inositol has been researched along with AIDS Dementia Complex in 21 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
AIDS Dementia Complex: A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To demonstrate the technical feasibility and reliability of a multi-center study characterizing regional levels of the brain metabolite ratios choline (Cho)/creatine (Cr) and myoinositol (MI)/Cr, markers of glial cell activity, and N-acetyl aspartate (NAA)/Cr, a marker of mature neurons, in subjects with AIDS dementia complex (ADC)." | 5.10 | A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis. ( Chang, L; Ernst, T; Gonzalez, RG; Jarvik, JG; Ketonen, LM; Kolson, DL; Kwok, EW; Lee, PL; Lenkinski, RE; Marra, CM; Meyerhoff, DJ; Navia, BA; Richards, TL; Schifitto, G; Simpson, D; Tang, CY; Yiannoutsos, CT, 2003) |
| "Using MRSI, subjects with HIV dementia also had a decreased N-acetyl aspartate (NAA)/Cho ratio (1." | 1.33 | A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia. ( Barker, PB; Bobo, L; Chang, L; Ernst, T; Mao, X; Marder, K; Pomper, MG; Sacktor, N; Schifitto, G; Selnes, O; Shibata, D; Shungu, DC; Skolasky, RL; Zhong, K, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (23.81) | 18.2507 |
| 2000's | 13 (61.90) | 29.6817 |
| 2010's | 3 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gongvatana, A | 1 |
| Harezlak, J | 1 |
| Buchthal, S | 2 |
| Daar, E | 1 |
| Schifitto, G | 4 |
| Campbell, T | 1 |
| Taylor, M | 1 |
| Singer, E | 1 |
| Algers, J | 1 |
| Zhong, J | 1 |
| Brown, M | 1 |
| McMahon, D | 1 |
| So, YT | 1 |
| Mi, D | 1 |
| Heaton, R | 1 |
| Robertson, K | 1 |
| Yiannoutsos, C | 1 |
| Cohen, RA | 1 |
| Navia, B | 1 |
| Van Dalen, YW | 1 |
| Blokhuis, C | 1 |
| Cohen, S | 1 |
| Ter Stege, JA | 1 |
| Teunissen, CE | 1 |
| Kuhle, J | 1 |
| Kootstra, NA | 1 |
| Scherpbier, HJ | 1 |
| Kuijpers, TW | 1 |
| Reiss, P | 1 |
| Majoie, CBLM | 1 |
| Caan, MWA | 1 |
| Pajkrt, D | 1 |
| Winston, A | 1 |
| Duncombe, C | 1 |
| Li, PC | 1 |
| Gill, JM | 1 |
| Kerr, SJ | 1 |
| Puls, RL | 1 |
| Taylor-Robinson, SD | 1 |
| Emery, S | 1 |
| Cooper, DA | 1 |
| Chang, L | 8 |
| Ernst, T | 8 |
| Witt, MD | 1 |
| Ames, N | 1 |
| Gaiefsky, M | 1 |
| Miller, E | 1 |
| Lee, PL | 2 |
| Yiannoutsos, CT | 3 |
| Marra, CM | 2 |
| Jarvik, JG | 3 |
| Richards, TL | 1 |
| Kwok, EW | 1 |
| Kolson, DL | 1 |
| Simpson, D | 1 |
| Tang, CY | 1 |
| Ketonen, LM | 1 |
| Meyerhoff, DJ | 1 |
| Lenkinski, RE | 3 |
| Gonzalez, RG | 4 |
| Navia, BA | 3 |
| Arnold, S | 1 |
| Tarasów, E | 2 |
| Wiercińska-Drapało, A | 2 |
| Walecki, J | 2 |
| Prokopowicz, D | 2 |
| Fuller, RA | 1 |
| Westmoreland, SV | 3 |
| Ratai, E | 1 |
| Greco, JB | 2 |
| Kim, JP | 1 |
| Lentz, MR | 3 |
| He, J | 2 |
| Sehgal, PK | 2 |
| Masliah, E | 2 |
| Halpern, E | 1 |
| Lackner, AA | 2 |
| Ratai, EM | 2 |
| Sakaie, K | 1 |
| St Hillaire, C | 1 |
| Conant, K | 1 |
| Richards, T | 1 |
| Kolson, D | 1 |
| Miller, EN | 2 |
| Lenkinski, R | 1 |
| Gonzalez, G | 1 |
| Sacktor, N | 1 |
| Skolasky, RL | 1 |
| Mao, X | 1 |
| Selnes, O | 1 |
| Pomper, MG | 1 |
| Zhong, K | 1 |
| Shungu, DC | 1 |
| Marder, K | 1 |
| Shibata, D | 1 |
| Bobo, L | 1 |
| Barker, PB | 1 |
| Jaroszewicz, J | 1 |
| Orzechowska-Bobkiewicz, A | 1 |
| Dzienis, W | 1 |
| Nakas, CT | 1 |
| Lee, V | 1 |
| Halpern, EF | 1 |
| Miller, BL | 1 |
| McBride, D | 1 |
| Cornford, M | 1 |
| Oropilla, G | 1 |
| Chiang, F | 1 |
| Aronow, H | 1 |
| Beck, CK | 1 |
| Cortey, A | 1 |
| Grossman, RI | 1 |
| Frank, I | 2 |
| Delivoria-Papadopoulos, M | 1 |
| López-Villegas, D | 1 |
| Laubenberger, J | 1 |
| Bayer, S | 1 |
| Thiel, T | 1 |
| Hennig, J | 1 |
| Langer, M | 1 |
| Leonido-Yee, M | 1 |
| Witt, M | 1 |
| Speck, O | 1 |
| Walot, I | 1 |
| von Giesen, HJ | 1 |
| Wittsack, HJ | 1 |
| Wenserski, F | 1 |
| Köller, H | 1 |
| Hefter, H | 1 |
| Arendt, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Cognitive Rehabilitation Program to Promote Treatment Adherence for Individuals Who Are HIV Positive With Mild Neurocognitive Difficulties[NCT02392884] | 60 participants (Anticipated) | Interventional | 2014-09-30 | Recruiting | |||
| Adaptive Working Memory and Physical Exercise Training to Improve Brain and Mitochondrial Function in MCI[NCT05948930] | 90 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for inositol and AIDS Dementia Complex
| Article | Year |
|---|---|
A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis.
