Page last updated: 2024-10-19

inositol and ADDH

inositol has been researched along with ADDH in 11 studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Research Excerpts

ExcerptRelevanceReference
"The authors' goal was to investigate phosphatidylinositol and glutamatergic metabolism in the anterior cingulate cortex of children and adolescents with attention deficit hyperactivity disorder (ADHD) alone, children with ADHD plus bipolar disorder, and children with no axis I diagnosis."3.73Differences in brain chemistry in children and adolescents with attention deficit hyperactivity disorder with and without comorbid bipolar disorder: a proton magnetic resonance spectroscopy study. ( Aleardi, M; Biederman, J; Dougherty, M; Hammerness, P; Harpold, T; Mick, E; Moore, CM; Randall, E; Renshaw, PF; Wardrop, M; Wozniak, J, 2006)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (54.55)29.6817
2010's5 (45.45)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dickstein, DP2
Towbin, KE2
Van Der Veen, JW2
Rich, BA1
Brotman, MA1
Knopf, L2
Onelio, L1
Pine, DS2
Leibenluft, E2
Ferreira, PE1
Palmini, A1
Bau, CH1
Grevet, EH1
Hoefel, JR1
Rohde, LA1
Anés, M1
Ferreira, EE1
Belmonte-de-Abreu, P1
Rüsch, N1
Boeker, M1
Büchert, M1
Glauche, V1
Bohrmann, C1
Ebert, D2
Lieb, K1
Hennig, J2
Tebartz Van Elst, L2
Parikh, SV1
LeBlanc, SR1
Ovanessian, MM1
Jain, M1
Vélez, JI2
Acosta, MT2
Palacio, LG1
Balog, J1
Roessler, E1
Pineda, D1
Londoño, AC2
Palacio, JD2
Arbelaez, A2
Lopera, F2
Elia, J1
Hakonarson, H1
Seitz, C1
Freitag, CM1
Palmason, H1
Meyer, J1
Romanos, M1
Walitza, S1
Hemminger, U1
Warnke, A1
Romanos, J1
Renner, T1
Jacob, C1
Lesch, KP1
Swanson, J1
Castellanos, FX2
Bailey-Wilson, JE1
Arcos-Burgos, M2
Muenke, M2
Pineda, DA1
Tafazoli, S1
O'Neill, J1
Bejjani, A1
Ly, R1
Salamon, N1
McCracken, JT1
Alger, JR1
Levitt, JG1
Moore, CM1
Biederman, J1
Wozniak, J1
Mick, E1
Aleardi, M1
Wardrop, M1
Dougherty, M1
Harpold, T1
Hammerness, P1
Randall, E1
Renshaw, PF1
Perlov, E1
Philipsen, A1
Hesslinger, B1
Buechert, M1
Ahrendts, J1
Feige, B1
Bubl, E1
Carrey, NJ1
MacMaster, FP1
Gaudet, L1
Schmidt, MH1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
1/2-MC4R Genotype and Pediatric Antipsychotic Drug- Induced Weight Gain[NCT01844700]Phase 414 participants (Actual)Interventional2013-07-31Terminated (stopped due to very slow recruitment, no sufficient results)
Measuring Glutamate and GABA Brain Levels in Adults With Attention Deficit Hyperactivity Disorder (ADHD) Using Magnetic Resonance Spectroscopy (MRS)[NCT04823364]60 participants (Anticipated)Interventional2022-10-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Percent Weight Change Compared to Baseline Weight

(NCT01844700)
Timeframe: baseline to week 12

Interventionpercentage of weight change (Mean)
Ziprasidone11.58
Aripiprazole, Quetiapine, Risperidone5.66

BMI Percentile

(NCT01844700)
Timeframe: baseline to week 12

,
InterventionBMI percentile (Mean)
baselineweek 12 (n=1, n=2)
Aripiprazole, Quetiapine, Risperidone37.6762.5
Ziprasidone3259

BMI Z-scores

(NCT01844700)
Timeframe: baseline to week 12

,
InterventionBMI z-score (Mean)
baselineweek 12 (n=1, n=2)
Aripiprazole, Quetiapine, Risperidone-0.370.38
Ziprasidone-0.510.22

Weight Change

(NCT01844700)
Timeframe: baseline to week 12

,
Interventionlbs (Mean)
baselineweek 12 (n=1,2)
Aripiprazole, Quetiapine, Risperidone118.5141
Ziprasidone120.5151

Trials

2 trials available for inositol and ADDH

ArticleYear
Randomized double-blind placebo-controlled trial of lithium in youths with severe mood dysregulation.
    Journal of child and adolescent psychopharmacology, 2009, Volume: 19, Issue:1

    Topics: Adolescent; Antimanic Agents; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Bipolar

2009
Proton magnetic resonance spectroscopy in youth with severe mood dysregulation.
    Psychiatry research, 2008, May-30, Volume: 163, Issue:1

    Topics: Antimanic Agents; Arousal; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Bipolar Dis

2008

Other Studies

9 other studies available for inositol and ADDH

ArticleYear
Differentiating attention-deficit/hyperactivity disorder inattentive and combined types: a (1)H-magnetic resonance spectroscopy study of fronto-striato-thalamic regions.
    Journal of neural transmission (Vienna, Austria : 1996), 2009, Volume: 116, Issue:5

    Topics: Adolescent; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Choline; Corpus Striatum;

2009
Neurochemical alterations in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder.
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2010, Volume: 11, Issue:2 Pt 2

    Topics: Adult; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Borderline Personality Disorder

2010
Advancing bipolar disorder: key lessons from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD).
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2010, Volume: 55, Issue:3

    Topics: Anticonvulsants; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Anxiety Disorders;

2010
A cooperative interaction between LPHN3 and 11q doubles the risk for ADHD.
    Molecular psychiatry, 2012, Volume: 17, Issue:7

    Topics: Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Brain; Case-Control Studies; Choline;

2012
Analysis of brain metabolism by proton magnetic resonance spectroscopy (1H-MRS) in attention-deficit/hyperactivity disorder suggests a generalized differential ontogenic pattern from controls.
    Attention deficit and hyperactivity disorders, 2012, Volume: 4, Issue:4

    Topics: Adolescent; Adult; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Brain; Case-Control

2012
1H MRSI of middle frontal gyrus in pediatric ADHD.
    Journal of psychiatric research, 2013, Volume: 47, Issue:4

    Topics: Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Child; Choline; Creatine; Femal

2013
Differences in brain chemistry in children and adolescents with attention deficit hyperactivity disorder with and without comorbid bipolar disorder: a proton magnetic resonance spectroscopy study.
    The American journal of psychiatry, 2006, Volume: 163, Issue:2

    Topics: Adolescent; Age Factors; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Brain Chem

2006
Reduced cingulate glutamate/glutamine-to-creatine ratios in adult patients with attention deficit/hyperactivity disorder -- a magnet resonance spectroscopy study.
    Journal of psychiatric research, 2007, Volume: 41, Issue:11

    Topics: Adult; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Choline; Creatine; Dominance, C

2007
Striatal creatine and glutamate/glutamine in attention-deficit/hyperactivity disorder.
    Journal of child and adolescent psychopharmacology, 2007, Volume: 17, Issue:1

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Choline; Co

2007