inositol has been researched along with Acquired-Immune Deficiency Syndrome Dementia Complex in 21 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To demonstrate the technical feasibility and reliability of a multi-center study characterizing regional levels of the brain metabolite ratios choline (Cho)/creatine (Cr) and myoinositol (MI)/Cr, markers of glial cell activity, and N-acetyl aspartate (NAA)/Cr, a marker of mature neurons, in subjects with AIDS dementia complex (ADC)." | 5.10 | A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis. ( Chang, L; Ernst, T; Gonzalez, RG; Jarvik, JG; Ketonen, LM; Kolson, DL; Kwok, EW; Lee, PL; Lenkinski, RE; Marra, CM; Meyerhoff, DJ; Navia, BA; Richards, TL; Schifitto, G; Simpson, D; Tang, CY; Yiannoutsos, CT, 2003) |
| "Using MRSI, subjects with HIV dementia also had a decreased N-acetyl aspartate (NAA)/Cho ratio (1." | 1.33 | A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia. ( Barker, PB; Bobo, L; Chang, L; Ernst, T; Mao, X; Marder, K; Pomper, MG; Sacktor, N; Schifitto, G; Selnes, O; Shibata, D; Shungu, DC; Skolasky, RL; Zhong, K, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (23.81) | 18.2507 |
| 2000's | 13 (61.90) | 29.6817 |
| 2010's | 3 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gongvatana, A | 1 |
| Harezlak, J | 1 |
| Buchthal, S | 2 |
| Daar, E | 1 |
| Schifitto, G | 4 |
| Campbell, T | 1 |
| Taylor, M | 1 |
| Singer, E | 1 |
| Algers, J | 1 |
| Zhong, J | 1 |
| Brown, M | 1 |
| McMahon, D | 1 |
| So, YT | 1 |
| Mi, D | 1 |
| Heaton, R | 1 |
| Robertson, K | 1 |
| Yiannoutsos, C | 1 |
| Cohen, RA | 1 |
| Navia, B | 1 |
| Van Dalen, YW | 1 |
| Blokhuis, C | 1 |
| Cohen, S | 1 |
| Ter Stege, JA | 1 |
| Teunissen, CE | 1 |
| Kuhle, J | 1 |
| Kootstra, NA | 1 |
| Scherpbier, HJ | 1 |
| Kuijpers, TW | 1 |
| Reiss, P | 1 |
| Majoie, CBLM | 1 |
| Caan, MWA | 1 |
| Pajkrt, D | 1 |
| Winston, A | 1 |
| Duncombe, C | 1 |
| Li, PC | 1 |
| Gill, JM | 1 |
| Kerr, SJ | 1 |
| Puls, RL | 1 |
| Taylor-Robinson, SD | 1 |
| Emery, S | 1 |
| Cooper, DA | 1 |
| Chang, L | 8 |
| Ernst, T | 8 |
| Witt, MD | 1 |
| Ames, N | 1 |
| Gaiefsky, M | 1 |
| Miller, E | 1 |
| Lee, PL | 2 |
| Yiannoutsos, CT | 3 |
| Marra, CM | 2 |
| Jarvik, JG | 3 |
| Richards, TL | 1 |
| Kwok, EW | 1 |
| Kolson, DL | 1 |
| Simpson, D | 1 |
| Tang, CY | 1 |
| Ketonen, LM | 1 |
| Meyerhoff, DJ | 1 |
| Lenkinski, RE | 3 |
| Gonzalez, RG | 4 |
| Navia, BA | 3 |
| Arnold, S | 1 |
| Tarasów, E | 2 |
| Wiercińska-Drapało, A | 2 |
| Walecki, J | 2 |
| Prokopowicz, D | 2 |
| Fuller, RA | 1 |
| Westmoreland, SV | 3 |
| Ratai, E | 1 |
| Greco, JB | 2 |
| Kim, JP | 1 |
| Lentz, MR | 3 |
| He, J | 2 |
| Sehgal, PK | 2 |
| Masliah, E | 2 |
| Halpern, E | 1 |
| Lackner, AA | 2 |
| Ratai, EM | 2 |
| Sakaie, K | 1 |
| St Hillaire, C | 1 |
| Conant, K | 1 |
| Richards, T | 1 |
| Kolson, D | 1 |
| Miller, EN | 2 |
| Lenkinski, R | 1 |
| Gonzalez, G | 1 |
| Sacktor, N | 1 |
| Skolasky, RL | 1 |
| Mao, X | 1 |
| Selnes, O | 1 |
| Pomper, MG | 1 |
| Zhong, K | 1 |
| Shungu, DC | 1 |
| Marder, K | 1 |
| Shibata, D | 1 |
| Bobo, L | 1 |
| Barker, PB | 1 |
| Jaroszewicz, J | 1 |
| Orzechowska-Bobkiewicz, A | 1 |
| Dzienis, W | 1 |
| Nakas, CT | 1 |
| Lee, V | 1 |
| Halpern, EF | 1 |
| Miller, BL | 1 |
| McBride, D | 1 |
| Cornford, M | 1 |
| Oropilla, G | 1 |
| Chiang, F | 1 |
| Aronow, H | 1 |
| Beck, CK | 1 |
| Cortey, A | 1 |
| Grossman, RI | 1 |
| Frank, I | 2 |
| Delivoria-Papadopoulos, M | 1 |
| López-Villegas, D | 1 |
| Laubenberger, J | 1 |
| Bayer, S | 1 |
| Thiel, T | 1 |
| Hennig, J | 1 |
| Langer, M | 1 |
| Leonido-Yee, M | 1 |
| Witt, M | 1 |
| Speck, O | 1 |
| Walot, I | 1 |
| von Giesen, HJ | 1 |
| Wittsack, HJ | 1 |
| Wenserski, F | 1 |
| Köller, H | 1 |
| Hefter, H | 1 |
| Arendt, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Cognitive Rehabilitation Program to Promote Treatment Adherence for Individuals Who Are HIV Positive With Mild Neurocognitive Difficulties[NCT02392884] | 60 participants (Anticipated) | Interventional | 2014-09-30 | Recruiting | |||
| Adaptive Working Memory and Physical Exercise Training to Improve Brain and Mitochondrial Function in MCI[NCT05948930] | 90 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for inositol and Acquired-Immune Deficiency Syndrome Dementia Complex
| Article | Year |
|---|---|
A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis.
