inositol-1-4-5-trisphosphate has been researched along with Neuroectodermal-Tumors--Primitive--Peripheral* in 1 studies
1 other study(ies) available for inositol-1-4-5-trisphosphate and Neuroectodermal-Tumors--Primitive--Peripheral
| Article | Year |
|---|---|
Signalling pathways involved in the chemotactic activity of CXCL12 in cultured rat cerebellar neurons and CHP100 neuroepithelioma cells.
We compared the signal transduction pathways activated by stromal cell-derived factor-1 (CXCL12) chemokine in two different cell systems: primary cultures of rat cerebellar granule neurons (CGN) and human neuroepithelioma CHP100 cells. Both cell types express functional CXC chemokine receptor 4 (CXCR4), which is coupled both to extracellular signal-regulated kinase (ERK) and Akt phosphorylation pathways. The activation of ERK shows different dependency on the phosphatidylinositol 3-kinase (PI3-K) pathway and different sensitivity to pertussis toxin (PTX) treatment, indicative of coupling to different G proteins in the two cell systems considered. We demonstrate that the inhibition of either the ERK kinase or the PI3-K pathways blocks the CXCL12 induced-chemotaxis in CHP100 cells; while only PI3-K activity is stringently necessary for CGN migration. Topics: Animals; Cell Movement; Cells, Cultured; Cerebellum; Chemokine CXCL12; Chemokines, CXC; Chemotactic Factors; Inositol 1,4,5-Trisphosphate; Mitogen-Activated Protein Kinases; Neuroectodermal Tumors, Primitive, Peripheral; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction | 2003 |