Topics: AIDS Dementia Complex; Analysis of Variance; Aspartic Acid; Brain; Choline; Creatine; Excitatory Ami | 2003 |
Antiretroviral treatment alters relationship between MCP-1 and neurometabolites in HIV patients.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Brain; Brain C | 2004 |
A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to age.
Topics: Adult; Age Factors; AIDS Dementia Complex; Anti-HIV Agents; Aspartic Acid; Basal Ganglia; Brain; Bra | 2004 |
18 other studies available for inositol and AIDS Dementia Complex
| Article | Year |
|---|---|
Progressive cerebral injury in the setting of chronic HIV infection and antiretroviral therapy.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Aspartic Acid; | 2013 |
Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children.
Topics: Adolescent; AIDS Dementia Complex; Aspartic Acid; Brain; CD4 Lymphocyte Count; Child; Choline; Cogni | 2016 |
Two patterns of cerebral metabolite abnormalities are detected on proton magnetic resonance spectroscopy in HIV-infected subjects commencing antiretroviral therapy.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Aspartic Acid; | 2012 |
Relationships among brain metabolites, cognitive function, and viral loads in antiretroviral-naïve HIV patients.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Basal Ganglia; Brain; CD4 Lymphocyte Count; Cerebral Co | 2002 |
Increased glial metabolites predict increased working memory network activation in HIV brain injury.
Topics: Adult; AIDS Dementia Complex; Attention; Basal Ganglia; Brain Mapping; Choline; Creatine; Frontal Lo | 2003 |
[CNS changes in HIV-infected patients: magnetic resonance spectroscopy].
Topics: AIDS Dementia Complex; Brain; Choline; Demyelinating Diseases; HIV Seropositivity; Humans; Inositol; | 2003 |
A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDS.
Topics: Acute Disease; AIDS Dementia Complex; Animals; Aspartic Acid; Brain; Choline; Chronic Disease; Creat | 2004 |
In vivo 1H MRS of brain injury and repair during acute SIV infection in the macaque model of neuroAIDS.
Topics: Acute Disease; AIDS Dementia Complex; Animals; Aspartic Acid; Brain; Choline; Creatine; Female; Fron | 2004 |
A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia.
Topics: Adult; AIDS Dementia Complex; Brain Chemistry; Creatinine; Female; Humans; Inositol; Magnetic Resona | 2005 |
Antiretroviral therapy and its influence on the stage of brain damage in patients with HIV - 1H MRS evaluation.
Topics: Adult; AIDS Dementia Complex; Antiretroviral Therapy, Highly Active; Aspartic Acid; Brain; Choline; | 2004 |
Assessing multiple-group diagnostic problems with multi-dimensional receiver operating characteristic surfaces: application to proton MR Spectroscopy (MRS) in HIV-related neurological injury.
Topics: Adult; Aging; AIDS Dementia Complex; Algorithms; Aspartic Acid; Basal Ganglia; Brain; Brain Chemistr | 2008 |
Metabolic markers of neuronal injury correlate with SIV CNS disease severity and inoculum in the macaque model of neuroAIDS.
Topics: AIDS Dementia Complex; Analysis of Variance; Animals; Aspartic Acid; Choline; Creatine; Disease Mode | 2008 |
Brain lesions in patients with AIDS: H-1 MR spectroscopy.
Topics: Abscess; Adult; AIDS Dementia Complex; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Crea | 1995 |
Proton MR spectroscopy of brain abnormalities in neonates born to HIV-positive mothers.
Topics: AIDS Dementia Complex; Aspartic Acid; Choline; Diagnosis, Differential; Energy Metabolism; Female; F | 1994 |
Biochemical changes in the frontal lobe of HIV-infected individuals detected by magnetic resonance spectroscopy.
Topics: Adult; AIDS Dementia Complex; Brain Chemistry; Creatine; Female; Frontal Lobe; HIV Infections; HIV-1 | 1997 |
[Clinical uses of proton magnetic resonance spectroscopy of the brain].
Topics: AIDS Dementia Complex; Alzheimer Disease; Animals; Aspartic Acid; Brain; Brain Diseases; Brain Disea | 1998 |
Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Brain; Female; Humans; Inositol; Magnetic Resonance S | 1999 |
Basal ganglia metabolite abnormalities in minor motor disorders associated with human immunodeficiency virus type 1.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Basal Ganglia; Choline; Creatine; Electrophysiology; HI | 2001 |