Topics: AIDS Dementia Complex; Analysis of Variance; Aspartic Acid; Brain; Choline; Creatine; Excitatory Ami | 2003 |
Antiretroviral treatment alters relationship between MCP-1 and neurometabolites in HIV patients.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Brain; Brain C | 2004 |
A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to age.
Topics: Adult; Age Factors; AIDS Dementia Complex; Anti-HIV Agents; Aspartic Acid; Basal Ganglia; Brain; Bra | 2004 |
18 other studies available for inositol and Acquired-Immune Deficiency Syndrome Dementia Complex
| Article | Year |
|---|---|
Progressive cerebral injury in the setting of chronic HIV infection and antiretroviral therapy.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Aspartic Acid; | 2013 |
Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children.
Topics: Adolescent; AIDS Dementia Complex; Aspartic Acid; Brain; CD4 Lymphocyte Count; Child; Choline; Cogni | 2016 |
Two patterns of cerebral metabolite abnormalities are detected on proton magnetic resonance spectroscopy in HIV-infected subjects commencing antiretroviral therapy.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Aspartic Acid; | 2012 |
Relationships among brain metabolites, cognitive function, and viral loads in antiretroviral-naïve HIV patients.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Basal Ganglia; Brain; CD4 Lymphocyte Count; Cerebral Co | 2002 |
Increased glial metabolites predict increased working memory network activation in HIV brain injury.
Topics: Adult; AIDS Dementia Complex; Attention; Basal Ganglia; Brain Mapping; Choline; Creatine; Frontal Lo | 2003 |
[CNS changes in HIV-infected patients: magnetic resonance spectroscopy].
Topics: AIDS Dementia Complex; Brain; Choline; Demyelinating Diseases; HIV Seropositivity; Humans; Inositol; | 2003 |
A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDS.
Topics: Acute Disease; AIDS Dementia Complex; Animals; Aspartic Acid; Brain; Choline; Chronic Disease; Creat | 2004 |
In vivo 1H MRS of brain injury and repair during acute SIV infection in the macaque model of neuroAIDS.
Topics: Acute Disease; AIDS Dementia Complex; Animals; Aspartic Acid; Brain; Choline; Creatine; Female; Fron | 2004 |
A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia.
Topics: Adult; AIDS Dementia Complex; Brain Chemistry; Creatinine; Female; Humans; Inositol; Magnetic Resona | 2005 |
Antiretroviral therapy and its influence on the stage of brain damage in patients with HIV - 1H MRS evaluation.
Topics: Adult; AIDS Dementia Complex; Antiretroviral Therapy, Highly Active; Aspartic Acid; Brain; Choline; | 2004 |
Assessing multiple-group diagnostic problems with multi-dimensional receiver operating characteristic surfaces: application to proton MR Spectroscopy (MRS) in HIV-related neurological injury.
Topics: Adult; Aging; AIDS Dementia Complex; Algorithms; Aspartic Acid; Basal Ganglia; Brain; Brain Chemistr | 2008 |
Metabolic markers of neuronal injury correlate with SIV CNS disease severity and inoculum in the macaque model of neuroAIDS.
Topics: AIDS Dementia Complex; Analysis of Variance; Animals; Aspartic Acid; Choline; Creatine; Disease Mode | 2008 |
Brain lesions in patients with AIDS: H-1 MR spectroscopy.
Topics: Abscess; Adult; AIDS Dementia Complex; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Crea | 1995 |
Proton MR spectroscopy of brain abnormalities in neonates born to HIV-positive mothers.
Topics: AIDS Dementia Complex; Aspartic Acid; Choline; Diagnosis, Differential; Energy Metabolism; Female; F | 1994 |
Biochemical changes in the frontal lobe of HIV-infected individuals detected by magnetic resonance spectroscopy.
Topics: Adult; AIDS Dementia Complex; Brain Chemistry; Creatine; Female; Frontal Lobe; HIV Infections; HIV-1 | 1997 |
[Clinical uses of proton magnetic resonance spectroscopy of the brain].
Topics: AIDS Dementia Complex; Alzheimer Disease; Animals; Aspartic Acid; Brain; Brain Diseases; Brain Disea | 1998 |
Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Brain; Female; Humans; Inositol; Magnetic Resonance S | 1999 |
Basal ganglia metabolite abnormalities in minor motor disorders associated with human immunodeficiency virus type 1.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Basal Ganglia; Choline; Creatine; Electrophysiology; HI | 2001 |