDM)."3.85Prevention of neural tube defects and maternal gestational diabetes through the inositol supplementation: preliminary results. ( Allegretti, A; Benedetto, M; Capalbo, A; D'Apice, MR; Dell'Edera, D; Epifania, AA; Lupo, MG; Sarlo, F; Simone, F, 2017)
"Myo-inositol (MI) deficiency is associated with an increased risk for neural tube defects (NTDs), mental disorders and metabolic diseases."3.83Quantification of plasma myo-inositol using gas chromatography-mass spectrometry. ( Guo, J; Niu, B; Shi, Y; Wang, J; Xu, C; Zhang, F; Zhang, T; Zhong, R, 2016)
"Neural tube defects (NTDs) are classified as folate sensitive (about 70%) and folate resistant (about 30%); although folic acid is able to prevent the former, several data have shown that inositol may prevent the latter."3.78Myo-inositol soft gel capsules may prevent the risk of coffee-induced neural tube defects. ( Carlomagno, G; Cavalli, P; De Grazia, S; Unfer, V, 2012)
"Neural tube defects (NTDs), most commonly spina bifida and anencephaly, can be prevented with periconceptional intake of folic acid in about 70% of cases."3.77Effects of inositol supplementation in a cohort of mothers at risk of producing an NTD pregnancy. ( Cavalli, P; Grosso, E; Poggiani, C; Tonni, G, 2011)
"Among mouse genetic mutants that develop neural tube defects (NTDs), some respond to folic acid administration during early pregnancy, whereas NTDs in other mutants are not prevented."3.71D-chiro-inositol is more effective than myo-inositol in preventing folate-resistant mouse neural tube defects. ( Allan, G; Cogram, P; Copp, AJ; Greene, ND; Tesh, J; Tesh, S; Wade, A, 2002)
" The present experiment was designed to determine: 1) if hyperglycemia-induced membrane injury is associated with intracellular and/or extracellular lipid disturbances; 2) if supplemental myo-inositol therapy prevents hyperglycemia-induced embryopathy; 3) if a correlation exists between dietary myo-inositol, serum and tissue levels of myo-inositol, and conceptus development; and 4) the cellular content of arachidonic acid following myo-inositol supplementation."3.70Dietary myo-inositol therapy in hyperglycemia-induced embryopathy. ( Borenstein, M; Khandelwal, M; Reece, EA; Wu, YK, 1998)
" It has been reported that a substantial proportion of NTD in humans can be prevented by folic acid (FA) supplementation prior to conception and during the first months of pregnancy, and myo-inositol (MI) was shown to reduce the incidence of NTD in curly tail mice which are not prevented by FA."3.70Folic acid supplementation of pregnant mice suppresses heat-induced neural tube defects in the offspring. ( Shin, JH; Shiota, K, 1999)
"Clinical trials demonstrate that up to 70% of neural tube defects (NTDs) can be prevented by folic acid supplementation in early pregnancy, whereas the remaining NTDs are resistant to folate."3.69Inositol prevents folate-resistant neural tube defects in the mouse. ( Copp, AJ; Greene, ND, 1997)
" The current investigation was undertaken to assess the use of dietary myo-inositol supplementation as a pharmacologic prophylaxis to obviate the teratogenic effects of hyperglycemia in an in vivo study."3.69Dietary intake of myo-inositol and neural tube defects in offspring of diabetic rats. ( Borenstein, M; Khandelwal, M; Reece, EA; Wu, YK, 1997)
"Mutants that have only exencephaly are fourfold more frequent than those that have spina bifida aperta with or without exencephaly."2.46An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure. ( Harris, MJ; Juriloff, DM, 2010)
"Valproic acid (VPA) is an anticonvulsant drug that is widely used therapeutically for a variety of neurological conditions."1.33Myo-inositol enhances teratogenicity of valproic acid in the mouse. ( Finnell, RH; Giavini, E; Massa, V; Wlodarczyk, B, 2006)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (28.57)18.2507
2000's9 (25.71)29.6817
2010's12 (34.29)24.3611
2020's4 (11.43)2.80

