Compounds > inositol-1-4-5-trisphosphate

inositol-1-4-5-trisphosphate and Vascular-Diseases

inositol-1-4-5-trisphosphate has been researched along with Vascular-Diseases* in 1 studies

Other Studies

1 other study(ies) available for inositol-1-4-5-trisphosphate and Vascular-Diseases

Article	Year
Effect of angiotensin II and thromboxane A2 on the production of matrix metalloproteinase by human aortic smooth muscle cells. Biochemistry and molecular biology international, 1995, Volume: 35, Issue:2 Angiotensin II (AGII) and thromboxane A2 (TXA2), potent vasoconstrictors, augmented the production of the precursor of tissue procollagenase/promatrixmetalloproteinase-1 (proMMP-1) and DNA synthesis in cultured human aortic smooth muscle cells (SMC) significantly compared with that in untreated SMC. Moreover, AGII and TXA2 stimulated hydrolysis of phosphoinositides and subsequent formation of inositol triphosphate (IP3), leading to an increase in the intracellular free Ca2+ concentration. These results suggest that the production of proMMP-1 increased by AGII and TXA2 in intimal SMC in relation to cell proliferation plays a role in arterial reconstruction in vascular diseases. Topics: Angiotensin II; Aorta, Thoracic; Calcium; Cell Division; Cells, Cultured; Collagenases; DNA; Enzyme Precursors; Humans; Inositol 1,4,5-Trisphosphate; Kinetics; Matrix Metalloproteinase 1; Muscle, Smooth, Vascular; Thromboxane A2; Thymidine; Vascular Diseases	1995

Article

Year

Effect of angiotensin II and thromboxane A2 on the production of matrix metalloproteinase by human aortic smooth muscle cells.

Biochemistry and molecular biology international, 1995, Volume: 35, Issue:2

Angiotensin II (AGII) and thromboxane A2 (TXA2), potent vasoconstrictors, augmented the production of the precursor of tissue procollagenase/promatrixmetalloproteinase-1 (proMMP-1) and DNA synthesis in cultured human aortic smooth muscle cells (SMC) significantly compared with that in untreated SMC. Moreover, AGII and TXA2 stimulated hydrolysis of phosphoinositides and subsequent formation of inositol triphosphate (IP3), leading to an increase in the intracellular free Ca2+ concentration. These results suggest that the production of proMMP-1 increased by AGII and TXA2 in intimal SMC in relation to cell proliferation plays a role in arterial reconstruction in vascular diseases.

Topics: Angiotensin II; Aorta, Thoracic; Calcium; Cell Division; Cells, Cultured; Collagenases; DNA; Enzyme Precursors; Humans; Inositol 1,4,5-Trisphosphate; Kinetics; Matrix Metalloproteinase 1; Muscle, Smooth, Vascular; Thromboxane A2; Thymidine; Vascular Diseases

1995