Authors

AuthorsStudies
Guan, Z3
Liang, Y1
Zhu, Z1
Yang, A1
Li, S2
Wang, X3
Wang, J4
D'Souza, SW1
Copp, AJ11
Greene, NDE2
Glazier, JD1
Facchinetti, F1
Cavalli, P5
D'Anna, R1
Kandaraki, E1
Unfer, V2
Luo, D1
Yue, H1
Lyu, J1
Yang, Y1
Gao, T1
Liu, Y1
Qin, J1
Wang, F2
Zhang, F2
Niu, B3
Zhang, T3
Zhong, R2
Guo, J3
Dell'Edera, D1
Sarlo, F1
Allegretti, A1
Epifania, AA1
Simone, F1
Lupo, MG1
Benedetto, M1
D'Apice, MR1
Capalbo, A1
Li, G1
Xie, Q1
Han, X1
Noventa, M1
Vitagliano, A1
Quaranta, M1
Borgato, S1
Abdulrahim, B1
Gizzo, S1
Greene, ND6
Leung, KY2
Gay, V1
Burren, K1
Mills, K1
Chitty, LS1
Shi, Y1
Xu, C1
Burren, KA1
Scott, JM1
Majerus, PW1
Wilson, DB1
Zhang, C1
Nicholas, PJ1
Wilson, MP1
Harris, MJ1
Juriloff, DM1
Tonni, G1
Grosso, E1
Poggiani, C1
De Grazia, S1
Carlomagno, G1
Benvenga, S1
Cogram, P2
Tesh, S1
Tesh, J1
Wade, A1
Allan, G1
Ting, SB1
Wilanowski, T1
Auden, A1
Hall, M1
Voss, AK1
Thomas, T1
Parekh, V1
Cunningham, JM1
Jane, SM1
Hynes, A1
Dunlevy, LP1
Franke, B1
Klootwijk, R1
Lemmers, B1
de Kovel, CG1
Steegers-Theunissen, RP1
Mariman, EC1
Shaw, GM1
Carmichael, SL1
Yang, W1
Schaffer, DM1
Massa, V1
Wlodarczyk, B1
Giavini, E1
Finnell, RH1
Tedoldi, S1
Riboli, B1
Shaw, G1
Hall, JG1
Reece, EA2
Khandelwal, M2
Wu, YK2
Borenstein, M2
Corcoran, J1
Shin, JH1
Shiota, K1
Cockroft, DL1
Brook, FA1
Baker, L1
Piddington, R1
Goldman, A1
Egler, J1
Moehring, J1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Myoinositol on Serum Asprosin Levels in Pregnant Women[NCT05943158]40 participants (Actual)Interventional2021-06-01Completed
"Influence of Espresso on Adsorption of Orally Administrated Myo-inositol in Humans"[NCT01244399]12 participants (Actual)Observational2010-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for inositol and Acrania

ArticleYear
An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs).
    Expert opinion on drug metabolism & toxicology, 2020, Volume: 16, Issue:12

    Topics: Animals; Diabetes, Gestational; Female; Humans; Infant, Newborn; Inositol; Insulin; Neural Tube Defe

2020
Preventive and Therapeutic Role of Dietary Inositol Supplementation in Periconceptional Period and During Pregnancy: A Summary of Evidences and Future Applications.
    Reproductive sciences (Thousand Oaks, Calif.), 2016, Volume: 23, Issue:3

    Topics: Animals; Dietary Supplements; Female; Folic Acid; Humans; Inositol; Neural Tube Defects; Preconcepti

2016
Inositol, neural tube closure and the prevention of neural tube defects.
    Birth defects research, 2017, 01-30, Volume: 109, Issue:2

    Topics: Animals; Clinical Trials as Topic; Dietary Supplements; Disease Models, Animal; Female; Folic Acid;

2017
An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure.
    Birth defects research. Part A, Clinical and molecular teratology, 2010, Volume: 88, Issue:8

    Topics: Animals; Ciliary Motility Disorders; Disease Models, Animal; Epigenomics; Female; Folic Acid; Humans

2010
Inositol prevents expression of a genetic model of neural tube defects in mice.
    Nutrition reviews, 1997, Volume: 55, Issue:5

    Topics: Animals; Gene Expression; Inositol; Mice; Mice, Neurologic Mutants; Neural Tube Defects

1997
What are the molecular mechanisms of neural tube defects?
    BioEssays : news and reviews in molecular, cellular and developmental biology, 1998, Volume: 20, Issue:1

    Topics: Animals; Disease Models, Animal; Drug Resistance; Female; Folic Acid; Humans; Inositol; Mice; Mice,

1998
Prevention of neural tube defects: vitamins, enzymes and genes.
    Current opinion in neurology, 1998, Volume: 11, Issue:2

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cystathionine beta-Synthase; Fem

1998

Trials

1 trial available for inositol and Acrania

ArticleYear
Inositol for the prevention of neural tube defects: a pilot randomised controlled trial.
    The British journal of nutrition, 2016, Mar-28, Volume: 115, Issue:6

    Topics: Adult; Cohort Studies; Dietary Supplements; Double-Blind Method; Feasibility Studies; Female; Folic

2016

Other Studies

27 other studies available for inositol and Acrania

ArticleYear
Genetic Effects of ITPK1 Polymorphisms on the Risk of Neural Tube Defects: a Population-Based Study.
    Reproductive sciences (Thousand Oaks, Calif.), 2023, Volume: 30, Issue:5

    Topics: Case-Control Studies; Female; Genotype; Humans; Inositol; Neural Tube Defects; Polymorphism, Single

2023
Maternal Inositol Status and Neural Tube Defects: A Role for the Human Yolk Sac in Embryonic Inositol Delivery?
    Advances in nutrition (Bethesda, Md.), 2021, 02-01, Volume: 12, Issue:1

    Topics: Female; Folic Acid; Humans; Inositol; Neural Tube Defects; Pregnancy; Spinal Dysraphism; Yolk Sac

2021
Neural tube defects: role of lithium carbonate exposure in embryonic neural development in a murine model.
    Pediatric research, 2021, Volume: 90, Issue:1

    Topics: 5'-Nucleotidase; Animals; Central Nervous System; Disease Models, Animal; Female; Glycogen Synthase

2021
Prevention of neural tube defects and maternal gestational diabetes through the inositol supplementation: preliminary results.
    European review for medical and pharmacological sciences, 2017, Volume: 21, Issue:14

    Topics: Adult; Diabetes, Gestational; Dietary Supplements; Female; Glucose Tolerance Test; Glycated Hemoglob

2017
The maternal ITPK1 gene polymorphism is associated with neural tube defects in a high-risk Chinese population.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Adult; Asian People; Case-Control Studies; China; Female; Genotype; Humans; Inositol; Inositol Phosp

2014
Quantification of plasma myo-inositol using gas chromatography-mass spectrometry.
    Clinica chimica acta; international journal of clinical chemistry, 2016, Sep-01, Volume: 460

    Topics: Anencephaly; Female; Gas Chromatography-Mass Spectrometry; Humans; Inositol; Male; Mass Screening; N

2016
The genetic background of the curly tail strain confers susceptibility to folate-deficiency-induced exencephaly.
    Birth defects research. Part A, Clinical and molecular teratology, 2010, Volume: 88, Issue:2

    Topics: Animals; Diet; DNA-Binding Proteins; Female; Folic Acid; Folic Acid Deficiency; Genetic Predispositi

2010
Expression of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) and its role in neural tube defects.
    Advances in enzyme regulation, 2010, Volume: 50, Issue:1

    Topics: Animals; Embryo, Mammalian; Humans; Inositol; Inositol Phosphates; Mice; Mice, Knockout; Molecular S

2010
Effects of inositol supplementation in a cohort of mothers at risk of producing an NTD pregnancy.
    Birth defects research. Part A, Clinical and molecular teratology, 2011, Volume: 91, Issue:11

    Topics: Adult; Cohort Studies; Dietary Supplements; Female; Folic Acid; Heterozygote; Humans; Infant, Newbor

2011
Myo-inositol soft gel capsules may prevent the risk of coffee-induced neural tube defects.
    Expert opinion on drug delivery, 2012, Volume: 9, Issue:9

    Topics: Adult; Biological Availability; Capsules; Coffee; Female; Gelatin; Gels; Humans; Inositol; Intestina

2012
(Soft) capsules of wisdom: preventing myo-inositol malabsorption caused by coffee.
    Expert opinion on drug delivery, 2012, Volume: 9, Issue:10

    Topics: Biological Availability; Capsules; Coffee; Female; Gelatin; Gels; Humans; Hypothyroidism; Inositol;

2012
D-chiro-inositol is more effective than myo-inositol in preventing folate-resistant mouse neural tube defects.
    Human reproduction (Oxford, England), 2002, Volume: 17, Issue:9

    Topics: Administration, Oral; Animals; Drug Resistance; Embryonic and Fetal Development; Female; Folic Acid;

2002
Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3.
    Nature medicine, 2003, Volume: 9, Issue:12

    Topics: Animals; DNA-Binding Proteins; Drug Resistance; Epithelium; Female; Folic Acid; Humans; Inositol; Mi

2003
Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol.
    Human molecular genetics, 2004, Jan-01, Volume: 13, Issue:1

    Topics: Animals; Blotting, Western; Disease Models, Animal; Embryo, Mammalian; Gene Expression Regulation, E

2004
Phenotype of the neural tube defect mouse model bent tail is not sensitive to maternal folinic acid, myo-inositol, or zinc supplementation.
    Birth defects research. Part A, Clinical and molecular teratology, 2003, Volume: 67, Issue:12

    Topics: Animals; Diet; Disease Models, Animal; DNA; Embryo Loss; Female; Genotype; Inositol; Leucovorin; Lit

2003
Periconceptional dietary intake of myo-inositol and neural tube defects in offspring.
    Birth defects research. Part A, Clinical and molecular teratology, 2005, Volume: 73, Issue:3

    Topics: Female; Humans; Inositol; Maternal Exposure; Neural Tube Defects; Pregnancy; Prenatal Exposure Delay

2005
Myo-inositol enhances teratogenicity of valproic acid in the mouse.
    Birth defects research. Part A, Clinical and molecular teratology, 2006, Volume: 76, Issue:3

    Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Anticonvulsants; Drug Synergism; Embryo

2006
Inositol supplementation in pregnancies at risk of apparently folate-resistant NTDs.
    Birth defects research. Part A, Clinical and molecular teratology, 2008, Volume: 82, Issue:7

    Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adult; Cystathionine beta-Synthase; Drug Resistanc

2008
Comments on inositol supplementation in pregnancies at risk of apparently folate-resistant NTDs.
    Birth defects research. Part A, Clinical and molecular teratology, 2008, Volume: 82, Issue:7

    Topics: Drug Resistance; Female; Folic Acid; Humans; Infant, Newborn; Inositol; Neural Tube Defects; Pregnan

2008
Give the embryo a chance.
    Nature medicine, 1997, Volume: 3, Issue:1

    Topics: Animals; Drug Administration Schedule; Embryo, Mammalian; Female; Fertilization; Folic Acid; Hematin

1997
Inositol prevents folate-resistant neural tube defects in the mouse.
    Nature medicine, 1997, Volume: 3, Issue:1

    Topics: Animals; Arachidonic Acid; Embryo, Mammalian; Female; Folic Acid; Gene Expression Regulation, Develo

1997
Dietary intake of myo-inositol and neural tube defects in offspring of diabetic rats.
    American journal of obstetrics and gynecology, 1997, Volume: 176, Issue:3

    Topics: Animals; Diabetes Mellitus, Experimental; Embryonic and Fetal Development; Female; Hyperglycemia; In

1997
Dietary myo-inositol therapy in hyperglycemia-induced embryopathy.
    Teratology, 1998, Volume: 57, Issue:2

    Topics: Animals; Arachidonic Acid; Blood Glucose; Diabetes Mellitus, Experimental; Embryo, Mammalian; Embryo

1998
Folic acid supplementation of pregnant mice suppresses heat-induced neural tube defects in the offspring.
    The Journal of nutrition, 1999, Volume: 129, Issue:11

    Topics: Analysis of Variance; Animals; Diet; Embryonic and Fetal Development; Female; Folic Acid; Hematinics

1999
Inositol and folate resistant neural tube defects.
    Journal of medical genetics, 2002, Volume: 39, Issue:2

    Topics: Adult; Female; Folic Acid; Humans; Inositol; Male; Neural Tube Defects; Pregnancy; Ultrasonography

2002
Inositol deficiency increases the susceptibility to neural tube defects of genetically predisposed (curly tail) mouse embryos in vitro.
    Teratology, 1992, Volume: 45, Issue:2

    Topics: Animals; Culture Media; Culture Techniques; Disease Susceptibility; Inositol; Mice; Mice, Inbred CBA

1992
Myo-inositol and prostaglandins reverse the glucose inhibition of neural tube fusion in cultured mouse embryos.
    Diabetologia, 1990, Volume: 33, Issue:10

    Topics: Animals; Dinoprostone; Embryo, Mammalian; Glucose; Indomethacin; Inositol; Mice; Mice, Inbred Strain

1990